Published in Cell Mol Life Sci on December 14, 2015
Co-expression of Foxa.a, Foxd and Fgf9/16/20 defines a transient mesendoderm regulatory state in ascidian embryos. Elife (2016) 0.75
WNT and BMP regulate roadblocks toward cardiomyocyte differentiation: lessons learned from embryos inform human stem cell differentiation. Stem Cell Investig (2016) 0.75
FGF and canonical Wnt signaling cooperate to induce paraxial mesoderm from tailbud neuromesodermal progenitors through regulation of a two-step epithelial to mesenchymal transition. Development (2017) 0.75
Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development. Cell (2008) 10.34
The Inheritance of Taillessness (Anury) in the House Mouse. Genetics (1936) 8.45
Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta. Science (1998) 8.27
Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature (1998) 8.02
Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes Dev (1995) 7.13
Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells. Curr Biol (1996) 6.88
A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo. Development (1999) 5.85
Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation. Nature (2000) 5.52
Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair. Cell (2004) 5.04
Expression pattern of the mouse T gene and its role in mesoderm formation. Nature (1990) 4.97
Forkhead transcription factors: key players in development and metabolism. Dev Biol (2002) 4.74
Requirement for Wnt3 in vertebrate axis formation. Nat Genet (1999) 4.68
Development of definitive endoderm from embryonic stem cells in culture. Development (2004) 4.61
Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos. Cell (1991) 4.31
Cloning of the T gene required in mesoderm formation in the mouse. Nature (1990) 4.20
Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos. Nature (1995) 4.14
HNF-3 beta is essential for node and notochord formation in mouse development. Cell (1994) 4.08
Xwnt11 is a target of Xenopus Brachyury: regulation of gastrulation movements via Dishevelled, but not through the canonical Wnt pathway. Development (2000) 4.06
Dorsal-ventral patterning and neural induction in Xenopus embryos. Annu Rev Cell Dev Biol (2004) 3.96
Biphasic role for Wnt/beta-catenin signaling in cardiac specification in zebrafish and embryonic stem cells. Proc Natl Acad Sci U S A (2007) 3.90
Requirement for Lim1 in head-organizer function. Nature (1995) 3.86
Expression of two myogenic regulatory factors myogenin and MyoD1 during mouse embryogenesis. Nature (1989) 3.73
The winged-helix transcription factor HNF-3 beta is required for notochord development in the mouse embryo. Cell (1994) 3.71
Smad4 and FAST-1 in the assembly of activin-responsive factor. Nature (1997) 3.66
Smad2 role in mesoderm formation, left-right patterning and craniofacial development. Nature (1998) 3.65
Formation and function of Spemann's organizer. Annu Rev Cell Dev Biol (1997) 3.62
Eomesodermin is required for mouse trophoblast development and mesoderm formation. Nature (2000) 3.53
Nodal signaling: developmental roles and regulation. Development (2007) 3.44
Maternal wnt11 activates the canonical wnt signaling pathway required for axis formation in Xenopus embryos. Cell (2005) 3.43
Ectopic expression of the proto-oncogene int-1 in Xenopus embryos leads to duplication of the embryonic axis. Cell (1989) 3.42
Expression of a Xenopus homolog of Brachyury (T) is an immediate-early response to mesoderm induction. Cell (1991) 3.40
Axis development and early asymmetry in mammals. Cell (1999) 3.34
Mesoderm induction in early Xenopus embryos by heparin-binding growth factors. Nature (1987) 3.31
Graded changes in dose of a Xenopus activin A homologue elicit stepwise transitions in embryonic cell fate. Nature (1990) 3.27
A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos. Nature (1992) 3.23
Molecular nature of Spemann's organizer: the role of the Xenopus homeobox gene goosecoid. Cell (1991) 3.23
Zebrafish organizer development and germ-layer formation require nodal-related signals. Nature (1998) 3.21
The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals. Nature (1999) 3.19
Synergistic induction of mesoderm by FGF and TGF-beta and the identification of an mRNA coding for FGF in the early Xenopus embryo. Cell (1987) 3.17
The EGF-CFC protein one-eyed pinhead is essential for nodal signaling. Cell (1999) 3.15
Regulation of Wnt signaling by Sox proteins: XSox17 alpha/beta and XSox3 physically interact with beta-catenin. Mol Cell (1999) 3.15
A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse. Development (1994) 3.12
Activities of the Wnt-1 class of secreted signaling factors are antagonized by the Wnt-5A class and by a dominant negative cadherin in early Xenopus development. J Cell Biol (1996) 3.01
Gata5 is required for the development of the heart and endoderm in zebrafish. Genes Dev (1999) 2.95
Differential expression of myogenic determination genes in muscle cells: possible autoactivation by the Myf gene products. EMBO J (1989) 2.88
Canonical Wnt signaling is required for development of embryonic stem cell-derived mesoderm. Development (2006) 2.82
Wnt, activin, and BMP signaling regulate distinct stages in the developmental pathway from embryonic stem cells to blood. Cell Stem Cell (2008) 2.77
Injected Xwnt-8 RNA acts early in Xenopus embryos to promote formation of a vegetal dorsalizing center. Cell (1991) 2.72
Beta-catenin translocation into nuclei demarcates the dorsalizing centers in frog and fish embryos. Mech Dev (1996) 2.72
The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. Genes Dev (1998) 2.72
beta-Trcp couples beta-catenin phosphorylation-degradation and regulates Xenopus axis formation. Proc Natl Acad Sci U S A (1999) 2.66
Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase. Cell (2005) 2.66
A molecular pathway determining left-right asymmetry in chick embryogenesis. Cell (1995) 2.65
Nodal signalling in the epiblast patterns the early mouse embryo. Nature (2001) 2.65
A maternal mRNA localized to the vegetal hemisphere in Xenopus eggs codes for a growth factor related to TGF-beta. Cell (1987) 2.64
Different phenotypes for mice deficient in either activins or activin receptor type II. Nature (1995) 2.62
Expression cloning of Siamois, a Xenopus homeobox gene expressed in dorsal-vegetal cells of blastulae and able to induce a complete secondary axis. Cell (1995) 2.61
Xwnt-5A: a maternal Wnt that affects morphogenetic movements after overexpression in embryos of Xenopus laevis. Development (1993) 2.58
Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer. Nature (1996) 2.54
Initiation of neural induction by FGF signalling before gastrulation. Nature (2000) 2.49
The role of maternal VegT in establishing the primary germ layers in Xenopus embryos. Cell (1998) 2.49
Axis determination in Xenopus involves biochemical interactions of axin, glycogen synthase kinase 3 and beta-catenin. Curr Biol (1998) 2.48
Nodal is a novel TGF-beta-like gene expressed in the mouse node during gastrulation. Nature (1993) 2.45
Role of glycogen synthase kinase 3 beta as a negative regulator of dorsoventral axis formation in Xenopus embryos. Proc Natl Acad Sci U S A (1995) 2.42
Frzb, a secreted protein expressed in the Spemann organizer, binds and inhibits Wnt-8. Cell (1997) 2.40
Axil, a member of the Axin family, interacts with both glycogen synthase kinase 3beta and beta-catenin and inhibits axis formation of Xenopus embryos. Mol Cell Biol (1998) 2.33
Sox17 and beta-catenin cooperate to regulate the transcription of endodermal genes. Development (2004) 2.33
The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation. Mech Dev (2003) 2.31
A homeobox gene essential for zebrafish notochord development. Nature (1995) 2.25
Wnt signaling in Xenopus embryos inhibits bmp4 expression and activates neural development. Genes Dev (1999) 2.24
Nodal antagonists in the anterior visceral endoderm prevent the formation of multiple primitive streaks. Dev Cell (2002) 2.24
Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures. Cell (1990) 2.22
Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin A. Nature (1990) 2.17
Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation. Development (1995) 2.16
Inhibition of Xbra transcription activation causes defects in mesodermal patterning and reveals autoregulation of Xbra in dorsal mesoderm. Development (1996) 2.13
Processed Vg1 protein is an axial mesoderm inducer in Xenopus. Cell (1993) 2.12
Churchill, a zinc finger transcriptional activator, regulates the transition between gastrulation and neurulation. Cell (2003) 2.10
Nodal morphogens. Cold Spring Harb Perspect Biol (2009) 2.09
The LIM domain-containing homeo box gene Xlim-1 is expressed specifically in the organizer region of Xenopus gastrula embryos. Genes Dev (1992) 2.04
GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis. Cell (1998) 2.03
Xsox17alpha and -beta mediate endoderm formation in Xenopus. Cell (1997) 1.97
Endodermal Nodal-related signals and mesoderm induction in Xenopus. Development (2000) 1.97
Beta-catenin, MAPK and Smad signaling during early Xenopus development. Development (2002) 1.95
The Brachyury gene encodes a novel DNA binding protein. EMBO J (1993) 1.94
Regionally specific induction by the Spemann-Mangold organizer. Nat Rev Genet (2004) 1.92
Endogenous patterns of TGFbeta superfamily signaling during early Xenopus development. Development (2000) 1.89
The T protein encoded by Brachyury is a tissue-specific transcription factor. EMBO J (1995) 1.89
Mesoderm induction in Xenopus caused by activation of MAP kinase. Nature (1995) 1.86
The transcription factor HNF3beta is required in visceral endoderm for normal primitive streak morphogenesis. Development (1998) 1.85
The Xenopus homeobox gene twin mediates Wnt induction of goosecoid in establishment of Spemann's organizer. Development (1997) 1.77
Establishment of the dorsal-ventral axis in Xenopus embryos coincides with the dorsal enrichment of dishevelled that is dependent on cortical rotation. J Cell Biol (1999) 1.73
Eomesodermin, a key early gene in Xenopus mesoderm differentiation. Cell (1996) 1.72
A method to recapitulate early embryonic spatial patterning in human embryonic stem cells. Nat Methods (2014) 1.70
Antagonizing the Spemann organizer: role of the homeobox gene Xvent-1. EMBO J (1995) 1.69
Mix.1, a homeobox mRNA inducible by mesoderm inducers, is expressed mostly in the presumptive endodermal cells of Xenopus embryos. Cell (1989) 1.67
The Xenopus Brachyury promoter is activated by FGF and low concentrations of activin and suppressed by high concentrations of activin and by paired-type homeodomain proteins. Genes Dev (1997) 1.66
SOX17 links gut endoderm morphogenesis and germ layer segregation. Nat Cell Biol (2014) 1.66
Integration of TGF-beta and Ras/MAPK signaling through p53 phosphorylation. Science (2007) 1.65
The presence of fibroblast growth factor in the frog egg: its role as a natural mesoderm inducer. Science (1988) 1.64
FGF signalling in the early specification of mesoderm in Xenopus. Development (1993) 1.63