Published in J Biol Chem on June 21, 2015
Deficiencies in Cellular Processes Modulated by the Retinoblastoma Protein Do Not Account for Reduced Human Cytomegalovirus Replication in Its Absence. J Virol (2015) 0.76
Proteomic Interaction Patterns between Human Cyclins, the Cyclin-Dependent Kinase Ortholog pUL97 and Additional Cytomegalovirus Proteins. Viruses (2016) 0.75
Human cytomegalovirus-encoded viral cyclin-dependent kinase (v-CDK) UL97 phosphorylates and inactivates the retinoblastoma protein-related p107 and p130 proteins. J Biol Chem (2017) 0.75
Phosphorylation of transcriptional regulators in the retinoblastoma protein pathway by UL97, the viral cyclin-dependent kinase encoded by human cytomegalovirus. Virology (2017) 0.75
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (2001) 414.27
The retinoblastoma protein and cell cycle control. Cell (1995) 20.21
A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature (1986) 13.96
Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature (1998) 8.75
Sibling rivalry in the E2F family. Nat Rev Mol Cell Biol (2002) 7.64
Global analysis of protein phosphorylation in yeast. Nature (2005) 7.46
Phosphorylation and functions of the RNA polymerase II CTD. Genes Dev (2006) 7.44
Oncolytic virotherapy. Nat Biotechnol (2012) 5.79
Mammalian cyclin-dependent kinases. Trends Biochem Sci (2005) 5.54
Cellular mechanisms of tumour suppression by the retinoblastoma gene. Nat Rev Cancer (2008) 5.19
Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression. Genes Dev (1994) 4.93
The E2F transcriptional network: old acquaintances with new faces. Oncogene (2005) 4.87
Identification of a growth suppression domain within the retinoblastoma gene product. Genes Dev (1992) 4.56
Human cytomegalovirus IE1 and IE2 proteins block apoptosis. J Virol (1995) 4.22
Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms. Oncogene (2009) 3.51
Differential regulation of E2F transactivation by cyclin/cdk2 complexes. Genes Dev (1994) 3.47
Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients. Nature (2015) 3.46
Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A. Proc Natl Acad Sci U S A (1998) 3.27
Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7. Nature (1998) 3.01
Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth. Genes Dev (1998) 3.01
Structure and cell cycle-regulated transcription of the human cyclin A gene. Proc Natl Acad Sci U S A (1994) 2.69
Why do viruses cause cancer? Highlights of the first century of human tumour virology. Nat Rev Cancer (2010) 2.68
Life and death decisions by the E2F transcription factors. Curr Opin Cell Biol (2007) 2.66
A recombinant human cytomegalovirus with a large deletion in UL97 has a severe replication deficiency. J Virol (1999) 2.58
Molecular mechanisms underlying RB protein function. Nat Rev Mol Cell Biol (2013) 2.58
Retinoblastoma protein partners. Adv Cancer Res (2001) 2.53
Manifestations of human cytomegalovirus infection: proposed mechanisms of acute and chronic disease. Curr Top Microbiol Immunol (2008) 2.52
Characterization of monoclonal antibodies and polyclonal immune sera directed against human cytomegalovirus virion proteins. Virology (1984) 2.48
Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation. Mol Cell Biol (1994) 2.44
Distinct and separate roles for herpesvirus-conserved UL97 kinase in cytomegalovirus DNA synthesis and encapsidation. Proc Natl Acad Sci U S A (2001) 2.10
The human cytomegalovirus UL97 protein is a protein kinase that autophosphorylates on serines and threonines. J Virol (1997) 2.06
Consensus on the role of human cytomegalovirus in glioblastoma. Neuro Oncol (2012) 2.02
Phosphorylation of retinoblastoma protein by viral protein with cyclin-dependent kinase function. Science (2008) 1.99
Structural basis for the inactivation of retinoblastoma tumor suppressor by SV40 large T antigen. EMBO J (2001) 1.93
C-terminal truncation of the retinoblastoma gene product leads to functional inactivation. Proc Natl Acad Sci U S A (1990) 1.91
Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release. Cell (2005) 1.90
Proteasome-dependent, ubiquitin-independent degradation of the Rb family of tumor suppressors by the human cytomegalovirus pp71 protein. Proc Natl Acad Sci U S A (2003) 1.88
Human cytomegalovirus pp71 stimulates cell cycle progression by inducing the proteasome-dependent degradation of the retinoblastoma family of tumor suppressors. Mol Cell Biol (2003) 1.87
Mechanisms by which DNA tumor virus oncoproteins target the Rb family of pocket proteins. Carcinogenesis (2003) 1.86
Expression of the HsOrc1 gene, a human ORC1 homolog, is regulated by cell proliferation via the E2F transcription factor. Mol Cell Biol (1996) 1.83
Is HCMV a tumor promoter? Virus Res (2010) 1.81
Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor. Genes Dev (2002) 1.70
Retinoblastoma protein contains a C-terminal motif that targets it for phosphorylation by cyclin-cdk complexes. Mol Cell Biol (1999) 1.68
The human cytomegalovirus IE1-72 protein interacts with the cellular p107 protein and relieves p107-mediated transcriptional repression of an E2F-responsive promoter. J Virol (1996) 1.63
Specific regulation of E2F family members by cyclin-dependent kinases. Mol Cell Biol (1997) 1.61
Significant association of multiple human cytomegalovirus genomic Loci with glioblastoma multiforme samples. J Virol (2011) 1.56
Division and apoptosis of E2f-deficient retinal progenitors. Nature (2009) 1.55
Regulation of the retinoblastoma tumor suppressor protein by cyclin/cdks. Biochim Biophys Acta (2001) 1.54
Human cytomegalovirus UL97 Kinase is required for the normal intranuclear distribution of pp65 and virion morphogenesis. J Virol (2005) 1.51
S-Phase entry upon ectopic expression of G1 cyclin-dependent kinases in the absence of retinoblastoma protein phosphorylation. Curr Biol (1997) 1.48
Human cytomegalovirus UL97 kinase activity is required for the hyperphosphorylation of retinoblastoma protein and inhibits the formation of nuclear aggresomes. J Virol (2008) 1.48
Deciphering the retinoblastoma protein phosphorylation code. Trends Biochem Sci (2012) 1.46
Conserved herpesvirus kinases target the DNA damage response pathway and TIP60 histone acetyltransferase to promote virus replication. Cell Host Microbe (2011) 1.43
Structures of inactive retinoblastoma protein reveal multiple mechanisms for cell cycle control. Genes Dev (2012) 1.37
Recombinant phenotyping of cytomegalovirus UL97 kinase sequence variants for ganciclovir resistance. Antimicrob Agents Chemother (2010) 1.34
Epstein-Barr virus BGLF4 kinase induces disassembly of the nuclear lamina to facilitate virion production. J Virol (2008) 1.31
RB1 in cancer: different mechanisms of RB1 inactivation and alterations of pRb pathway in tumorigenesis. J Cell Physiol (2013) 1.30
Effect of cell culture conditions on the anticytomegalovirus activity of maribavir. Antimicrob Agents Chemother (2006) 1.29
Accelerated evolution of maribavir resistance in a cytomegalovirus exonuclease domain II mutant. J Virol (2007) 1.27
Multiple functions of D-type cyclins can antagonize pRb-mediated suppression of proliferation. Cell Cycle (2005) 1.23
Structure-function analysis of the retinoblastoma tumor suppressor protein - is the whole a sum of its parts? Cell Div (2007) 1.22
Differential initiation of innate immune responses induced by human cytomegalovirus entry into fibroblast cells. J Immunol (2008) 1.21
Establishment of irreversible growth arrest in myogenic differentiation requires the RB LXCXE-binding function. Mol Cell Biol (2000) 1.19
Identification of a viral kinase that phosphorylates specific E2Fs and pocket proteins. Mol Cell Biol (1997) 1.18
Phosphorylation of E2F-1 by cyclin A-cdk2. Oncogene (1995) 1.12
Phosphorylation of the RNA polymerase II carboxyl-terminal domain in human cytomegalovirus-infected cells and in vitro by the viral UL97 protein kinase. Virology (2004) 1.11
Cyclin-dependent kinase-like function is shared by the beta- and gamma- subset of the conserved herpesvirus protein kinases. PLoS Pathog (2010) 1.10
Crystal structure of the retinoblastoma protein N domain provides insight into tumor suppression, ligand interaction, and holoprotein architecture. Mol Cell (2007) 1.09
Regulatory roles of protein kinases in cytomegalovirus replication. Adv Virus Res (2011) 1.06
Diverse cytomegalovirus UL27 mutations adapt to loss of viral UL97 kinase activity under maribavir. Antimicrob Agents Chemother (2008) 1.05
Regulation of the retinoblastoma proteins by the human herpesviruses. Cell Div (2009) 1.02
Phosphorylation of a specific cdk site in E2F-1 affects its electrophoretic mobility and promotes pRB-binding in vitro. Oncogene (1995) 0.98
The viral tropism of two distinct oncolytic viruses, reovirus and myxoma virus, is modulated by cellular tumor suppressor gene status. Oncogene (2010) 0.98
Emerging roles of RB family: new defense mechanisms against tumor progression. J Cell Physiol (2013) 0.96
The multiple connections between pRB and cell metabolism. Curr Opin Cell Biol (2013) 0.95
Interactions of SV40 large T antigen and other viral proteins with retinoblastoma tumour suppressor. Rev Med Virol (2002) 0.95
Oncolytic adenovirus: preclinical and clinical studies in patients with human malignant gliomas. Curr Gene Ther (2009) 0.94
Conserved retinoblastoma protein-binding motif in human cytomegalovirus UL97 kinase minimally impacts viral replication but affects susceptibility to maribavir. Virol J (2009) 0.94
Tale of a tegument transactivator: the past, present and future of human CMV pp71. Future Virol (2012) 0.94
ATM regulates Cdt1 stability during the unperturbed S phase to prevent re-replication. Cell Cycle (2013) 0.91
Enhanced phosphorylation of transcription factor sp1 in response to herpes simplex virus type 1 infection is dependent on the ataxia telangiectasia-mutated protein. J Virol (2007) 0.90
Myeloblastic cell lines mimic some but not all aspects of human cytomegalovirus experimental latency defined in primary CD34+ cell populations. J Virol (2013) 0.89
Cytomegalovirus UL97 kinase catalytic domain mutations that confer multidrug resistance. Antimicrob Agents Chemother (2013) 0.89
Human cytomegalovirus pUL97 regulates the viral major immediate early promoter by phosphorylation-mediated disruption of histone deacetylase 1 binding. J Virol (2013) 0.88
Identification and characterization of small molecule antagonists of pRb inactivation by viral oncoproteins. Chem Biol (2012) 0.86
Hsp90 inhibitor 17-DMAG decreases expression of conserved herpesvirus protein kinases and reduces virus production in Epstein-Barr virus-infected cells. J Virol (2013) 0.85
Understanding the targeting of the RB family proteins by viral oncoproteins to defeat their oncogenic machinery. J Cell Physiol (2013) 0.85
Transcription factor E2F1 suppresses dendritic cell maturation. J Immunol (2010) 0.85
The retinoblastoma tumor suppressor promotes efficient human cytomegalovirus lytic replication. J Virol (2015) 0.80
Phosphorylation puts the pRb tumor suppressor into shape. Genes Dev (2012) 0.79