Published in Viruses on June 26, 2015
SignalP 4.0: discriminating signal peptides from transmembrane regions. Nat Methods (2011) 33.90
Membrane protein folding and stability: physical principles. Annu Rev Biophys Biomol Struct (1999) 10.13
Experimentally determined hydrophobicity scale for proteins at membrane interfaces. Nat Struct Biol (1996) 8.57
Recognition of transmembrane helices by the endoplasmic reticulum translocon. Nature (2005) 7.72
Gene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysis. Proc Natl Acad Sci U S A (1991) 7.15
Structure and mechanism of the M2 proton channel of influenza A virus. Nature (2008) 6.79
Membrane protein folding and oligomerization: the two-stage model. Biochemistry (1990) 4.86
Molecular code for transmembrane-helix recognition by the Sec61 translocon. Nature (2007) 4.60
Influenza virus M2 protein mediates ESCRT-independent membrane scission. Cell (2010) 4.33
Protein translocation across the endoplasmic reticulum. I. Detection in the microsomal membrane of a receptor for the signal recognition particle. J Cell Biol (1982) 4.10
Transcending the impenetrable: how proteins come to terms with membranes. Biochim Biophys Acta (1988) 4.08
Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers. Nature (2010) 3.95
The p7 protein of hepatitis C virus forms an ion channel that is blocked by the antiviral drug, Amantadine. FEBS Lett (2003) 3.49
Insight into the mechanism of the influenza A proton channel from a structure in a lipid bilayer. Science (2010) 3.32
The transmembrane domain of influenza A M2 protein forms amantadine-sensitive proton channels in planar lipid bilayers. Virology (1992) 3.19
Specific structural alteration of the influenza haemagglutinin by amantadine. EMBO J (1990) 2.93
Backbone structure of the amantadine-blocked trans-membrane domain M2 proton channel from Influenza A virus. Biophys J (2007) 2.68
The biology of influenza viruses. Vaccine (2008) 2.58
Viroporins. FEBS Lett (2003) 2.57
Conformational transition of Sec machinery inferred from bacterial SecYE structures. Nature (2008) 2.48
The Sec61p complex mediates the integration of a membrane protein by allowing lipid partitioning of the transmembrane domain. Cell (2000) 2.46
Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus. Proc Natl Acad Sci U S A (2010) 2.43
Initial structural and dynamic characterization of the M2 protein transmembrane and amphipathic helices in lipid bilayers. Protein Sci (2003) 2.43
Sequential triage of transmembrane segments by Sec61alpha during biogenesis of a native multispanning membrane protein. Nat Struct Mol Biol (2005) 2.33
Identification of the functional core of the influenza A virus A/M2 proton-selective ion channel. Proc Natl Acad Sci U S A (2009) 2.32
The protein-conducting channel in the membrane of the endoplasmic reticulum is open laterally toward the lipid bilayer. Cell (1995) 2.27
The influenza virus M2 protein cytoplasmic tail interacts with the M1 protein and influences virus assembly at the site of virus budding. J Virol (2008) 2.12
Modification of membrane permeability by animal viruses. Adv Virus Res (1995) 2.11
SRP keeps polypeptides translocation-competent by slowing translation to match limiting ER-targeting sites. Cell (2008) 2.09
Total chemical synthesis of the integral membrane protein influenza A virus M2: role of its C-terminal domain in tetramer assembly. Biochemistry (1999) 2.02
The structure of melittin in membranes. Biophys J (1986) 1.85
Signal recognition particle binds to ribosome-bound signal sequences with fluorescence-detected subnanomolar affinity that does not diminish as the nascent chain lengthens. J Biol Chem (2003) 1.71
Unassisted translocation of large polypeptide domains across phospholipid bilayers. J Cell Biol (2006) 1.69
The NS2 protein of hepatitis C virus is a transmembrane polypeptide. J Virol (1995) 1.61
Lateral opening of a translocon upon entry of protein suggests the mechanism of insertion into membranes. Proc Natl Acad Sci U S A (2010) 1.57
Viroporins: structure and biological functions. Nat Rev Microbiol (2012) 1.56
Structural and dynamic mechanisms for the function and inhibition of the M2 proton channel from influenza A virus. Curr Opin Struct Biol (2011) 1.56
Signal recognition particle mediates post-translational targeting in eukaryotes. EMBO J (2004) 1.46
Membrane leakiness after viral infection and a new approach to the development of antiviral agents. Nature (1978) 1.46
Hepatitis C virus and host cell lipids: an intimate connection. RNA Biol (2011) 1.45
Integration of a small integral membrane protein, M2, of influenza virus into the endoplasmic reticulum: analysis of the internal signal-anchor domain of a protein with an ectoplasmic NH2 terminus. J Cell Biol (1988) 1.44
A precursor-specific role for Hsp40/Hsc70 during tail-anchored protein integration at the endoplasmic reticulum. J Biol Chem (2008) 1.44
Unusual architecture of the p7 channel from hepatitis C virus. Nature (2013) 1.39
How do helix-helix interactions help determine the folds of membrane proteins? Perspectives from the study of homo-oligomeric helical bundles. Protein Sci (2003) 1.38
Turns in transmembrane helices: determination of the minimal length of a "helical hairpin" and derivation of a fine-grained turn propensity scale. J Mol Biol (1999) 1.36
Different conformations of nascent polypeptides during translocation across the ER membrane. BMC Cell Biol (2000) 1.34
Asn- and Asp-mediated interactions between transmembrane helices during translocon-mediated membrane protein assembly. EMBO Rep (2006) 1.33
Insertion of short transmembrane helices by the Sec61 translocon. Proc Natl Acad Sci U S A (2009) 1.31
Cooperation of transmembrane segments during the integration of a double-spanning protein into the ER membrane. EMBO J (2003) 1.27
The M2 ectodomain is important for its incorporation into influenza A virions. J Virol (1998) 1.25
Amiloride derivatives block ion channel activity and enhancement of virus-like particle budding caused by HIV-1 protein Vpu. Eur Biophys J (2002) 1.24
Viroporins from RNA viruses induce caspase-dependent apoptosis. Cell Microbiol (2007) 1.22
Molecular code for protein insertion in the endoplasmic reticulum membrane is similar for N(in)-C(out) and N(out)-C(in) transmembrane helices. Proc Natl Acad Sci U S A (2008) 1.21
Membrane protein folding: how important are hydrogen bonds? Curr Opin Struct Biol (2010) 1.19
Influenza A virus lacking M2 protein as a live attenuated vaccine. J Virol (2009) 1.16
Inserting membrane proteins: the YidC/Oxa1/Alb3 machinery in bacteria, mitochondria, and chloroplasts. Biochim Biophys Acta (2010) 1.15
Membrane insertion of marginally hydrophobic transmembrane helices depends on sequence context. J Mol Biol (2009) 1.07
Similar energetic contributions of packing in the core of membrane and water-soluble proteins. J Am Chem Soc (2009) 1.06
Protein folding in membranes. Cell Mol Life Sci (2010) 1.06
Membrane pore formation at protein-lipid interfaces. Trends Biochem Sci (2014) 1.06
The multifaceted poliovirus 2A protease: regulation of gene expression by picornavirus proteases. J Biomed Biotechnol (2011) 1.05
Influenza virus A M2 protein generates negative Gaussian membrane curvature necessary for budding and scission. J Am Chem Soc (2013) 1.04
Transmembrane helix-helix interactions: comparative simulations of the glycophorin a dimer. Biochemistry (2006) 1.04
A novel antimicrobial peptide from the loach, Misgurnus anguillicaudatus. FEBS Lett (1997) 1.03
Specific transmembrane segments are selectively delayed at the ER translocon during opsin biogenesis. Biochem J (2008) 0.99
A frequent, GxxxG-mediated, transmembrane association motif is optimized for the formation of interhelical Cα-H hydrogen bonds. Proc Natl Acad Sci U S A (2014) 0.98
The YidC/Oxa1/Alb3 protein family: common principles and distinct features. Biol Chem (2012) 0.98
Subcellular localization and membrane association of SARS-CoV 3a protein. Virus Res (2005) 0.97
The surfactant peptide KL4 sequence is inserted with a transmembrane orientation into the endoplasmic reticulum membrane. Biophys J (2008) 0.93
Hepatitis C virus p7-a viroporin crucial for virus assembly and an emerging target for antiviral therapy. Viruses (2010) 0.93
Membrane integration of the second transmembrane segment of band 3 requires a closely apposed preceding signal-anchor sequence. J Biol Chem (2000) 0.92
Sec61alpha and TRAM are sequentially adjacent to a nascent viral membrane protein during its ER integration. J Mol Biol (2006) 0.92
Modeling the membrane environment has implications for membrane protein structure and function: influenza A M2 protein. Protein Sci (2013) 0.92
Membrane integration of poliovirus 2B viroporin. J Virol (2011) 0.91
Biogenesis of mitochondrial proteins. Adv Exp Med Biol (2012) 0.90
Mitochondria as functional targets of proteins coded by human tumor viruses. Adv Cancer Res (2005) 0.90
Double-spanning plant viral movement protein integration into the endoplasmic reticulum membrane is signal recognition particle-dependent, translocon-mediated, and concerted. J Biol Chem (2005) 0.88
Structure-based statistical analysis of transmembrane helices. Eur Biophys J (2012) 0.88
Plasma membrane-porating domain in poliovirus 2B protein. A short peptide mimics viroporin activity. J Mol Biol (2007) 0.88
Incorporation of hepatitis C virus E1 and E2 glycoproteins: the keystones on a peculiar virion. Viruses (2014) 0.88
Charge pair interactions in transmembrane helices and turn propensity of the connecting sequence promote helical hairpin insertion. J Mol Biol (2012) 0.86
Polar/Ionizable residues in transmembrane segments: effects on helix-helix packing. PLoS One (2012) 0.85
Viral M2 ion channel protein: a promising target for anti-influenza drug discovery. Mini Rev Med Chem (2014) 0.85
The minimalist architectures of viroporins and their therapeutic implications. Biochim Biophys Acta (2013) 0.84
Haemolytic activity of stonustoxin from stonefish (Synanceja horrida) venom: pore formation and the role of cationic amino acid residues. Biochem J (1997) 0.84
The elusive function of the hepatitis C virus p7 protein. Virology (2014) 0.83
Membrane protein integration into the endoplasmic reticulum. FEBS J (2011) 0.83
Positive charges of translocating polypeptide chain retrieve an upstream marginal hydrophobic segment from the endoplasmic reticulum lumen to the translocon. Mol Biol Cell (2010) 0.82
Assembly of Viral Membrane Proteins. J Chem Theory Comput (2009) 0.81
Pore-forming activity of pestivirus p7 in a minimal model system supports genus-specific viroporin function. Antiviral Res (2013) 0.80
Toward understanding driving forces in membrane protein folding. Arch Biochem Biophys (2014) 0.80
Antivirals--current trends in fighting influenza. Acta Biochim Pol (2014) 0.80
A dimer is the minimal proton-conducting unit of the influenza a virus M2 channel. J Mol Biol (2014) 0.79
Assembling viral channel forming proteins: Vpu from HIV-1. Biopolymers (2013) 0.78
Stitching proteins into membranes, not sew simple. Biol Chem (2014) 0.76