Published in RNA on April 17, 2017
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A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science (2001) 31.33
Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans. Genes Dev (2001) 21.82
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Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate. EMBO J (2001) 12.88
A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans. Science (2001) 11.86
R2D2, a bridge between the initiation and effector steps of the Drosophila RNAi pathway. Science (2003) 9.53
Endogenous siRNAs derived from transposons and mRNAs in Drosophila somatic cells. Science (2008) 8.62
Single processing center models for human Dicer and bacterial RNase III. Cell (2004) 8.19
An endogenous small interfering RNA pathway in Drosophila. Nature (2008) 7.88
Structural basis for double-stranded RNA processing by Dicer. Science (2006) 5.86
Drosophila endogenous small RNAs bind to Argonaute 2 in somatic cells. Nature (2008) 5.59
Slicer function of Drosophila Argonautes and its involvement in RISC formation. Genes Dev (2005) 5.29
Drosophila microRNAs are sorted into functionally distinct argonaute complexes after production by dicer-1. Cell (2007) 5.26
The Drosophila hairpin RNA pathway generates endogenous short interfering RNAs. Nature (2008) 5.05
Ribonuclease activity and RNA binding of recombinant human Dicer. EMBO J (2002) 4.73
Making a better RNAi vector for Drosophila: use of intron spacers. Methods (2003) 4.42
Two distinct mechanisms generate endogenous siRNAs from bidirectional transcription in Drosophila melanogaster. Nat Struct Mol Biol (2008) 3.40
Structural determinants of RNA recognition and cleavage by Dicer. Nat Struct Mol Biol (2007) 2.67
Autoinhibition of human dicer by its internal helicase domain. J Mol Biol (2008) 2.62
Dicer recognizes the 5' end of RNA for efficient and accurate processing. Nature (2011) 2.49
The loop position of shRNAs and pre-miRNAs is critical for the accuracy of dicer processing in vivo. Cell (2012) 1.84
Recognition of the pre-miRNA structure by Drosophila Dicer-1. Nat Struct Mol Biol (2011) 1.61
Noncoding RNA. piRNA-guided transposon cleavage initiates Zucchini-dependent, phased piRNA production. Science (2015) 1.57
Dicer partner proteins tune the length of mature miRNAs in flies and mammals. Cell (2012) 1.57
Characterization of the miRNA-RISC loading complex and miRNA-RISC formed in the Drosophila miRNA pathway. RNA (2009) 1.55
The molecular architecture of human Dicer. Nat Struct Mol Biol (2012) 1.53
Dicer's helicase domain discriminates dsRNA termini to promote an altered reaction mode. Mol Cell (2011) 1.49
Functional anatomy of the Drosophila microRNA-generating enzyme. J Biol Chem (2007) 1.40
The long and short of antiviral defense: small RNA-based immunity in insects. Curr Opin Virol (2014) 1.39
A retrotransposon-driven dicer isoform directs endogenous small interfering RNA production in mouse oocytes. Cell (2013) 1.37
Phosphate and R2D2 restrict the substrate specificity of Dicer-2, an ATP-driven ribonuclease. Mol Cell (2011) 1.36
Loqs-PD and R2D2 define independent pathways for RISC generation in Drosophila. Nucleic Acids Res (2011) 1.19
Target RNA-directed tailing and trimming purifies the sorting of endo-siRNAs between the two Drosophila Argonaute proteins. RNA (2010) 1.19
Substrate-specific structural rearrangements of human Dicer. Nat Struct Mol Biol (2013) 1.08
Functional small RNAs are generated from select miRNA hairpin loops in flies and mammals. Genes Dev (2013) 1.01
The role of human Dicer-dsRBD in processing small regulatory RNAs. PLoS One (2012) 0.97
Roles of R2D2, a cytoplasmic D2 body component, in the endogenous siRNA pathway in Drosophila. Mol Cell (2013) 0.96
RNAi and antiviral defense in Drosophila: setting up a systemic immune response. Dev Comp Immunol (2013) 0.96
piPipes: a set of pipelines for piRNA and transposon analysis via small RNA-seq, RNA-seq, degradome- and CAGE-seq, ChIP-seq and genomic DNA sequencing. Bioinformatics (2014) 0.95
Biological mechanisms determining the success of RNA interference in insects. Int Rev Cell Mol Biol (2014) 0.88
Production of functional small interfering RNAs by an amino-terminal deletion mutant of human Dicer. Proc Natl Acad Sci U S A (2015) 0.85
Drosophila dicer-2 cleavage is mediated by helicase- and dsRNA termini-dependent states that are modulated by Loquacious-PD. Mol Cell (2015) 0.84
Inorganic phosphate blocks binding of pre-miRNA to Dicer-2 via its PAZ domain. EMBO J (2014) 0.84
Host control of insect endogenous retroviruses: small RNA silencing and immune response. Viruses (2014) 0.78
A universal small molecule, inorganic phosphate, restricts the substrate specificity of Dicer-2 in small RNA biogenesis. Cell Cycle (2014) 0.78
Phosphate-binding pocket in Dicer-2 PAZ domain for high-fidelity siRNA production. Proc Natl Acad Sci U S A (2016) 0.75