Nucleotides regulate the mechanical hierarchy between subdomains of the nucleotide binding domain of the Hsp70 chaperone DnaK.

Computational Analysis of Residue Interaction Networks and Coevolutionary Relationships in the Hsp70 Chaperones: A Community-Hopping Model of Allosteric Regulation and Communication. PLoS Comput Biol (2017) 0.77

Stabilizing the Hsp70-Tau Complex Promotes Turnover in Models of Tauopathy. Cell Chem Biol (2016) 0.75

Domain Mapping of the Heat Shock Protein 70 reveals that Glutamic acid 446 and Arginine 447 are Critical for Regulating Superoxide Dismutase-2 Function. J Biol Chem (2016) 0.75

Entropic elasticity of lambda-phage DNA. Science (1994) 15.40

Molecular chaperones in protein folding and proteostasis. Nature (2011) 8.63

LigPlot+: multiple ligand-protein interaction diagrams for drug discovery. J Chem Inf Model (2011) 6.49

An ATPase domain common to prokaryotic cell cycle proteins, sugar kinases, actin, and hsp70 heat shock proteins. Proc Natl Acad Sci U S A (1992) 6.18

Mechanical unfolding intermediates in titin modules. Nature (1999) 6.12

Direct observation of the three-state folding of a single protein molecule. Science (2005) 4.48

The heat shock protein 70 family: Highly homologous proteins with overlapping and distinct functions. FEBS Lett (2007) 4.23

Sending signals dynamically. Science (2009) 3.64

Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate. Proc Natl Acad Sci U S A (2009) 2.77

Genetic dissection of the roles of chaperones and proteases in protein folding and degradation in the Escherichia coli cytosol. Mol Microbiol (2001) 2.54

Atomic force microscopy captures length phenotypes in single proteins. Proc Natl Acad Sci U S A (1999) 2.28

Mechanoenzymatics of titin kinase. Proc Natl Acad Sci U S A (2008) 2.17

Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP. Nat Struct Mol Biol (2013) 2.14

A mechanical unfolding intermediate in an actin-crosslinking protein. Nat Struct Mol Biol (2003) 2.12

Allosteric regulation of Hsp70 chaperones involves a conserved interdomain linker. J Biol Chem (2006) 1.90

The Hsp70 chaperone machines of Escherichia coli: a paradigm for the repartition of chaperone functions. Mol Microbiol (2007) 1.87

Structure and dynamics of the ATP-bound open conformation of Hsp70 chaperones. Mol Cell (2012) 1.84

Revealing the bifurcation in the unfolding pathways of GFP by using single-molecule experiments and simulations. Proc Natl Acad Sci U S A (2007) 1.74

Mechanism of fibrin(ogen) forced unfolding. Structure (2011) 1.72

Pathways and kinetic barriers in mechanical unfolding and refolding of RNA and proteins. Structure (2006) 1.58

Allosteric signal transmission in the nucleotide-binding domain of 70-kDa heat shock protein (Hsp70) molecular chaperones. Proc Natl Acad Sci U S A (2011) 1.55

Mechanical control of the directional stepping dynamics of the kinesin motor. Proc Natl Acad Sci U S A (2007) 1.54

DnaK functions as a central hub in the E. coli chaperone network. Cell Rep (2012) 1.52

Comparing proteins by their unfolding pattern. Biophys J (2008) 1.23

Locating ligand binding and activation of a single antiporter. EMBO Rep (2005) 1.15

Influence of substrate binding on the mechanical stability of mouse dihydrofolate reductase. Biophys J (2005) 1.11

Thermodynamic and structural analysis of the folding/unfolding transitions of the Escherichia coli molecular chaperone DnaK. J Mol Biol (1993) 1.02

Sop-GPU: accelerating biomolecular simulations in the centisecond timescale using graphics processors. Proteins (2010) 0.98

Collapse kinetics and chevron plots from simulations of denaturant-dependent folding of globular proteins. Proc Natl Acad Sci U S A (2011) 0.96

ATPase-defective derivatives of Escherichia coli DnaK that behave differently with respect to ATP-induced conformational change and peptide release. J Bacteriol (2001) 0.96

Auto- and cross-power spectral analysis of dual trap optical tweezer experiments using Bayesian inference. Rev Sci Instrum (2012) 0.96

Tubulin bond energies and microtubule biomechanics determined from nanoindentation in silico. J Am Chem Soc (2014) 0.93

Resolving the molecular mechanism of cadherin catch bond formation. Nat Commun (2014) 0.93

Differentiating ligand and inhibitor interactions of a single antiporter. J Mol Biol (2006) 0.93

Structural transitions and energy landscape for Cowpea Chlorotic Mottle Virus capsid mechanics from nanomanipulation in vitro and in silico. Biophys J (2013) 0.93

Denaturant-dependent folding of GFP. Proc Natl Acad Sci U S A (2012) 0.92

From valleys to ridges: exploring the dynamic energy landscape of single membrane proteins. Chemphyschem (2008) 0.91

Ultrafast folding kinetics and cooperativity of villin headpiece in single-molecule force spectroscopy. Proc Natl Acad Sci U S A (2013) 0.91

Three-state denaturation of DnaK induced by guanidine hydrochloride. Evidence for an expandable intermediate. Biochemistry (1993) 0.86

The molecular mechanism underlying mechanical anisotropy of the protein GB1. Biophys J (2012) 0.84

Dynamics of protein folding and cofactor binding monitored by single-molecule force spectroscopy. Biophys J (2011) 0.84

Molecular investigations into the mechanics of actin in different nucleotide states. J Phys Chem B (2010) 0.79

Knotting and unknotting of a protein in single molecule experiments. Proc Natl Acad Sci U S A (2016) 0.77