Published in Science on May 15, 2015
Oncogenic transformation of Drosophila somatic cells induces a functional piRNA pathway. Genes Dev (2016) 1.47
A One Precursor One siRNA Model for Pol IV-Dependent siRNA Biogenesis. Cell (2015) 1.09
One Loop to Rule Them All: The Ping-Pong Cycle and piRNA-Guided Silencing. Trends Biochem Sci (2016) 1.08
piRNA-guided slicing of transposon transcripts enforces their transcriptional silencing via specifying the nuclear piRNA repertoire. Genes Dev (2015) 0.96
Slicing and Binding by Ago3 or Aub Trigger Piwi-Bound piRNA Production by Distinct Mechanisms. Mol Cell (2015) 0.95
Identification and Functional Analysis of the Pre-piRNA 3' Trimmer in Silkworms. Cell (2016) 0.90
The RNase PARN-1 Trims piRNA 3' Ends to Promote Transcriptome Surveillance in C. elegans. Cell (2016) 0.87
PIWI Slicing and EXD1 Drive Biogenesis of Nuclear piRNAs from Cytosolic Targets of the Mouse piRNA Pathway. Mol Cell (2015) 0.87
Small RNA Profiling in Dengue Virus 2-Infected Aedes Mosquito Cells Reveals Viral piRNAs and Novel Host miRNAs. PLoS Negl Trop Dis (2016) 0.82
Loss of l(3)mbt leads to acquisition of the ping-pong cycle in Drosophila ovarian somatic cells. Genes Dev (2016) 0.80
Genetic and mechanistic diversity of piRNA 3'-end formation. Nature (2016) 0.80
Paramutation in Drosophila Requires Both Nuclear and Cytoplasmic Actors of the piRNA Pathway and Induces Cis-spreading of piRNA Production. Genetics (2015) 0.79
piRNA pathway is not required for antiviral defense in Drosophila melanogaster. Proc Natl Acad Sci U S A (2016) 0.79
Antagonistic roles of Nibbler and Hen1 in modulating piRNA 3' ends in Drosophila. Development (2015) 0.79
RNA. Phased piRNAs tackle transposons. Science (2015) 0.79
PMS1T, producing phased small-interfering RNAs, regulates photoperiod-sensitive male sterility in rice. Proc Natl Acad Sci U S A (2016) 0.79
Biogenesis of diverse plant phasiRNAs involves an miRNA-trigger and Dicer-processing. J Plant Res (2016) 0.79
PIWIs Go Viral: Arbovirus-Derived piRNAs in Vector Mosquitoes. PLoS Pathog (2016) 0.78
A Small RNA-Based Immune System Defends Germ Cells against Mobile Genetic Elements. Stem Cells Int (2015) 0.77
A MILI-independent piRNA biogenesis pathway empowers partial germline reprogramming. Nat Struct Mol Biol (2017) 0.76
Increased production of piRNAs from euchromatic clusters and genes in Anopheles gambiae compared with Drosophila melanogaster. Epigenetics Chromatin (2015) 0.76
Paramutation and related phenomena in diverse species. Nat Rev Genet (2016) 0.76
Kc167, a widely used Drosophila cell line, contains an active primary piRNA pathway. RNA (2016) 0.76
A Fleeting Glimpse Inside microRNA, Epigenetics, and Micropeptidomics. Adv Exp Med Biol (2015) 0.76
Tudor-domain containing proteins act to make the piRNA pathways more robust in Drosophila. Fly (Austin) (2015) 0.76
Artificial "ping-pong" cascade of PIWI-interacting RNA in silkworm cells. RNA (2016) 0.75
Xenopus Piwi proteins interact with a broad proportion of the oocyte transcriptome. RNA (2016) 0.75
Increasing cell density globally enhances the biogenesis of Piwi-interacting RNAs in Bombyx mori germ cells. Sci Rep (2017) 0.75
An XIST-related small RNA regulates KRAS G-quadruplex formation beyond X-inactivation. Oncotarget (2016) 0.75
Recurrent Gene Duplication Diversifies Genome Defense Repertoire in Drosophila. Mol Biol Evol (2016) 0.75
Genome-wide identification of endogenous RNA-directed DNA methylation loci associated with abundant 21-nucleotide siRNAs in Arabidopsis. Sci Rep (2016) 0.75
Phosphate-binding pocket in Dicer-2 PAZ domain for high-fidelity siRNA production. Proc Natl Acad Sci U S A (2016) 0.75
Co-chaperone Hsp70/Hsp90-organizing protein (Hop) is required for transposon silencing and Piwi-interacting RNA (piRNA) biogenesis. J Biol Chem (2017) 0.75
Histone-derived piRNA biogenesis depends on the ping-pong partners Piwi5 and Ago3 in Aedes aegypti. Nucleic Acids Res (2017) 0.75
PNLDC1 is essential for piRNA 3' end trimming and transposon silencing during spermatogenesis in mice. Nat Commun (2017) 0.75
Switching of dominant retrotransposon silencing strategies from posttranscriptional to transcriptional mechanisms during male germ-cell development in mice. PLoS Genet (2017) 0.75
Small RNAs from a Big Genome: The piRNA Pathway and Transposable Elements in the Salamander Species Desmognathus fuscus. J Mol Evol (2016) 0.75
Distinct Roles of RNA Helicases MVH and TDRD9 in PIWI Slicing-Triggered Mammalian piRNA Biogenesis and Function. Dev Cell (2017) 0.75
Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila. Cell (2007) 18.35
A distinct small RNA pathway silences selfish genetic elements in the germline. Science (2006) 11.63
A slicer-mediated mechanism for repeat-associated siRNA 5' end formation in Drosophila. Science (2007) 10.73
Specialized piRNA pathways act in germline and somatic tissues of the Drosophila ovary. Cell (2009) 6.39
A pathway for the biogenesis of trans-acting siRNAs in Arabidopsis. Genes Dev (2005) 6.04
DICER-LIKE 4 functions in trans-acting small interfering RNA biogenesis and vegetative phase change in Arabidopsis thaliana. Proc Natl Acad Sci U S A (2005) 5.16
An epigenetic role for maternally inherited piRNAs in transposon silencing. Science (2008) 5.05
Molecular memory of prior infections activates the CRISPR/Cas adaptive bacterial immunity system. Nat Commun (2012) 4.04
zucchini and squash encode two putative nucleases required for rasiRNA production in the Drosophila germline. Dev Cell (2007) 3.29
Function, targets, and evolution of Caenorhabditis elegans piRNAs. Science (2012) 3.11
CRISPR interference directs strand specific spacer acquisition. PLoS One (2012) 3.10
Transcriptional silencing of transposons by Piwi and maelstrom and its impact on chromatin state and gene expression. Cell (2012) 3.04
Abundant primary piRNAs, endo-siRNAs, and microRNAs in a Drosophila ovary cell line. Genome Res (2009) 2.68
C. elegans piRNAs mediate the genome-wide surveillance of germline transcripts. Cell (2012) 2.65
An in vivo RNAi assay identifies major genetic and cellular requirements for primary piRNA biogenesis in Drosophila. EMBO J (2010) 2.51
Paramutation in Drosophila linked to emergence of a piRNA-producing locus. Nature (2012) 2.24
The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis. Nature (2012) 1.97
PIWI-interacting RNAs: from generation to transgenerational epigenetics. Nat Rev Genet (2013) 1.92
Structure and function of Zucchini endoribonuclease in piRNA biogenesis. Nature (2012) 1.90
Heterotypic piRNA Ping-Pong requires qin, a protein with both E3 ligase and Tudor domains. Mol Cell (2011) 1.79
A transcriptome-wide RNAi screen in the Drosophila ovary reveals factors of the germline piRNA pathway. Mol Cell (2013) 1.48
The genetic makeup of the Drosophila piRNA pathway. Mol Cell (2013) 1.35
Transgenerationally inherited piRNAs trigger piRNA biogenesis by changing the chromatin of piRNA clusters and inducing precursor processing. Genes Dev (2014) 1.31
Tdrkh is essential for spermatogenesis and participates in primary piRNA biogenesis in the germline. EMBO J (2013) 1.22
Mitochondrial protein BmPAPI modulates the length of mature piRNAs. RNA (2013) 1.07
Crystal structure of the primary piRNA biogenesis factor Zucchini reveals similarity to the bacterial PLD endonuclease Nuc. RNA (2012) 1.00
The initial uridine of primary piRNAs does not create the tenth adenine that Is the hallmark of secondary piRNAs. Mol Cell (2014) 0.96
Minotaur is critical for primary piRNA biogenesis. RNA (2013) 0.83