Published in Mol Cell Biol on November 01, 1989
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Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells. Proc Natl Acad Sci U S A (2004) 7.03
Mechanism and regulation of eukaryotic protein synthesis. Microbiol Rev (1992) 6.27
Context effects and inefficient initiation at non-AUG codons in eucaryotic cell-free translation systems. Mol Cell Biol (1989) 5.16
Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. EMBO J (1990) 5.05
Deadenylation is a widespread effect of miRNA regulation. RNA (2008) 3.98
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The fragile X mental retardation protein binds specifically to its mRNA via a purine quartet motif. EMBO J (2001) 3.42
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Evidence to implicate translation by ribosomes in the mechanism by which nonsense codons reduce the nuclear level of human triosephosphate isomerase mRNA. Proc Natl Acad Sci U S A (1993) 2.98
Multiple isoforms of the mouse retinoic acid receptor alpha are generated by alternative splicing and differential induction by retinoic acid. EMBO J (1991) 2.84
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A novel function of the MA-3 domains in transformation and translation suppressor Pdcd4 is essential for its binding to eukaryotic translation initiation factor 4A. Mol Cell Biol (2004) 2.38
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Identification and characterization of a sequence motif involved in nonsense-mediated mRNA decay. Mol Cell Biol (1995) 2.31
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Modification of the Creator recombination system for proteomics applications--improved expression by addition of splice sites. BMC Biotechnol (2006) 2.01
Eukaryotic coupled translation of tandem cistrons: identification of the influenza B virus BM2 polypeptide. EMBO J (1990) 1.95
Functional characterization of a non-AUUUA AU-rich element from the c-jun proto-oncogene mRNA: evidence for a novel class of AU-rich elements. Mol Cell Biol (1996) 1.90
The human immunodeficiency virus type 1 gag gene encodes an internal ribosome entry site. J Virol (2001) 1.87
5' and 3' untranslated regions of pestivirus genome: primary and secondary structure analyses. Nucleic Acids Res (1993) 1.86
Tat-responsive region RNA of human immunodeficiency virus 1 can prevent activation of the double-stranded-RNA-activated protein kinase. Proc Natl Acad Sci U S A (1990) 1.81
An internal ribosomal entry mechanism promotes translation of murine leukemia virus gag polyprotein precursors. J Virol (1995) 1.80
Two dominant mutations in the mouse fused gene are the result of transposon insertions. Genetics (1997) 1.76
CART classification of human 5' UTR sequences. Genome Res (2000) 1.75
Identification of the motifs within the tobacco mosaic virus 5'-leader responsible for enhancing translation. Nucleic Acids Res (1992) 1.73
Translational repression by a complex between the iron-responsive element of ferritin mRNA and its specific cytoplasmic binding protein is position-dependent in vivo. EMBO J (1990) 1.70
A methyl jasmonate-induced shift in the length of the 5' untranslated region impairs translation of the plastid rbcL transcript in barley. EMBO J (1993) 1.69
Control of mammalian translation by mRNA structure near caps. RNA (2006) 1.66
mRNA sequence features that contribute to translational regulation in Arabidopsis. Nucleic Acids Res (2005) 1.63
Sendai virus Y proteins are initiated by a ribosomal shunt. Mol Cell Biol (1998) 1.63
The human immunodeficiency virus type 1 5' packaging signal structure affects translation but does not function as an internal ribosome entry site structure. J Virol (1996) 1.57
Cap-independent translation of plant viral RNAs. Virus Res (2005) 1.56
Control of cyclin-dependent kinase inhibitor p27 expression by cap-independent translation. Mol Cell Biol (2001) 1.50
5'-untranslated regions with multiple upstream AUG codons can support low-level translation via leaky scanning and reinitiation. Nucleic Acids Res (2004) 1.47
Folding free energies of 5'-UTRs impact post-transcriptional regulation on a genomic scale in yeast. PLoS Comput Biol (2005) 1.46
Role of the open reading frames of Rous sarcoma virus leader RNA in translation and genome packaging. EMBO J (1992) 1.44
MxA-dependent inhibition of measles virus glycoprotein synthesis in a stably transfected human monocytic cell line. J Virol (1993) 1.43
Translation of the human LINE-1 element, L1Hs. Proc Natl Acad Sci U S A (1993) 1.42
Translation of a polycistronic mRNA in the presence of the cauliflower mosaic virus transactivator protein. EMBO J (1991) 1.42
Human papillomavirus type 18 E1 protein is translated from polycistronic mRNA by a discontinuous scanning mechanism. J Virol (1999) 1.41
Ribosomal scanning past the primary initiation codon as a mechanism for expression of CTL epitopes encoded in alternative reading frames. J Exp Med (1996) 1.39
Positive and negative control of translation by the leader sequence of cauliflower mosaic virus pregenomic 35S RNA. EMBO J (1990) 1.37
Bacteriophage and spliceosomal proteins function as position-dependent cis/trans repressors of mRNA translation in vitro. Nucleic Acids Res (1992) 1.36
The 5'-7-methylguanosine cap on eukaryotic mRNAs serves both to stimulate canonical translation initiation and to block an alternative pathway. Mol Cell (2010) 1.35
Tat-dependent adenosine-to-inosine modification of wild-type transactivation response RNA. Proc Natl Acad Sci U S A (1991) 1.35
Control of translation by the 5'- and 3'-terminal regions of the dengue virus genome. J Virol (2005) 1.33
DEAD-box protein DDX3 associates with eIF4F to promote translation of selected mRNAs. EMBO J (2012) 1.31
Position-dependent ATT initiation during plant pararetrovirus rice tungro bacilliform virus translation. J Virol (1996) 1.31
Rapid degradation of AU-rich element (ARE) mRNAs is activated by ribosome transit and blocked by secondary structure at any position 5' to the ARE. Mol Cell Biol (1995) 1.30
Unanticipated antigens: translation initiation at CUG with leucine. PLoS Biol (2004) 1.29
A search for structurally similar cellular internal ribosome entry sites. Nucleic Acids Res (2007) 1.29
Differential utilization of upstream AUGs in the beta-secretase mRNA suggests that a shunting mechanism regulates translation. Proc Natl Acad Sci U S A (2004) 1.26
Repeat associated non-ATG translation initiation: one DNA, two transcripts, seven reading frames, potentially nine toxic entities! PLoS Genet (2011) 1.25
Translation by the adenovirus tripartite leader: elements which determine independence from cap-binding protein complex. J Virol (1990) 1.25
Close spacing of AUG initiation codons confers dicistronic character on a eukaryotic mRNA. RNA (2006) 1.24
Target-specific arrest of mRNA translation by antisense 2'-O-alkyloligoribonucleotides. Nucleic Acids Res (1994) 1.24
Characterization of Mayven, a novel actin-binding protein predominantly expressed in brain. Mol Biol Cell (1999) 1.23
Control of start codon choice on a plant viral RNA encoding overlapping genes. Plant Cell (1993) 1.23
mRNA pseudoknot structures can act as ribosomal roadblocks. Nucleic Acids Res (2011) 1.22
Analysis of a 3'-translation enhancer in a tombusvirus: a dynamic model for RNA-RNA interactions of mRNA termini. RNA (2006) 1.22
Cap-independent translational enhancement by the 3' untranslated region of red clover necrotic mosaic virus RNA1. J Virol (2003) 1.20
A common strategy for host RNA degradation by divergent viruses. J Virol (2012) 1.18
Regulation of RAR beta 2 mRNA expression: evidence for an inhibitory peptide encoded in the 5'-untranslated region. J Cell Biol (1996) 1.18
Dengue virus utilizes a novel strategy for translation initiation when cap-dependent translation is inhibited. J Virol (2006) 1.17
5' sequences of rubella virus RNA stimulate translation of chimeric RNAs and specifically interact with two host-encoded proteins. J Virol (1993) 1.15
Genomic organization and expression of Tpl-2 in normal cells and Moloney murine leukemia virus-induced rat T-cell lymphomas: activation by provirus insertion. J Virol (1993) 1.14
Unique translation initiation of mRNAs-containing TISU element. Nucleic Acids Res (2011) 1.12
Small molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex. Org Biomol Chem (2010) 1.11
Leaky scanning and reinitiation regulate BACE1 gene expression. Mol Cell Biol (2006) 1.11
Oscillating kissing stem-loop interactions mediate 5' scanning-dependent translation by a viral 3'-cap-independent translation element. RNA (2006) 1.10
Translational regulation of the human cytomegalovirus pp28 (UL99) late gene. J Virol (1997) 1.10
Purification, cDNA cloning, functional expression, and characterization of a 26-kDa endogenous mammalian carboxypeptidase inhibitor. Proc Natl Acad Sci U S A (1995) 1.10
Translational frameshifting mediated by a viral sequence in plant cells. Proc Natl Acad Sci U S A (1992) 1.09
Comparison of computational methods for identifying translation initiation sites in EST data. BMC Bioinformatics (2004) 1.09
Leaky scanning is the predominant mechanism for translation of human papillomavirus type 16 E7 oncoprotein from E6/E7 bicistronic mRNA. J Virol (2000) 1.08
The herpes simplex virus 1 vhs protein enhances translation of viral true late mRNAs and virus production in a cell type-dependent manner. J Virol (2011) 1.08
Structural analysis of the mouse mdr1a (P-glycoprotein) promoter reveals the basis for differential transcript heterogeneity in multidrug-resistant J774.2 cells. Mol Cell Biol (1990) 1.08
Ribosome traffic on mRNAs maps to gene ontology: genome-wide quantification of translation initiation rates and polysome size regulation. PLoS Comput Biol (2013) 1.08
Mechanism of selective translation of vaccinia virus mRNAs: differential role of poly(A) and initiation factors in the translation of viral and cellular mRNAs. J Virol (1991) 1.08
A new type of IRES within gag coding region recruits three initiation complexes on HIV-2 genomic RNA. Nucleic Acids Res (2009) 1.07
Unidirectional constant rate motion of the ribosomal scanning particle during eukaryotic translation initiation. Nucleic Acids Res (2011) 1.06
eIF3 targets cell-proliferation messenger RNAs for translational activation or repression. Nature (2015) 1.06
A stable hairpin preceded by a short open reading frame promotes nonlinear ribosome migration on a synthetic mRNA leader. RNA (1999) 1.05
Attenuated APC alleles produce functional protein from internal translation initiation. Proc Natl Acad Sci U S A (2002) 1.05
Drosophila maternal Hsp83 mRNA destabilization is directed by multiple SMAUG recognition elements in the open reading frame. Mol Cell Biol (2008) 1.04
Developing mRNA-vaccine technologies. RNA Biol (2012) 1.04
Ribosomal pausing and scanning arrest as mechanisms of translational regulation from cap-distal iron-responsive elements. Mol Cell Biol (1999) 1.03
Complex translational regulation of BACE1 involves upstream AUGs and stimulatory elements within the 5' untranslated region. Nucleic Acids Res (2007) 1.03
Developmentally regulated instability of the GPI-PLC mRNA is dependent on a short-lived protein factor. Nucleic Acids Res (2005) 1.03
Tuning gene expression with synthetic upstream open reading frames. Proc Natl Acad Sci U S A (2013) 1.02
A new framework for understanding IRES-mediated translation. Gene (2012) 1.01
An internal ribosomal entry signal in the rat VL30 region of the Harvey murine sarcoma virus leader and its use in dicistronic retroviral vectors. J Virol (1995) 1.00
Improved estimation of secondary structure in ribonucleic acids. Nat New Biol (1973) 46.33
Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. Cell (1986) 42.45
An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Acids Res (1987) 36.83
The scanning model for translation: an update. J Cell Biol (1989) 31.23
Capping of eucaryotic mRNAs. Cell (1976) 10.84
At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells. J Mol Biol (1987) 9.21
Influences of mRNA secondary structure on initiation by eukaryotic ribosomes. Proc Natl Acad Sci U S A (1986) 8.00
Point mutations close to the AUG initiator codon affect the efficiency of translation of rat preproinsulin in vivo. Nature (1984) 7.54
Injected anti-sense RNAs specifically block messenger RNA translation in vivo. Proc Natl Acad Sci U S A (1985) 5.09
Binding of a cytosolic protein to the iron-responsive element of human ferritin messenger RNA. Science (1988) 4.35
Genomic RNAs of influenza viruses are held in a circular conformation in virions and in infected cells by a terminal panhandle. Proc Natl Acad Sci U S A (1987) 4.31
The ribonuclease III site flanking 23S sequences in the 30S ribosomal precursor RNA of E. coli. Cell (1980) 4.19
mRNA cap binding proteins: essential factors for initiating translation. Cell (1985) 4.07
Selective and reversible inhibition of initiation of protein synthesis in mammalian cells. J Mol Biol (1974) 3.41
Mutations at a Zn(II) finger motif in the yeast eIF-2 beta gene alter ribosomal start-site selection during the scanning process. Cell (1988) 3.40
Role of RNase H in hybrid-arrested translation by antisense oligonucleotides. Proc Natl Acad Sci U S A (1988) 2.98
tRNAi(met) functions in directing the scanning ribosome to the start site of translation. Science (1988) 2.84
Migration of 40 S ribosomal subunits on messenger RNA in the presence of edeine. J Biol Chem (1978) 2.84
Translation of insulin-related polypeptides from messenger RNAs with tandemly reiterated copies of the ribosome binding site. Cell (1983) 2.77
Activation of double-stranded RNA-dependent kinase (dsl) by the TAR region of HIV-1 mRNA: a novel translational control mechanism. Cell (1989) 2.43
RNA-mediated gene duplication: the rat preproinsulin I gene is a functional retroposon. Mol Cell Biol (1985) 2.35
The 5' untranslated sequence of the c-sis/platelet-derived growth factor 2 transcript is a potent translational inhibitor. Mol Cell Biol (1988) 2.22
Leader length and secondary structure modulate mRNA function under conditions of stress. Mol Cell Biol (1988) 2.16
Sequences and properties of two ribosome binding sites from the small size class of reovirus messenger RNA. J Biol Chem (1977) 1.93
Sequence and translation of the murine coronavirus 5'-end genomic RNA reveals the N-terminal structure of the putative RNA polymerase. J Virol (1987) 1.89
Growth-rate-dependent regulation of 6-phosphogluconate dehydrogenase level mediated by an anti-Shine-Dalgarno sequence located within the Escherichia coli gnd structural gene. Proc Natl Acad Sci U S A (1989) 1.88
Characterization of ribosome-protected fragments from reovirus messenger RNA. J Biol Chem (1976) 1.87
Electron microscopic evidence for the circular form of RNA in the cytoplasm of eukaryotic cells. Nature (1979) 1.78
Circular polysomes predominate on the rough endoplasmic reticulum of somatotropes and mammotropes in the rat anterior pituitary. Am J Anat (1987) 1.67
Sequences of two 5'-terminal ribosome-protected fragments from reovirus messenger RNAs. J Mol Biol (1977) 1.53
Analysis of the transcript of the herpes simplex virus DNA polymerase gene provides evidence that polymerase expression is inefficient at the level of translation. J Virol (1988) 1.43
Translation efficiency of zein mRNA is reduced by hybrid formation between the 5'- and 3'-untranslated region. EMBO J (1985) 1.39
Long-range translational coupling in the rplJL-rpoBC operon of Escherichia coli. J Mol Biol (1989) 1.22
Differential kinetics of changes in the state of phosphorylation of ribosomal protein S6 and in the rate of protein synthesis in MPC 11 cells during tonicity shifts. EMBO J (1984) 1.14
A highly conserved, 5' untranslated, inverted repeat sequence is ineffective in translational control of the alpha 1(I) collagen gene. Nucleic Acids Res (1988) 0.94
The scanning model for translation: an update. J Cell Biol (1989) 31.23
Effects of intercistronic length on the efficiency of reinitiation by eucaryotic ribosomes. Mol Cell Biol (1987) 6.67
Context effects and inefficient initiation at non-AUG codons in eucaryotic cell-free translation systems. Mol Cell Biol (1989) 5.16
Leader length and secondary structure modulate mRNA function under conditions of stress. Mol Cell Biol (1988) 2.16
A profusion of controls. J Cell Biol (1988) 1.48