Published in Chromosoma on January 21, 2016
POLD1: Central mediator of DNA replication and repair, and implication in cancer and other pathologies. Gene (2016) 0.85
Alternative lengthening of human telomeres is a conservative DNA replication process with features of break-induced replication. EMBO Rep (2016) 0.84
The Role of the Transcriptional Response to DNA Replication Stress. Genes (Basel) (2017) 0.79
A Model to Investigate Single-Strand DNA Responses in G1 Human Cells via a Telomere-Targeted, Nuclease-Deficient CRISPR-Cas9 System. PLoS One (2017) 0.75
DNA Replication Origins and Fork Progression at Mammalian Telomeres. Genes (Basel) (2017) 0.75
The Causes and Consequences of Topological Stress during DNA Replication. Genes (Basel) (2016) 0.75
How MCM loading and spreading specify eukaryotic DNA replication initiation sites. F1000Res (2016) 0.75
Mrc1/Claspin: a new role for regulation of origin firing. Curr Genet (2017) 0.75
Shortage of dNTPs underlies altered replication dynamics and DNA breakage in the absence of the APC/C cofactor Cdh1. Oncogene (2017) 0.75
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature (2005) 26.32
Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions. Science (2015) 21.42
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature (2005) 19.13
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science (2003) 18.29
RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. Nature (2002) 14.63
ATR: an essential regulator of genome integrity. Nat Rev Mol Cell Biol (2008) 11.86
An oncogene-induced DNA damage model for cancer development. Science (2008) 11.60
Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication. Nature (2006) 11.18
The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta. Nature (1999) 10.87
Molecular origins of cancer: Molecular basis of colorectal cancer. N Engl J Med (2009) 10.01
Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J Biol Chem (1985) 8.60
DNA damage, aging, and cancer. N Engl J Med (2009) 7.56
Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects. Science (2002) 7.46
The DNA replication checkpoint response stabilizes stalled replication forks. Nature (2001) 7.04
Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair. Cell (2007) 6.68
Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint. Nature (2001) 6.55
S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex. Nature (2003) 6.43
GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks. Nat Cell Biol (2006) 6.36
Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation. Nature (2003) 6.31
Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage. Mol Cell (2004) 6.12
Replicon clusters are stable units of chromosome structure: evidence that nuclear organization contributes to the efficient activation and propagation of S phase in human cells. J Cell Biol (1998) 6.12
Stems cells and the pathways to aging and cancer. Cell (2008) 5.99
Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint. Genes Dev (2005) 5.53
Cotranscriptionally formed DNA:RNA hybrids mediate transcription elongation impairment and transcription-associated recombination. Mol Cell (2003) 5.48
Chromosome fragile sites. Annu Rev Genet (2007) 4.95
The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair. Science (2009) 4.85
Nucleotide deficiency promotes genomic instability in early stages of cancer development. Cell (2011) 4.83
Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress. Genes Dev (2007) 4.60
Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair. Mol Cell (2010) 4.57
Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage. Mol Cell Biol (2005) 4.54
Mechanism of replication-coupled DNA interstrand crosslink repair. Cell (2008) 4.53
Multiple mechanisms control chromosome integrity after replication fork uncoupling and restart at irreparable UV lesions. Mol Cell (2006) 4.44
Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11. Cell (2011) 4.41
Fidelity of human DNA polymerase eta. J Biol Chem (2000) 4.39
S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51. Blood (2002) 4.27
RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments. Genes Dev (2007) 4.16
Strength in numbers: preventing rereplication via multiple mechanisms in eukaryotic cells. Genes Dev (2007) 4.11
Identification of early replicating fragile sites that contribute to genome instability. Cell (2013) 3.99
Survival of DNA damage in yeast directly depends on increased dNTP levels allowed by relaxed feedback inhibition of ribonucleotide reductase. Cell (2003) 3.91
The Saccharomyces cerevisiae helicase Rrm3p facilitates replication past nonhistone protein-DNA complexes. Mol Cell (2003) 3.72
Causes and consequences of replication stress. Nat Cell Biol (2014) 3.70
DNA replication through G-quadruplex motifs is promoted by the Saccharomyces cerevisiae Pif1 DNA helicase. Cell (2011) 3.70
Checking on the fork: the DNA-replication stress-response pathway. Trends Cell Biol (2002) 3.66
RecQ helicases: multifunctional genome caretakers. Nat Rev Cancer (2009) 3.63
The structural determinants of checkpoint activation. Genes Dev (2007) 3.53
Replication fork stalling at natural impediments. Microbiol Mol Biol Rev (2007) 3.47
Y-family DNA polymerases and their role in tolerance of cellular DNA damage. Nat Rev Mol Cell Biol (2012) 3.43
Fanconi anaemia and the repair of Watson and Crick DNA crosslinks. Nature (2013) 3.40
Replication fork reactivation downstream of a blocked nascent leading strand. Nature (2006) 3.40
The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks. Nat Struct Mol Biol (2007) 3.38
Break-induced replication and telomerase-independent telomere maintenance require Pol32. Nature (2007) 3.37
A viable allele of Mcm4 causes chromosome instability and mammary adenocarcinomas in mice. Nat Genet (2006) 3.35
Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication. Proc Natl Acad Sci U S A (2008) 3.29
Pathways of mammalian replication fork restart. Nat Rev Mol Cell Biol (2010) 3.26
A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2. Cancer Cell (2012) 3.26
Eukaryotic chromosome DNA replication: where, when, and how? Annu Rev Biochem (2010) 3.17
DNA polymerase stabilization at stalled replication forks requires Mec1 and the RecQ helicase Sgs1. EMBO J (2003) 3.15
Potential role for the BLM helicase in recombinational repair via a conserved interaction with RAD51. J Biol Chem (2001) 3.05
Chromosome catastrophes involve replication mechanisms generating complex genomic rearrangements. Cell (2011) 3.03
ATR prohibits replication catastrophe by preventing global exhaustion of RPA. Cell (2013) 2.99
An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication. Mol Cell (2003) 2.96
The formation, isolation and characterization of DNA adducts produced by anticancer platinum complexes. Pharmacol Ther (1987) 2.96
DNA polymerase alpha inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes. Hum Genet (1984) 2.92
Rad51-dependent DNA structures accumulate at damaged replication forks in sgs1 mutants defective in the yeast ortholog of BLM RecQ helicase. Genes Dev (2005) 2.91
Cell cycle-dependent chromatin loading of the Fanconi anemia core complex by FANCM/FAAP24. Blood (2008) 2.83
Novel pro- and anti-recombination activities of the Bloom's syndrome helicase. Genes Dev (2007) 2.82
SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response. Mol Cell (2006) 2.75
A double Holliday junction dissolvasome comprising BLM, topoisomerase IIIalpha, and BLAP75. J Biol Chem (2006) 2.69
Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesis. EMBO J (2003) 2.69
Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site. Nature (2011) 2.69
Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells. Nature (2014) 2.67
Collisions between replication and transcription complexes cause common fragile site instability at the longest human genes. Mol Cell (2011) 2.66
The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores. Cell (2011) 2.65
Mutant chromatin remodeling protein SMARCAL1 causes Schimke immuno-osseous dysplasia. Nat Genet (2002) 2.64
Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription. Nat Cell Biol (2009) 2.60
Saccharomyces Rrm3p, a 5' to 3' DNA helicase that promotes replication fork progression through telomeric and subtelomeric DNA. Genes Dev (2002) 2.59
The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks. Genes Dev (2009) 2.50
Deregulation of cyclin E in human cells interferes with prereplication complex assembly. J Cell Biol (2004) 2.48
RNase H and multiple RNA biogenesis factors cooperate to prevent RNA:DNA hybrids from generating genome instability. Mol Cell (2011) 2.48
Exo1 processes stalled replication forks and counteracts fork reversal in checkpoint-defective cells. Mol Cell (2005) 2.47
The RAD6 DNA damage tolerance pathway operates uncoupled from the replication fork and is functional beyond S phase. Cell (2010) 2.46
Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress. Mol Cell (2006) 2.45
Break-induced replication is highly inaccurate. PLoS Biol (2011) 2.45
Chk1 regulates the density of active replication origins during the vertebrate S phase. EMBO J (2007) 2.44
Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors. Nat Struct Mol Biol (2011) 2.42
Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis. Nat Struct Mol Biol (2010) 2.40
RECQL5 controls transcript elongation and suppresses genome instability associated with transcription stress. Cell (2014) 2.38
G4 DNA unwinding by BLM and Sgs1p: substrate specificity and substrate-specific inhibition. Nucleic Acids Res (2002) 2.37
Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals. EMBO J (2009) 2.37
PCNA ubiquitination and REV1 define temporally distinct mechanisms for controlling translesion synthesis in the avian cell line DT40. Mol Cell (2008) 2.29
Coordinated control of replication and transcription by a SAPK protects genomic integrity. Nature (2012) 2.28
Bone marrow failure in Fanconi anemia is triggered by an exacerbated p53/p21 DNA damage response that impairs hematopoietic stem and progenitor cells. Cell Stem Cell (2012) 2.26
PrimPol Is Required for Replicative Tolerance of G Quadruplexes in Vertebrate Cells. Mol Cell (2015) 2.22
The annealing helicase HARP protects stalled replication forks. Genes Dev (2009) 2.19
Understanding nucleotide excision repair and its roles in cancer and ageing. Nat Rev Mol Cell Biol (2014) 2.19
Mutations in origin recognition complex gene ORC4 cause Meier-Gorlin syndrome. Nat Genet (2011) 2.18
Replisome instability, fork collapse, and gross chromosomal rearrangements arise synergistically from Mec1 kinase and RecQ helicase mutations. Genes Dev (2005) 2.17
A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase alpha within the eukaryotic replisome. EMBO J (2009) 2.17
SUMOylation regulates Rad18-mediated template switch. Nature (2008) 2.14
Regulated eukaryotic DNA replication origin firing with purified proteins. Nature (2015) 2.07