Published in Nature on July 09, 2014
The spliceosome is a therapeutic vulnerability in MYC-driven cancer. Nature (2015) 2.63
MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells. Cell Metab (2015) 2.51
MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis. Nature (2015) 1.90
MYC regulates the antitumor immune response through CD47 and PD-L1. Science (2016) 1.87
Redeployment of Myc and E2f1-3 drives Rb-deficient cell cycles. Nat Cell Biol (2015) 1.61
Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause. Cell (2016) 1.59
Hyperglycemia repression of miR-24 coordinately upregulates endothelial cell expression and secretion of von Willebrand factor. Blood (2015) 1.56
MYC: connecting selective transcriptional control to global RNA production. Nat Rev Cancer (2015) 1.47
The Interaction of Myc with Miz1 Defines Medulloblastoma Subgroup Identity. Cancer Cell (2016) 1.47
The role of histone demethylase KDM4B in Myc signaling in neuroblastoma. J Natl Cancer Inst (2015) 1.46
MYC, Metabolism, and Cancer. Cancer Discov (2015) 1.29
Telomerase regulates MYC-driven oncogenesis independent of its reverse transcriptase activity. J Clin Invest (2015) 1.21
Taming of the beast: shaping Myc-dependent amplification. Trends Cell Biol (2014) 1.19
Interaction with WDR5 promotes target gene recognition and tumorigenesis by MYC. Mol Cell (2015) 1.16
MINCR is a MYC-induced lncRNA able to modulate MYC's transcriptional network in Burkitt lymphoma cells. Proc Natl Acad Sci U S A (2015) 1.11
The dynamic control of signal transduction networks in cancer cells. Nat Rev Cancer (2015) 1.09
MYC and metabolism on the path to cancer. Semin Cell Dev Biol (2015) 1.09
CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma. Genes Dev (2014) 1.07
cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions. Cell Res (2015) 1.06
Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase. EMBO Mol Med (2014) 1.03
MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation. Nat Commun (2016) 1.01
MYC and EGR1 synergize to trigger tumor cell death by controlling NOXA and BIM transcription upon treatment with the proteasome inhibitor bortezomib. Nucleic Acids Res (2014) 0.94
Different promoter affinities account for specificity in MYC-dependent gene regulation. Elife (2016) 0.93
The utility of Apc-mutant rats in modeling human colon cancer. Dis Model Mech (2014) 0.92
Oncogenic Myc Induces Expression of Glutamine Synthetase through Promoter Demethylation. Cell Metab (2015) 0.92
Repression of SRF target genes is critical for Myc-dependent apoptosis of epithelial cells. EMBO J (2015) 0.87
Gas6/Axl is the sensor of arginine-auxotrophic response in targeted chemotherapy with arginine-depleting agents. Oncogene (2015) 0.86
High-throughput single-cell gene-expression profiling with multiplexed error-robust fluorescence in situ hybridization. Proc Natl Acad Sci U S A (2016) 0.86
MYC in pancreatic cancer: novel mechanistic insights and their translation into therapeutic strategies. Oncogene (2015) 0.86
Myc Induces miRNA-Mediated Apoptosis in Response to HDAC Inhibition in Hematologic Malignancies. Cancer Res (2015) 0.86
Metabolic reprogramming in triple-negative breast cancer through Myc suppression of TXNIP. Proc Natl Acad Sci U S A (2015) 0.85
Gene regulation: fine-tuned amplification in cells. Nature (2014) 0.85
HDAC1 and HDAC2 integrate the expression of p53 mutants in pancreatic cancer. Oncogene (2016) 0.83
Variation in transcriptome size: are we getting the message? Chromosoma (2014) 0.82
Decoding c-Myc networks of cell cycle and apoptosis regulated genes in a transgenic mouse model of papillary lung adenocarcinomas. Oncotarget (2015) 0.82
Myc coordinates transcription and translation to enhance transformation and suppress invasiveness. EMBO Rep (2015) 0.82
Strategically targeting MYC in cancer. F1000Res (2016) 0.81
Integrative omics reveals MYCN as a global suppressor of cellular signalling and enables network-based therapeutic target discovery in neuroblastoma. Oncotarget (2015) 0.81
Kras(G12D) induces EGFR-MYC cross signaling in murine primary pancreatic ductal epithelial cells. Oncogene (2015) 0.79
CRY2 and FBXL3 Cooperatively Degrade c-MYC. Mol Cell (2016) 0.79
c-Myc and AMPK Control Cellular Energy Levels by Cooperatively Regulating Mitochondrial Structure and Function. PLoS One (2015) 0.79
High-performance multiplexed fluorescence in situ hybridization in culture and tissue with matrix imprinting and clearing. Proc Natl Acad Sci U S A (2016) 0.79
Identifying core gene modules in glioblastoma based on multilayer factor-mediated dysfunctional regulatory networks through integrating multi-dimensional genomic data. Nucleic Acids Res (2015) 0.79
Convergence of cMyc and β-catenin on Tcf7l1 enables endoderm specification. EMBO J (2015) 0.79
Metabolic vulnerabilities of MYC-induced cancer. Oncotarget (2016) 0.78
snoRNAs are a novel class of biologically relevant Myc targets. BMC Biol (2015) 0.78
Oncosuppressive functions of decorin. Mol Cell Oncol (2015) 0.78
OmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors. Oncogene (2016) 0.77
Deubiquitinating c-Myc: USP36 steps up in the nucleolus. Cell Cycle (2015) 0.77
Tipping the MYC-MIZ1 balance: targeting the HUWE1 ubiquitin ligase selectively blocks MYC-activated genes. EMBO Mol Med (2014) 0.77
Identification of c-MYC SUMOylation by mass spectrometry. PLoS One (2014) 0.77
Interactions between Myc and MondoA transcription factors in metabolism and tumourigenesis. Br J Cancer (2015) 0.77
Patterns of Chromosomal Aberrations in Solid Tumors. Recent Results Cancer Res (2015) 0.77
Multi-focal control of mitochondrial gene expression by oncogenic MYC provides potential therapeutic targets in cancer. Oncotarget (2016) 0.77
The Quest for Targets Executing MYC-Dependent Cell Transformation. Front Oncol (2016) 0.76
Physical Interactions and Functional Coordination between the Core Subunits of Set1/Mll Complexes and the Reprogramming Factors. PLoS One (2015) 0.76
The interplay of long non-coding RNAs and MYC in cancer. AIMS Biophys (2015) 0.76
mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer. Cancer Res (2016) 0.76
The mitochondrial translation machinery as a therapeutic target in Myc-driven lymphomas. Oncotarget (2016) 0.76
RUNX3 is oncogenic in natural killer/T-cell lymphoma and is transcriptionally regulated by MYC. Leukemia (2017) 0.76
Somatic polyploidy is associated with the upregulation of c-MYC interacting genes and EMT-like signature. Oncotarget (2016) 0.75
Enhanced Generation of Integration-free iPSCs from Human Adult Peripheral Blood Mononuclear Cells with an Optimal Combination of Episomal Vectors. Stem Cell Reports (2016) 0.75
Controlling the Master: Chromatin Dynamics at the MYC Promoter Integrate Developmental Signaling. Genes (Basel) (2017) 0.75
c-Myc targeted regulators of cell metabolism in a transgenic mouse model of papillary lung adenocarcinoma. Oncotarget (2016) 0.75
Structural Insights into c-Myc Interacting Zinc Finger Protein-1 (Miz-1) Delineate Domains Required for DNA Scanning and Sequence-specific Binding. J Biol Chem (2016) 0.75
Small genomic insertions form enhancers that misregulate oncogenes. Nat Commun (2017) 0.75
MYC: Master Regulator of Immune Privilege. Trends Immunol (2017) 0.75
MYC and AMPK-Save Energy or Die! Front Cell Dev Biol (2017) 0.75
TEAD activity is restrained by MYC and stratifies human breast cancer subtypes. Cell Cycle (2016) 0.75
Gene expression profiling of patient-derived pancreatic cancer xenografts predicts sensitivity to the BET bromodomain inhibitor JQ1: implications for individualized medicine efforts. EMBO Mol Med (2017) 0.75
BIM's up first. Mol Cell Oncol (2014) 0.75
Reconstruction of gene regulatory networks reveals chromatin remodelers and key transcription factors in tumorigenesis. Genome Med (2016) 0.75
Tuning the MYC response. Elife (2016) 0.75
MYC-induced apoptosis in mammary epithelial cells is associated with repression of lineage-specific gene signatures. Cell Cycle (2016) 0.75
Registered report: transcriptional amplification in tumor cells with elevated c-Myc. Elife (2015) 0.75
Correspondence: Oncogenic MYC persistently upregulates the molecular clock component REV-ERBα. Nat Commun (2017) 0.75
Characterization of pancreatic glucagon-producing tumors and pituitary gland tumors in transgenic mice overexpressing MYCN in hGFAP-positive cells. Oncotarget (2016) 0.75
Btg2 is a Negative Regulator of Cardiomyocyte Hypertrophy through a Decrease in Cytosolic RNA. Sci Rep (2016) 0.75
Human p53 interacts with the elongating RNAPII complex and is required for the release of actinomycin D induced transcription blockage. Sci Rep (2017) 0.75
Resetting cancer stem cell regulatory nodes upon MYC inhibition. EMBO Rep (2016) 0.75
Interferon-γ-induced p27KIP1 binds to and targets MYC for proteasome-mediated degradation. Oncotarget (2016) 0.75
MYC Mediates mRNA Cap Methylation of Canonical Wnt/beta-catenin Signaling Transcripts by Recruiting CDK7 and RNA Methyltransferase. Mol Cancer Res (2016) 0.75
FOXR2 Interacts with MYC to Promote Its Transcriptional Activities and Tumorigenesis. Cell Rep (2016) 0.75
Multiple Roles of MYC in Integrating Regulatory Networks of Pluripotent Stem Cells. Front Cell Dev Biol (2017) 0.75
MYC Modulation around the CDK2/p27/SKP2 Axis. Genes (Basel) (2017) 0.75
Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC. Proc Natl Acad Sci U S A (2017) 0.75
The cohesin complex prevents Myc-induced replication stress. Cell Death Dis (2017) 0.75
Integrative analysis of RNA polymerase II and transcriptional dynamics upon MYC activation. Genome Res (2017) 0.75
MYC-Master Regulator of the Cancer Epigenome and Transcriptome. Genes (Basel) (2017) 0.75
lncRNAs and MYC: An Intricate Relationship. Int J Mol Sci (2017) 0.75
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A (2005) 167.46
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc (2009) 137.99
edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics (2009) 67.17
BEDTools: a flexible suite of utilities for comparing genomic features. Bioinformatics (2010) 53.23
Model-based analysis of ChIP-Seq (MACS). Genome Biol (2008) 51.63
Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell (2008) 28.29
Induction of apoptosis in fibroblasts by c-myc protein. Cell (1992) 16.95
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell (2005) 14.21
c-Myc regulates transcriptional pause release. Cell (2010) 11.64
The Integrated Genome Browser: free software for distribution and exploration of genome-scale datasets. Bioinformatics (2009) 10.30
Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector. Proc Natl Acad Sci U S A (1996) 9.15
Transcriptional amplification in tumor cells with elevated c-Myc. Cell (2012) 8.24
MEME-ChIP: motif analysis of large DNA datasets. Bioinformatics (2011) 6.52
c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells. Cell (2012) 6.49
Global mapping of c-Myc binding sites and target gene networks in human B cells. Proc Natl Acad Sci U S A (2006) 5.27
c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I. Nat Cell Biol (2005) 4.89
Myc-binding-site recognition in the human genome is determined by chromatin context. Nat Cell Biol (2006) 4.71
Repression of p15INK4b expression by Myc through association with Miz-1. Nat Cell Biol (2001) 4.22
Analysis of C-MYC function in normal cells via conditional gene-targeted mutation. Immunity (2001) 4.09
Binding of myc proteins to canonical and noncanonical DNA sequences. Mol Cell Biol (1993) 4.08
seqMINER: an integrated ChIP-seq data interpretation platform. Nucleic Acids Res (2010) 3.74
Myc represses the p21(WAF1/CIP1) promoter and interacts with Sp1/Sp3. Proc Natl Acad Sci U S A (2001) 3.02
Negative regulation of the mammalian UV response by Myc through association with Miz-1. Mol Cell (2002) 2.99
Myc recruits P-TEFb to mediate the final step in the transcriptional activation of the cad promoter. J Biol Chem (2002) 2.68
Myc versus USF: discrimination at the cad gene is determined by core promoter elements. Mol Cell Biol (1997) 2.62
The RNA polymerase II CTD coordinates transcription and RNA processing. Genes Dev (2012) 2.55
c-Myc mediates activation of the cad promoter via a post-RNA polymerase II recruitment mechanism. J Biol Chem (2001) 2.36
Myc-induced proliferation and transformation require Akt-mediated phosphorylation of FoxO proteins. EMBO J (2004) 2.19
Pol II and its associated epigenetic marks are present at Pol III-transcribed noncoding RNA genes. Nat Struct Mol Biol (2010) 1.93
MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition. J Exp Med (2012) 1.85
The interaction between Myc and Miz1 is required to antagonize TGFbeta-dependent autocrine signaling during lymphoma formation and maintenance. Genes Dev (2010) 1.81
Functional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification. Proc Natl Acad Sci U S A (2012) 1.46
A SP1/MIZ1/MYCN repression complex recruits HDAC1 at the TRKA and p75NTR promoters and affects neuroblastoma malignancy by inhibiting the cell response to NGF. Cancer Res (2010) 1.29
Induction of ectopic Myc target gene JAG2 augments hypoxic growth and tumorigenesis in a human B-cell model. Proc Natl Acad Sci U S A (2010) 1.25
Transcription factor miz-1 is required to regulate interleukin-7 receptor signaling at early commitment stages of B cell differentiation. Immunity (2010) 1.21
Miz1 is required to maintain autophagic flux. Nat Commun (2013) 1.12
The role of MIZ-1 in MYC-dependent tumorigenesis. Cold Spring Harb Perspect Med (2013) 1.10
Small molecule inhibitors of aurora-a induce proteasomal degradation of N-myc in childhood neuroblastoma. Cancer Cell (2013) 1.85
Targeting Translation Initiation Bypasses Signaling Crosstalk Mechanisms That Maintain High MYC Levels in Colorectal Cancer. Cancer Discov (2015) 1.48
A MYC-Driven Change in Mitochondrial Dynamics Limits YAP/TAZ Function in Mammary Epithelial Cells and Breast Cancer. Cancer Cell (2015) 0.91