Published in Sci Rep on August 06, 2015
Rescue of CAMDI deletion-induced delayed radial migration and psychiatric behaviors by HDAC6 inhibitor. EMBO Rep (2016) 0.86
Cilium assembly and disassembly. Nat Cell Biol (2016) 0.80
Functional interplay between cylindromatosis and histone deacetylase 6 in ciliary homeostasis revealed by phenotypic analysis of double knockout mice. Oncotarget (2016) 0.80
Amyloid β oligomers elicit mitochondrial transport defects and fragmentation in a time-dependent and pathway-specific manner. Mol Brain (2016) 0.77
Phosphorylation of EB1 regulates the recruitment of CLIP-170 and p150glued to the plus ends of astral microtubules. Oncotarget (2017) 0.75
Neurons acetylate their way to migration. EMBO Rep (2016) 0.75
Histone deacetylase inhibition prevents cell death induced by loss of tricellular tight junction proteins in temperature-sensitive mouse cochlear cells. PLoS One (2017) 0.75
Chlamydomonas FAP265 is a tubulin polymerization promoting protein, essential for flagellar reassembly and hatching of daughter cells from the sporangium. PLoS One (2017) 0.75
HDAC6 is a microtubule-associated deacetylase. Nature (2002) 12.76
Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella. J Cell Biol (2000) 7.04
HEF1-dependent Aurora A activation induces disassembly of the primary cilium. Cell (2007) 6.50
HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. Mol Cell (2005) 6.00
Centrioles, centrosomes, and cilia in health and disease. Cell (2009) 5.82
Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation. Proc Natl Acad Sci U S A (2003) 5.56
In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation. EMBO J (2002) 4.28
Ciliogenesis: building the cell's antenna. Nat Rev Mol Cell Biol (2011) 4.26
Cortactin promotes and stabilizes Arp2/3-induced actin filament network formation. Curr Biol (2001) 4.16
HDAC6 modulates cell motility by altering the acetylation level of cortactin. Mol Cell (2007) 3.99
HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo. EMBO J (2003) 3.96
Cep164, a novel centriole appendage protein required for primary cilium formation. J Cell Biol (2007) 3.88
Functional genomic screen for modulators of ciliogenesis and cilium length. Nature (2010) 3.63
Cortactin, an 80/85-kilodalton pp60src substrate, is a filamentous actin-binding protein enriched in the cell cortex. J Cell Biol (1993) 3.56
Cep97 and CP110 suppress a cilia assembly program. Cell (2007) 3.15
MKS1, encoding a component of the flagellar apparatus basal body proteome, is mutated in Meckel syndrome. Nat Genet (2006) 2.75
HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1-induced Charcot-Marie-Tooth disease. Nat Med (2011) 2.60
Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A. J Am Chem Soc (2010) 2.50
HDAC6 is a target for protection and regeneration following injury in the nervous system. Proc Natl Acad Sci U S A (2009) 2.14
MIM and cortactin antagonism regulates ciliogenesis and hedgehog signaling. Dev Cell (2010) 2.11
HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation. Proc Natl Acad Sci U S A (2008) 2.10
Cilia in vertebrate development and disease. Development (2012) 1.50
The nephronophthisis gene product NPHP2/Inversin interacts with Aurora A and interferes with HDAC6-mediated cilia disassembly. Nephrol Dial Transplant (2013) 1.47
The small GTPases ARL-13 and ARL-3 coordinate intraflagellar transport and ciliogenesis. J Cell Biol (2010) 1.41
Mainzer-Saldino syndrome is a ciliopathy caused by IFT140 mutations. Am J Hum Genet (2012) 1.38
miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics. Nat Cell Biol (2012) 1.34
Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction. J Clin Invest (2013) 1.29
CYLD regulates spindle orientation by stabilizing astral microtubules and promoting dishevelled-NuMA-dynein/dynactin complex formation. Proc Natl Acad Sci U S A (2014) 1.15
PCM1 recruits Plk1 to the pericentriolar matrix to promote primary cilia disassembly before mitotic entry. J Cell Sci (2013) 1.15
Calmodulin activation of Aurora-A kinase (AURKA) is required during ciliary disassembly and in mitosis. Mol Biol Cell (2012) 1.13
Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin. EMBO J (2011) 1.12
Microtubule-associated deacetylase HDAC6 promotes angiogenesis by regulating cell migration in an EB1-dependent manner. Protein Cell (2011) 1.12
HDAC6 inhibition restores ciliary expression and decreases tumor growth. Cancer Res (2013) 1.11
Regulation of Tat acetylation and transactivation activity by the microtubule-associated deacetylase HDAC6. J Biol Chem (2011) 1.10
Expanding horizons: ciliary proteins reach beyond cilia. Annu Rev Genet (2013) 1.04
CYLD mediates ciliogenesis in multiple organs by deubiquitinating Cep70 and inactivating HDAC6. Cell Res (2014) 0.99
Heat shock induces rapid resorption of primary cilia. J Cell Sci (2012) 0.95
Histone deacetylase 6 and cytoplasmic linker protein 170 function together to regulate the motility of pancreatic cancer cells. Protein Cell (2014) 0.94
Lineage specificity of primary cilia in the mouse embryo. Nat Cell Biol (2015) 0.91
The MST1/2-SAV1 complex of the Hippo pathway promotes ciliogenesis. Nat Commun (2014) 0.89
Dido3-dependent HDAC6 targeting controls cilium size. Nat Commun (2014) 0.88
Primary cilia in stem cells and neural progenitors are regulated by neutral sphingomyelinase 2 and ceramide. Mol Biol Cell (2014) 0.87
β-catenin links von Hippel-Lindau to aurora kinase A and loss of primary cilia in renal cell carcinoma. J Am Soc Nephrol (2014) 0.86
Proteomic identification and functional characterization of MYH9, Hsc70, and DNAJA1 as novel substrates of HDAC6 deacetylase activity. Protein Cell (2014) 0.85
Nucleus accumbens-associated 1 contributes to cortactin deacetylation and augments the migration of melanoma cells. J Invest Dermatol (2011) 0.82
CYLD regulates spindle orientation by stabilizing astral microtubules and promoting dishevelled-NuMA-dynein/dynactin complex formation. Proc Natl Acad Sci U S A (2014) 1.15
CYLD mediates ciliogenesis in multiple organs by deubiquitinating Cep70 and inactivating HDAC6. Cell Res (2014) 0.99
CYLD - a deubiquitylase that acts to fine-tune microtubule properties and functions. J Cell Sci (2016) 0.81
Functional interplay between cylindromatosis and histone deacetylase 6 in ciliary homeostasis revealed by phenotypic analysis of double knockout mice. Oncotarget (2016) 0.80
Cep70 overexpression stimulates pancreatic cancer by inducing centrosome abnormality and microtubule disorganization. Sci Rep (2016) 0.78
Proto-Oncogenic Src Phosphorylates EB1 to Regulate the Microtubule-Focal Adhesion Crosstalk and Stimulate Cell Migration. Theranostics (2016) 0.78
Ciliopathies: Does HDAC6 Represent a New Therapeutic Target? Trends Pharmacol Sci (2015) 0.78
New HDAC6-mediated deacetylation sites of tubulin in the mouse brain identified by quantitative mass spectrometry. Sci Rep (2015) 0.76
Phosphorylation of EB1 regulates the recruitment of CLIP-170 and p150glued to the plus ends of astral microtubules. Oncotarget (2017) 0.75
Apoptosis signal-regulating kinase 1 exhibits oncogenic activity in pancreatic cancer. Oncotarget (2016) 0.75
HDAC6 regulates IL-17 expression in T lymphocytes: implications for HDAC6-targeted therapies. Theranostics (2017) 0.75
Palmitoylation-dependent activation of MC1R prevents melanomagenesis. Nature (2017) 0.75
The B-box module of CYLD is responsible for its intermolecular interaction and cytoplasmic localization. Oncotarget (2017) 0.75
The B-box module of CYLD is responsible for its intermolecular interaction and cytoplasmic localization. Oncotarget (2017) 0.75
The tumor suppressor CYLD controls epithelial morphogenesis and homeostasis by regulating mitotic spindle behavior and adherens junction assembly. J Genet Genomics (2017) 0.75