Published in J Cell Biol on February 22, 2016
Autophagy Promotes Focal Adhesion Disassembly and Cell Motility of Metastatic Tumor Cells through the Direct Interaction of Paxillin with LC3. Cell Rep (2016) 1.01
Recent insights into the function of autophagy in cancer. Genes Dev (2016) 0.86
Autophagy in cancer metastasis. Oncogene (2016) 0.81
Therapeutic Targeting of Autophagy. EBioMedicine (2016) 0.79
GABARAPL1 suppresses metastasis by counteracting PI3K/Akt pathway in prostate cancer. Oncotarget (2016) 0.77
Autophagy in adhesion and migration. J Cell Sci (2016) 0.76
The ubiquitin-proteasome system regulates focal adhesions at the leading edge of migrating cells. Elife (2016) 0.76
Expanding perspectives on the significance of mitophagy in cancer. Semin Cancer Biol (2017) 0.76
Autophagy and epithelial-mesenchymal transition: an intricate interplay in cancer. Cell Death Dis (2016) 0.75
The Interconnections Between Autophagy and Integrin-Mediated Cell Adhesion. J Mol Biol (2016) 0.75
Autophagy promotes cell motility by driving focal adhesion turnover. Autophagy (2016) 0.75
The Autophagy Machinery: A New Player in Chemotactic Cell Migration. Front Neurosci (2017) 0.75
Autophagic degradation of focal adhesions underlies metastatic cancer dissemination. Mol Cell Oncol (2016) 0.75
Gastrin activates autophagy and increases migration and survival of gastric adenocarcinoma cells. BMC Cancer (2017) 0.75
Chemotactic G protein-coupled receptors control cell migration by repressing autophagosome biogenesis. Autophagy (2016) 0.75
Adenomatous polyposis coli nucleates actin assembly to drive cell migration and microtubule-induced focal adhesion turnover. J Cell Biol (2017) 0.75
Cell migration: integrating signals from front to back. Science (2003) 29.13
Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods (2003) 18.51
A third-generation lentivirus vector with a conditional packaging system. J Virol (1998) 16.07
FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly. Nat Cell Biol (2004) 9.31
A stable human-derived packaging cell line for production of high titer retrovirus/vesicular stomatitis virus G pseudotypes. Proc Natl Acad Sci U S A (1996) 8.53
Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness. Nature (1997) 8.52
A role for NBR1 in autophagosomal degradation of ubiquitinated substrates. Mol Cell (2009) 6.88
Selective autophagy mediated by autophagic adapter proteins. Autophagy (2011) 6.88
Retrovirus-mediated gene transfer and expression cloning: powerful tools in functional genomics. Exp Hematol (2003) 6.61
Spatiotemporal feedback between actomyosin and focal-adhesion systems optimizes rapid cell migration. Cell (2006) 6.02
Plasticity of cell migration: a multiscale tuning model. J Cell Biol (2009) 5.82
Differential transmission of actin motion within focal adhesions. Science (2007) 5.36
Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase. Nat Cell Biol (2005) 4.99
Mathematical model for the effects of adhesion and mechanics on cell migration speed. Biophys J (1991) 4.68
Calpain-mediated proteolysis of talin regulates adhesion dynamics. Nat Cell Biol (2004) 4.29
Mechanical integration of actin and adhesion dynamics in cell migration. Annu Rev Cell Dev Biol (2010) 4.06
A versatile viral system for expression and depletion of proteins in mammalian cells. PLoS One (2009) 3.83
Maximal migration of human smooth muscle cells on fibronectin and type IV collagen occurs at an intermediate attachment strength. J Cell Biol (1993) 3.74
Selective autophagy: ubiquitin-mediated recognition and beyond. Nat Cell Biol (2010) 3.74
The kinase domain of titin controls muscle gene expression and protein turnover. Science (2005) 3.68
Cell spreading and focal adhesion dynamics are regulated by spacing of integrin ligands. Biophys J (2007) 3.57
Induction of autophagy during extracellular matrix detachment promotes cell survival. Mol Biol Cell (2007) 3.37
Modulation of cell migration by integrin-mediated cytoskeletal linkages and ligand-binding affinity. J Cell Biol (1996) 3.18
The machinery of macroautophagy. Cell Res (2013) 3.13
Molecular architecture and function of matrix adhesions. Cold Spring Harb Perspect Biol (2011) 2.82
Interactions between autophagy receptors and ubiquitin-like proteins form the molecular basis for selective autophagy. Mol Cell (2014) 2.79
Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity. Nat Cell Biol (2011) 2.65
Clathrin mediates integrin endocytosis for focal adhesion disassembly in migrating cells. J Cell Biol (2009) 2.28
Lentiviral transduction of mammary stem cells for analysis of gene function during development and cancer. Cell Stem Cell (2008) 2.24
Autophagy as a stress-response and quality-control mechanism: implications for cell injury and human disease. Annu Rev Pathol (2012) 2.20
p62 Targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding. J Cell Biol (2011) 2.16
The LIR motif - crucial for selective autophagy. J Cell Sci (2013) 2.02
Effect of ablation or inhibition of stromal matrix metalloproteinase-9 on lung metastasis in a breast cancer model is dependent on genetic background. Cancer Res (2008) 1.88
Regulation of adhesion dynamics by calpain-mediated proteolysis of focal adhesion kinase (FAK). J Biol Chem (2010) 1.75
Midbody ring disposal by autophagy is a post-abscission event of cytokinesis. Nat Cell Biol (2008) 1.70
Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy. Nature (2014) 1.65
Focal adhesion disassembly requires clathrin-dependent endocytosis of integrins. FEBS Lett (2009) 1.61
The integrin adhesome: from genes and proteins to human disease. Nat Rev Mol Cell Biol (2014) 1.57
Dynamic regulation of the structure and functions of integrin adhesions. Dev Cell (2013) 1.57
Immortalized mouse epithelial cell models to study the role of apoptosis in cancer. Methods Enzymol (2008) 1.47
Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. Nat Cell Biol (2014) 1.46
The autophagy-associated factors DRAM1 and p62 regulate cell migration and invasion in glioblastoma stem cells. Oncogene (2012) 1.34
CLASPs link focal-adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover. Nat Cell Biol (2014) 1.30
Autophagy-dependent production of secreted factors facilitates oncogenic RAS-driven invasion. Cancer Discov (2014) 1.28
Temporal analysis of recruitment of mammalian ATG proteins to the autophagosome formation site. Autophagy (2013) 1.25
Calpain-mediated proteolysis of paxillin negatively regulates focal adhesion dynamics and cell migration. J Biol Chem (2011) 1.23
Mechanosensitivity and compositional dynamics of cell-matrix adhesions. EMBO Rep (2013) 1.22
Opening the floodgates: proteomics and the integrin adhesome. Curr Opin Cell Biol (2012) 1.21
NBR1 acts as an autophagy receptor for peroxisomes. J Cell Sci (2012) 1.16
P130Cas Src-binding and substrate domains have distinct roles in sustaining focal adhesion disassembly and promoting cell migration. PLoS One (2010) 1.14
Interactions with LC3 and polyubiquitin chains link nbr1 to autophagic protein turnover. FEBS Lett (2009) 1.10
Autophagy facilitates TLR4- and TLR3-triggered migration and invasion of lung cancer cells through the promotion of TRAF6 ubiquitination. Autophagy (2013) 1.04
Autophagy modulates cell migration and β1 integrin membrane recycling. Cell Cycle (2013) 1.04
MT1-MMP regulates the turnover and endocytosis of extracellular matrix fibronectin. J Cell Sci (2011) 1.02
NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube. Eur J Biochem (2002) 0.98
E3 ubiquitin ligases in regulating stress fiber, lamellipodium, and focal adhesion dynamics. Cell Adh Migr (2013) 0.84
Analysis of focal adhesion turnover: a quantitative live-cell imaging example. Methods Cell Biol (2014) 0.80
Crystal structure of the PB1 domain of NBR1. FEBS Lett (2005) 0.76