Published in Front Microbiol on September 15, 2015
Towards Engineering Novel PE-Based Immunotoxins by Targeting Them to the Nucleus. Toxins (Basel) (2016) 0.79
Glypican-3 Targeting Immunotoxins for the Treatment of Liver Cancer. Toxins (Basel) (2016) 0.78
Augmenting the Efficacy of Immunotoxins and Other Targeted Protein Toxins by Endosomal Escape Enhancers. Toxins (Basel) (2016) 0.78
Pseudomonas aeruginosa Lifestyle: A Paradigm for Adaptation, Survival, and Persistence. Front Cell Infect Microbiol (2017) 0.76
In vitro and in vivo effects of a recombinant anti-PSMA immunotoxin in combination with docetaxel against prostate cancer. Oncotarget (2016) 0.75
Anti-Biofilm and Antivirulence Activities of Metabolites from Plectosphaerella cucumerina against Pseudomonas aeruginosa. Front Microbiol (2017) 0.75
Targeting and inactivation of bacterial toxins by human defensins. Biol Chem (2017) 0.75
Determinants for persistence of Pseudomonas aeruginosa in hospitals: interplay between resistance, virulence and biofilm formation. Eur J Clin Microbiol Infect Dis (2016) 0.75
Rab proteins as membrane organizers. Nat Rev Mol Cell Biol (2001) 19.95
Cystic fibrosis. N Engl J Med (2005) 8.09
Extracellular toxins of Pseudomonas aeruginosa. J Infect Dis (1974) 5.17
Cloning, nucleotide sequence, and expression in Escherichia coli of the exotoxin A structural gene of Pseudomonas aeruginosa. Proc Natl Acad Sci U S A (1984) 3.98
The epidemiology, pathogenesis and treatment of Pseudomonas aeruginosa infections. Drugs (2007) 3.63
Mechanism of action of Pseudomonas aeruginosa exotoxin Aiadenosine diphosphate-ribosylation of mammalian elongation factor 2 in vitro and in vivo. Infect Immun (1977) 3.17
Rab6 coordinates a novel Golgi to ER retrograde transport pathway in live cells. J Cell Biol (1999) 2.85
Siderophore-mediated signaling regulates virulence factor production in Pseudomonasaeruginosa. Proc Natl Acad Sci U S A (2002) 2.66
Accumulating evidence suggests that several AB-toxins subvert the endoplasmic reticulum-associated protein degradation pathway to enter target cells. Biochemistry (1997) 2.59
Population structure of Pseudomonas aeruginosa. Proc Natl Acad Sci U S A (2007) 2.56
Convergent evolution and adaptation of Pseudomonas aeruginosa within patients with cystic fibrosis. Nat Genet (2014) 2.42
The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds and internalizes Pseudomonas exotoxin A. J Biol Chem (1992) 2.40
The multiple signaling systems regulating virulence in Pseudomonas aeruginosa. Microbiol Mol Biol Rev (2012) 2.36
Pseudomonas aeruginosa: new insights into pathogenesis and host defenses. Pathog Dis (2013) 2.32
Processing of Pseudomonas exotoxin by a cellular protease results in the generation of a 37,000-Da toxin fragment that is translocated to the cytosol. J Biol Chem (1990) 2.04
Evolving stealth: genetic adaptation of Pseudomonas aeruginosa during cystic fibrosis infections. Proc Natl Acad Sci U S A (2006) 1.93
A dynamic and intricate regulatory network determines Pseudomonas aeruginosa virulence. Nucleic Acids Res (2012) 1.70
Pseudomonas aeruginosa population structure revisited. PLoS One (2009) 1.68
Opportunistic infections in lung disease: Pseudomonas infections in cystic fibrosis. Curr Opin Pharmacol (2007) 1.62
Global regulatory pathways and cross-talk control pseudomonas aeruginosa environmental lifestyle and virulence phenotype. Curr Issues Mol Biol (2012) 1.61
Proteolytic activation of bacterial toxins: role of bacterial and host cell proteases. Infect Immun (1994) 1.61
Functional analysis of domains II, Ib, and III of Pseudomonas exotoxin. J Biol Chem (1989) 1.54
Three conserved consensus sequences identify the NAD-binding site of ADP-ribosylating enzymes, expressed by eukaryotes, bacteria and T-even bacteriophages. Mol Microbiol (1996) 1.47
Exotoxin A-eEF2 complex structure indicates ADP ribosylation by ribosome mimicry. Nature (2005) 1.41
Export of antigenic peptides from the endoplasmic reticulum intersects with retrograde protein translocation through the Sec61p channel. Immunity (2000) 1.41
The KDEL retrieval system is exploited by Pseudomonas exotoxin A, but not by Shiga-like toxin-1, during retrograde transport from the Golgi complex to the endoplasmic reticulum. J Cell Sci (1999) 1.40
Cell-mediated cleavage of Pseudomonas exotoxin between Arg279 and Gly280 generates the enzymatically active fragment which translocates to the cytosol. J Biol Chem (1992) 1.38
Toxin entry: how reversible is the secretory pathway? Trends Cell Biol (1992) 1.29
Peptide-chain elongation in eukaryotes. Mol Biol Rep (1994) 1.28
Pseudomonas exotoxin A-mediated apoptosis is Bak dependent and preceded by the degradation of Mcl-1. Mol Cell Biol (2010) 1.23
Importance of the glutamate residue of KDEL in increasing the cytotoxicity of Pseudomonas exotoxin derivatives and for increased binding to the KDEL receptor. Biochem J (1995) 1.19
Refined crystallographic structure of Pseudomonas aeruginosa exotoxin A and its implications for the molecular mechanism of toxicity. J Mol Biol (2001) 1.18
On the path to uncover the bacterial type II secretion system. Philos Trans R Soc Lond B Biol Sci (2012) 1.15
Crystal structure of the catalytic domain of Pseudomonas exotoxin A complexed with a nicotinamide adenine dinucleotide analog: implications for the activation process and for ADP ribosylation. Proc Natl Acad Sci U S A (1996) 1.13
Reduction of furin-nicked Pseudomonas exotoxin A: an unfolding story. Biochemistry (1999) 1.07
Review of the incidence and prognosis of Pseudomonas aeruginosa infections in cancer patients in the 1990s. Eur J Clin Microbiol Infect Dis (2000) 1.07
Pseudomonas exotoxin A: from virulence factor to anti-cancer agent. Int J Med Microbiol (2008) 1.05
Pseudomonas aeruginosa adapts its iron uptake strategies in function of the type of infections. Front Cell Infect Microbiol (2013) 1.04
Prospects of bacterial and plant protein-based immunotoxins for treatment of cancer. Cancer Genomics Proteomics (2014) 1.04
Pseudomonas aeruginosa exotoxin A induces human mast cell apoptosis by a caspase-8 and -3-dependent mechanism. J Biol Chem (2004) 1.04
Internalized Pseudomonas exotoxin A can exploit multiple pathways to reach the endoplasmic reticulum. Traffic (2006) 1.04
Identification of XcpP domains that confer functionality and specificity to the Pseudomonas aeruginosa type II secretion apparatus. Mol Microbiol (2002) 1.00
The N-terminal region of the 37-kDa translocated fragment of Pseudomonas exotoxin A aborts translocation by promoting its own export after microsomal membrane insertion. Proc Natl Acad Sci U S A (1993) 1.00
Dominant-negative mutant phenotypes and the regulation of translation elongation factor 2 levels in yeast. Nucleic Acids Res (2005) 0.99
Influence of deletions within domain II of exotoxin A on its extracellular secretion from Pseudomonas aeruginosa. J Bacteriol (2000) 0.99
Investigation into the catalytic role for the tryptophan residues within domain III of Pseudomonas aeruginosa exotoxin A. Biochemistry (1996) 0.95
An early step in Pseudomonas exotoxin action is removal of the terminal lysine residue, which allows binding to the KDEL receptor. Biochemistry (1997) 0.92
The biosynthesis and biological function of diphthamide. Crit Rev Biochem Mol Biol (2013) 0.92
Quorum sensing communication between bacteria and human cells: signals, targets, and functions. Front Plant Sci (2014) 0.91
The Pseudomonas aeruginosa alternative sigma factor PvdS controls exotoxin A expression and is expressed in lung infections associated with cystic fibrosis. Microbiology (2002) 0.89
Anaerobic Pseudomonas aeruginosa and other obligately anaerobic bacterial biofilms growing in the thick airway mucus of chronically infected cystic fibrosis patients: an emerging paradigm or "Old Hat"? Expert Opin Ther Targets (2012) 0.88
AB toxins: a paradigm switch from deadly to desirable. Toxins (Basel) (2010) 0.88
GPR107, a G-protein-coupled receptor essential for intoxication by Pseudomonas aeruginosa exotoxin A, localizes to the Golgi and is cleaved by furin. J Biol Chem (2014) 0.88
Genes for carbon metabolism and the ToxA virulence factor in Pseudomonas aeruginosa are regulated through molecular interactions of PtxR and PtxS. PLoS One (2012) 0.87
Elucidation of eukaryotic elongation factor-2 contact sites within the catalytic domain of Pseudomonas aeruginosa exotoxin A. Biochem J (2004) 0.86
Characterization of competitive inhibitors for the transferase activity of Pseudomonas aeruginosa exotoxin A. J Enzyme Inhib Med Chem (2002) 0.85
A periplasmic intermediate in the extracellular secretion pathway of Pseudomonas aeruginosa exotoxin A. J Bacteriol (1993) 0.84
Insights into diphthamide, key diphtheria toxin effector. Toxins (Basel) (2013) 0.84
Regulation of Golgi signaling and trafficking by the KDEL receptor. Histochem Cell Biol (2013) 0.81
Expression of 14-3-3delta, cdc2 and cyclin B proteins related to exotoxin A-induced apoptosis in HeLa S3 cells. Int Immunopharmacol (2007) 0.80
Proteolysis of Pseudomonas exotoxin A within hepatic endosomes by cathepsins B and D produces fragments displaying in vitro ADP-ribosylating and apoptotic effects. FEBS J (2010) 0.80
Protective effect of DNA vaccine encoding pseudomonas exotoxin A and PcrV against acute pulmonary P. aeruginosa Infection. PLoS One (2014) 0.78
GtrS and GltR form a two-component system: the central role of 2-ketogluconate in the expression of exotoxin A and glucose catabolic enzymes in Pseudomonas aeruginosa. Nucleic Acids Res (2014) 0.76
Protective efficacy of recombinant exotoxin A--flagellin fusion protein against Pseudomonas aeruginosa infection. Can J Microbiol (2015) 0.76