Published in Database (Oxford) on June 27, 2015
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Identification of genomic sites for CRISPR/Cas9-based genome editing in the Vitis vinifera genome. BMC Plant Biol (2016) 0.80
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RNA-guided human genome engineering via Cas9. Science (2013) 48.29
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science (2012) 48.17
One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell (2013) 24.00
Breaking the code of DNA binding specificity of TAL-type III effectors. Science (2009) 22.33
Efficient genome editing in zebrafish using a CRISPR-Cas system. Nat Biotechnol (2013) 21.32
CRISPR/Cas, the immune system of bacteria and archaea. Science (2010) 18.72
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Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases. Nat Biotechnol (2008) 10.29
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Targeted chromosomal cleavage and mutagenesis in Drosophila using zinc-finger nucleases. Genetics (2002) 9.09
Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases. Nat Biotechnol (2007) 8.88
Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV. N Engl J Med (2014) 7.64
Cas9 as a versatile tool for engineering biology. Nat Methods (2013) 6.87
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Heritable genome editing in C. elegans via a CRISPR-Cas9 system. Nat Methods (2013) 5.93
Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in Escherichia coli, and identification of the gene product. J Bacteriol (1987) 5.28
Genome engineering with zinc-finger nucleases. Genetics (2011) 4.66
CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity. Nucleic Acids Res (2013) 4.11
Multiplex and homologous recombination-mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9. Nat Biotechnol (2013) 3.84
CRISPR-mediated direct mutation of cancer genes in the mouse liver. Nature (2014) 3.28
Optimized CRISPR/Cas tools for efficient germline and somatic genome engineering in Drosophila. Proc Natl Acad Sci U S A (2014) 2.97
Prevention of muscular dystrophy in mice by CRISPR/Cas9-mediated editing of germline DNA. Science (2014) 2.93
Generation of mutant mice by pronuclear injection of circular plasmid expressing Cas9 and single guided RNA. Sci Rep (2013) 2.41
RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection. Proc Natl Acad Sci U S A (2014) 2.32
Optimized gene editing technology for Drosophila melanogaster using germ line-specific Cas9. Proc Natl Acad Sci U S A (2013) 2.13
Allele-specific genome editing and correction of disease-associated phenotypes in rats using the CRISPR-Cas platform. Nat Commun (2014) 1.88
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Application of the CRISPR-Cas system for efficient genome engineering in plants. Mol Plant (2013) 1.63
Seamless gene correction of β-thalassemia mutations in patient-specific iPSCs using CRISPR/Cas9 and piggyBac. Genome Res (2014) 1.63
Large chromosomal deletions and heritable small genetic changes induced by CRISPR/Cas9 in rice. Nucleic Acids Res (2014) 1.58
CRISPR/Cas9 nuclease-mediated gene knock-in in bovine-induced pluripotent cells. Stem Cells Dev (2014) 1.47
The CRISPR/Cas9 System Facilitates Clearance of the Intrahepatic HBV Templates In Vivo. Mol Ther Nucleic Acids (2014) 1.46
Conditional knockouts generated by engineered CRISPR-Cas9 endonuclease reveal the roles of coronin in C. elegans neural development. Dev Cell (2014) 1.29
A PCR based protocol for detecting indel mutations induced by TALENs and CRISPR/Cas9 in zebrafish. PLoS One (2014) 1.23
Efficient in vivo deletion of a large imprinted lncRNA by CRISPR/Cas9. RNA Biol (2014) 1.16
Heritable multiplex genetic engineering in rats using CRISPR/Cas9. PLoS One (2014) 1.14
Precise gene deletion and replacement using the CRISPR/Cas9 system in human cells. Biotechniques (2014) 1.07
Efficient, complete deletion of synaptic proteins using CRISPR. Neuron (2014) 1.06
Genome engineering of mammalian haploid embryonic stem cells using the Cas9/RNA system. PeerJ (2013) 1.00
CRISPR-Cas: an efficient tool for genome engineering of virulent bacteriophages. Nucleic Acids Res (2014) 0.96
One-step generation of phenotype-expressing triple-knockout mice with heritable mutated alleles by the CRISPR/Cas9 system. J Reprod Dev (2014) 0.92
CRISPR/Cas9-mediated gene knockout in the ascidian Ciona intestinalis. Dev Growth Differ (2014) 0.91
Tissue-specific genome editing in Ciona embryos by CRISPR/Cas9. Development (2014) 0.90
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Disruption of HPV16-E7 by CRISPR/Cas system induces apoptosis and growth inhibition in HPV16 positive human cervical cancer cells. Biomed Res Int (2014) 0.87
A CRISPR-based approach for proteomic analysis of a single genomic locus. Epigenetics (2014) 0.81