AMP-Activated Protein Kinase Signalling in Cancer and Cardiac Hypertrophy.

PubWeight™: 0.76‹?›

🔗 View Article (PMID 26798768)

Published in Cardiovasc Pharm Open Access on August 31, 2015

Authors

Yulia Lipovka1, John P Konhilas1

Author Affiliations

1: Department of Physiology, University of Arizona, Sarver Molecular Cardiovascular Research Program, USA.

Articles cited by this

Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science (2009) 49.82

The protein kinase complement of the human genome. Science (2002) 35.36

TSC2 mediates cellular energy response to control cell growth and survival. Cell (2003) 20.21

The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab (2008) 18.87

AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell (2008) 16.72

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J Biol (2003) 12.91

A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. Nature (1998) 10.35

LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr Biol (2003) 9.14

Brick by brick: metabolism and tumor cell growth. Curr Opin Genet Dev (2008) 7.87

Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. Nat Genet (1998) 7.36

Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase. J Biol Chem (1996) 7.23

Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib. Lancet (2007) 6.76

The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis. Eur J Biochem (1997) 6.04

Structure of mammalian AMPK and its regulation by ADP. Nature (2011) 4.27

Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding. Biochem J (2000) 3.91

AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress. Nature (2012) 3.85

MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. EMBO J (2003) 3.77

Mammalian AMP-activated protein kinase subfamily. J Biol Chem (1996) 3.47

AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo. Cell Metab (2012) 3.35

Dissecting the role of 5'-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase. J Biol Chem (2006) 3.31

Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia. Curr Biol (2000) 3.28

Structural basis for AMP binding to mammalian AMP-activated protein kinase. Nature (2007) 3.26

The glycogen-binding domain on the AMPK beta subunit allows the kinase to act as a glycogen sensor. Cell Metab (2009) 2.92

The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation. Cell (2013) 2.74

Identification of phosphorylation sites in AMP-activated protein kinase (AMPK) for upstream AMPK kinases and study of their roles by site-directed mutagenesis. J Biol Chem (2003) 2.45

β-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK). Proc Natl Acad Sci U S A (2010) 2.28

Structural insight into the autoinhibition mechanism of AMP-activated protein kinase. Nature (2009) 2.25

Increased adenosine monophosphate-activated protein kinase activity in rat hearts with pressure-overload hypertrophy. Circulation (2001) 2.19

AMPK beta subunit targets metabolic stress sensing to glycogen. Curr Biol (2003) 2.19

Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte. J Biol Chem (2004) 2.16

AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5. Diabetes (2008) 2.13

Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta. J Biol Chem (1998) 2.10

AMPK alterations in cardiac physiology and pathology: enemy or ally? J Physiol (2006) 2.09

Mechanisms for increased glycolysis in the hypertrophied rat heart. Hypertension (2004) 1.99

Identification of a novel AMP-activated protein kinase beta subunit isoform that is highly expressed in skeletal muscle. J Biol Chem (1998) 1.92

Exacerbation of heart failure in adiponectin-deficient mice due to impaired regulation of AMPK and glucose metabolism. Cardiovasc Res (2005) 1.84

Cardiotoxicity of anticancer treatments: what the cardiologist needs to know. Nat Rev Cardiol (2010) 1.80

Cellular mechanisms of cardiac hypertrophy. J Mol Med (Berl) (1998) 1.73

The LKB1 tumor suppressor kinase in human disease. Biochim Biophys Acta (2006) 1.67

Energy metabolism in the hypertrophied heart. Heart Fail Rev (2002) 1.58

Structural basis of AMPK regulation by small molecule activators. Nat Commun (2013) 1.58

Phosphorylation-activity relationships of AMPK and acetyl-CoA carboxylase in muscle. J Appl Physiol (1985) (2002) 1.56

Inhibition of AMPK signalling by doxorubicin: at the crossroads of the cardiac responses to energetic, oxidative, and genotoxic stress. Cardiovasc Res (2012) 1.55

Conserved alpha-helix acts as autoinhibitory sequence in AMP-activated protein kinase alpha subunits. J Biol Chem (2006) 1.54

AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells. Cancer Res (2012) 1.52

Resveratrol inhibits cardiac hypertrophy via AMP-activated protein kinase and Akt. J Biol Chem (2008) 1.52

AMP-activated protein kinase promotes human prostate cancer cell growth and survival. Mol Cancer Ther (2009) 1.48

The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation. Blood (2010) 1.38

Histological evaluation of AMPK signalling in primary breast cancer. BMC Cancer (2009) 1.38

Contraction-induced fatty acid translocase/CD36 translocation in rat cardiac myocytes is mediated through AMP-activated protein kinase signaling. Diabetes (2003) 1.37

Prognostic significance of AMPK activation and therapeutic effects of metformin in hepatocellular carcinoma. Clin Cancer Res (2013) 1.32

Expression profiling of the gamma-subunit isoforms of AMP-activated protein kinase suggests a major role for gamma3 in white skeletal muscle. Am J Physiol Endocrinol Metab (2003) 1.32

Modulation of anthracycline-induced cardiotoxicity by aerobic exercise in breast cancer: current evidence and underlying mechanisms. Circulation (2011) 1.30

Retracted Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPK. Nature (2012) 1.29

Sunitinib-induced cardiotoxicity is mediated by off-target inhibition of AMP-activated protein kinase. Clin Transl Sci (2009) 1.28

Stimulation of AMP-activated protein kinase (AMPK) is associated with enhancement of Glut1-mediated glucose transport. Arch Biochem Biophys (2000) 1.25

Structure of a CBS-domain pair from the regulatory gamma1 subunit of human AMPK in complex with AMP and ZMP. Acta Crystallogr D Biol Crystallogr (2007) 1.20

Activation of AMP-activated protein kinase by human EGF receptor 2/EGF receptor tyrosine kinase inhibitor protects cardiac cells. Proc Natl Acad Sci U S A (2007) 1.18

Cancer therapy-induced cardiotoxicity: basic mechanisms and potential cardioprotective therapies. J Am Heart Assoc (2014) 1.18

Structural basis for AMPK activation: natural and synthetic ligands regulate kinase activity from opposite poles by different molecular mechanisms. Structure (2014) 1.16

Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1α. Proc Natl Acad Sci U S A (2014) 1.14

Metabolic switch and hypertrophy of cardiomyocytes following treatment with angiotensin II are prevented by AMP-activated protein kinase. J Biol Chem (2008) 1.12

Role of PP2C in cardiac lipid accumulation in obese rodents and its prevention by troglitazone. Am J Physiol Endocrinol Metab (2004) 1.12

Calorie restriction prevents hypertension and cardiac hypertrophy in the spontaneously hypertensive rat. Hypertension (2010) 1.11

Androgens regulate prostate cancer cell growth via an AMPK-PGC-1α-mediated metabolic switch. Oncogene (2013) 1.08

Activation of AMPK is necessary for killing cancer cells and sparing cardiac cells. Cell Cycle (2008) 1.06

AMPK reverses the mesenchymal phenotype of cancer cells by targeting the Akt-MDM2-Foxo3a signaling axis. Cancer Res (2014) 1.04

AMPK activation by oncogenesis is required to maintain cancer cell proliferation in astrocytic tumors. Cancer Res (2013) 1.03

AMP-activated protein kinase control of fat metabolism in skeletal muscle. Acta Physiol (Oxf) (2009) 1.00

Regulation of glycogen synthase by glucose and glycogen: a possible role for AMP-activated protein kinase. Diabetes (2003) 1.00

Structural insights into the architecture and allostery of full-length AMP-activated protein kinase. Structure (2011) 0.99

Functional role of AMP-activated protein kinase in the heart during exercise. FEBS Lett (2005) 0.97

Prolonged AMPK activation increases the expression of fatty acid transporters in cardiac myocytes and perfused hearts. Mol Cell Biochem (2006) 0.97

Breast cancer risk in postmenopausal women using estradiol-progestogen therapy. Obstet Gynecol (2009) 0.96

Activation of AMPK inhibits cervical cancer cell growth through AKT/FOXO3a/FOXM1 signaling cascade. BMC Cancer (2013) 0.96

AMPK enhances insulin-stimulated GLUT4 regulation via lowering membrane cholesterol. Endocrinology (2012) 0.95

AMP-Activated Protein Kinase α 2 Isoform Suppression in Primary Breast Cancer Alters AMPK Growth Control and Apoptotic Signaling. Genes Cancer (2013) 0.94

AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase. Biochem J (2012) 0.94

AMPK activity is regulated by calcium-mediated protein phosphatase 2A activity. Cell Calcium (2013) 0.92

Acute toxicity of doxorubicin on isolated perfused heart: response of kinases regulating energy supply. Am J Physiol Heart Circ Physiol (2005) 0.90

The AMPK β2 subunit is required for energy homeostasis during metabolic stress. Mol Cell Biol (2012) 0.90

Negative regulation of mTOR activity by LKB1-AMPK signaling in non-small cell lung cancer cells. Acta Pharmacol Sin (2012) 0.87

Metabolic functions of AMPK: aspects of structure and of natural mutations in the regulatory gamma subunits. IUBMB Life (2010) 0.83

Prognostic significance of AMPK activation in advanced stage colorectal cancer treated with chemotherapy plus bevacizumab. Br J Cancer (2014) 0.83

5'-AMP-activated protein kinase (AMPK) supports the growth of aggressive experimental human breast cancer tumors. J Biol Chem (2014) 0.81

Different expression of the catalytic alpha subunits of the AMP activated protein kinase--an immunohistochemical study in human tissue. Histol Histopathol (2011) 0.81