Pharmacology and physiology of gastrointestinal enteroendocrine cells.

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🔗 View Article (PMC 4506687)

Published in Pharmacol Res Perspect on July 07, 2015

Authors

O J Mace1, B Tehan1, F Marshall1

Author Affiliations

1: Heptares Therapeutics Ltd BioPark, Broadwater Road, Welwyn Garden City, AL7 3AX, United Kingdom.

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Glucose sensing in L cells: a primary cell study. Cell Metab (2008) 5.53

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Cholecystokinin bioactivity in human plasma. Molecular forms, responses to feeding, and relationship to gallbladder contraction. J Clin Invest (1985) 2.64

International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states. Pharmacol Rev (2007) 2.50

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Critical role for peptide YY in protein-mediated satiation and body-weight regulation. Cell Metab (2006) 2.23

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Glucagon-like peptide-1 (7-36)amide and glucose-dependent insulinotropic polypeptide secretion in response to nutrient ingestion in man: acute post-prandial and 24-h secretion patterns. J Endocrinol (1993) 2.12

Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon. Am J Physiol Gastrointest Liver Physiol (2006) 2.07

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Expression of short-chain fatty acid receptor GPR41 in the human colon. Biomed Res (2009) 1.41

The extracellular calcium-sensing receptor is required for cholecystokinin secretion in response to L-phenylalanine in acutely isolated intestinal I cells. Am J Physiol Gastrointest Liver Physiol (2011) 1.41

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Free fatty acid receptors FFAR1 and GPR120 as novel therapeutic targets for metabolic disorders. J Pharm Sci (2011) 1.20

G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons. Nature (2015) 1.20

GPR119 as a fat sensor. Trends Pharmacol Sci (2012) 1.20

Release of glucagon-like peptide-1 (GLP-1) by carbohydrates in the perfused rat ileum. Acta Diabetol (1997) 1.19

Positive and negative allosteric modulators of the Ca2+-sensing receptor interact within overlapping but not identical binding sites in the transmembrane domain. J Biol Chem (2004) 1.19

High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875. Nature (2014) 1.19

The agonist-binding domain of the calcium-sensing receptor is located at the amino-terminal domain. J Biol Chem (1999) 1.18

Calcium absorption by Cav1.3 induces terminal web myosin II phosphorylation and apical GLUT2 insertion in rat intestine. J Physiol (2007) 1.18

The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor. BMC Struct Biol (2007) 1.17

Discovery of the first potent and orally efficacious agonist of the orphan G-protein coupled receptor 119. J Med Chem (2008) 1.16

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An enteroendocrine cell-enteric glia connection revealed by 3D electron microscopy. PLoS One (2014) 1.15

Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells. Mol Metab (2013) 1.14

Discovery of 3-aryl-4-isoxazolecarboxamides as TGR5 receptor agonists. J Med Chem (2009) 1.13

GPR93 activation by protein hydrolysate induces CCK transcription and secretion in STC-1 cells. Am J Physiol Gastrointest Liver Physiol (2007) 1.13

AMG 837: a potent, orally bioavailable GPR40 agonist. Bioorg Med Chem Lett (2011) 1.13

AMG 837: a novel GPR40/FFA1 agonist that enhances insulin secretion and lowers glucose levels in rodents. PLoS One (2011) 1.13