Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.

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Published in Nat Genet on July 27, 2015

Authors

Martin Hrabě de Angelis1,2,3, George Nicholson4, Mohammed Selloum5,6,7,8, Jacqui White9, Hugh Morgan10, Ramiro Ramirez-Solis9, Tania Sorg5,6,7,8, Sara Wells10, Helmut Fuchs1, Martin Fray10, David J Adams9, Niels C Adams9, Thure Adler1,11, Antonio Aguilar-Pimentel1,12, Dalila Ali-Hadji5,6,7,8, Gregory Amann5,6,7,8, Philippe André5,6,7,8, Sarah Atkins10, Aurelie Auburtin5,6,7,8, Abdel Ayadi5,6,7,8, Julien Becker5,6,7,8, Lore Becker1,13, Elodie Bedu5,6,7,8, Raffi Bekeredjian1,14, Marie-Christine Birling5,6,7,8, Andrew Blake10, Joanna Bottomley9, Mike Bowl10, Véronique Brault15,6,7,8, Dirk H Busch11, James N Bussell9, Julia Calzada-Wack16, Heather Cater10, Marie-France Champy5,6,7,8, Philippe Charles5,6,7,8, Claire Chevalier15,6,7,8, Francesco Chiani17, Gemma F Codner10, Roy Combe5,6,7,8, Roger Cox10, Emilie Dalloneau15,6,7,8, André Dierich5,6,7,8, Armida Di Fenza10, Brendan Doe17, Arnaud Duchon15,6,7,8, Oliver Eickelberg18, Chris T Esapa10, Lahcen El Fertak5,6,7,8, Tanja Feigel10, Irina Emelyanova10, Jeanne Estabel9, Jack Favor19, Ann Flenniken20, Alessia Gambadoro17, Lilian Garrett21, Hilary Gates10, Anna-Karin Gerdin9, George Gkoutos22, Simon Greenaway10, Lisa Glasl21, Patrice Goetz5,6,7,8, Isabelle Goncalves Da Cruz5,6,7,8, Alexander Götz18, Jochen Graw21, Alain Guimond5,6,7,8, Wolfgang Hans1, Geoff Hicks23, Sabine M Hölter21, Heinz Höfler13, John M Hancock10, Robert Hoehndorf24, Tertius Hough10, Richard Houghton9, Anja Hurt1, Boris Ivandic1,14, Hughes Jacobs5,6,7,8, Sylvie Jacquot5,6,7,8, Nora Jones20, Natasha A Karp9, Hugo A Katus1,14, Sharon Kitchen10, Tanja Klein-Rodewald16, Martin Klingenspor1,25, Thomas Klopstock1,13, Valerie Lalanne5,6,7,8, Sophie Leblanc5,6,7,8, Christoph Lengger1, Elise le Marchand5,6,7,8, Tonia Ludwig1, Aline Lux5,6,7,8, Colin McKerlie26,27, Holger Maier1, Jean-Louis Mandel5,15,6,7,8, Susan Marschall1, Manuel Mark5,15,6,7,8, David G Melvin9, Hamid Meziane5,6,7,8, Kateryna Micklich1, Christophe Mittelhauser5,6,7,8, Laurent Monassier5,6,7,8, David Moulaert5,6,7,8, Stéphanie Muller5,6,7,8, Beatrix Naton1, Frauke Neff16, Patrick M Nolan10, Lauryl Mj Nutter27, Markus Ollert1,12, Guillaume Pavlovic5,6,7,8, Natalia S Pellegata16, Emilie Peter5,6,7,8, Benoit Petit-Demoulière5,6,7,8, Amanda Pickard10, Christine Podrini9, Paul Potter10, Laurent Pouilly5,6,7,8, Oliver Puk21, David Richardson9, Stephane Rousseau5,6,7,8, Leticia Quintanilla-Fend16, Mohamed M Quwailid10, Ildiko Racz1,28, Birgit Rathkolb1,29, Fabrice Riet5,6,7,8, Janet Rossant27, Michel Roux5,15,6,7,8, Jan Rozman1,25, Ed Ryder9, Jennifer Salisbury9, Luis Santos10, Karl-Heinz Schäble1, Evelyn Schiller1, Anja Schrewe1, Holger Schulz18, Ralf Steinkamp1, Michelle Simon10, Michelle Stewart10, Claudia Stöger1, Tobias Stöger18, Minxuan Sun21, David Sunter9, Lydia Teboul10, Isabelle Tilly5,6,7,8, Glauco P Tocchini-Valentini17, Monica Tost16, Irina Treise1, Laurent Vasseur5,6,7,8, Emilie Velot15,6,7,8, Daniela Vogt-Weisenhorn21, Christelle Wagner5,15,6,7,8, Alison Walling10, Bruno Weber5,6,7,8, Olivia Wendling5,15,6,7,8, Henrik Westerberg10, Monja Willershäuser1, Eckhard Wolf29,1, Anne Wolter5,6,7,8, Joe Wood10, Wolfgang Wurst21,2,30,31, Ali Önder Yildirim18, Ramona Zeh1, Andreas Zimmer1,28, Annemarie Zimprich21, EUMODIC Consortium, Chris Holmes4, Karen P Steel9, Yann Herault5,15,6,7,8, Valérie Gailus-Durner1, Ann-Marie Mallon10, Steve Dm Brown10, Steve D M Brown32

Author Affiliations

1: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
2: School of Life Sciences Weihenstephan, Technische Universität München, Freising, Germany.
3: German Center for Diabetes Research (DZD), Neuherberg, Germany.
4: Department of Statistics, University of Oxford, Oxford, UK.
5: Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
6: Centre National de la Recherche Scientifique, Illkirch, France.
7: Institut National de la Santé et de la Recherche Médicale, Illkirch, France.
8: Université de Strasbourg, Illkirch, France.
9: The Wellcome Trust Sanger Institute, Hinxton, UK.
10: MRC Harwell, Medical Research Council, Harwell, UK.
11: Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, Munich, Germany.
12: Division of Environmental Dermatology and Allergy (UDA), Helmholtz Zentrum München/ Technische Universität München, and Clinical Research Division of Molecular and Clinical Allergotoxicology, Department of Dermatology and Allergy, Technische Universität München, Munich, Germany.
13: Deptartment of Neurology, Klinikum der Ludwig-Maximilians-Universität München, Germany.
14: Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany.
15: Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.
16: Institute of Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
17: Institute of Cell Biology and Neurology, CNR (National Research Council), Rome, Italy.
18: Institute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
19: Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
20: Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada.
21: Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
22: Department of Computer Science, University of Aberystwyth, UK.
23: Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada.
24: Computational Bioscience Research Center, King Abdullah University of Science and Technology, Kingdom of Saudi Arabia.
25: Else Kröner-Fresenius Center for Nutrional Medicine, Technische Universität München, Freising-Weihenstephan, Germany.
26: Toronto Centre for Phenogenomics, Toronto, Canada.
27: The Hospital for Sick Children, Toronto, Canada.
28: Institute of Molecular Psychiatry, University of Bonn, Bonn, Germany.
29: Institute of Molecular Animal Breeding and Biotechnology, Ludwigs-Maximilians-University Munich, Munich, Germany.
30: Max-Planck-Institute of Psychiatry, Munich, Germany.
31: Deutsches Zentrum für Neurodegenerative Erkrankungen, Munich, Germany.
32: Medical Research Council, MRC-Harwell, Harwell, UK.

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