Editorial overview: Mechanistic biology: Dynamic interactions in biology-sensing change.

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Published in Curr Opin Chem Biol on November 18, 2015

Authors

Paula J Booth, Lynne Regan

Articles by these authors

(truncated to the top 100)

TPR proteins: the versatile helix. Trends Biochem Sci (2003) 7.37

Membrane proteins, lipids and detergents: not just a soap opera. Biochim Biophys Acta (2004) 3.47

Design of stable alpha-helical arrays from an idealized TPR motif. Structure (2003) 3.17

Detecting protein-protein interactions with a green fluorescent protein fragment reassembly trap: scope and mechanism. J Am Chem Soc (2005) 2.95

Structure and function of KH domains. FEBS J (2008) 2.48

Micelles protect membrane complexes from solution to vacuum. Science (2008) 2.40

Self-assembling cages from coiled-coil peptide modules. Science (2013) 2.24

A recurring theme in protein engineering: the design, stability and folding of repeat proteins. Curr Opin Struct Biol (2005) 1.58

A new folding paradigm for repeat proteins. J Am Chem Soc (2005) 1.57

The interface of protein structure, protein biophysics, and molecular evolution. Protein Sci (2012) 1.54

Detecting protein-protein interactions with GFP-fragment reassembly. Nat Methods (2004) 1.45

The folding and design of repeat proteins: reaching a consensus. Curr Opin Struct Biol (2003) 1.43

Sequence variation in ligand binding sites in proteins. BMC Bioinformatics (2005) 1.37

Structure and stability of designed TPR protein superhelices: unusual crystal packing and implications for natural TPR proteins. Acta Crystallogr D Biol Crystallogr (2007) 1.33

Combined kinetic and thermodynamic analysis of alpha-helical membrane protein unfolding. Proc Natl Acad Sci U S A (2007) 1.31

A de novo peptide hexamer with a mutable channel. Nat Chem Biol (2011) 1.30

A direct interaction between the Utp6 half-a-tetratricopeptide repeat domain and a specific peptide in Utp21 is essential for efficient pre-rRNA processing. Mol Cell Biol (2008) 1.30

Protein design to understand peptide ligand recognition by tetratricopeptide repeat proteins. Protein Eng Des Sel (2004) 1.28

Designed TPR modules as novel anticancer agents. ACS Chem Biol (2008) 1.28

Local and long-range stability in tandemly arrayed tetratricopeptide repeats. Proc Natl Acad Sci U S A (2005) 1.28

Ligand binding by TPR domains. Protein Sci (2006) 1.25

Protein-protein interactions: general trends in the relationship between binding affinity and interfacial buried surface area. Protein Sci (2013) 1.20

A novel class of small molecule inhibitors of Hsp90. ACS Chem Biol (2008) 1.19

Ligand binding by repeat proteins: natural and designed. Curr Opin Struct Biol (2008) 1.19

Fragile X mental retardation syndrome: structure of the KH1-KH2 domains of fragile X mental retardation protein. Structure (2007) 1.18

Balance between folding and degradation for Hsp90-dependent client proteins: a key role for CHIP. Biochemistry (2010) 1.17

Beyond consensus: statistical free energies reveal hidden interactions in the design of a TPR motif. J Mol Biol (2004) 1.14

Opsin stability and folding: modulation by phospholipid bicelles. J Mol Biol (2007) 1.13

The transition state for integral membrane protein folding. Proc Natl Acad Sci U S A (2009) 1.12

Identification of residues on Hsp70 and Hsp90 ubiquitinated by the cochaperone CHIP. J Mol Biol (2009) 1.11

Ion mobility mass spectrometry of two tetrameric membrane protein complexes reveals compact structures and differences in stability and packing. J Am Chem Soc (2010) 1.07

In vitro unfolding and refolding of the small multidrug transporter EmrE. J Mol Biol (2009) 1.05

A new bright green-emitting fluorescent protein--engineered monomeric and dimeric forms. FEBS J (2010) 1.04

Insertion kinetics of a denatured alpha helical membrane protein into phospholipid bilayer vesicles. J Mol Biol (2004) 1.03

Consensus design as a tool for engineering repeat proteins. Methods Mol Biol (2006) 1.01

Exceptional overproduction of a functional human membrane protein. Protein Expr Purif (2007) 1.01

A basis set of de novo coiled-coil peptide oligomers for rational protein design and synthetic biology. ACS Synth Biol (2012) 1.00

Revisiting the Ramachandran plot from a new angle. Protein Sci (2011) 1.00

Unfolding free energy of a two-domain transmembrane sugar transport protein. Proc Natl Acad Sci U S A (2010) 1.00

Combinatorial approaches to protein stability and structure. Eur J Biochem (2004) 0.99

Expression, purification, and reconstitution of a diatom silicon transporter. Biochemistry (2012) 0.98

Covariation of backbone motion throughout a small protein domain. Nat Struct Biol (2003) 0.98

Stable folding core in the folding transition state of an alpha-helical integral membrane protein. Proc Natl Acad Sci U S A (2011) 0.97

The crystal structure of NlpI. A prokaryotic tetratricopeptide repeat protein with a globular fold. FEBS J (2005) 0.97

Crystal structure of a designed tetratricopeptide repeat module in complex with its peptide ligand. FEBS J (2010) 0.96

Redesign of a protein-peptide interaction: characterization and applications. Protein Sci (2009) 0.96

Electrostatic interactions of Hsp-organizing protein tetratricopeptide domains with Hsp70 and Hsp90: computational analysis and protein engineering. J Biol Chem (2009) 0.95

A compound that inhibits the HOP-Hsp90 complex formation and has unique killing effects in breast cancer cell lines. Mol Pharm (2011) 0.95

Mutations in the B1 domain of protein G that delay the onset of amyloid fibril formation in vitro. Protein Sci (2003) 0.94

Mapping the energy landscape of repeat proteins using NMR-detected hydrogen exchange. J Mol Biol (2008) 0.94

Folding and stability of membrane transport proteins in vitro. Biochim Biophys Acta (2011) 0.93

Controlling the folding efficiency of an integral membrane protein. J Mol Biol (2004) 0.93

Screening libraries to identify proteins with desired binding activities using a split-GFP reassembly assay. ACS Chem Biol (2010) 0.93

The activation energy for insertion of transmembrane alpha-helices is dependent on membrane composition. J Mol Biol (2002) 0.92

HOP is a monomer: investigation of the oligomeric state of the co-chaperone HOP. Protein Sci (2010) 0.92

A cell-based screen for function of the four-helix bundle protein Rop: a new tool for combinatorial experiments in biophysics. Protein Eng Des Sel (2004) 0.92

Non-random-coil behavior as a consequence of extensive PPII structure in the denatured state. J Mol Biol (2008) 0.92

Lipid bilayer composition influences small multidrug transporters. BMC Biochem (2008) 0.91

Engineering de novo membrane-mediated protein-protein communication networks. J Am Chem Soc (2012) 0.91

Kinetics of an individual transmembrane helix during bacteriorhodopsin folding. J Mol Biol (2006) 0.90

Kinetics and thermodynamics of phenotype: unwinding and rewinding the nucleosome. J Mol Biol (2012) 0.90

An AlphaScreen-based high-throughput screen to identify inhibitors of Hsp90-cochaperone interaction. J Biomol Screen (2009) 0.90

Calorimetric study of a series of designed repeat proteins: modular structure and modular folding. Protein Sci (2011) 0.90

Phosphatidylglycerol lipids enhance folding of an alpha helical membrane protein. J Mol Biol (2008) 0.89

A new method for the covalent attachment of DNA to a surface for single-molecule studies. Colloids Surf B Biointerfaces (2010) 0.89

Folding kinetics of an alpha helical membrane protein in phospholipid bilayer vesicles. J Mol Biol (2004) 0.89

Designed proteins to modulate cellular networks. ACS Chem Biol (2010) 0.89

Stimuli-responsive smart gels realized via modular protein design. J Am Chem Soc (2010) 0.89

A twisted four-sheeted model for an amyloid fibril. Structure (2005) 0.88

Creating novel proteins by combining design and selection. Protein Eng Des Sel (2010) 0.87

The reconstitution and activity of the small multidrug transporter EmrE is modulated by non-bilayer lipid composition. J Mol Biol (2004) 0.87

Reassembled GFP: detecting protein-protein interactions and protein expression patterns. Methods Biochem Anal (2006) 0.85

Analysis of side chain mobility among protein G B1 domain mutants with widely varying stabilities. Protein Sci (2004) 0.85

The contribution of a covalently bound cofactor to the folding and thermodynamic stability of an integral membrane protein. J Mol Biol (2010) 0.85

A modular approach to the design of protein-based smart gels. Biopolymers (2012) 0.85

Repeat motions and backbone flexibility in designed proteins with different numbers of identical consensus tetratricopeptide repeats. Biochemistry (2006) 0.84

Opsin stability and folding: the role of Cys185 and abnormal disulfide bond formation in the intradiscal domain. J Mol Biol (2007) 0.84

A structural model for the HAT domain of Utp6 incorporating bioinformatics and genetics. Protein Eng Des Sel (2009) 0.84

Measurements of the effect of membrane asymmetry on the mechanical properties of lipid bilayers. Chem Commun (Camb) (2015) 0.83

Does the location of a mutation determine the ability to form amyloid fibrils? J Mol Biol (2002) 0.83

New insights into Fragile X syndrome. Relating genotype to phenotype at the molecular level. FEBS J (2005) 0.82

The power of hard-sphere models: explaining side-chain dihedral angle distributions of Thr and Val. Biophys J (2012) 0.82

Characterization of folding the four-helix bundle protein Rop by real-time NMR. Protein Eng Des Sel (2008) 0.82

Designed phosphoprotein recognition in Escherichia coli. ACS Chem Biol (2014) 0.81

Urea unfolding of opsin in phospholipid bicelles. Photochem Photobiol (2009) 0.81

In vitro folding and assembly of the Escherichia coli ATP-binding cassette transporter, BtuCD. J Biol Chem (2011) 0.81

Translocation of the cell-penetrating Tat peptide across artificial bilayers and into living cells. Biochem Soc Symp (2005) 0.81

Predicting the side-chain dihedral angle distributions of nonpolar, aromatic, and polar amino acids using hard sphere models. Proteins (2014) 0.81

Unravelling the folding and stability of an ABC (ATP-binding cassette) transporter. Biochem Soc Trans (2011) 0.80

Folding alpha-helical membrane proteins into liposomes in vitro and determination of secondary structure. Methods Mol Biol (2013) 0.79

The biological significance of lipid-protein interactions. J Phys Condens Matter (2006) 0.79

Conservation of mechanism, variation of rate: folding kinetics of three homologous four-helix bundle proteins. Protein Eng Des Sel (2008) 0.79

Modulating repeat protein stability: the effect of individual helix stability on the collective behavior of the ensemble. Protein Sci (2011) 0.79

Protocell design through modular compartmentalization. J R Soc Interface (2013) 0.78

New materials from proteins and peptides. Curr Opin Struct Biol (2012) 0.78

Nanostructured functional films from engineered repeat proteins. J R Soc Interface (2013) 0.78

New insights into the interdependence between amino acid stereochemistry and protein structure. Biophys J (2013) 0.77

Membrane proteins by accident or design. Curr Opin Chem Biol (2013) 0.77

The use of isothermal titration calorimetry to study multidrug transport proteins in liposomes. Methods Mol Biol (2010) 0.76

Probing the Molecular Origin of Native-State Flexibility in Repeat Proteins. J Am Chem Soc (2015) 0.76