Published in J Biol Chem on June 17, 2015
Toll-Like Receptor 2 Stimulation of Osteoblasts Mediates Staphylococcus Aureus Induced Bone Resorption and Osteoclastogenesis through Enhanced RANKL. PLoS One (2016) 0.77
Inflammatory osteolysis: a conspiracy against bone. J Clin Invest (2017) 0.76
Porphyromonas gingivalis infection exacerbates the onset of rheumatoid arthritis in SKG mice. Clin Exp Immunol (2016) 0.75
CCL11, a novel mediator of inflammatory bone resorption. Sci Rep (2017) 0.75
Participation of endotoxin in root canal infections: A systematic review and meta-analysis. Eur J Dent (2017) 0.75
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol (2010) 24.08
Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity (1998) 18.12
Periodontal diseases. Lancet (2005) 10.13
The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc Natl Acad Sci U S A (2000) 9.67
Matrix-embedded cells control osteoclast formation. Nat Med (2011) 5.77
Evidence for osteocyte regulation of bone homeostasis through RANKL expression. Nat Med (2011) 5.66
Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia: the "red complex", a prototype polybacterial pathogenic consortium in periodontitis. Periodontol 2000 (2005) 3.80
Identification and characterization of the new osteoclast progenitor with macrophage phenotypes being able to differentiate into mature osteoclasts. J Bone Miner Res (2000) 3.47
Endogenous ligands of TLR2 and TLR4: agonists or assistants? J Leukoc Biol (2010) 2.85
Porphyromonas gingivalis lipopolysaccharide contains multiple lipid A species that functionally interact with both toll-like receptors 2 and 4. Infect Immun (2004) 2.74
Expression of Toll-like receptor 2 on CD16+ blood monocytes and synovial tissue macrophages in rheumatoid arthritis. Arthritis Rheum (2004) 2.52
Osteoimmunology: interactions of the bone and immune system. Endocr Rev (2008) 2.32
Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment. Nat Rev Rheumatol (2012) 2.28
Cutting Edge: TLR2 is required for the innate response to Porphyromonas gingivalis: activation leads to bacterial persistence and TLR2 deficiency attenuates induced alveolar bone resorption. J Immunol (2006) 2.28
Destructive and protective roles of cytokines in periodontitis: a re-appraisal from host defense and tissue destruction viewpoints. J Dent Res (2010) 2.26
Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis. Arthritis Rheum (2012) 2.24
Antibodies to porphyromonas gingivalis are associated with anticitrullinated protein antibodies in patients with rheumatoid arthritis and their relatives. J Rheumatol (2010) 2.21
Periodontitis in systemic rheumatic diseases. Nat Rev Rheumatol (2009) 2.14
Expression of toll-like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin-12 and interleukin-18 via interferon-gamma. Arthritis Rheum (2004) 2.03
Association among rheumatoid arthritis, oral hygiene, and periodontitis. J Periodontol (2008) 1.99
Periodontitis in RA-the citrullinated enolase connection. Nat Rev Rheumatol (2010) 1.98
Overexpression of toll-like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: toll-like receptor expression in early and longstanding arthritis. Arthritis Rheum (2008) 1.84
Is there a relationship between rheumatoid arthritis and periodontal disease? J Clin Periodontol (2000) 1.70
Periodontal therapy reduces the severity of active rheumatoid arthritis in patients treated with or without tumor necrosis factor inhibitors. J Periodontol (2009) 1.44
Heat shock protein 96 is elevated in rheumatoid arthritis and activates macrophages primarily via TLR2 signaling. J Immunol (2009) 1.43
Bone remodeling in rheumatic disease: a question of balance. Immunol Rev (2010) 1.42
MyD88 but not TRIF is essential for osteoclastogenesis induced by lipopolysaccharide, diacyl lipopeptide, and IL-1alpha. J Exp Med (2004) 1.36
Control of periodontal infection reduces the severity of active rheumatoid arthritis. J Clin Rheumatol (2007) 1.35
The role of cytokines in inflammatory bone loss. Immunol Invest (2013) 1.30
Lipopolysaccharide promotes the survival of osteoclasts via Toll-like receptor 4, but cytokine production of osteoclasts in response to lipopolysaccharide is different from that of macrophages. J Immunol (2003) 1.29
Synovial inflammation in active rheumatoid arthritis and psoriatic arthritis facilitates trapping of a variety of oral bacterial DNAs. Clin Exp Rheumatol (2007) 1.28
Cytokine responses against periodontal infection: protective and destructive roles. Periodontol 2000 (2010) 1.27
Mechanisms and control of pathologic bone loss in periodontitis. Periodontol 2000 (2010) 1.26
Detection of periodontal bacterial DNA in serum and synovial fluid in refractory rheumatoid arthritis patients. J Clin Periodontol (2009) 1.25
Pre-existing periodontitis exacerbates experimental arthritis in a mouse model. J Clin Periodontol (2011) 1.22
Macrophage-specific TLR2 signaling mediates pathogen-induced TNF-dependent inflammatory oral bone loss. J Immunol (2012) 1.18
Periodontal pathogens directly promote autoimmune experimental arthritis by inducing a TLR2- and IL-1-driven Th17 response. J Immunol (2014) 1.15
Taking a toll on the bones: regulation of bone metabolism by innate immune regulators. Autoimmunity (2008) 1.06
Effect of Porphyromonas gingivalis-induced inflammation on the development of rheumatoid arthritis. J Clin Periodontol (2010) 1.04
TLR2-dependent modulation of osteoclastogenesis by Porphyromonas gingivalis through differential induction of NFATc1 and NF-kappaB. J Biol Chem (2011) 1.03
Porphyromonas gingivalis exacerbates ligature-induced, RANKL-dependent alveolar bone resorption via differential regulation of Toll-like receptor 2 (TLR2) and TLR4. Infect Immun (2014) 0.97
Stimulation of resorption in cultured mouse calvarial bones by thiazolidinediones. Endocrinology (2005) 0.93
Modifications of the mouse calvarial technique improve the responsiveness to stimulators of bone resorption. J Bone Miner Res (1987) 0.92
Small molecule inhibitors of IkappaB kinase signaling inhibit osteoclast formation in vitro and prevent ovariectomy-induced bone loss in vivo. FASEB J (2010) 0.91
SNAPIN: an endogenous Toll-like receptor ligand in rheumatoid arthritis. Ann Rheum Dis (2012) 0.90
In vitro studies on bone resorption in neonatal mouse calvariae using a modified dissection technique giving four samples of bone from each calvaria. J Bone Miner Res (1991) 0.88
Impact of interactions of cigarette smoking with NAT2 polymorphisms on rheumatoid arthritis risk in African Americans. Arthritis Rheum (2012) 0.87
Lack of Toll-like receptor 4 decreases lipopolysaccharide-induced bone resorption in C3H/HeJ mice in vivo. Oral Microbiol Immunol (2008) 0.86
Heat shock protein 60 causes osteoclastic bone resorption via toll-like receptor-2 in estrogen deficiency. Bone (2009) 0.84
Retinoids stimulate periosteal bone resorption by enhancing the protein RANKL, a response inhibited by monomeric glucocorticoid receptor. J Biol Chem (2011) 0.82
Impaired osteoclastogenesis by staphylococcal lipoteichoic acid through Toll-like receptor 2 with partial involvement of MyD88. J Leukoc Biol (2009) 0.82
Lipoproteins are an important bacterial component responsible for bone destruction through the induction of osteoclast differentiation and activation. J Bone Miner Res (2013) 0.81
Osteoclast progenitor cells present in significant amounts in mouse calvarial osteoblast isolations and osteoclastogenesis increased by BMP-2. Bone (2012) 0.79