Mitochondria and Cancer.

Recent insights into the function of autophagy in cancer. Genes Dev (2016) 0.86

Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells. Genes Dev (2016) 0.84

The transcriptional regulator of the chaperone response HSF1 controls hepatic bioenergetics and protein homeostasis. J Cell Biol (2017) 0.81

A neuronal network of mitochondrial dynamics regulates metastasis. Nat Commun (2016) 0.79

Mitochondrial dynamics as regulators of cancer biology. Cell Mol Life Sci (2017) 0.79

Mitochondria play an important role in the cell proliferation suppressing activity of berberine. Sci Rep (2017) 0.79

ATP/ADP Turnover and Import of Glycolytic ATP into Mitochondria in Cancer Cells Is Independent of the Adenine Nucleotide Translocator. J Biol Chem (2016) 0.78

Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications. Chem Rev (2017) 0.76

Mitochondrial respiratory gene expression is suppressed in many cancers. Elife (2017) 0.76

Expanding perspectives on the significance of mitophagy in cancer. Semin Cancer Biol (2017) 0.76

Sesamol Induces Human Hepatocellular Carcinoma Cells Apoptosis by Impairing Mitochondrial Function and Suppressing Autophagy. Sci Rep (2017) 0.75

Systems biology analysis of drivers underlying hallmarks of cancer cell metabolism. Sci Rep (2017) 0.75

Cryptolepine inhibits melanoma cell growth through coordinated changes in mitochondrial biogenesis, dynamics and metabolic tumor suppressor AMPKα1/2-LKB1. Sci Rep (2017) 0.75

Antioxidant Activity during Tumor Progression: A Necessity for the Survival of Cancer Cells? Cancers (Basel) (2016) 0.75

Tubeimoside-1 induces oxidative stress-mediated apoptosis and G0/G1 phase arrest in human prostate carcinoma cells in vitro. Acta Pharmacol Sin (2016) 0.75

Amplification of USP13 drives ovarian cancer metabolism. Nat Commun (2016) 0.75

Sending Out an SOS: Mitochondria as a Signaling Hub. Front Cell Dev Biol (2016) 0.75

Tumour microenvironment factors shaping the cancer metabolism landscape. Br J Cancer (2016) 0.75

Triphenyl Phosphine-Functionalized Chitosan Nanoparticles Enhanced Antitumor Efficiency Through Targeted Delivery of Doxorubicin to Mitochondria. Nanoscale Res Lett (2017) 0.75

The Antibiotic Drug Tigecycline: A Focus on its Promising Anticancer Properties. Front Pharmacol (2016) 0.75

Mevalonate Cascade Inhibition by Simvastatin Induces the Intrinsic Apoptosis Pathway via Depletion of Isoprenoids in Tumor Cells. Sci Rep (2017) 0.75

PGC-1 Coactivators: Shepherding the Mitochondrial Biogenesis of Tumors. Trends Cancer (2016) 0.75

The branched-chain amino acid transaminase 1 sustains growth of antiestrogen-resistant and ERα-negative breast cancer. Oncogene (2017) 0.75

Mitochondria and Iron: current questions. Expert Rev Hematol (2016) 0.75

Mitochondrial protein 18 (MTP18) plays a pro-apoptotic role in chemotherapy-induced gastric cancer cell apoptosis. Oncotarget (2017) 0.75

Dynamics of absorption, metabolism, and excretion of 5-aminolevulinic acid in human intestinal Caco-2 cells. Biochem Biophys Rep (2017) 0.75

Numtogenesis as a Mechanism for Development of Cancer. Semin Cancer Biol (2017) 0.75

A novel deubiquitinase inhibitor b-AP15 triggers apoptosis in both androgen receptor-dependent and -independent prostate cancers. Oncotarget (2017) 0.75

An Emergence Framework of Carcinogenesis. Front Oncol (2017) 0.75

Mitochondria on the move: emerging paradigms of organelle trafficking in tumour plasticity and metastasis. Br J Cancer (2017) 0.75

Syntaphilin controls a mitochondrial rheostat for proliferation-motility decisions in cancer. J Clin Invest (2017) 0.75

Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science (2009) 49.82

On the origin of cancer cells. Science (1956) 49.55

The cancer genome. Nature (2009) 23.13

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature (2009) 19.65

Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc Natl Acad Sci U S A (2007) 15.88

On respiratory impairment in cancer cells. Science (1956) 14.07

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature (2009) 13.28

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction. Proc Natl Acad Sci U S A (2008) 11.71

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity. Proc Natl Acad Sci U S A (2010) 8.12

Bidirectional transport of amino acids regulates mTOR and autophagy. Cell (2009) 7.88

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev (2011) 7.43

Reductive carboxylation supports growth in tumour cells with defective mitochondria. Nature (2011) 6.57

Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells. J Cell Biol (2007) 6.54

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. Nature (2013) 6.53

Glutamine addiction: a new therapeutic target in cancer. Trends Biochem Sci (2010) 6.30

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy. Nat Rev Mol Cell Biol (2014) 6.25

Pancreatic cancers require autophagy for tumor growth. Genes Dev (2011) 6.17

NIX is required for programmed mitochondrial clearance during reticulocyte maturation. Proc Natl Acad Sci U S A (2007) 5.14

An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science (2013) 5.10

Mitochondria and cancer. Nat Rev Cancer (2012) 4.81

Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase. Nature (2011) 4.32

p53 status determines the role of autophagy in pancreatic tumour development. Nature (2013) 4.31

Oxidative stress inhibits distant metastasis by human melanoma cells. Nature (2015) 3.87

Mitochondrial DNA stress primes the antiviral innate immune response. Nature (2015) 3.82

The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type. Cell Metab (2012) 3.81

Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation. Science (2013) 3.72

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function. Nature (2014) 3.34

Serine, glycine and one-carbon units: cancer metabolism in full circle. Nat Rev Cancer (2013) 3.23

Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth. Mol Syst Biol (2011) 3.15

Cancer metabolism: facts, fantasy, and fiction. Biochem Biophys Res Commun (2004) 3.06

Mitochondrial genome acquisition restores respiratory function and tumorigenic potential of cancer cells without mitochondrial DNA. Cell Metab (2015) 3.06

Altered regulation of metabolic pathways in human lung cancer discerned by (13)C stable isotope-resolved metabolomics (SIRM). Mol Cancer (2009) 3.05

Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling. Cancer Cell (2011) 3.00

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy. Nature (2015) 2.96

Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis. Genes Dev (2013) 2.90

Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH. Science (2015) 2.89

Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo. Cell Metab (2012) 2.86

Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid. N Engl J Med (1948) 2.81

The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1. Mol Cell (2013) 2.79

Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells. Cancer Res (2004) 2.78

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells. Nat Cell Biol (2012) 2.56

Metabolic regulation of epigenetics. Cell Metab (2012) 2.55

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis. Elife (2014) 2.48

Autophagy is required for glucose homeostasis and lung tumor maintenance. Cancer Discov (2014) 2.44

What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer. Genes Dev (2013) 2.31

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides. Nature (2014) 2.27

The role for autophagy in cancer. J Clin Invest (2015) 2.11

Autophagy sustains mitochondrial glutamine metabolism and growth of BrafV600E-driven lung tumors. Cancer Discov (2013) 2.08

Autophagy-mediated tumor promotion. Cell (2013) 2.08

Metabolism of [U-13 C]glucose in human brain tumors in vivo. NMR Biomed (2012) 2.06

An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis. Cell (2015) 2.03

Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism. Nature (2015) 2.00

Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations. Cancer Discov (2014) 1.97

A dual role for autophagy in a murine model of lung cancer. Nat Commun (2014) 1.97

Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells. Cell (2015) 1.90

Acetate is a bioenergetic substrate for human glioblastoma and brain metastases. Cell (2014) 1.90

Glutamine synthetase is a genetic determinant of cell type-specific glutamine independence in breast epithelia. PLoS Genet (2011) 1.90

Acetate dependence of tumors. Cell (2014) 1.80

Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer. Nat Commun (2014) 1.75

Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis. J Clin Invest (2015) 1.67

Many players in BCL-2 family affairs. Trends Biochem Sci (2014) 1.64

Potential applications for biguanides in oncology. J Clin Invest (2013) 1.63

Modulation of glutamine metabolism by the PI(3)K-PKB-FOXO network regulates autophagy. Nat Cell Biol (2012) 1.63

Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia. Mol Syst Biol (2013) 1.56

The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling. Mol Cell (2013) 1.54

Serine catabolism regulates mitochondrial redox control during hypoxia. Cancer Discov (2014) 1.53

Positron Emission Tomography (PET) in Oncology. Cancers (Basel) (2014) 1.41

Learning from oncocytic tumors: Why choose inefficient mitochondria? Biochim Biophys Acta (2010) 1.40

Mitochondria in the regulation of innate and adaptive immunity. Immunity (2015) 1.40

Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer. Elife (2014) 1.39

Self and nonself: how autophagy targets mitochondria and bacteria. Cell Host Microbe (2014) 1.36

Autophagy opposes p53-mediated tumor barrier to facilitate tumorigenesis in a model of PALB2-associated hereditary breast cancer. Cancer Discov (2013) 1.32

Mitochondrial C1-tetrahydrofolate synthase (MTHFD1L) supports the flow of mitochondrial one-carbon units into the methyl cycle in embryos. J Biol Chem (2009) 1.31

Metformin targets the metabolic achilles heel of human pancreatic cancer stem cells. PLoS One (2013) 1.29

Pyrimidine biosynthesis links mitochondrial respiration to the p53 pathway. Proc Natl Acad Sci U S A (2010) 1.26

Defects in mitochondrial metabolism and cancer. Cancer Metab (2014) 1.24

Mitochondrial ROS Signaling in Organismal Homeostasis. Cell (2015) 1.23

SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance. Nature (2015) 1.22

Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis. Nat Cell Biol (2015) 1.22

Mitochondrial reactive oxygen species and cancer. Cancer Metab (2014) 1.20

Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma. Nat Cell Biol (2015) 1.17

Regulation of mitochondrial oxidative metabolism by tumor suppressor FLCN. J Natl Cancer Inst (2012) 1.16

MYC oncogene overexpression drives renal cell carcinoma in a mouse model through glutamine metabolism. Proc Natl Acad Sci U S A (2015) 1.07

Overexpression of the mitochondrial folate and glycine-serine pathway: a new determinant of methotrexate selectivity in tumors. Cancer Res (2012) 1.06

Atg7 Overcomes Senescence and Promotes Growth of BrafV600E-Driven Melanoma. Cancer Discov (2015) 1.02

Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress. Neuron (2015) 1.00

Evolution of Mitochondria as Signaling Organelles. Cell Metab (2015) 0.99

Autophagy is required for mitochondrial function, lipid metabolism, growth, and fate of KRAS(G12D)-driven lung tumors. Autophagy (2013) 0.98

Impairment of mitochondrial respiration in mouse fibroblasts by oncogenic H-RAS(Q61L). Cancer Biol Ther (2010) 0.98

Autophagy, Metabolism, and Cancer. Clin Cancer Res (2015) 0.95

Glutamine synthetase in muscle is required for glutamine production during fasting and extrahepatic ammonia detoxification. J Biol Chem (2010) 0.95

Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation. Nat Commun (2015) 0.94

Oncogenic Myc Induces Expression of Glutamine Synthetase through Promoter Demethylation. Cell Metab (2015) 0.92

Metabolic consequences of oncogenic IDH mutations. Pharmacol Ther (2015) 0.90

Rare insights into cancer biology. Oncogene (2013) 0.89

Simultaneous DNA and RNA Mapping of Somatic Mitochondrial Mutations across Diverse Human Cancers. PLoS Genet (2015) 0.89

Beyond indigestion: emerging roles for lysosome-based signaling in human disease. Curr Opin Cell Biol (2015) 0.89

Non-clear cell renal cancer: disease-based management and opportunities for targeted therapeutic approaches. Semin Oncol (2013) 0.89

The Genomic Landscape of Renal Oncocytoma Identifies a Metabolic Barrier to Tumorigenesis. Cell Rep (2015) 0.85

Mitochondrial disorders: aetiologies, models systems, and candidate therapies. Trends Genet (2013) 0.85