Published in Structure on September 01, 2005
Toxic fibrillar oligomers of amyloid-β have cross-β structure. Proc Natl Acad Sci U S A (2012) 1.53
Beta arcades: recurring motifs in naturally occurring and disease-related amyloid fibrils. FASEB J (2009) 1.37
Molecular dynamics analyses of cross-beta-spine steric zipper models: beta-sheet twisting and aggregation. Proc Natl Acad Sci U S A (2006) 1.22
Molecular dynamics simulations on the oligomer-formation process of the GNNQQNY peptide from yeast prion protein Sup35. Biophys J (2007) 1.05
Amyloid-like fibrils from a domain-swapping protein feature a parallel, in-register conformation without native-like interactions. J Biol Chem (2011) 0.84
Structural characterization of semen coagulum-derived SEM1(86-107) amyloid fibrils that enhance HIV-1 infection. Biochemistry (2014) 0.79
TPR proteins: the versatile helix. Trends Biochem Sci (2003) 7.37
Design of stable alpha-helical arrays from an idealized TPR motif. Structure (2003) 3.17
Detecting protein-protein interactions with a green fluorescent protein fragment reassembly trap: scope and mechanism. J Am Chem Soc (2005) 2.95
Structure and function of KH domains. FEBS J (2008) 2.48
A recurring theme in protein engineering: the design, stability and folding of repeat proteins. Curr Opin Struct Biol (2005) 1.58
A new folding paradigm for repeat proteins. J Am Chem Soc (2005) 1.57
The interface of protein structure, protein biophysics, and molecular evolution. Protein Sci (2012) 1.54
Altered dimer interface decreases stability in an amyloidogenic protein. J Biol Chem (2008) 1.50
Detecting protein-protein interactions with GFP-fragment reassembly. Nat Methods (2004) 1.45
The folding and design of repeat proteins: reaching a consensus. Curr Opin Struct Biol (2003) 1.43
The effects of sodium sulfate, glycosaminoglycans, and Congo red on the structure, stability, and amyloid formation of an immunoglobulin light-chain protein. Protein Sci (2006) 1.42
Sequence variation in ligand binding sites in proteins. BMC Bioinformatics (2005) 1.37
Systemic amyloidoses. Annu Rev Biochem (2013) 1.34
Structure and stability of designed TPR protein superhelices: unusual crystal packing and implications for natural TPR proteins. Acta Crystallogr D Biol Crystallogr (2007) 1.33
A direct interaction between the Utp6 half-a-tetratricopeptide repeat domain and a specific peptide in Utp21 is essential for efficient pre-rRNA processing. Mol Cell Biol (2008) 1.30
Protein design to understand peptide ligand recognition by tetratricopeptide repeat proteins. Protein Eng Des Sel (2004) 1.28
Designed TPR modules as novel anticancer agents. ACS Chem Biol (2008) 1.28
Local and long-range stability in tandemly arrayed tetratricopeptide repeats. Proc Natl Acad Sci U S A (2005) 1.28
Ligand binding by TPR domains. Protein Sci (2006) 1.25
Biologic and genetic characterization of the novel amyloidogenic lambda light chain-secreting human cell lines, ALMC-1 and ALMC-2. Blood (2008) 1.21
Human thiopurine S-methyltransferase pharmacogenetics: variant allozyme misfolding and aggresome formation. Proc Natl Acad Sci U S A (2005) 1.20
Protein-protein interactions: general trends in the relationship between binding affinity and interfacial buried surface area. Protein Sci (2013) 1.20
In vivo targeting of antibody fragments to the nervous system for Alzheimer's disease immunotherapy and molecular imaging of amyloid plaques. J Neurochem (2007) 1.19
Ligand binding by repeat proteins: natural and designed. Curr Opin Struct Biol (2008) 1.19
A novel class of small molecule inhibitors of Hsp90. ACS Chem Biol (2008) 1.19
Fragile X mental retardation syndrome: structure of the KH1-KH2 domains of fragile X mental retardation protein. Structure (2007) 1.18
Balance between folding and degradation for Hsp90-dependent client proteins: a key role for CHIP. Biochemistry (2010) 1.17
Beyond consensus: statistical free energies reveal hidden interactions in the design of a TPR motif. J Mol Biol (2004) 1.14
Structural insights into the role of mutations in amyloidogenesis. J Biol Chem (2008) 1.12
Salts enhance both protein stability and amyloid formation of an immunoglobulin light chain. Biophys Chem (2008) 1.11
Identification of residues on Hsp70 and Hsp90 ubiquitinated by the cochaperone CHIP. J Mol Biol (2009) 1.11
Serum immunoglobulin free light-chain measurement in primary amyloidosis: prognostic value and correlations with clinical features. Blood (2010) 1.08
A new bright green-emitting fluorescent protein--engineered monomeric and dimeric forms. FEBS J (2010) 1.04
Comparison of amyloid fibril formation by two closely related immunoglobulin light chain variable domains. Amyloid (2010) 1.03
Biochemical and aggregation analysis of Bence Jones proteins from different light chain diseases. Amyloid (2008) 1.01
Consensus design as a tool for engineering repeat proteins. Methods Mol Biol (2006) 1.01
Celastrol inhibits Hsp90 chaperoning of steroid receptors by inducing fibrillization of the Co-chaperone p23. J Biol Chem (2009) 1.01
Structural alterations within native amyloidogenic immunoglobulin light chains. J Mol Biol (2009) 1.01
Mutations in specific structural regions of immunoglobulin light chains are associated with free light chain levels in patients with AL amyloidosis. PLoS One (2009) 1.01
Revisiting the Ramachandran plot from a new angle. Protein Sci (2011) 1.00
Combinatorial approaches to protein stability and structure. Eur J Biochem (2004) 0.99
Covariation of backbone motion throughout a small protein domain. Nat Struct Biol (2003) 0.98
The crystal structure of NlpI. A prokaryotic tetratricopeptide repeat protein with a globular fold. FEBS J (2005) 0.97
Crystal structure of a designed tetratricopeptide repeat module in complex with its peptide ligand. FEBS J (2010) 0.96
Role of mutations in the cellular internalization of amyloidogenic light chains into cardiomyocytes. Sci Rep (2013) 0.96
Redesign of a protein-peptide interaction: characterization and applications. Protein Sci (2009) 0.96
Electrostatic interactions of Hsp-organizing protein tetratricopeptide domains with Hsp70 and Hsp90: computational analysis and protein engineering. J Biol Chem (2009) 0.95
A compound that inhibits the HOP-Hsp90 complex formation and has unique killing effects in breast cancer cell lines. Mol Pharm (2011) 0.95
A single mutation promotes amyloidogenicity through a highly promiscuous dimer interface. Structure (2010) 0.95
Mutations in the B1 domain of protein G that delay the onset of amyloid fibril formation in vitro. Protein Sci (2003) 0.94
Mapping the energy landscape of repeat proteins using NMR-detected hydrogen exchange. J Mol Biol (2008) 0.94
Renal failure due to combined cast nephropathy, amyloidosis and light-chain deposition disease. Nephrol Dial Transplant (2010) 0.94
Screening libraries to identify proteins with desired binding activities using a split-GFP reassembly assay. ACS Chem Biol (2010) 0.93
HOP is a monomer: investigation of the oligomeric state of the co-chaperone HOP. Protein Sci (2010) 0.92
Non-random-coil behavior as a consequence of extensive PPII structure in the denatured state. J Mol Biol (2008) 0.92
A cell-based screen for function of the four-helix bundle protein Rop: a new tool for combinatorial experiments in biophysics. Protein Eng Des Sel (2004) 0.92
Domain:domain interactions within Hop, the Hsp70/Hsp90 organizing protein, are required for protein stability and structure. Protein Sci (2006) 0.92
A distal point mutation in the streptavidin-biotin complex preserves structure but diminishes binding affinity: experimental evidence of electronic polarization effects? Biochemistry (2010) 0.90
An AlphaScreen-based high-throughput screen to identify inhibitors of Hsp90-cochaperone interaction. J Biomol Screen (2009) 0.90
Calorimetric study of a series of designed repeat proteins: modular structure and modular folding. Protein Sci (2011) 0.90
Kinetics and thermodynamics of phenotype: unwinding and rewinding the nucleosome. J Mol Biol (2012) 0.90
Structural and functional studies of truncated hemolysin A from Proteus mirabilis. J Biol Chem (2009) 0.89
Designed proteins to modulate cellular networks. ACS Chem Biol (2010) 0.89
A new method for the covalent attachment of DNA to a surface for single-molecule studies. Colloids Surf B Biointerfaces (2010) 0.89
Stimuli-responsive smart gels realized via modular protein design. J Am Chem Soc (2010) 0.89
Evaluation of the BH3-only protein Puma as a direct Bak activator. J Biol Chem (2013) 0.88
Tyrosine residues mediate fibril formation in a dynamic light chain dimer interface. J Biol Chem (2012) 0.88
Thermal stability threshold for amyloid formation in light chain amyloidosis. Int J Mol Sci (2013) 0.88
Creating novel proteins by combining design and selection. Protein Eng Des Sel (2010) 0.87
Urinary albumin excretion patterns of patients with cast nephropathy and other monoclonal gammopathy-related kidney diseases. Clin J Am Soc Nephrol (2012) 0.85
Analysis of side chain mobility among protein G B1 domain mutants with widely varying stabilities. Protein Sci (2004) 0.85
Reassembled GFP: detecting protein-protein interactions and protein expression patterns. Methods Biochem Anal (2006) 0.85
A modular approach to the design of protein-based smart gels. Biopolymers (2012) 0.85
Repeat motions and backbone flexibility in designed proteins with different numbers of identical consensus tetratricopeptide repeats. Biochemistry (2006) 0.84
A structural model for the HAT domain of Utp6 incorporating bioinformatics and genetics. Protein Eng Des Sel (2009) 0.84
Does the location of a mutation determine the ability to form amyloid fibrils? J Mol Biol (2002) 0.83
Alzheimer's disease amyloid β-protein mutations and deletions that define neuronal binding/internalization as early stage nonfibrillar/fibrillar aggregates and late stage fibrils. Biochemistry (2012) 0.83
Nanoliposomes protect against AL amyloid light chain protein-induced endothelial injury. J Liposome Res (2013) 0.83
Improving the tolerance of a protein a analogue to repeated alkaline exposures using a bypass mutagenesis approach. Proteins (2004) 0.83
The power of hard-sphere models: explaining side-chain dihedral angle distributions of Thr and Val. Biophys J (2012) 0.82
RNA-p53 interactions in vitro. Biochemistry (2007) 0.82
New insights into Fragile X syndrome. Relating genotype to phenotype at the molecular level. FEBS J (2005) 0.82
Second-contact shell mutation diminishes streptavidin-biotin binding affinity through transmitted effects on equilibrium dynamics. Biochemistry (2012) 0.82
Characterization of folding the four-helix bundle protein Rop by real-time NMR. Protein Eng Des Sel (2008) 0.82
Glycosaminoglycans promote fibril formation by amyloidogenic immunoglobulin light chains through a transient interaction. Biophys Chem (2011) 0.81
The Pneumocystis meiotic PCRan1p kinase exhibits unique temperature-regulated activity. Am J Respir Cell Mol Biol (2009) 0.81
Predicting the side-chain dihedral angle distributions of nonpolar, aromatic, and polar amino acids using hard sphere models. Proteins (2014) 0.81
Designed phosphoprotein recognition in Escherichia coli. ACS Chem Biol (2014) 0.81
Evaluation of different linker regions for multimerization and coupling chemistry for immobilization of a proteinaceous affinity ligand. Protein Eng (2003) 0.79
Conservation of mechanism, variation of rate: folding kinetics of three homologous four-helix bundle proteins. Protein Eng Des Sel (2008) 0.79
Modulating repeat protein stability: the effect of individual helix stability on the collective behavior of the ensemble. Protein Sci (2011) 0.79
Physiological and biophysical factors that influence Alzheimer's disease amyloid plaque targeting of native and putrescine modified human amyloid beta40. J Pharmacol Exp Ther (2006) 0.79
New materials from proteins and peptides. Curr Opin Struct Biol (2012) 0.78
Nanostructured functional films from engineered repeat proteins. J R Soc Interface (2013) 0.78
Affinity ligands for industrial protein purification. Protein Pept Lett (2005) 0.77
New insights into the interdependence between amino acid stereochemistry and protein structure. Biophys J (2013) 0.77
Isolation and biochemical characterization of plasma monoclonal free light chains in amyloidosis and multiple myeloma: a pilot study of intact and truncated forms of light chains and their charge properties. Clin Chem Lab Med (2008) 0.76
Probing the Molecular Origin of Native-State Flexibility in Repeat Proteins. J Am Chem Soc (2015) 0.76