An Atlas of the Human Kinome Reveals the Mutational Landscape Underlying Dysregulated Phosphorylation Cascades in Cancer.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 26921330)

Published in Cancer Res on February 26, 2016

Authors

Aleksandra Olow1, Zhongzhong Chen2, R Hannes Niedner1, Denise M Wolf1, Christina Yau1, Aleksandr Pankov1, Evelyn Pei Rong Lee1, Lamorna Brown-Swigart1, Laura J van 't Veer1, Jean-Philippe Coppé3

Author Affiliations

1: Department of Laboratory Medicine, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, California.
2: The State Key Laboratory of Genetic Engineering, Ministry of Education (MOE) Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China.
3: Department of Laboratory Medicine, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, California. Jean-Philippe.Coppe@ucsf.edu.

Articles cited by this

Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res (2003) 103.76

The protein kinase complement of the human genome. Science (2002) 35.36

Towards a proteome-scale map of the human protein-protein interaction network. Nature (2005) 24.76

Human Protein Reference Database--2009 update. Nucleic Acids Res (2008) 21.25

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell (2006) 20.92

GENCODE: the reference human genome annotation for The ENCODE Project. Genome Res (2012) 19.19

A human protein-protein interaction network: a resource for annotating the proteome. Cell (2005) 18.97

Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell (2007) 17.98

Mutational landscape and significance across 12 major cancer types. Nature (2013) 14.91

Signaling--2000 and beyond. Cell (2000) 11.78

Discovery and saturation analysis of cancer genes across 21 tumour types. Nature (2014) 11.68

STRING v10: protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Res (2014) 10.79

COSMIC: exploring the world's knowledge of somatic mutations in human cancer. Nucleic Acids Res (2014) 10.77

Proteomics. Tissue-based map of the human proteome. Science (2015) 10.21

A tissue-specific atlas of mouse protein phosphorylation and expression. Cell (2010) 8.65

The Reactome pathway knowledgebase. Nucleic Acids Res (2013) 8.56

Systematic discovery of in vivo phosphorylation networks. Cell (2007) 6.94

A draft map of the human proteome. Nature (2014) 6.58

Emerging landscape of oncogenic signatures across human cancers. Nat Genet (2013) 6.48

Mass-spectrometry-based draft of the human proteome. Nature (2014) 6.32

MINT, the molecular interaction database: 2012 update. Nucleic Acids Res (2011) 5.25

Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin. Cell (2014) 4.17

The BioGRID interaction database: 2015 update. Nucleic Acids Res (2014) 4.06

Proteogenomic characterization of human colon and rectal cancer. Nature (2014) 3.61

Phospho.ELM: a database of phosphorylation sites--update 2011. Nucleic Acids Res (2010) 3.38

Protein interaction data curation: the International Molecular Exchange (IMEx) consortium. Nat Methods (2012) 3.17

Pan-cancer network analysis identifies combinations of rare somatic mutations across pathways and protein complexes. Nat Genet (2014) 2.91

PhosphoSitePlus, 2014: mutations, PTMs and recalibrations. Nucleic Acids Res (2014) 2.66

Integrated network analysis platform for protein-protein interactions. Nat Methods (2008) 2.63

Synonymous mutations frequently act as driver mutations in human cancers. Cell (2014) 2.62

The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell (2015) 2.41

A pan-cancer proteomic perspective on The Cancer Genome Atlas. Nat Commun (2014) 2.25

Integrative approaches for finding modular structure in biological networks. Nat Rev Genet (2013) 2.19

Widespread macromolecular interaction perturbations in human genetic disorders. Cell (2015) 2.11

Structural basis and prediction of substrate specificity in protein serine/threonine kinases. Proc Natl Acad Sci U S A (2002) 2.07

Predicting cancer-specific vulnerability via data-driven detection of synthetic lethality. Cell (2014) 1.96

The GOA database: gene Ontology annotation updates for 2015. Nucleic Acids Res (2014) 1.73

Assessing the clinical utility of cancer genomic and proteomic data across tumor types. Nat Biotechnol (2014) 1.71

PhosphoPOINT: a comprehensive human kinase interactome and phospho-protein database. Bioinformatics (2008) 1.47

A kinase sequence database: sequence alignments and family assignment. Bioinformatics (2002) 1.33

Systematic identification of cancer driving signaling pathways based on mutual exclusivity of genomic alterations. Genome Biol (2015) 1.14

A missing link in genotype-directed cancer therapy. Cell (2012) 1.14

KinG: a database of protein kinases in genomes. Nucleic Acids Res (2004) 1.13

Systematic analysis of human kinase genes: a large number of genes and alternative splicing events result in functional and structural diversity. BMC Bioinformatics (2005) 1.09

Integrating multiple genomic data to predict disease-causing nonsynonymous single nucleotide variants in exome sequencing studies. PLoS Genet (2014) 1.02

Protein kinase resource: an integrated environment for phosphorylation research. Proteins (2006) 1.01

Evolutionary triage governs fitness in driver and passenger mutations and suggests targeting never mutations. Nat Commun (2014) 0.97

The cancer cell map initiative: defining the hallmark networks of cancer. Mol Cell (2015) 0.94

RegPhos 2.0: an updated resource to explore protein kinase-substrate phosphorylation networks in mammals. Database (Oxford) (2014) 0.90

Pan-Cancer Analysis of Mutation Hotspots in Protein Domains. Cell Syst (2015) 0.89

Human germline and pan-cancer variomes and their distinct functional profiles. Nucleic Acids Res (2014) 0.84

GeneSense: a new approach for human gene annotation integrated with protein-protein interaction networks. Sci Rep (2014) 0.77