Published in Mol Cell on May 27, 2005
The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat Rev Genet (2009) 9.68
HSP90 at the hub of protein homeostasis: emerging mechanistic insights. Nat Rev Mol Cell Biol (2010) 7.16
Lysine acetylation: codified crosstalk with other posttranslational modifications. Mol Cell (2008) 6.93
The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men. Nat Rev Mol Cell Biol (2008) 6.90
Targeting the dynamic HSP90 complex in cancer. Nat Rev Cancer (2010) 6.81
Epigenetic protein families: a new frontier for drug discovery. Nat Rev Drug Discov (2012) 6.70
The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell (2008) 6.44
HDAC6 modulates cell motility by altering the acetylation level of cortactin. Mol Cell (2007) 3.99
New and emerging HDAC inhibitors for cancer treatment. J Clin Invest (2014) 3.35
Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally. Mol Cell Biol (2008) 2.85
An acetylation site in the middle domain of Hsp90 regulates chaperone function. Mol Cell (2007) 2.75
Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis. Nat Chem Biol (2009) 2.70
HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. Genes Dev (2007) 2.56
HDAC6-p97/VCP controlled polyubiquitin chain turnover. EMBO J (2006) 2.52
Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A. J Am Chem Soc (2010) 2.50
AR, the cell cycle, and prostate cancer. Nucl Recept Signal (2008) 2.44
The deacetylase HDAC6 is a novel critical component of stress granules involved in the stress response. Genes Dev (2007) 2.43
Histone deacetylase 6 regulates growth factor-induced actin remodeling and endocytosis. Mol Cell Biol (2007) 2.25
Post-translational modifications in signal integration. Nat Struct Mol Biol (2010) 2.23
The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis. Cancer Res (2008) 2.17
Histone deacetylases 1 and 2 act in concert to promote the G1-to-S progression. Genes Dev (2010) 2.14
HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation. Proc Natl Acad Sci U S A (2008) 2.10
Heat shock proteins: essential proteins for apoptosis regulation. J Cell Mol Med (2008) 1.93
Histone deacetylase inhibitors induce VHL and ubiquitin-independent proteasomal degradation of hypoxia-inducible factor 1alpha. Mol Cell Biol (2006) 1.89
Role of acetylation and extracellular location of heat shock protein 90alpha in tumor cell invasion. Cancer Res (2008) 1.88
Glucocorticosteroids: current and future directions. Br J Pharmacol (2011) 1.85
Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3(+) T-regulatory cells. Mol Cell Biol (2011) 1.82
The Hsp90 chaperone machinery regulates signaling by modulating ligand binding clefts. J Biol Chem (2008) 1.82
The clinical development of histone deacetylase inhibitors as targeted anticancer drugs. Expert Opin Investig Drugs (2010) 1.79
The role of HDAC6 in cancer. J Biomed Biotechnol (2010) 1.77
SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis. Cell Death Differ (2011) 1.76
The shock of aging: molecular chaperones and the heat shock response in longevity and aging--a mini-review. Gerontology (2009) 1.69
Aggresome formation and neurodegenerative diseases: therapeutic implications. Curr Med Chem (2008) 1.68
HDAC inhibitor-based therapies: can we interpret the code? Mol Oncol (2012) 1.67
Selective inhibition of histone deacetylase 6 (HDAC6) induces DNA damage and sensitizes transformed cells to anticancer agents. Proc Natl Acad Sci U S A (2010) 1.62
Conformational dynamics of the molecular chaperone Hsp90. Q Rev Biophys (2011) 1.61
All-you-can-eat: autophagy in neurodegeneration and neuroprotection. Mol Neurodegener (2009) 1.60
Histone deacetylase inhibitor suberoylanilide hydroxamic acid attenuates Toll-like receptor 4 signaling in lipopolysaccharide-stimulated mouse macrophages. J Surg Res (2012) 1.59
Inhibition of histone deacetylases promotes ubiquitin-dependent proteasomal degradation of DNA methyltransferase 1 in human breast cancer cells. Mol Cancer Res (2008) 1.59
Requirement of HDAC6 for transforming growth factor-beta1-induced epithelial-mesenchymal transition. J Biol Chem (2008) 1.57
Minireview: the intersection of steroid receptors with molecular chaperones: observations and questions. Mol Endocrinol (2008) 1.57
Post-translational modifications of Hsp90 and their contributions to chaperone regulation. Biochim Biophys Acta (2011) 1.56
Physical and functional HAT/HDAC interplay regulates protein acetylation balance. J Biomed Biotechnol (2010) 1.55
Histone deacetylase: a potential therapeutic target for fibrotic disorders. J Pharmacol Exp Ther (2010) 1.51
Proposal for a role of the Hsp90/Hsp70-based chaperone machinery in making triage decisions when proteins undergo oxidative and toxic damage. Exp Biol Med (Maywood) (2010) 1.50
The tale of protein lysine acetylation in the cytoplasm. J Biomed Biotechnol (2010) 1.44
Selective Raf inhibition in cancer therapy. Expert Opin Ther Targets (2007) 1.44
Targeting HSP90 for cancer therapy. Br J Cancer (2009) 1.44
Vorinostat in solid and hematologic malignancies. J Hematol Oncol (2009) 1.42
GRP94: An HSP90-like protein specialized for protein folding and quality control in the endoplasmic reticulum. Biochim Biophys Acta (2011) 1.42
Acetylation goes global: the emergence of acetylation biology. Sci Signal (2009) 1.41
The small GTPases ARL-13 and ARL-3 coordinate intraflagellar transport and ciliogenesis. J Cell Biol (2010) 1.41
Positive and negative regulation of the innate antiviral response and beta interferon gene expression by deacetylation. Mol Cell Biol (2006) 1.39
Histone deacetylase inhibitors (HDACIs): multitargeted anticancer agents. Biologics (2013) 1.38
Histone deacetylase 6 interacts with the microtubule-associated protein tau. J Neurochem (2008) 1.38
Histone deacetylase 6 regulates human immunodeficiency virus type 1 infection. Mol Biol Cell (2005) 1.37
Hsp90 regulates activation of interferon regulatory factor 3 and TBK-1 stabilization in Sendai virus-infected cells. Mol Biol Cell (2006) 1.37
The microtubule-associated histone deacetylase 6 (HDAC6) regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation. J Biol Chem (2010) 1.36
Histone deacetylase inhibitors: a chemical genetics approach to understanding cellular functions. Biochim Biophys Acta (2010) 1.35
Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperone. Biochem Biophys Res Commun (2006) 1.33
The middle domain of Hsp90 acts as a discriminator between different types of client proteins. Mol Cell Biol (2006) 1.33
Hsp90, an unlikely ally in the war on cancer. FEBS J (2013) 1.33
HDAC6 is required for epidermal growth factor-induced beta-catenin nuclear localization. J Biol Chem (2008) 1.31
Lymphocyte chemotaxis is regulated by histone deacetylase 6, independently of its deacetylase activity. Mol Biol Cell (2006) 1.29
The Hsp90 cochaperone p23 is essential for perinatal survival. Mol Cell Biol (2006) 1.28
New developments in Hsp90 inhibitors as anti-cancer therapeutics: mechanisms, clinical perspective and more potential. Drug Resist Updat (2009) 1.27
HDAC6 modulates Hsp90 chaperone activity and regulates activation of aryl hydrocarbon receptor signaling. J Biol Chem (2009) 1.26
Regulating the regulators: the post-translational code of class I HDAC1 and HDAC2. J Biomed Biotechnol (2010) 1.26
Histone deacetylase inhibitors repress the transactivation potential of hypoxia-inducible factors independently of direct acetylation of HIF-alpha. J Biol Chem (2006) 1.24
The redox basis of epigenetic modifications: from mechanisms to functional consequences. Antioxid Redox Signal (2011) 1.24
Inhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression. J Exp Med (2012) 1.23
Sulforaphane destabilizes the androgen receptor in prostate cancer cells by inactivating histone deacetylase 6. Proc Natl Acad Sci U S A (2009) 1.23
The role of histone deacetylases in prostate cancer. Epigenetics (2008) 1.21
Inhibitors of deacetylases suppress oncogenic KIT signaling, acetylate HSP90, and induce apoptosis in gastrointestinal stromal tumors. Cancer Res (2009) 1.18
JNK1 mediates degradation HIF-1alpha by a VHL-independent mechanism that involves the chaperones Hsp90/Hsp70. Cancer Res (2010) 1.18
Histone/protein deacetylases control Foxp3 expression and the heat shock response of T-regulatory cells. Curr Opin Immunol (2011) 1.17
Histone deacetylase 6 (HDAC6) is an essential modifier of glucocorticoid-induced hepatic gluconeogenesis. Diabetes (2011) 1.15
HDAC6 regulates androgen receptor hypersensitivity and nuclear localization via modulating Hsp90 acetylation in castration-resistant prostate cancer. Mol Endocrinol (2009) 1.15
PKC alpha regulates Sendai virus-mediated interferon induction through HDAC6 and β-catenin. EMBO J (2011) 1.13
Targeting Huntington's disease through histone deacetylases. Clin Epigenetics (2011) 1.13
The 'active life' of Hsp90 complexes. Biochim Biophys Acta (2011) 1.13
Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin. EMBO J (2011) 1.12
Enhancement of stress resilience through histone deacetylase 6-mediated regulation of glucocorticoid receptor chaperone dynamics. Biol Psychiatry (2014) 1.12
Advances in the discovery and development of heat-shock protein 90 inhibitors for cancer treatment. Expert Opin Drug Discov (2011) 1.12
Berberine suppresses androgen receptor signaling in prostate cancer. Mol Cancer Ther (2011) 1.11
The novel deacetylase inhibitor AR-42 demonstrates pre-clinical activity in B-cell malignancies in vitro and in vivo. PLoS One (2010) 1.11
Protein homeostasis as a therapeutic target for diseases of protein conformation. Curr Top Med Chem (2012) 1.10
Regulation of Tat acetylation and transactivation activity by the microtubule-associated deacetylase HDAC6. J Biol Chem (2011) 1.10
Uropathogenic Escherichia coli invades host cells via an HDAC6-modulated microtubule-dependent pathway. J Biol Chem (2008) 1.09
Functional activation of the estrogen receptor-α and aromatase by the HDAC inhibitor entinostat sensitizes ER-negative tumors to letrozole. Cancer Res (2011) 1.09
Histone deacetylase inhibitors downregulate checkpoint kinase 1 expression to induce cell death in non-small cell lung cancer cells. PLoS One (2010) 1.09
Loss of deacetylation activity of Hdac6 affects emotional behavior in mice. PLoS One (2012) 1.08
Molecular basis for primary and secondary tyrosine kinase inhibitor resistance in gastrointestinal stromal tumor. Cancer Chemother Pharmacol (2010) 1.08
HDAC6 regulates glucocorticoid receptor signaling in serotonin pathways with critical impact on stress resilience. J Neurosci (2012) 1.08
Beyond histone and deacetylase: an overview of cytoplasmic histone deacetylases and their nonhistone substrates. J Biomed Biotechnol (2010) 1.08
Hdac6 knock-out increases tubulin acetylation but does not modify disease progression in the R6/2 mouse model of Huntington's disease. PLoS One (2011) 1.07
Identification of novel modulators of mitochondrial function by a genome-wide RNAi screen in Drosophila melanogaster. Genome Res (2007) 1.07
Histone deacetylase inhibitors prevent the degradation and restore the activity of glucocerebrosidase in Gaucher disease. Proc Natl Acad Sci U S A (2011) 1.06
Posttranslational modification and quality control. Circ Res (2013) 1.06
Modulation of antigen-presenting cells by HDAC inhibitors: implications in autoimmunity and cancer. Immunol Cell Biol (2011) 1.05
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
HDAC6 is a microtubule-associated deacetylase. Nature (2002) 12.76
Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery. Exp Biol Med (Maywood) (2003) 8.04
HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature (2007) 7.74
ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat Biotechnol (2006) 5.46
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA. Nat Chem Biol (2007) 4.95
In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation. EMBO J (2002) 4.28
Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β. Nature (2012) 4.15
HDAC6 modulates cell motility by altering the acetylation level of cortactin. Mol Cell (2007) 3.99
HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy. EMBO J (2010) 3.90
RNA-methylation-dependent RNA processing controls the speed of the circadian clock. Cell (2013) 3.64
Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy. J Cell Biol (2010) 3.37
MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation. EMBO J (2002) 3.29
Ureteral stent encrustation, incrustation, and coloring: morbidity related to indwelling times. J Endourol (2011) 3.29
Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase. Nat Cell Biol (2004) 3.14
VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD. Autophagy (2010) 2.99
FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases. Cancer Res (2002) 2.90
Drug screening for ALS using patient-specific induced pluripotent stem cells. Sci Transl Med (2012) 2.80
HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. Genes Dev (2007) 2.56
The DRiP hypothesis decennial: support, controversy, refinement and extension. Trends Immunol (2006) 2.42
Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoter. Mol Cell Biol (2002) 2.35
Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications. Mol Cell Biol (2005) 2.28
Histone deacetylase 6 regulates growth factor-induced actin remodeling and endocytosis. Mol Cell Biol (2007) 2.25
HDAC6 deacetylation of tubulin modulates dynamics of cellular adhesions. J Cell Sci (2007) 2.22
Molecular cloning and characterization of a novel histone deacetylase HDAC10. J Biol Chem (2001) 2.18
E3 ubiquitin ligase that recognizes sugar chains. Nature (2002) 2.17
The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis. Cancer Res (2008) 2.17
The cytoplasmic shuttling and subsequent degradation of p27Kip1 mediated by Jab1/CSN5 and the COP9 signalosome complex. J Biol Chem (2001) 2.16
Bone morphogenetic protein-2 stimulates Runx2 acetylation. J Biol Chem (2006) 2.15
Ureteroscopy assisted retrograde nephrostomy: a new technique for percutaneous nephrolithotomy (PCNL). BJU Int (2011) 2.14
Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export. J Biol Chem (2002) 2.12
Acetylation of yeast AMPK controls intrinsic aging independently of caloric restriction. Cell (2011) 2.10
Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment. J Biol Chem (2005) 2.01
Intracellular trafficking of histone deacetylase 4 regulates neuronal cell death. J Neurosci (2005) 2.00
Partitioning and translation of mRNAs encoding soluble proteins on membrane-bound ribosomes. RNA (2003) 1.87
Regulation of the dynamics of hsp90 action on the glucocorticoid receptor by acetylation/deacetylation of the chaperone. J Biol Chem (2005) 1.81
Total synthesis of (+)-chaetocin and its analogues: their histone methyltransferase G9a inhibitory activity. J Am Chem Soc (2010) 1.80
Hsp90 inhibition depletes Chk1 and sensitizes tumor cells to replication stress. J Biol Chem (2003) 1.80
Significance of HDAC6 regulation via estrogen signaling for cell motility and prognosis in estrogen receptor-positive breast cancer. Oncogene (2005) 1.79
Breastfeeding of newborns by mothers carrying hepatitis B virus: a meta-analysis and systematic review. Arch Pediatr Adolesc Med (2011) 1.76
VHL tumor suppressor gene alterations associated with good prognosis in sporadic clear-cell renal carcinoma. J Natl Cancer Inst (2002) 1.75
Rare codons regulate KRas oncogenesis. Curr Biol (2012) 1.74
Ginkgolic acid inhibits protein SUMOylation by blocking formation of the E1-SUMO intermediate. Chem Biol (2009) 1.70
The histone deacetylase HDAC4 connects neural activity to muscle transcriptional reprogramming. J Biol Chem (2007) 1.70
VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations. Neuron (2013) 1.70
Effect of miR-21 on renal fibrosis by regulating MMP-9 and TIMP1 in kk-ay diabetic nephropathy mice. Cell Biochem Biophys (2013) 1.70
Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms. Differentiation (2005) 1.68
Real-time imaging of histone H4K12-specific acetylation determines the modes of action of histone deacetylase and bromodomain inhibitors. Chem Biol (2011) 1.65
Role of molecular chaperones in steroid receptor action. Essays Biochem (2004) 1.64
Scavenger receptor-A mediates gp96/GRP94 and calreticulin internalization by antigen-presenting cells. EMBO J (2003) 1.60
Rational design of a structural and functional nitric oxide reductase. Nature (2009) 1.60
Minireview: the intersection of steroid receptors with molecular chaperones: observations and questions. Mol Endocrinol (2008) 1.57
Primary role for endoplasmic reticulum-bound ribosomes in cellular translation identified by ribosome profiling. J Biol Chem (2011) 1.56
Comprehensive mutational analysis of the VHL gene in sporadic renal cell carcinoma: relationship to clinicopathological parameters. Genes Chromosomes Cancer (2002) 1.52
A phase I trial of twice-weekly 17-allylamino-demethoxy-geldanamycin in patients with advanced cancer. Clin Cancer Res (2006) 1.51
PP1 control of M phase entry exerted through 14-3-3-regulated Cdc25 dephosphorylation. EMBO J (2003) 1.50
Loss of von Hippel-Lindau protein causes cell density dependent deregulation of CyclinD1 expression through hypoxia-inducible factor. Oncogene (2003) 1.50
Deactylase inhibitors disrupt cellular complexes containing protein phosphatases and deacetylases. J Biol Chem (2003) 1.50
Heme regulates gene expression by triggering Crm1-dependent nuclear export of Bach1. EMBO J (2004) 1.49
Signal sequence- and translation-independent mRNA localization to the endoplasmic reticulum. RNA (2008) 1.49
The assembly and intermolecular properties of the hsp70-Hop-hsp90 molecular chaperone complex. J Biol Chem (2002) 1.48
Proteomic analysis of organ-specific post-translational lysine-acetylation and -methylation in mice by use of anti-acetyllysine and -methyllysine mouse monoclonal antibodies. Proteomics (2005) 1.46
Translocation of sickle cell erythrocyte microRNAs into Plasmodium falciparum inhibits parasite translation and contributes to malaria resistance. Cell Host Microbe (2012) 1.45
Patterns of target tissue reinnervation and trophic factor expression after nerve grafting. Plast Reconstr Surg (2013) 1.44
Heat shock protein 96 is elevated in rheumatoid arthritis and activates macrophages primarily via TLR2 signaling. J Immunol (2009) 1.43
CHIP deletion reveals functional redundancy of E3 ligases in promoting degradation of both signaling proteins and expanded glutamine proteins. Hum Mol Genet (2008) 1.43
Up-regulation of heat shock protein 27 induces resistance to 17-allylamino-demethoxygeldanamycin through a glutathione-mediated mechanism. Cancer Res (2006) 1.42
Acetylation goes global: the emergence of acetylation biology. Sci Signal (2009) 1.41
HSP40 binding is the first step in the HSP90 chaperoning pathway for the progesterone receptor. J Biol Chem (2002) 1.41
Translational control of cell division by Elongator. Cell Rep (2012) 1.41
Impulse inhibition in people with Internet addiction disorder: electrophysiological evidence from a Go/NoGo study. Neurosci Lett (2010) 1.40
Attenuation of Neuropathic Pain by Inhibiting Electrical Synapses in the Anterior Cingulate Cortex. Anesthesiology (2016) 1.40
The organometallic active site of [Fe]hydrogenase: models and entatic states. Proc Natl Acad Sci U S A (2003) 1.40
HDAC6 a new cellular stress surveillance factor. Cell Cycle (2007) 1.40
AcK-knowledge reversible acetylation. Sci STKE (2004) 1.39
Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation. Nat Chem Biol (2012) 1.37
Trichostatin A, a histone deacetylase inhibitor, suppresses collagen synthesis and prevents TGF-beta(1)-induced fibrogenesis in skin fibroblasts. Exp Cell Res (2002) 1.36
The microtubule-associated histone deacetylase 6 (HDAC6) regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation. J Biol Chem (2010) 1.36
FKBP51 promotes assembly of the Hsp90 chaperone complex and regulates androgen receptor signaling in prostate cancer cells. Mol Cell Biol (2010) 1.36
Chaperoning checkpoint kinase 1 (Chk1), an Hsp90 client, with purified chaperones. J Biol Chem (2005) 1.36
Regulation of heat shock protein 90 ATPase activity by sequences in the carboxyl terminus. J Biol Chem (2001) 1.34
p23, a simple protein with complex activities. Cell Stress Chaperones (2003) 1.34
Identification of SAP155 as the target of GEX1A (Herboxidiene), an antitumor natural product. ACS Chem Biol (2011) 1.34
13-Deoxytedanolide, a marine sponge-derived antitumor macrolide, binds to the 60S large ribosomal subunit. Bioorg Med Chem (2005) 1.32
Molecular chaperones function as steroid receptor nuclear mobility factors. Proc Natl Acad Sci U S A (2004) 1.32
Parathyroid hormone-related peptide represses chondrocyte hypertrophy through a protein phosphatase 2A/histone deacetylase 4/MEF2 pathway. Mol Cell Biol (2009) 1.31
A role for PP1 in the Cdc2/Cyclin B-mediated positive feedback activation of Cdc25. Mol Biol Cell (2006) 1.31
HDAC6 is required for epidermal growth factor-induced beta-catenin nuclear localization. J Biol Chem (2008) 1.31
Precursor or sequela: pathological disorders in people with Internet addiction disorder. PLoS One (2011) 1.30
The exception that reinforces the rule: crosspriming by cytosolic peptides that escape degradation. Immunity (2008) 1.30
Inhibition of hsp70 by methylene blue affects signaling protein function and ubiquitination and modulates polyglutamine protein degradation. J Biol Chem (2010) 1.29
Analysis of mRNA partitioning between the cytosol and endoplasmic reticulum compartments of mammalian cells. Methods Mol Biol (2008) 1.28
The synergistic combination of the farnesyl transferase inhibitor lonafarnib and paclitaxel enhances tubulin acetylation and requires a functional tubulin deacetylase. Cancer Res (2005) 1.28
GEX1 compounds, novel antitumor antibiotics related to herboxidiene, produced by Streptomyces sp. II. The effects on cell cycle progression and gene expression. J Antibiot (Tokyo) (2002) 1.27
Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B. Nat Commun (2012) 1.27
Androgen receptor acetylation site mutations cause trafficking defects, misfolding, and aggregation similar to expanded glutamine tracts. J Biol Chem (2003) 1.27
Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma. J Med Chem (2005) 1.27
Interaction of TLR2 and TLR4 ligands with the N-terminal domain of Gp96 amplifies innate and adaptive immune responses. J Biol Chem (2006) 1.26