Further characterisation of the 'ileal brake' reflex in man--effect of ileal infusion of partial digests of fat, protein, and starch on jejunal motility and release of neurotensin, enteroglucagon, and peptide YY.

PubWeight™: 1.36‹?› | Rank: Top 10%

🔗 View Article (PMC 1433910)

Published in Gut on August 01, 1988

Authors

R C Spiller1, I F Trotman, T E Adrian, S R Bloom, J J Misiewicz, D B Silk

Author Affiliations

1: Department of Gastroenterology and Nutrition, Central Middlesex Hospital, London.

Articles citing this

Gastrointestinal hormones in short bowel syndrome. Peptide YY may be the 'colonic brake' to gastric emptying. Gut (1996) 1.60

An exaggerated sensory component of the gastrocolonic response in patients with irritable bowel syndrome. Gut (2001) 1.26

Human pancreatic exocrine response to nutrients in health and disease. Gut (2005) 1.16

Stimulation of incretin secretion by dietary lipid: is it dose dependent? Am J Physiol Gastrointest Liver Physiol (2009) 1.08

Is irritable bowel syndrome an organic disorder? World J Gastroenterol (2014) 1.01

Gut chemosensing mechanisms. J Clin Invest (2015) 0.96

Disturbed gastric emptying in the short bowel syndrome. Evidence for a 'colonic brake'. Gut (1993) 0.95

Endocrine cells in the ileum of patients with irritable bowel syndrome. World J Gastroenterol (2014) 0.93

Distal small bowel hormones: correlation with fasting antroduodenal motility and gastric emptying. Dig Dis Sci (1998) 0.92

Differential responses of the incretin hormones GIP and GLP-1 to increasing doses of dietary carbohydrate but not dietary protein in lean rats. Am J Physiol Gastrointest Liver Physiol (2010) 0.91

The role of peptide YY in gastrointestinal diseases and disorders (review). Int J Mol Med (2012) 0.90

Using the lymphatics to study nutrient absorption and the secretion of gastrointestinal hormones. Physiol Behav (2011) 0.84

Sites of symptomatic gas retention during intestinal lipid perfusion in healthy subjects. Gut (2004) 0.83

Slowing of gastrointestinal transit by oleic acid: a preliminary report of a novel, nutrient-based treatment in humans. Dig Dis Sci (2001) 0.83

Ileal brake activation: macronutrient-specific effects on eating behavior? Int J Obes (Lond) (2014) 0.83

Intestinal transit is more potently inhibited by fat in the distal (ileal brake) than in the proximal (jejunal brake) gut. Dig Dis Sci (1997) 0.82

Expression of ileal glucagon and peptide tyrosine-tyrosine genes. Response to inhibition of polyamine synthesis in the presence of massive small-bowel resection. Biochem J (1992) 0.81

Effect of intestinal resection on human small bowel motility. Gut (1996) 0.81

Effect of dietary fat on the distribution of mucosal mass and cell proliferation along the small intestine. Gut (1992) 0.79

Inflammation in irritable bowel syndrome: Myth or new treatment target? World J Gastroenterol (2016) 0.79

Rapid distal small bowel transit associated with sympathetic denervation in type I diabetes mellitus. Gut (1996) 0.78

Intestinal transit of fat depends on accelerating effect of cholecystokinin and slowing effect of an opioid pathway. Dig Dis Sci (2002) 0.78

Basal and fat-stimulated plasma peptide YY levels in celiac disease. Dig Dis Sci (2001) 0.78

Canine small bowel motor activity in response to intraduodenal infusion of nutrient mixtures of increasing caloric load in dogs. Dig Dis Sci (2003) 0.78

Modulatory role of PYY in transport and metabolism of cholesterol in intestinal epithelial cells. PLoS One (2012) 0.77

Does the Ileal Brake Contribute to Delayed Gastric Emptying After Pancreatoduodenectomy? Dig Dis Sci (2016) 0.77

Does the fatty acid profile of dietary fat influence its trophic effect on the small intestinal mucosa? Gut (1993) 0.76

Importance of colonic bacterial fermentation in short bowel patients: small intestinal malabsorption of easily digestible carbohydrate. Dig Dis Sci (1999) 0.76

Effect of ingestion of fat on ileostomy effluent. Gut (1990) 0.75

Liver disease secondary to intestinal failure. Biomed Res Int (2014) 0.75

Hydroxypropylation of high-amylose maize starch changes digestion and fermentation-dependent parameters in rats. J Nutr Sci (2013) 0.75

Pharmacology and physiology of gastrointestinal enteroendocrine cells. Pharmacol Res Perspect (2015) 0.75

Intestinal absorptive function. Gut (1994) 0.75

Pathophysiology, Evaluation, and Management of Chronic Watery Diarrhea. Gastroenterology (2016) 0.75

Effects of Bolus and Continuous Nasogastric Feeding on Gastric Emptying, Small Bowel Water Content, Superior Mesenteric Artery Blood Flow, and Plasma Hormone Concentrations in Healthy Adults: A Randomized Crossover Study. Ann Surg (2016) 0.75

Exploring hypotheses and rationale for causes of infantile colic. Neurogastroenterol Motil (2016) 0.75

Chronic high-fat feeding increases GIP and GLP-1 secretion without altering body weight. Am J Physiol Gastrointest Liver Physiol (2015) 0.75

Gastrointestinal Nutrient Infusion Site and Eating Behavior: Evidence for A Proximal to Distal Gradient within the Small Intestine? Nutrients (2016) 0.75

Dietary fiber in irritable bowel syndrome (Review). Int J Mol Med (2017) 0.75

The relationship between the esophageal tissue content of neurotensin and the presence or absence of esophageal inflammation. Dig Dis Sci (2004) 0.75

Abnormalities in ileal stem, neurogenin 3, and enteroendocrine cells in patients with irritable bowel syndrome. BMC Gastroenterol (2017) 0.75

Articles cited by this

Human distribution and release of a putative new gut hormone, peptide YY. Gastroenterology (1985) 3.36

Interrelationships between the absorptions of glucose, sodium and water by the normal human jejunum. Clin Sci (1969) 2.68

Effect of infusion of nutrient solutions into the ileum on gastrointestinal transit and plasma levels of neurotensin and enteroglucagon. Gastroenterology (1984) 2.42

Isolation of two novel candidate hormones using a chemical method for finding naturally occurring polypeptides. Nature (1980) 2.31

The ileal brake--inhibition of jejunal motility after ileal fat perfusion in man. Gut (1984) 2.11

Effects of oleic and ricinoleic acids on net jejunal water and electrolyte movement. Perfusion studies in man. J Clin Invest (1974) 1.92

A radioimmunoassay for neurotensin in human plasma. J Endocrinol (1979) 1.66

Effect of neurotensin on gastric function in man. Lancet (1980) 1.55

Absorption of medium and long chain triglycerides: factors influencing their hydrolysis and transport. J Clin Invest (1966) 1.44

Postprandial patterns of canine jejunal motility and transit of luminal content. Gastroenterology (1986) 1.33

Peptide YY abnormalities in gastrointestinal diseases. Gastroenterology (1986) 1.32

Studies on the site of fat absorption: 1. The sites of absorption of increasing doses of I-labelled triolein in the rat. Gut (1961) 1.31

Calories and gastric emptying: a regulatory capacity with implications for feeding. Am J Physiol (1979) 1.28

Decreased fluid tolerance, accelerated transit, and abnormal motility of the human colon induced by oleic acid. Gastroenterology (1986) 1.26

Molecular forms of human enteroglucagon in tissue and plasma: plasma responses to nutrient stimuli in health and in disorders of the upper gastrointestinal tract. J Clin Endocrinol Metab (1983) 1.23

Effect of vagotomy on intraluminal digestion of fat in man. Gut (1965) 1.22

Effects of peptide YY and neuropeptide Y on gastric emptying in man. Digestion (1984) 1.13

(Gln4)-neurotensin changes the motility pattern of the duodenum and proximal jejunum from a fasting-type to a fed-type. Gastroenterology (1982) 0.94

Fecal fat concentration in patients with steatorrhea. Gastroenterology (1984) 0.90

Delayed mouth-caecum transit of a lactulose labelled liquid test meal in patients with steatorrhoea caused by partially treated coeliac disease. Gut (1987) 0.84

Articles by these authors

Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature (1998) 7.36

Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab (2001) 6.41

A role for glucagon-like peptide-1 in the central regulation of feeding. Nature (1996) 6.03

Variation of bowel habit in two population samples. Br Med J (1965) 5.78

Glucagon-like peptide-1 7-36: a physiological incretin in man. Lancet (1987) 4.97

One week eradication regimen for Helicobacter pylori. Lancet (1991) 4.50

Comparison of the effects of ranitidine, cimetidine and placebo on the 24 hour intragastric acidity and nocturnal acid secretion in patients with duodenal ulcer. Gut (1981) 4.30

The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology (2000) 3.80

Effect of cimetidine on 24-hour intragastric acidity in normal subjects. Gut (1976) 3.75

Ghrelin causes hyperphagia and obesity in rats. Diabetes (2001) 3.62

A glucagonoma syndrome. Lancet (1974) 3.56

Prevention of pancreatic cancer induction in hamsters by metformin. Gastroenterology (2001) 3.38

Human distribution and release of a putative new gut hormone, peptide YY. Gastroenterology (1985) 3.36

Vasoactive intestinal peptide and watery-diarrhoea syndrome. Lancet (1973) 3.22

Possible dual role for vasoactive intestinal peptide as gastrointestinal hormone and neurotransmitter substance. Lancet (1976) 3.08

Distribution and release of human pancreatic polypeptide. Gut (1976) 3.02

Attenuated peptide YY release in obese subjects is associated with reduced satiety. Endocrinology (2005) 2.80

Endocrine tumour in kidney affecting small bowel structure, motility, and absorptive function. Gut (1971) 2.75

24-hour control of intragastric acidity by cimetidine in duodenal-ulcer patients. Lancet (1975) 2.67

Inhibition of gastrin and gastric-acid secretion by growth-hormone release-inhibiting hormone. Lancet (1974) 2.65

Neuron-specific enolase is produced by neuroendocrine tumours. Lancet (1981) 2.63

Treatment of fulminant hepatic failure by polyacrylonitrile-membrane haemodialysis. Lancet (1977) 2.53

Breast vs bottle: endocrine responses are different with formula feeding. Lancet (1980) 2.52

Measurement of fasting and postprandial plasma VIP in man. Gut (1978) 2.48

Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice. J Clin Invest (1999) 2.48

Nesidioblastosis of the pancreas: definition of the syndrome and the management of the severe neonatal hyperinsulinaemic hypoglycaemia. Arch Dis Child (1981) 2.36

ABC of the upper gastrointestinal tract. Management of Helicobacter pylori infection. BMJ (2001) 2.32

Observations on the mechanism of abdominal pain. Gut (1969) 2.30

Effect of catheter tunnelling and a nutrition nurse on catheter sepsis during parenteral nutrition. A controlled trial. Lancet (1983) 2.30

Central and peripheral administration of kisspeptin-10 stimulates the hypothalamic-pituitary-gonadal axis. J Neuroendocrinol (2004) 2.27

Inhibition of nocturnal acid secretion in duodenal ulcer by one oral dose of metiamide. Lancet (1974) 2.26

Misleading response of malignant gastric ulcers to cimetidine. Lancet (1978) 2.25

Gut-hormone profile in coeliac disease. Lancet (1978) 2.25

Saturation of fat and cholecystokinin release: implications for pancreatic carcinogenesis. Lancet (1989) 2.25

Exendin-4 reduces fasting and postprandial glucose and decreases energy intake in healthy volunteers. Am J Physiol Endocrinol Metab (2001) 2.24

Changes in the intragastric distribution of Helicobacter pylori during treatment with omeprazole. Gut (1995) 2.20

Requirement for leptin in the induction and progression of autoimmune encephalomyelitis. J Immunol (2001) 2.20

Characterization of a gastrin releasing peptide from porcine non-antral gastric tissue. Biochem Biophys Res Commun (1979) 2.16

Gut hormones and appetite control. Gastroenterology (2007) 2.16

Factors controlling colonic motility: colonic pressures and transit after meals in patients with total gastrectomy, pernicious anaemia or duodenal ulcer. Gut (1970) 2.14

A C-terminal fragment of Agouti-related protein increases feeding and antagonizes the effect of alpha-melanocyte stimulating hormone in vivo. Endocrinology (1998) 2.14

Pancreatic polypeptide in insulinomas, gastrinomas, vipomas, and glucagonomas. Lancet (1976) 2.13

The ileal brake--inhibition of jejunal motility after ileal fat perfusion in man. Gut (1984) 2.11

Neuropeptide Y distribution in the rat brain. Science (1983) 2.10

Propulsion (mass movements) in the human colon and its relationship to meals and somatic activity. Gut (1970) 2.05

Growth-hormone release-inhibiting hormone in gastrointestinal and pancreatic D cells. Lancet (1975) 2.04

Simplified single sample 13Carbon urea breath test for Helicobacter pylori: comparison with histology, culture, and ELISA serology. Gut (1991) 2.04

The role of the sympathetic innervation in the control of plasma glucagon concentration in the calf. J Physiol (1973) 2.01

Motor responses of human gastrointestinal tract to 5-hydroxytryptamine in vivo and in vitro. Gut (1966) 2.00

Achalasia of the cardia: pharmacology and histopathology of isolated cardiac sphincteric muscle from patients with and without achalasia. Q J Med (1969) 1.97

Reversible finger clubbing in a case of purgative abuse. Gastroenterology (1975) 1.97

Advanced carcinoma of the prostate: treatment with a gonadotrophin releasing hormone agonist. Br Med J (Clin Res Ed) (1983) 1.93

Evaluation of 13C-urea breath test in the detection of Helicobacter pylori and in monitoring the effect of tripotassium dicitratobismuthate in non-ulcer dyspepsia. Gut (1990) 1.92

Progressive rise in gut hormone levels after Roux-en-Y gastric bypass suggests gut adaptation and explains altered satiety. Br J Surg (2006) 1.91

Use of ethanol-induced tumor necrosis to palliate dysphagia in patients with esophagogastric cancer. Gastrointest Endosc (1990) 1.91

Glucagon-like peptide 1 has a physiological role in the control of postprandial glucose in humans: studies with the antagonist exendin 9-39. Diabetes (1999) 1.90

Comparison of the effect of meals and prostigmine on the proximal and distal colon in patients with and without diarrhoea. Gut (1966) 1.89

Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice. J Clin Invest (1997) 1.89

Calcitonin gene-related peptide immunoreactivity in the spinal cord of man and of eight other species. J Neurosci (1984) 1.88

Short term benefits of post-operative oral dietary supplements in surgical patients. Clin Nutr (1992) 1.87

24-hour intragastric acidity and nocturnal acid secretion in patients with duodenal ulcer during oral administration of cimetidine and atropine. Gut (1977) 1.87

Effects of stimulation of the chorda tympani in bursts on submaxillary responses in the cat. J Physiol (1982) 1.84

Inhibition of food-stimulated gastric acid secretion by cimetidine. Gut (1976) 1.82

Suppression of pancreatic endocrine tumour secretion by long-acting somatostatin analogue. Lancet (1979) 1.81

Assessment of the reproducibility of the lactulose H2 breath test as a measure of mouth to caecum transit time. Gut (1983) 1.81

Current European concepts in the management of Helicobacter pylori infection--the Maastricht Consensus Report. The European Helicobacter Pylori Study Group (EHPSG). Eur J Gastroenterol Hepatol (1997) 1.81

Development of neuroendocrine tumors in the gastrointestinal tract of transgenic mice. Heterogeneity of hormone expression. Am J Pathol (1990) 1.80

Motor responses of the human alimentary tract to near-maximal infusions of pentagastrin. Gut (1967) 1.76

Eradication of Helicobacter pylori with clarithromycin and omeprazole. Gut (1994) 1.75

Enkephalin-like immunoreactivity in the human gastrointestinal tract. Lancet (1977) 1.75

Increased leptin levels in serum and peritoneal fluid of patients with pelvic endometriosis. J Clin Endocrinol Metab (2000) 1.75

Melanin-concentrating hormone acutely stimulates feeding, but chronic administration has no effect on body weight. Endocrinology (1997) 1.74

The effect of truncal and selective vagotomy on the release of pancreatic glucagon, insulin and enteroglucagon. Br J Surg (1974) 1.73

Bombesin-like immunoreactivity in the lung. Nature (1978) 1.73

Localization of insulinomas by selective intraarterial calcium injection. J Clin Endocrinol Metab (1996) 1.72

Effects of growth-hormone release-inhibiting hormone on circulating glucagon, insulin, and growth hormone in normal, diabetic, acromegalic, and hypopituitary patients. Lancet (1974) 1.71

Pancreatic polypeptide reduces appetite and food intake in humans. J Clin Endocrinol Metab (2003) 1.71

Abnormalities of vasoactive intestinal polypeptide-containing nerves in Crohn's disease. Gastroenterology (1980) 1.70

Bromocriptine treatment of acromegaly. Br Med J (1975) 1.70

An enteroglucagon tumour. Gut (1972) 1.69

Free radical scavengers prevent reflux esophagitis in rats. Dig Dis Sci (1995) 1.69

Mechanism of pancreatic polypeptide release in man. Lancet (1977) 1.68

Effects of peptide YY (PYY) on mouth to caecum intestinal transit time and on the rate of gastric emptying in healthy volunteers. Gut (1987) 1.68

Abdominal tuberculosis in urban Britain--a common disease. Gut (1985) 1.68

Motilin and the interdigestive migrating motor complex in man. Dig Dis Sci (1979) 1.67

Oral rehydration in acute infantile diarrhoea with a glucose-polymer electrolyte solution. Arch Dis Child (1982) 1.67

Neuropeptide Y distribution in human brain. Nature (1984) 1.66