Senescence and cancer: An evolving inflammatory paradox.

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Published in Biochim Biophys Acta on October 08, 2015

Authors

Megan K Ruhland1, Lisa M Coussens2, Sheila A Stewart3

Author Affiliations

1: Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, MO, USA.
2: Department of Cell, Developmental & Cancer Biology, and Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA. Electronic address: coussenl@ohsu.edu.
3: Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, MO, USA; Department of Cell Biology and Physiology, ICCE Institute, Washington University School of Medicine, Saint Louis, MO, USA; Department of Medicine, ICCE Institute, Washington University School of Medicine, Saint Louis, MO, USA. Electronic address: sheila.stewart@wustl.edu.

Associated clinical trials:

A Study to Assess the Effect of Tocilizumab + Methotrexate on Signs and Symptoms in Patients With Moderate to Severe Active Rheumatoid Arthritis Currently on Methotrexate Therapy | NCT00106522

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Macrophage plasticity and polarization: in vivo veritas. J Clin Invest (2012) 13.44

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Paradoxical roles of the immune system during cancer development. Nat Rev Cancer (2006) 10.57

The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide. J Hepatol (2006) 10.21

Global burden of cancers attributable to infections in 2008: a review and synthetic analysis. Lancet Oncol (2012) 9.28

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Ink4a/Arf expression is a biomarker of aging. J Clin Invest (2004) 8.30

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Aspirin use and reduced risk of fatal colon cancer. N Engl J Med (1991) 7.85

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Chemokine signaling via the CXCR2 receptor reinforces senescence. Cell (2008) 7.65

Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome. Nature (2013) 7.51

A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer. N Engl J Med (2003) 6.99

Four faces of cellular senescence. J Cell Biol (2011) 6.86

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Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol Cell (2004) 6.48

Senescence in tumours: evidence from mice and humans. Nat Rev Cancer (2010) 6.34

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A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents. Cancer Res (1999) 2.67

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Therapy-induced senescence in cancer. J Natl Cancer Inst (2010) 2.45

Non-cell-autonomous tumor suppression by p53. Cell (2013) 2.40

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Senescent cells as a source of inflammatory factors for tumor progression. Cancer Metastasis Rev (2010) 2.32

N-nitrosodiethylamine mechanistic data and risk assessment: bioactivation, DNA-adduct formation, mutagenicity, and tumor initiation. Pharmacol Ther (1996) 2.24

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Oncogene-induced senescence: putting the brakes on tumor development. Cancer Res (2006) 2.04

Cellular senescence, cancer and aging: the telomere connection. Exp Gerontol (2001) 1.98

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Tumour-infiltrating Gr-1+ myeloid cells antagonize senescence in cancer. Nature (2014) 1.88

Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas. Hum Pathol (2001) 1.88

Inflammation is responsible for the development of wound-induced tumors in chickens infected with Rous sarcoma virus. Cancer Res (1994) 1.86

Human fibroblast commitment to a senescence-like state in response to histone deacetylase inhibitors is cell cycle dependent. Mol Cell Biol (1996) 1.78

Increase of plasma IL-6 concentration with age in healthy subjects. Life Sci (1992) 1.78

FDA approval: siltuximab for the treatment of patients with multicentric Castleman disease. Clin Cancer Res (2015) 1.53

How chronic inflammation can affect the brain and support the development of Alzheimer's disease in old age: the role of microglia and astrocytes. Aging Cell (2004) 1.51

Association of circulating TNF-alpha and IL-6 with ageing and parkinsonism. Acta Neurol Scand (1999) 1.38

Senescent stromal-derived osteopontin promotes preneoplastic cell growth. Cancer Res (2009) 1.38

Enhancing chemotherapy efficacy in Pten-deficient prostate tumors by activating the senescence-associated antitumor immunity. Cell Rep (2014) 1.35

Cytokine expression and signaling in drug-induced cellular senescence. Oncogene (2009) 1.34

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Cellular mechanisms for low-dose ionizing radiation-induced perturbation of the breast tissue microenvironment. Cancer Res (2005) 1.28

p38MAPK plays a crucial role in stromal-mediated tumorigenesis. Cancer Discov (2014) 1.27

A senescence-inflammatory switch from cancer-inhibitory to cancer-promoting mechanism. Cancer Cell (2013) 1.22

Blood CD33(+)HLA-DR(-) myeloid-derived suppressor cells are increased with age and a history of cancer. J Leukoc Biol (2013) 1.22

Chromatin remodeling underlies the senescence-associated secretory phenotype of tumor stromal fibroblasts that supports cancer progression. Cancer Res (2012) 1.17

Senescence and the pro-tumorigenic stroma. Crit Rev Oncog (2013) 1.16

Advancing age and insulin resistance: role of plasma tumor necrosis factor-alpha. Am J Physiol (1998) 1.15

Increased expression of extracellular proteins as a hallmark of human endothelial cell in vitro senescence. Exp Gerontol (2006) 1.08

Case-control study of aspirin use and risk of pancreatic cancer. Cancer Epidemiol Biomarkers Prev (2014) 1.00

Aspirin use and survival after the diagnosis of breast cancer: a population-based cohort study. Br J Cancer (2014) 0.97

Innate inflammation in Parkinson's disease. Cold Spring Harb Perspect Med (2012) 0.96

Senescence-associated inflammatory responses: aging and cancer perspectives. Trends Immunol (2015) 0.94

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IL-6 receptor inhibition positively modulates bone balance in rheumatoid arthritis patients with an inadequate response to anti-tumor necrosis factor therapy: biochemical marker analysis of bone metabolism in the tocilizumab RADIATE study (NCT00106522). Semin Arthritis Rheum (2012) 0.90

Senescence: the good the bad and the dysfunctional. Curr Opin Genet Dev (2008) 0.88