Intracerebellar infusion of the protein kinase M zeta (PKMζ) inhibitor zeta-inhibitory peptide (ZIP) disrupts eyeblink classical conditioning.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 26949968)

Published in Behav Neurosci on March 07, 2016

Authors

Kutibh Chihabi1, Anthony D Morielli2, John T Green3

Author Affiliations

1: Neuroscience Graduate Program.
2: Department of Pharmacology.
3: Department of Psychological Science.

Articles cited by this

Storage of spatial information by the maintenance mechanism of LTP. Science (2006) 6.71

Synaptic AMPA receptor plasticity and behavior. Neuron (2009) 5.58

Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory. Cell (1997) 4.83

Rapid erasure of long-term memory associations in the cortex by an inhibitor of PKM zeta. Science (2007) 3.91

Heteromultimeric K+ channels in terminal and juxtaparanodal regions of neurons. Nature (1993) 3.15

Anisomycin, an inhibitor of protein synthesis, blocks late phases of LTP phenomena in the hippocampal CA1 region in vitro. Brain Res (1988) 2.77

Cerebellum: essential involvement in the classically conditioned eyelid response. Science (1984) 2.68

PKMzeta maintains spatial, instrumental, and classically conditioned long-term memories. PLoS Biol (2008) 2.58

Protein kinase M zeta synthesis from a brain mRNA encoding an independent protein kinase C zeta catalytic domain. Implications for the molecular mechanism of memory. J Biol Chem (2003) 2.28

PKMzeta maintains memories by regulating GluR2-dependent AMPA receptor trafficking. Nat Neurosci (2010) 2.28

PKM-ζ is not required for hippocampal synaptic plasticity, learning and memory. Nature (2013) 2.26

PKM zeta maintains late long-term potentiation by N-ethylmaleimide-sensitive factor/GluR2-dependent trafficking of postsynaptic AMPA receptors. J Neurosci (2008) 2.26

Purkinje cell-specific knockout of the protein phosphatase PP2B impairs potentiation and cerebellar motor learning. Neuron (2010) 2.23

Cerebellar cortex lesions disrupt learning-dependent timing of conditioned eyelid responses. J Neurosci (1993) 2.11

Prkcz null mice show normal learning and memory. Nature (2013) 2.06

Distributed synergistic plasticity and cerebellar learning. Nat Rev Neurosci (2012) 2.04

Molecular cloning and characterization of PKC iota, an atypical isoform of protein kinase C derived from insulin-secreting cells. J Biol Chem (1993) 2.01

Persistent phosphorylation by protein kinase Mzeta maintains late-phase long-term potentiation. J Neurosci (2005) 1.86

Enhancement of consolidated long-term memory by overexpression of protein kinase Mzeta in the neocortex. Science (2011) 1.84

The role of the cerebellum in classical conditioning of discrete behavioral responses. Neuroscience (2009) 1.77

Reevaluating the role of LTD in cerebellar motor learning. Neuron (2011) 1.76

Neuronal responses of the rabbit cerebellum during acquisition and performance of a classically conditioned nictitating membrane-eyelid response. J Neurosci (1984) 1.63

Protein kinase Mzeta enhances excitatory synaptic transmission by increasing the number of active postsynaptic AMPA receptors. Hippocampus (2006) 1.55

Differential stimulation of PKC phosphorylation of potassium channels by ZIP1 and ZIP2. Science (1999) 1.55

Patch-clamp recordings from cerebellar basket cell bodies and their presynaptic terminals reveal an asymmetric distribution of voltage-gated potassium channels. J Neurosci (1998) 1.50

Acquisition of classical conditioning without cerebellar cortex. Behav Brain Res (1989) 1.48

Inhibition of PKMzeta in nucleus accumbens core abolishes long-term drug reward memory. J Neurosci (2011) 1.40

Complex subunit assembly of neuronal voltage-gated K+ channels. Basis for high-affinity toxin interactions and pharmacology. J Biol Chem (1997) 1.35

PKMzeta maintains 1-day- and 6-day-old long-term object location but not object identity memory in dorsal hippocampus. Hippocampus (2010) 1.35

ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2. J Biol Chem (2002) 1.30

Protein kinase Mzeta maintains fear memory in the amygdala but not in the hippocampus. Behav Neurosci (2009) 1.28

Boundary conditions for the maintenance of memory by PKMzeta in neocortex. Learn Mem (2009) 1.22

Subunit composition of Kv1 channels in human CNS. J Neurochem (1999) 1.22

Matching biochemical and functional efficacies confirm ZIP as a potent competitive inhibitor of PKMζ in neurons. Neuropharmacology (2012) 1.20

PKMζ maintains drug reward and aversion memory in the basolateral amygdala and extinction memory in the infralimbic cortex. Neuropsychopharmacology (2011) 1.16

Ultrastructural localization of Shaker-related potassium channel subunits and synapse-associated protein 90 to septate-like junctions in rat cerebellar Pinceaux. Brain Res Mol Brain Res (1996) 1.16

Ipsilateral cerebellar lesions prevent learning of the classically conditioned nictitating membrane/eyelid response. Brain Res (1982) 1.13

Differential expression of atypical PKCs in the adult mouse brain. Brain Res Mol Brain Res (2004) 1.06

PKMzeta inhibition reverses learning-induced increases in hippocampal synaptic strength and memory during trace eyeblink conditioning. PLoS One (2010) 1.03

Bidirectional regulation of protein kinase M zeta in the maintenance of long-term potentiation and long-term depression. J Neurosci (1996) 1.03

Erasing sensorimotor memories via PKMzeta inhibition. PLoS One (2010) 1.00

Modulation of inhibitory post-synaptic currents (IPSCs) in mouse cerebellar Purkinje and basket cells by snake and scorpion toxin K+ channel blockers. Br J Pharmacol (1998) 0.98

Inactivation of PKMζ in the NAc shell abolished cocaine-conditioned reward. J Mol Neurosci (2011) 0.97

Kv1 channels selectively prevent dendritic hyperexcitability in rat Purkinje cells. J Physiol (2005) 0.96

Reacquisition of classical conditioning after removal of cerebellar cortex. Exp Brain Res (1987) 0.95

Inhibiting PKMζ reveals dorsal lateral and dorsal medial striatum store the different memories needed to support adaptive behavior. Learn Mem (2012) 0.94

Intra-amygdala ZIP injections impair the memory of learned active avoidance responses and attenuate conditioned taste-aversion acquisition in rats. Learn Mem (2011) 0.93

Immunohistochemical study on the distribution of six members of the Kv1 channel subunits in the rat cerebellum. Brain Res (2001) 0.92

Effect of bilateral lesions of the dentate and interpositus cerebellar nuclei on conditioning of heart-rate and nictitating membrane/eyelid responses in the rabbit. Brain Res (1984) 0.92

Appropriate application of ZIP for PKMζ inhibition, LTP reversal, and memory erasure. Hippocampus (2011) 0.91

Activation of PKCzeta and PKMzeta in the nucleus accumbens core is necessary for the retrieval, consolidation and reconsolidation of drug memory. PLoS One (2012) 0.87

Cerebellar learning mechanisms. Brain Res (2014) 0.85

Cellular mechanisms and behavioral consequences of Kv1.2 regulation in the rat cerebellum. J Neurosci (2012) 0.85

Cerebellar long-term potentiation: cellular mechanisms and role in learning. Int Rev Neurobiol (2014) 0.81

Early memory formation disrupted by atypical PKC inhibitor ZIP in the medial prefrontal cortex but not hippocampus. Hippocampus (2014) 0.80

Atypical PKCs in memory maintenance: the roles of feedback and redundancy. Learn Mem (2015) 0.80

Differential downregulation of protein kinase C isoforms in spreading depression. Neurosci Lett (1996) 0.77

Cerebellar secretin modulates eyeblink classical conditioning. Learn Mem (2014) 0.77

When the B-team runs plasticity: GluR2 receptor trafficking in cerebellar long-term potentiation. Proc Natl Acad Sci U S A (2005) 0.77