The tumor microenvironment in esophageal cancer.

Personalized and targeted therapy of esophageal squamous cell carcinoma: an update. Ann N Y Acad Sci (2016) 0.82

Dynamic Microenvironment Induces Phenotypic Plasticity of Esophageal Cancer Cells Under Flow. Sci Rep (2016) 0.75

TNF-Alpha Promotes Invasion and Metastasis via NF-Kappa B Pathway in Oral Squamous Cell Carcinoma. Med Sci Monit Basic Res (2017) 0.75

Subcloning and characterization of highly metastatic cells derived from human esophageal squamous cell carcinoma KYSE150 cells by in vivo selection. Oncotarget (2017) 0.75

Regulation of immunity and inflammation by hypoxia in immunological niches. Nat Rev Immunol (2017) 0.75

Potential role of P2X7R in esophageal squamous cell carcinoma proliferation. Purinergic Signal (2017) 0.75

Inflammation and cancer. Nature (2002) 53.78

Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med (2012) 52.99

Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol (2009) 25.96

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med (2004) 22.96

Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med (2000) 19.81

Fibroblasts in cancer. Nat Rev Cancer (2006) 18.95

Function and activation of NF-kappa B in the immune system. Annu Rev Immunol (1994) 17.04

STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer (2009) 15.45

Met, metastasis, motility and more. Nat Rev Mol Cell Biol (2003) 14.30

Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell (2006) 13.79

Matrix metalloproteinases: regulators of the tumor microenvironment. Cell (2010) 12.90

NF-kappaB in cancer: from innocent bystander to major culprit. Nat Rev Cancer (2002) 11.39

Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J (2003) 10.77

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Nat Immunol (2010) 9.59

Myeloid-derived suppressor cells: linking inflammation and cancer. J Immunol (2009) 9.41

Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer. Nat Rev Cancer (2006) 8.59

Microenvironmental regulation of tumor progression and metastasis. Nat Med (2013) 8.37

Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome. Nature (2013) 7.51

The interleukin-8 pathway in cancer. Clin Cancer Res (2008) 7.12

Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells. Nat Med (2003) 5.96

Esophageal carcinoma. N Engl J Med (2014) 5.77

Oesophageal carcinoma. Lancet (2013) 5.48

The role of IL-6 and STAT3 in inflammation and cancer. Eur J Cancer (2005) 5.07

The tumor microenvironment and its role in promoting tumor growth. Oncogene (2008) 4.66

Overweight, obesity, and cancer risk. Lancet Oncol (2002) 4.44

Clinical significance of programmed death-1 ligand-1 and programmed death-1 ligand-2 expression in human esophageal cancer. Clin Cancer Res (2005) 4.42

Neutralizing tumor-promoting chronic inflammation: a magic bullet? Science (2013) 3.91

Revisiting STAT3 signalling in cancer: new and unexpected biological functions. Nat Rev Cancer (2014) 3.70

Myeloid-derived suppressor cells promote cross-tolerance in B-cell lymphoma by expanding regulatory T cells. Cancer Res (2008) 3.57

Myeloid suppressor lines inhibit T cell responses by an NO-dependent mechanism. J Immunol (2002) 3.56

T(H)17 cells in tumour immunity and immunotherapy. Nat Rev Immunol (2010) 3.39

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid. Nature (2014) 3.31

CXCL12 / CXCR4 / CXCR7 chemokine axis and cancer progression. Cancer Metastasis Rev (2010) 3.24

Identification of genomic alterations in oesophageal squamous cell cancer. Nature (2014) 3.10

Targeting CD38 with Daratumumab Monotherapy in Multiple Myeloma. N Engl J Med (2015) 3.05

Oxidative stress and oxidative damage in carcinogenesis. Toxicol Pathol (2009) 3.00

Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer. Dis Model Mech (2011) 2.97

Elevated myeloid-derived suppressor cells in pancreatic, esophageal and gastric cancer are an independent prognostic factor and are associated with significant elevation of the Th2 cytokine interleukin-13. Cancer Immunol Immunother (2011) 2.97

Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-alpha and IL-6. Diabetes Res Clin Pract (2004) 2.95

Myeloid-derived suppressor cells inhibit T-cell activation by depleting cystine and cysteine. Cancer Res (2009) 2.90

Chemoprevention of esophageal adenocarcinoma by COX-2 inhibitors in an animal model of Barrett's esophagus. Gastroenterology (2002) 2.88

Remodelling the extracellular matrix in development and disease. Nat Rev Mol Cell Biol (2014) 2.74

The involvement of IL-1 in tumorigenesis, tumor invasiveness, metastasis and tumor-host interactions. Cancer Metastasis Rev (2006) 2.74

VEGF targets the tumour cell. Nat Rev Cancer (2013) 2.71

Inflammation and intestinal metaplasia of the distal esophagus are associated with alterations in the microbiome. Gastroenterology (2009) 2.55

Increased populations of regulatory T cells in peripheral blood and tumor-infiltrating lymphocytes in patients with gastric and esophageal cancers. Clin Cancer Res (2003) 2.45

Expansion of spleen myeloid suppressor cells represses NK cell cytotoxicity in tumor-bearing host. Blood (2007) 2.35

The roles of TGFβ in the tumour microenvironment. Nat Rev Cancer (2013) 2.35

Mixed reflux of gastric and duodenal juices is more harmful to the esophagus than gastric juice alone. The need for surgical therapy re-emphasized. Ann Surg (1995) 2.17

Bile acid and inflammation activate gastric cardia stem cells in a mouse model of Barrett-like metaplasia. Cancer Cell (2012) 2.16

The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation. Genes Dev (2007) 2.16

Deletion of p120-catenin results in a tumor microenvironment with inflammation and cancer that establishes it as a tumor suppressor gene. Cancer Cell (2011) 2.10

Paired exome analysis of Barrett's esophagus and adenocarcinoma. Nat Genet (2015) 2.10

Frequent mutation of the p53 gene in human esophageal cancer. Proc Natl Acad Sci U S A (1990) 2.07

Denervation suppresses gastric tumorigenesis. Sci Transl Med (2014) 1.96

Cyclooxygenase 2 expression in Barrett's esophagus and adenocarcinoma: Ex vivo induction by bile salts and acid exposure. Gastroenterology (2000) 1.84

Stat3 and Gfi-1 transcription factors control Th17 cell immunosuppressive activity via the regulation of ectonucleotidase expression. Immunity (2012) 1.82

CD4(+)CD25high regulatory T cells increase with tumor stage in patients with gastric and esophageal cancers. Cancer Immunol Immunother (2005) 1.80

MicroRNAs reprogram normal fibroblasts into cancer-associated fibroblasts in ovarian cancer. Cancer Discov (2012) 1.75

Breast cancer - one term, many entities? J Clin Invest (2011) 1.72

The major inflammatory mediator interleukin-6 and obesity. Inflamm Res (2009) 1.67

Tumor-cell homing to lymph nodes and bone marrow and CXCR4 expression in esophageal cancer. J Natl Cancer Inst (2005) 1.60

Bile acids in combination with low pH induce oxidative stress and oxidative DNA damage: relevance to the pathogenesis of Barrett's oesophagus. Gut (2006) 1.58

Proinflammatory cytokine and nuclear factor kappa-B expression along the inflammation-metaplasia-dysplasia-adenocarcinoma sequence in the esophagus. Am J Gastroenterol (2005) 1.56

Role of oxidative DNA damage in cancer initiation and promotion. Eur J Cancer Prev (1998) 1.56

Leptin stimulates proliferation and inhibits apoptosis in Barrett's esophageal adenocarcinoma cells by cyclooxygenase-2-dependent, prostaglandin-E2-mediated transactivation of the epidermal growth factor receptor and c-Jun NH2-terminal kinase activation. Endocrinology (2006) 1.52

Selective inhibition of cyclooxygenase-2 suppresses growth and induces apoptosis in human esophageal adenocarcinoma cells. Cancer Res (2000) 1.51

Therapeutic opportunities for manipulating T(Reg) cells in autoimmunity and cancer. Nat Rev Drug Discov (2013) 1.50

Cyclooxygenase-2 expression in the Barrett's metaplasia-dysplasia-adenocarcinoma sequence. Am J Gastroenterol (2001) 1.49

Interleukin-6 acts as an antiapoptotic factor in human esophageal carcinoma cells through the activation of both STAT3 and mitogen-activated protein kinase pathways. Oncogene (2003) 1.43

Association of adiponectin multimers with Barrett's oesophagus. Gut (2009) 1.43

Pretherapy nuclear factor-kappaB status, chemoradiation resistance, and metastatic progression in esophageal carcinoma. Mol Cancer Ther (2006) 1.41

Inflammatory gradient in Barrett's oesophagus: implications for disease complications. Gut (2002) 1.38

Fibroblast-secreted hepatocyte growth factor plays a functional role in esophageal squamous cell carcinoma invasion. Proc Natl Acad Sci U S A (2010) 1.37

Epidermal growth factor receptor and cyclin D1 are independently amplified and overexpressed in esophageal squamous cell carcinoma. J Cancer Res Clin Oncol (2004) 1.34

The essential role of fibroblasts in esophageal squamous cell carcinoma-induced angiogenesis. Gastroenterology (2008) 1.34

Th17 cells in cancer: the ultimate identity crisis. Front Immunol (2014) 1.33

Aberrant epithelial-mesenchymal Hedgehog signaling characterizes Barrett's metaplasia. Gastroenterology (2010) 1.33

Matrix metalloproteinases expression correlates with survival in patients with esophageal squamous cell carcinoma. Am J Gastroenterol (2005) 1.31

Significance of macrophage chemoattractant protein-1 expression and macrophage infiltration in squamous cell carcinoma of the esophagus. Am J Gastroenterol (2004) 1.31

Hyaluronan distribution in the normal epithelium of esophagus, stomach, and colon and their cancers. Am J Pathol (1996) 1.31

NF-kappaB activation in esophageal adenocarcinoma: relationship to Barrett's metaplasia, survival, and response to neoadjuvant chemoradiotherapy. Ann Surg (2004) 1.31

beta-Catenin/TCF pathway upregulates STAT3 expression in human esophageal squamous cell carcinoma. Cancer Lett (2008) 1.30

STAT3 Target Genes Relevant to Human Cancers. Cancers (Basel) (2014) 1.29

Association between markers of obesity and progression from Barrett's esophagus to esophageal adenocarcinoma. Clin Gastroenterol Hepatol (2013) 1.29

Hepatocyte growth factor promotes cancer cell migration and angiogenic factors expression: a prognostic marker of human esophageal squamous cell carcinomas. Clin Cancer Res (2005) 1.29

Tumour necrosis factor-alpha in Barrett's oesophagus: a potential novel mechanism of action. Oncogene (2002) 1.25

Reactive oxygen species: are they involved in the pathogenesis of GERD, Barrett's esophagus, and the latter's progression toward esophageal cancer? Am J Gastroenterol (2002) 1.24

Fibroblast growth factor receptor 2-positive fibroblasts provide a suitable microenvironment for tumor development and progression in esophageal carcinoma. Clin Cancer Res (2009) 1.24

Activation of the interleukin-6/STAT3 antiapoptotic pathway in esophageal cells by bile acids and low pH: relevance to barrett's esophagus. Clin Cancer Res (2007) 1.21

The bile acid deoxycholic acid (DCA) at neutral pH activates NF-kappaB and induces IL-8 expression in oesophageal cells in vitro. Carcinogenesis (2003) 1.20

The inflammatory network in the gastrointestinal tumor microenvironment: lessons from mouse models. J Gastroenterol (2012) 1.20

Excess body weight and obesity--the link with gastrointestinal and hepatobiliary cancer. Nat Rev Gastroenterol Hepatol (2011) 1.18

Reduced expression of transforming growth factor-beta receptors is an unfavorable prognostic factor in human esophageal squamous cell carcinoma. Int J Cancer (2003) 1.17

Inflammation and esophageal carcinogenesis. Curr Opin Pharmacol (2009) 1.17

Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells. J Exp Med (2014) 1.16

The significance of bile in reflux esophagitis. Surg Gynecol Obstet (1972) 1.16

Re-polarization of tumor-associated macrophages to pro-inflammatory M1 macrophages by microRNA-155. J Mol Cell Biol (2012) 1.16

Oxidative stress has a role in malignant transformation in Barrett's oesophagus. Int J Cancer (2002) 1.16

Chemoprevention of carcinogenic progression to esophageal adenocarcinoma by the manganese superoxide dismutase supplementation. Clin Cancer Res (2007) 1.14