GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis.

PubWeight™: 2.03‹?› | Rank: Top 2%

🔗 View Article (PMID 9635432)

Published in Cell on June 12, 1998

Authors

C Yost1, G H Farr, S B Pierce, D M Ferkey, M M Chen, D Kimelman

Author Affiliations

1: Department of Biochemistry, University of Washington, Seattle 98195-7350, USA.

Articles citing this

GSK-3: tricks of the trade for a multi-tasking kinase. J Cell Sci (2003) 10.89

Glycogen synthase kinase-3beta haploinsufficiency mimics the behavioral and molecular effects of lithium. J Neurosci (2004) 3.12

Glycogen synthase kinase 3 phosphorylates kinesin light chains and negatively regulates kinesin-based motility. EMBO J (2002) 2.70

Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex. EMBO J (2003) 2.33

Wnt signaling in Xenopus embryos inhibits bmp4 expression and activates neural development. Genes Dev (1999) 2.24

Cell autonomous regulation of multiple Dishevelled-dependent pathways by mammalian Nkd. Proc Natl Acad Sci U S A (2001) 2.22

Pontin52 and reptin52 function as antagonistic regulators of beta-catenin signalling activity. EMBO J (2000) 2.15

Evidence that fold-change, and not absolute level, of beta-catenin dictates Wnt signaling. Mol Cell (2009) 2.11

Stabilization of beta-catenin by a Wnt-independent mechanism regulates cardiomyocyte growth. Proc Natl Acad Sci U S A (2003) 2.01

Direct, activating interaction between glycogen synthase kinase-3beta and p53 after DNA damage. Proc Natl Acad Sci U S A (2002) 1.96

A divergent canonical WNT-signaling pathway regulates microtubule dynamics: dishevelled signals locally to stabilize microtubules. J Cell Biol (2004) 1.90

Physiological regulation of [beta]-catenin stability by Tcf3 and CK1epsilon. J Cell Biol (2001) 1.80

Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis. J Cell Biol (2002) 1.75

Establishment of the dorsal-ventral axis in Xenopus embryos coincides with the dorsal enrichment of dishevelled that is dependent on cortical rotation. J Cell Biol (1999) 1.73

Two putative BIN2 substrates are nuclear components of brassinosteroid signaling. Plant Physiol (2002) 1.64

Interaction among GSK-3, GBP, axin, and APC in Xenopus axis specification. J Cell Biol (2000) 1.63

Early stages of zebrafish eye formation require the coordinated activity of Wnt11, Fz5, and the Wnt/beta-catenin pathway. Neuron (2005) 1.62

Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex. EMBO J (2007) 1.55

Regulation of glycogen synthase kinase 3beta and downstream Wnt signaling by axin. Mol Cell Biol (1999) 1.50

Nuclear localization and formation of beta-catenin-lymphoid enhancer factor 1 complexes are not sufficient for activation of gene expression. Mol Cell Biol (1999) 1.49

GSK-3 Inhibitors: Preclinical and Clinical Focus on CNS. Front Mol Neurosci (2011) 1.47

Wnt/beta-catenin signaling and small molecule inhibitors. Curr Pharm Des (2013) 1.44

Frizzled and LRP5/6 receptors for Wnt/β-catenin signaling. Cold Spring Harb Perspect Biol (2012) 1.43

Lithium blocks the c-Jun stress response and protects neurons via its action on glycogen synthase kinase 3. Mol Cell Biol (2003) 1.41

The way Wnt works: components and mechanism. Growth Factors (2012) 1.37

Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein. Mol Cell Biol (2001) 1.36

Endostatin is a potential inhibitor of Wnt signaling. J Cell Biol (2002) 1.34

Validating GSK3 as an in vivo target of lithium action. Biochem Soc Trans (2009) 1.27

Interaction of dishevelled and Xenopus axin-related protein is required for wnt signal transduction. Mol Cell Biol (2000) 1.23

Deconstructing GSK-3: The Fine Regulation of Its Activity. Int J Alzheimers Dis (2011) 1.22

Functional studies of shaggy/glycogen synthase kinase 3 phosphorylation sites in Drosophila melanogaster. Mol Cell Biol (2004) 1.15

Genotype-specific responses in Atlantic salmon (Salmo salar) subject to dietary fish oil replacement by vegetable oil: a liver transcriptomic analysis. BMC Genomics (2011) 1.13

Glycogen synthase kinase-3 enhances nuclear export of a Dictyostelium STAT protein. EMBO J (2000) 1.08

Elevated levels of beta-catenin and fibronectin in three-dimensional collagen cultures of Dupuytren's disease cells are regulated by tension in vitro. BMC Musculoskelet Disord (2003) 1.06

Wnt signaling in vertebrate axis specification. Cold Spring Harb Perspect Biol (2013) 1.03

Wingless directly represses DPP morphogen expression via an armadillo/TCF/Brinker complex. PLoS One (2007) 0.99

Lithium inhibits Smad3/4 transactivation via increased CREB activity induced by enhanced PKA and AKT signaling. Mol Cell Neurosci (2007) 0.98

Exposure to the herbicide acetochlor alters thyroid hormone-dependent gene expression and metamorphosis in Xenopus Laevis. Environ Health Perspect (2002) 0.97

Light and electron microscopy study of glycogen synthase kinase-3beta in the mouse brain. PLoS One (2010) 0.92

Lithium regulates keratinocyte proliferation via glycogen synthase kinase 3 and NFAT2 (nuclear factor of activated T cells 2). J Cell Physiol (2012) 0.92

Modulation of GSK-3 as a Therapeutic Strategy on Tau Pathologies. Front Mol Neurosci (2011) 0.91

Analysis of dishevelled localization and function in the early sea urchin embryo. Dev Biol (2007) 0.89

Vegetally localized Xenopus trim36 regulates cortical rotation and dorsal axis formation. Development (2009) 0.89

Tissue microarray analysis of human FRAT1 expression and its correlation with the subcellular localisation of beta-catenin in ovarian tumours. Br J Cancer (2006) 0.88

Disturbed Wnt Signalling due to a Mutation in CCDC88C Causes an Autosomal Recessive Non-Syndromic Hydrocephalus with Medial Diverticulum. Mol Syndromol (2010) 0.88

Testosterone prevents the heat shock-induced overactivation of glycogen synthase kinase-3 beta but not of cyclin-dependent kinase 5 and c-Jun NH2-terminal kinase and concomitantly abolishes hyperphosphorylation of tau: implications for Alzheimer's disease. Proc Natl Acad Sci U S A (2002) 0.88

Frat is dispensable for canonical Wnt signaling in mammals. Genes Dev (2005) 0.87

Knockdown of FRAT1 expression by RNA interference inhibits human glioblastoma cell growth, migration and invasion. PLoS One (2013) 0.86

Rap2 is required for Wnt/beta-catenin signaling pathway in Xenopus early development. EMBO J (2005) 0.86

The maternally localized RNA fatvg is required for cortical rotation and germ cell formation. Mech Dev (2007) 0.83

Crosstalk between Nrf2 and Notch signaling. Free Radic Biol Med (2015) 0.82

GSK-3β dysregulation contributes to parkinson's-like pathophysiology with associated region-specific phosphorylation and accumulation of tau and α-synuclein. Cell Death Differ (2014) 0.82

Overexpression of FRAT1 is associated with malignant phenotype and poor prognosis in human gliomas. Dis Markers (2015) 0.81

Characterization of the interaction between latency-associated nuclear antigen and glycogen synthase kinase 3beta. J Virol (2009) 0.80

Molecular specification of germ layers in vertebrate embryos. Cell Mol Life Sci (2015) 0.80

Protein interactions in Xenopus germ plasm RNP particles. PLoS One (2013) 0.80

GSK3-mediated instability of tubulin polymers is responsible for the failure of immature CD4+CD8+ thymocytes to polarize their MTOC in response to TCR stimulation. Int Immunol (2011) 0.77

Wnt signaling during tooth replacement in zebrafish (Danio rerio): pitfalls and perspectives. Front Physiol (2014) 0.77

Parallel microtubules and other conserved elements of dorsal axial specification in the direct developing frog, Eleutherodactylus coqui. Dev Genes Evol (2002) 0.77

Silencing of FRAT1 by siRNA inhibits the proliferation of SGC7901 human gastric adenocarcinoma cells. Biomed Rep (2016) 0.76

Frequently rearranged in advanced T‑cell lymphomas‑1 demonstrates oncogenic properties in prostate cancer. Mol Med Rep (2016) 0.75

Gtpbp2 is a positive regulator of Wnt signaling and maintains low levels of the Wnt negative regulator Axin. Cell Commun Signal (2016) 0.75

Articles by these authors

The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3. Genes Dev (1996) 7.78

Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway. Mol Cell (2001) 5.19

Methods for measuring levels of well-being for a health status index. Health Serv Res (1973) 4.18

A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus. Genes Dev (1997) 3.80

Microsatellite instability and 8p allelic imbalance in stage B2 and C colorectal cancers. J Natl Cancer Inst (1999) 3.46

Toward an operational definition of health. J Health Soc Behav (1973) 3.39

Microsatellite instability in colorectal cancer: different mutator phenotypes and the principal involvement of hMLH1. Cancer Res (1998) 3.36

Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1. EMBO J (1999) 3.18

Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity. Proc Natl Acad Sci U S A (1987) 2.99

Crystal structure of a beta-catenin/Tcf complex. Cell (2000) 2.93

Myosarcomas of the stomach: natural history, prognostic factors and management. Cancer (1982) 2.85

Role of glycogen synthase kinase-3beta in neuronal apoptosis induced by trophic withdrawal. J Neurosci (2000) 2.70

E1a regions of the human adenoviruses and of the highly oncogenic simian adenovirus 7 are closely related. J Virol (1985) 2.59

XCtBP is a XTcf-3 co-repressor with roles throughout Xenopus development. Development (1999) 2.56

Establishment of the dorso-ventral axis in Xenopus embryos is presaged by early asymmetries in beta-catenin that are modulated by the Wnt signaling pathway. J Cell Biol (1997) 2.42

A homeobox gene essential for zebrafish notochord development. Nature (1995) 2.25

The events of the midblastula transition in Xenopus are regulated by changes in the cell cycle. Cell (1987) 2.22

Regulation of Spemann organizer formation by the intracellular kinase Xgsk-3. Development (1995) 2.18

From cortical rotation to organizer gene expression: toward a molecular explanation of axis specification in Xenopus. Bioessays (1998) 1.91

Expression of the human fibroblast interferon gene in Escherichia coli. Proc Natl Acad Sci U S A (1980) 1.84

Expression and characterization of a functional human insulin-like growth factor I receptor. J Biol Chem (1988) 1.83

Anorectal melanoma. Cancer (1981) 1.77

Molecular identification of spadetail: regulation of zebrafish trunk and tail mesoderm formation by T-box genes. Development (1998) 1.77

Interaction among GSK-3, GBP, axin, and APC in Xenopus axis specification. J Cell Biol (2000) 1.63

Metformin in the treatment of non-alcoholic steatohepatitis: a pilot open label trial. Aliment Pharmacol Ther (2004) 1.61

Induction of the Xenopus organizer: expression and regulation of Xnot, a novel FGF and activin-regulated homeo box gene. Genes Dev (1993) 1.56

An ABC of apolipoprotein C-III: a clinically useful new cardiovascular risk factor? Int J Clin Pract (2008) 1.55

Activation of Siamois by the Wnt pathway. Dev Biol (1996) 1.47

Nervous system involvement in type IV glycogenosis. Arch Pathol Lab Med (1979) 1.40

Myosarcomas of the small and large intestine: a clinicopathologic study. J Surg Oncol (1983) 1.39

Individual adenovirus type 5 early region 1A gene products elicit distinct alterations of cellular morphology and gene expression. J Virol (1985) 1.38

Tcf4 can specifically recognize beta-catenin using alternative conformations. Nat Struct Biol (2001) 1.35

Processing of the Drosophila Sog protein creates a novel BMP inhibitory activity. Development (2000) 1.35

In vivo cross-linking of protein disulfide isomerase to immunoglobulins. Biochemistry (1987) 1.32

The homeobox genes vox and vent are redundant repressors of dorsal fates in zebrafish. Development (2001) 1.27

Calculation of protein tertiary structure. J Mol Biol (1976) 1.27

Maximizing health system output with political and administrative constraints using mathematical programming. Inquiry (1976) 1.27

Increased GLUT-4 translocation mediates enhanced insulin sensitivity of muscle glucose transport after exercise. J Appl Physiol (1985) (1998) 1.22

Activin-mediated mesoderm induction requires FGF. Development (1994) 1.20

A high fat diet impairs stimulation of glucose transport in muscle. Functional evaluation of potential mechanisms. J Biol Chem (1998) 1.12

Advanced glycosylation end products up-regulate connective tissue growth factor (insulin-like growth factor-binding protein-related protein 2) in human fibroblasts: a potential mechanism for expansion of extracellular matrix in diabetes mellitus. Endocrinology (2001) 1.12

GSK-3: new thoughts on an old enzyme. Dev Biol (2000) 1.09

Regulation of dorsal-ventral patterning: the ventralizing effects of the novel Xenopus homeobox gene Vox. Development (1996) 1.09

A role for notochord in axial vascular development revealed by analysis of phenotype and the expression of VEGR-2 in zebrafish flh and ntl mutant embryos. Mech Dev (1997) 1.08

Microvascular contributions in tissue heat transfer. Ann N Y Acad Sci (1980) 1.06

Patterning the early zebrafish by the opposing actions of bozozok and vox/vent. Dev Biol (2000) 1.04

The role of the yolk syncytial layer in germ layer patterning in zebrafish. Development (2000) 1.02

Rapid reversal of adaptive increases in muscle GLUT-4 and glucose transport capacity after training cessation. J Appl Physiol (1985) (1998) 1.02

Localized BMP-4 mediates dorsal/ventral patterning in the early Xenopus embryo. Dev Biol (1995) 1.01

Identification of adenovirus 12-encoded E1A tumor antigens synthesized in infected and transformed mammalian cells and in Escherichia coli. J Virol (1984) 1.01

Production of a monospecific antiserum against the early region 1A proteins of adenovirus 12 and adenovirus 5 by an adenovirus 12 early region 1A-beta-galactosidase fusion protein antigen expressed in bacteria. J Virol (1984) 1.01

The retinoid X receptor ligand, 9-cis-retinoic acid, is a potential regulator of early Xenopus development. Proc Natl Acad Sci U S A (1994) 1.00

v-erbA and citral reduce the teratogenic effects of all-trans retinoic acid and retinol, respectively, in Xenopus embryogenesis. Development (1993) 0.99

Drosophila short gastrulation induces an ectopic axis in Xenopus: evidence for conserved mechanisms of dorsal-ventral patterning. Development (1995) 0.99

Protein-lipid interactions. Studies of the M13 coat protein in dimyristoylphosphatidylcholine vesicles using parinaric acid. Biochemistry (1979) 0.99

Image-guided core-needle breast biopsy is an accurate technique to evaluate patients with nonpalpable imaging abnormalities. Ann Surg (1998) 0.98

Gastric cancer surgery and its hazards: post operative infection is the most important complication. Hepatogastroenterology (2009) 0.98

Desquamative interstitial pneumonia. An electron microscopic study. Am J Pathol (1970) 0.98

A conserved role for H15-related T-box transcription factors in zebrafish and Drosophila heart formation. Dev Biol (2000) 0.97

Spatial regulation of floating head expression in the developing notochord. Dev Dyn (1997) 0.96

The receptor for insulin-like growth factor II mediates an insulin-like response. EMBO J (1987) 0.96

Prognostic value of c-erbB2 overexpression in axillary lymph node positive breast cancer. Results from a randomized adjuvant treatment protocol. Cancer (1994) 0.95

Effects of endurance exercise training on muscle glycogen accumulation in humans. J Appl Physiol (1985) (1999) 0.94

Nodular regenerative hyperplasia: a controversial indication for orthotopic liver transplantation. Transpl Int (1994) 0.93

FGF is a prospective competence factor for early activin-type signals in Xenopus mesoderm induction. Development (1995) 0.92

Irradiation-induced chondrosarcoma. A case report. J Bone Joint Surg Am (1976) 0.92

Effects of growth hormone and testosterone on cortical bone formation and bone density in aged orchiectomized rats. Bone (1999) 0.92

Conservation of intracellular Wnt signaling components in dorsal-ventral axis formation in zebrafish. Dev Genes Evol (1999) 0.92

Regulation of dorsal gene expression in Xenopus by the ventralizing homeodomain gene Vox. Dev Biol (1999) 0.91

Intraobserver and interobserver reliability of waist circumference and the waist-to-hip ratio. Obes Res (2001) 0.91

Brunner's gland cystadenoma of the duodenum. Am J Surg (1973) 0.91

The use of new technologies by rural family physicians. J Fam Pract (1994) 0.91

The pitx2 homeobox protein is required early for endoderm formation and nodal signaling. . Dev Biol (2001) 0.90

Influence of exercise on cancellous bone of the aged female rat. J Bone Miner Res (1993) 0.90

Radial scar of the breast: radiologic-pathologic correlation in 22 cases. Radiographics (1999) 0.90

Epidemiology of breast carcinoma: Age, menstrual status, and exogenous hormone usage in patients with lobular carcinoma in situ. Surgery (1979) 0.90

Wilms' tumor with metastasis to the left testis. Am Surg (1990) 0.90

Appropriate management of atypical ductal hyperplasia diagnosed by stereotactic core needle breast biopsy. Ann Surg Oncol (1997) 0.89

Biopsy technique has no impact on local recurrence after breast-conserving therapy. Breast J (2001) 0.89

Temporal distribution, localization and metabolism of all-trans-retinol, didehydroretinol and all-trans-retinal during Xenopus development. Biochem J (1994) 0.89

Fibroblast growth factor, but not activin, is a potent activator of mitogen-activated protein kinase in Xenopus explants. Proc Natl Acad Sci U S A (1994) 0.88

Dorsal-ventral differences in Xcad-3 expression in response to FGF-mediated induction in Xenopus. Dev Biol (1994) 0.88

Telangiectatic osteogenic sarcoma. A review of twenty-eight cases. Cancer (1974) 0.88

DHEA treatment reduces fat accumulation and protects against insulin resistance in male rats. J Gerontol A Biol Sci Med Sci (1998) 0.88

A mass on breast imaging predicts coexisting invasive carcinoma in patients with a core biopsy diagnosis of ductal carcinoma in situ. Am Surg (2001) 0.88

Benign diagnosis by image-guided core-needle breast biopsy. Am Surg (2000) 0.87

Glycogen supercompensation masks the effect of a traininginduced increase in GLUT-4 on muscle glucose transport. J Appl Physiol (1985) (1998) 0.87

Post-operative complications of gastric cancer surgery: female gender at high risk. Eur J Cancer Care (Engl) (2009) 0.87

Ischemia-reperfusion injury of the spinal cord: protective effect of the hydroxyl radical scavenger dimethylthiourea. J Vasc Surg (1994) 0.87

The Xenopus laevis homeobox gene Xgbx-2 is an early marker of anteroposterior patterning in the ectoderm. Mech Dev (1996) 0.86

Improved survival after pulmonary resection of metastatic colorectal carcinoma. J Surg Oncol (1990) 0.85

Pulse-decay method for measuring the thermal conductivity of living tissues. J Biomech Eng (1981) 0.85

Comparison of estrogen receptor determinations by a biochemical ligand-binding assay and immunohistochemical staining with monoclonal antibody ER1D5 in females with lymph node positive breast carcinoma entered on two prospective clinical trials. Cancer (1996) 0.85

Overlapping expression of zebrafish T-brain-1 and eomesodermin during forebrain development. Mech Dev (2001) 0.85

BDNF or IGF-I potentiates free radical-mediated injury in cortical cell cultures. Neuroreport (1995) 0.85