Published in Nature on May 23, 2002
Histone deacetylases (HDACs): characterization of the classical HDAC family. Biochem J (2003) 11.27
The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat Rev Genet (2009) 9.68
HDAC2 negatively regulates memory formation and synaptic plasticity. Nature (2009) 6.96
Lysine acetylation: codified crosstalk with other posttranslational modifications. Mol Cell (2008) 6.93
The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men. Nat Rev Mol Cell Biol (2008) 6.90
Epigenetic protein families: a new frontier for drug discovery. Nat Rev Drug Discov (2012) 6.70
HEF1-dependent Aurora A activation induces disassembly of the primary cilium. Cell (2007) 6.50
Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation. Proc Natl Acad Sci U S A (2003) 5.56
HDAC6 modulates cell motility by altering the acetylation level of cortactin. Mol Cell (2007) 3.99
HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo. EMBO J (2003) 3.96
HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy. EMBO J (2010) 3.90
Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions. Nat Rev Mol Cell Biol (2011) 3.53
Tubulin modifications and their cellular functions. Curr Opin Cell Biol (2008) 3.52
Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy. J Cell Biol (2010) 3.37
New and emerging HDAC inhibitors for cancer treatment. J Clin Invest (2014) 3.35
Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron (2010) 3.15
Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome. Nat Immunol (2013) 3.08
Class II histone deacetylases: from sequence to function, regulation, and clinical implication. Mol Cell Biol (2005) 3.05
Sirtuins: Sir2-related NAD-dependent protein deacetylases. Genome Biol (2004) 3.00
Multiple roles of HDAC inhibition in neurodegenerative conditions. Trends Neurosci (2009) 2.95
Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally. Mol Cell Biol (2008) 2.85
Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes. Nucleic Acids Res (2002) 2.79
Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control. Mol Cell (2008) 2.71
Suppression of class I and II histone deacetylases blunts pressure-overload cardiac hypertrophy. Circulation (2006) 2.70
Analysis of microtubule dynamic instability using a plus-end growth marker. Nat Methods (2010) 2.67
MEC-17 is an alpha-tubulin acetyltransferase. Nature (2010) 2.64
HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1-induced Charcot-Marie-Tooth disease. Nat Med (2011) 2.60
HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. Genes Dev (2007) 2.56
HDAC6-p97/VCP controlled polyubiquitin chain turnover. EMBO J (2006) 2.52
Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A. J Am Chem Soc (2010) 2.50
Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks. EMBO J (2008) 2.44
The deacetylase HDAC6 is a novel critical component of stress granules involved in the stress response. Genes Dev (2007) 2.43
Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6. EMBO J (2009) 2.37
ER sliding dynamics and ER-mitochondrial contacts occur on acetylated microtubules. J Cell Biol (2010) 2.34
Histone deacetylase 6 regulates growth factor-induced actin remodeling and endocytosis. Mol Cell Biol (2007) 2.25
The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis. Cancer Res (2008) 2.17
Histone deacetylases 1 and 2 act in concert to promote the G1-to-S progression. Genes Dev (2010) 2.14
HDAC6 is a target for protection and regeneration following injury in the nervous system. Proc Natl Acad Sci U S A (2009) 2.14
Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity. J Biol Chem (2008) 2.12
Cell biology: Tubulin acetylation and cell motility. Nature (2003) 2.10
HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation. Proc Natl Acad Sci U S A (2008) 2.10
Role for histone deacetylase 1 in human tumor cell proliferation. Mol Cell Biol (2007) 2.07
The control of HIV transcription: keeping RNA polymerase II on track. Cell Host Microbe (2011) 2.05
Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2. Mol Cell Biol (2006) 2.01
The acetylation of tau inhibits its function and promotes pathological tau aggregation. Nat Commun (2011) 2.00
Posttranslational modifications of tubulin and the polarized transport of kinesin-1 in neurons. Mol Biol Cell (2009) 1.93
Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes. Proc Natl Acad Sci U S A (2002) 1.89
Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3(+) T-regulatory cells. Mol Cell Biol (2011) 1.82
Molecular basis for age-dependent microtubule acetylation by tubulin acetyltransferase. Cell (2014) 1.79
The role of HDAC6 in cancer. J Biomed Biotechnol (2010) 1.77
The tumor suppressor p53 and histone deacetylase 1 are antagonistic regulators of the cyclin-dependent kinase inhibitor p21/WAF1/CIP1 gene. Mol Cell Biol (2003) 1.77
Post-translational modifications of microtubules. J Cell Sci (2010) 1.72
The multiassembly problem: reconstructing multiple transcript isoforms from EST fragment mixtures. Genome Res (2004) 1.70
Carboplatin and Paclitaxel in combination with either vorinostat or placebo for first-line therapy of advanced non-small-cell lung cancer. J Clin Oncol (2009) 1.70
Aggresome formation and neurodegenerative diseases: therapeutic implications. Curr Med Chem (2008) 1.68
HDAC4 promotes growth of colon cancer cells via repression of p21. Mol Biol Cell (2008) 1.67
Myc-nick: a cytoplasmic cleavage product of Myc that promotes alpha-tubulin acetylation and cell differentiation. Cell (2010) 1.67
HDAC1 nuclear export induced by pathological conditions is essential for the onset of axonal damage. Nat Neurosci (2009) 1.67
HDAC6 regulates mitochondrial transport in hippocampal neurons. PLoS One (2010) 1.63
The functional interactome landscape of the human histone deacetylase family. Mol Syst Biol (2013) 1.63
The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility. J Cell Biol (2008) 1.63
Selective inhibition of histone deacetylase 6 (HDAC6) induces DNA damage and sensitizes transformed cells to anticancer agents. Proc Natl Acad Sci U S A (2010) 1.62
The tubulin code: molecular components, readout mechanisms, and functions. J Cell Biol (2014) 1.60
Functional interaction between class II histone deacetylases and ICP0 of herpes simplex virus type 1. J Virol (2004) 1.59
Stages of ciliogenesis and regulation of ciliary length. Differentiation (2011) 1.59
Inhibition of histone deacetylases promotes ubiquitin-dependent proteasomal degradation of DNA methyltransferase 1 in human breast cancer cells. Mol Cancer Res (2008) 1.59
Requirement of HDAC6 for transforming growth factor-beta1-induced epithelial-mesenchymal transition. J Biol Chem (2008) 1.57
HDAC5 is a novel injury-regulated tubulin deacetylase controlling axon regeneration. EMBO J (2012) 1.55
Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Mol Cell Proteomics (2012) 1.54
Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex. Genes Dev (2002) 1.53
Lack of adenomatous polyposis coli protein correlates with a decrease in cell migration and overall changes in microtubule stability. Mol Biol Cell (2006) 1.50
Histone deacetylase inhibitors prevent exocytosis of interleukin-1beta-containing secretory lysosomes: role of microtubules. Blood (2006) 1.48
Nonhistone protein acetylation as cancer therapy targets. Expert Rev Anticancer Ther (2010) 1.45
The Caenorhabditis elegans Elongator complex regulates neuronal alpha-tubulin acetylation. PLoS Genet (2010) 1.45
The tale of protein lysine acetylation in the cytoplasm. J Biomed Biotechnol (2010) 1.44
Nuclear receptor co-repressors are required for the histone-deacetylase activity of HDAC3 in vivo. Nat Struct Mol Biol (2013) 1.43
Hydroxamate-based histone deacetylase inhibitors can protect neurons from oxidative stress via a histone deacetylase-independent catalase-like mechanism. Chem Biol (2015) 1.42
Acetylation goes global: the emergence of acetylation biology. Sci Signal (2009) 1.41
The small GTPases ARL-13 and ARL-3 coordinate intraflagellar transport and ciliogenesis. J Cell Biol (2010) 1.41
Soluble levels of cytosolic tubulin regulate ciliary length control. Mol Biol Cell (2011) 1.41
HDAC6 activity is a non-oncogene addiction hub for inflammatory breast cancers. Breast Cancer Res (2015) 1.40
Acetylation of microtubules influences their sensitivity to severing by katanin in neurons and fibroblasts. J Neurosci (2010) 1.39
Positive and negative regulation of the innate antiviral response and beta interferon gene expression by deacetylation. Mol Cell Biol (2006) 1.39
Endogenous modulators and pharmacological inhibitors of histone deacetylases in cancer therapy. Oncogene (2011) 1.38
TDP-43 functions and pathogenic mechanisms implicated in TDP-43 proteinopathies. Trends Mol Med (2011) 1.38
Histone deacetylase 6 interacts with the microtubule-associated protein tau. J Neurochem (2008) 1.38
Functional genomics identifies five distinct molecular subtypes with clinical relevance and pathways for growth control in epithelial ovarian cancer. EMBO Mol Med (2013) 1.38
Histone deacetylase 6 regulates human immunodeficiency virus type 1 infection. Mol Biol Cell (2005) 1.37
Chemical modifier screen identifies HDAC inhibitors as suppressors of PKD models. Proc Natl Acad Sci U S A (2009) 1.36
The microtubule-associated histone deacetylase 6 (HDAC6) regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation. J Biol Chem (2010) 1.36
Rational therapeutic combinations with histone deacetylase inhibitors for the treatment of cancer. Future Oncol (2011) 1.34
Ubiquitin proteasome system stress underlies synergistic killing of ovarian cancer cells by bortezomib and a novel HDAC6 inhibitor. Clin Cancer Res (2008) 1.33
The chemical complexity of cellular microtubules: tubulin post-translational modification enzymes and their roles in tuning microtubule functions. Cytoskeleton (Hoboken) (2012) 1.32
HDAC6 is required for epidermal growth factor-induced beta-catenin nuclear localization. J Biol Chem (2008) 1.31
Histone deacetylase 3 localizes to the mitotic spindle and is required for kinetochore-microtubule attachment. Proc Natl Acad Sci U S A (2008) 1.30
Retracted Epigenetic enhancement of BDNF signaling rescues synaptic plasticity in aging. J Neurosci (2011) 1.30
Lymphocyte chemotaxis is regulated by histone deacetylase 6, independently of its deacetylase activity. Mol Biol Cell (2006) 1.29
Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease. EMBO Mol Med (2012) 1.28
The ATAC acetyl transferase complex controls mitotic progression by targeting non-histone substrates. EMBO J (2010) 1.28
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature (2007) 7.74
The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress. Cell (2003) 7.71
HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. Mol Cell (2005) 6.00
ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat Biotechnol (2006) 5.46
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA. Nat Chem Biol (2007) 4.95
In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation. EMBO J (2002) 4.28
HDAC6 modulates cell motility by altering the acetylation level of cortactin. Mol Cell (2007) 3.99
HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy. EMBO J (2010) 3.90
Signaling cross-talk between TGF-beta/BMP and other pathways. Cell Res (2009) 3.66
RNA-methylation-dependent RNA processing controls the speed of the circadian clock. Cell (2013) 3.64
Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway. Cancer Cell (2004) 3.63
Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy. J Cell Biol (2010) 3.37
MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation. EMBO J (2002) 3.29
Ureteral stent encrustation, incrustation, and coloring: morbidity related to indwelling times. J Endourol (2011) 3.29
Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase. Nat Cell Biol (2004) 3.14
Essential role of Smad3 in infarct healing and in the pathogenesis of cardiac remodeling. Circulation (2007) 3.07
Notch promotes radioresistance of glioma stem cells. Stem Cells (2010) 3.07
VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD. Autophagy (2010) 2.99
FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases. Cancer Res (2002) 2.90
Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice. Am J Physiol Lung Cell Mol Physiol (2002) 2.83
Drug screening for ALS using patient-specific induced pluripotent stem cells. Sci Transl Med (2012) 2.80
TGF-β-miR-34a-CCL22 signaling-induced Treg cell recruitment promotes venous metastases of HBV-positive hepatocellular carcinoma. Cancer Cell (2012) 2.60
HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. Genes Dev (2007) 2.56
Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression. Mol Cell Biol (2004) 2.49
Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoter. Mol Cell Biol (2002) 2.35
Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling. Science (2003) 2.31
Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications. Mol Cell Biol (2005) 2.28
Histone deacetylase 6 regulates growth factor-induced actin remodeling and endocytosis. Mol Cell Biol (2007) 2.25
HDAC6 deacetylation of tubulin modulates dynamics of cellular adhesions. J Cell Sci (2007) 2.22
Molecular cloning and characterization of a novel histone deacetylase HDAC10. J Biol Chem (2001) 2.18
E3 ubiquitin ligase that recognizes sugar chains. Nature (2002) 2.17
The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis. Cancer Res (2008) 2.17
The cytoplasmic shuttling and subsequent degradation of p27Kip1 mediated by Jab1/CSN5 and the COP9 signalosome complex. J Biol Chem (2001) 2.16
Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis. Cell (2006) 2.15
Bone morphogenetic protein-2 stimulates Runx2 acetylation. J Biol Chem (2006) 2.15
Smad3-dependent nuclear translocation of beta-catenin is required for TGF-beta1-induced proliferation of bone marrow-derived adult human mesenchymal stem cells. Genes Dev (2006) 2.15
Ureteroscopy assisted retrograde nephrostomy: a new technique for percutaneous nephrolithotomy (PCNL). BJU Int (2011) 2.14
Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export. J Biol Chem (2002) 2.12
Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment. J Biol Chem (2005) 2.01
Extracellular matrix protein betaig-h3/TGFBI promotes metastasis of colon cancer by enhancing cell extravasation. Genes Dev (2008) 2.00
Intracellular trafficking of histone deacetylase 4 regulates neuronal cell death. J Neurosci (2005) 2.00
Targeting interleukin 6 signaling suppresses glioma stem cell survival and tumor growth. Stem Cells (2009) 1.97
Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction. Circ Res (2010) 1.94
Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling. Genes Dev (2008) 1.93
Transduction of a mesenchyme-specific gene periostin into 293T cells induces cell invasive activity through epithelial-mesenchymal transformation. J Biol Chem (2006) 1.85
Long-term results of expansive laminoplasty for ossification of the posterior longitudinal ligament of the cervical spine: more than 10 years follow up. J Neurosurg (2002) 1.81
Regulation of the dynamics of hsp90 action on the glucocorticoid receptor by acetylation/deacetylation of the chaperone. J Biol Chem (2005) 1.81
Total synthesis of (+)-chaetocin and its analogues: their histone methyltransferase G9a inhibitory activity. J Am Chem Soc (2010) 1.80
Significance of HDAC6 regulation via estrogen signaling for cell motility and prognosis in estrogen receptor-positive breast cancer. Oncogene (2005) 1.79
miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis. Nat Cell Biol (2013) 1.79
Transforming growth factor beta-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element. Mol Cell Biol (2004) 1.77
VHL tumor suppressor gene alterations associated with good prognosis in sporadic clear-cell renal carcinoma. J Natl Cancer Inst (2002) 1.75
Adjacent segment disease after anterior cervical interbody fusion. Spine J (2004) 1.75
TGFbeta-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFbeta switch. EMBO J (2008) 1.74
GATA3 inhibits breast cancer metastasis through the reversal of epithelial-mesenchymal transition. J Biol Chem (2010) 1.73
Ginkgolic acid inhibits protein SUMOylation by blocking formation of the E1-SUMO intermediate. Chem Biol (2009) 1.70
VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations. Neuron (2013) 1.70
The histone deacetylase HDAC4 connects neural activity to muscle transcriptional reprogramming. J Biol Chem (2007) 1.70
A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease. Nat Genet (2005) 1.69
Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms. Differentiation (2005) 1.68
Combination therapy of inhibitors of epidermal growth factor receptor/vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offers improved glioblastoma tumor growth inhibition. Mol Cancer Ther (2005) 1.66
Real-time imaging of histone H4K12-specific acetylation determines the modes of action of histone deacetylase and bromodomain inhibitors. Chem Biol (2011) 1.65
Abnormal mouse lung alveolarization caused by Smad3 deficiency is a developmental antecedent of centrilobular emphysema. Am J Physiol Lung Cell Mol Physiol (2004) 1.56
Nerves at the ventral prostatic capsule contribute to erectile function: initial electrophysiological assessment in humans. Eur Urol (2008) 1.53
Comprehensive mutational analysis of the VHL gene in sporadic renal cell carcinoma: relationship to clinicopathological parameters. Genes Chromosomes Cancer (2002) 1.52
Bone-related genes expressed in advanced malignancies induce invasion and metastasis in a genetically defined human cancer model. J Biol Chem (2003) 1.52
PP1 control of M phase entry exerted through 14-3-3-regulated Cdc25 dephosphorylation. EMBO J (2003) 1.50
Loss of von Hippel-Lindau protein causes cell density dependent deregulation of CyclinD1 expression through hypoxia-inducible factor. Oncogene (2003) 1.50
Role of YKL-40 in the angiogenesis, radioresistance, and progression of glioblastoma. J Biol Chem (2011) 1.50
Deactylase inhibitors disrupt cellular complexes containing protein phosphatases and deacetylases. J Biol Chem (2003) 1.50
Heme regulates gene expression by triggering Crm1-dependent nuclear export of Bach1. EMBO J (2004) 1.49
Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation. Genes Dev (2004) 1.47
Laparoscopic simultaneous bilateral adrenalectomy: assessment of feasibility and potential indications. Int J Urol (2011) 1.46
Proteomic analysis of organ-specific post-translational lysine-acetylation and -methylation in mice by use of anti-acetyllysine and -methyllysine mouse monoclonal antibodies. Proteomics (2005) 1.46
Acetylation goes global: the emergence of acetylation biology. Sci Signal (2009) 1.41
Translational control of cell division by Elongator. Cell Rep (2012) 1.41
Iron oxide nanoparticles induce human microvascular endothelial cell permeability through reactive oxygen species production and microtubule remodeling. Part Fibre Toxicol (2009) 1.41
HDAC6 a new cellular stress surveillance factor. Cell Cycle (2007) 1.40
AcK-knowledge reversible acetylation. Sci STKE (2004) 1.39
In situ androgen producing enzymes in human prostate cancer. Endocr Relat Cancer (2005) 1.37
ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background. EMBO J (2004) 1.36
The microtubule-associated histone deacetylase 6 (HDAC6) regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation. J Biol Chem (2010) 1.36
Trichostatin A, a histone deacetylase inhibitor, suppresses collagen synthesis and prevents TGF-beta(1)-induced fibrogenesis in skin fibroblasts. Exp Cell Res (2002) 1.36
Prospective clinical study of EUS-guided choledochoduodenostomy for malignant lower biliary tract obstruction. Am J Gastroenterol (2011) 1.35
SB-431542, a small molecule transforming growth factor-beta-receptor antagonist, inhibits human glioma cell line proliferation and motility. Mol Cancer Ther (2004) 1.35
Identification of SAP155 as the target of GEX1A (Herboxidiene), an antitumor natural product. ACS Chem Biol (2011) 1.34
A YKL-40-neutralizing antibody blocks tumor angiogenesis and progression: a potential therapeutic agent in cancers. Mol Cancer Ther (2011) 1.34
13-Deoxytedanolide, a marine sponge-derived antitumor macrolide, binds to the 60S large ribosomal subunit. Bioorg Med Chem (2005) 1.32