Published in Cell on March 10, 2016
Prior Dietary Practices and Connections to a Human Gut Microbial Metacommunity Alter Responses to Diet Interventions. Cell Host Microbe (2016) 1.43
Microbiome-wide association studies link dynamic microbial consortia to disease. Nature (2016) 0.93
Role of gut microbiota in atherosclerosis. Nat Rev Cardiol (2016) 0.90
Intestinal Microbiota-Generated Metabolite Trimethylamine-N-Oxide and 5-Year Mortality Risk in Stable Coronary Artery Disease: The Contributory Role of Intestinal Microbiota in a COURAGE-Like Patient Cohort. J Am Heart Assoc (2016) 0.83
The gut microbiome in atherosclerotic cardiovascular disease. Nat Commun (2017) 0.82
Metabolomics and Metabolic Diseases: Where Do We Stand? Cell Metab (2016) 0.81
The Gut Microbiome as Therapeutic Target in Central Nervous System Diseases: Implications for Stroke. Neurotherapeutics (2016) 0.81
Cerebral Vascular Disease and Neurovascular Injury in Ischemic Stroke. Circ Res (2017) 0.80
Microbiome, trimethylamine N-oxide, and cardiometabolic disease. Transl Res (2016) 0.80
Human risk of diseases associated with red meat intake: Analysis of current theories and proposed role for metabolic incorporation of a non-human sialic acid. Mol Aspects Med (2016) 0.79
Dysbiosis and the immune system. Nat Rev Immunol (2017) 0.79
Linking the Microbiota, Chronic Disease, and the Immune System. Trends Endocrinol Metab (2016) 0.79
Diet and Gut Microbial Function in Metabolic and Cardiovascular Disease Risk. Curr Diab Rep (2016) 0.78
Ischemia/Reperfusion. Compr Physiol (2016) 0.78
Gut Microbiota in Cardiovascular Health and Disease. Circ Res (2017) 0.77
An overview of renal metabolomics. Kidney Int (2016) 0.77
Pathogenic mechanisms following ischemic stroke. Neurol Sci (2017) 0.76
HIV-associated changes in the enteric microbial community: potential role in loss of homeostasis and development of systemic inflammation. Curr Opin Infect Dis (2016) 0.76
Regulation of inflammation by microbiota interactions with the host. Nat Immunol (2017) 0.75
Fecal microbiota transplantation in metabolic syndrome: History, present and future. Gut Microbes (2017) 0.75
Atherosclerosis in 2016: Advances in new therapeutic targets for atherosclerosis. Nat Rev Cardiol (2017) 0.75
Host-Microbiome Interaction and Cancer: Potential Application in Precision Medicine. Front Physiol (2016) 0.75
Élie Metchnikoff (1845-1916): celebrating 100 years of cellular immunology and beyond. Nat Rev Immunol (2016) 0.75
Genetic Variant in Flavin-Containing Monooxygenase 3 Alters Lipid Metabolism in Laying Hens in a Diet-Specific Manner. Int J Biol Sci (2016) 0.75
The Gut Microbiome and Its Role in Cardiovascular Diseases. Circulation (2017) 0.75
Microbiota-Dependent Metabolite Trimethylamine N-Oxide and Coronary Artery Calcium in the Coronary Artery Risk Development in Young Adults Study (CARDIA). J Am Heart Assoc (2016) 0.75
Thrombosis: Gut microbes modulate platelet function and thrombosis risk. Nat Rev Cardiol (2016) 0.75
Clinical Evidence for the Microbiome in Inflammatory Diseases. Front Immunol (2017) 0.75
Challenges in fecal donor selection and screening for fecal microbiota transplantation: A review. Gut Microbes (2017) 0.75
Trimethylamine N-Oxide: The Good, the Bad and the Unknown. Toxins (Basel) (2016) 0.75
Xenobiotic Receptor-Mediated Regulation of Intestinal Barrier Function and Innate Immunity. Nucl Receptor Res (2016) 0.75
Impacts of canine distemper virus infection on the giant panda population from the perspective of gut microbiota. Sci Rep (2017) 0.75
Non-alcoholic fatty liver and the gut microbiota. Mol Metab (2016) 0.75
The systemic nature of CKD. Nat Rev Nephrol (2017) 0.75
The Plot Thickens: Diet Microbe Interactions May Modulate Thrombosis Risk. Cell Metab (2016) 0.75
Relationships between gut microbiota, plasma metabolites, and metabolic syndrome traits in the METSIM cohort. Genome Biol (2017) 0.75
Atherosclerosis: Association between the gut microbiome and atherosclerosis. Nat Rev Cardiol (2017) 0.75
Genomics and metagenomics of trimethylamine-utilizing Archaea in the human gut microbiome. ISME J (2017) 0.75
NMR quantification of trimethylamine-N-oxide in human serum and plasma in the clinical laboratory setting. Clin Biochem (2017) 0.75
Novel Risk Stratification Assays for Acute Coronary Syndrome. Curr Cardiol Rep (2017) 0.75
Emerging roles of xenobiotic detoxification enzymes in metabolic diseases. Rev Environ Health (2016) 0.75
Visceral Congestion in Heart Failure: Right Ventricular Dysfunction, Splanchnic Hemodynamics, and the Intestinal Microenvironment. Curr Heart Fail Rep (2017) 0.75
The gut-kidney axis. Pediatr Nephrol (2016) 0.75
Serum Trimethylamine N-oxide, Carnitine, Choline and Betaine in Relation to Colorectal Cancer Risk in the Alpha Tocopherol and Beta Carotene Study. Cancer Epidemiol Biomarkers Prev (2017) 0.75
Brain-Heart Interaction: Cardiac Complications After Stroke. Circ Res (2017) 0.75
Metagenomic data-mining reveals contrasting microbial populations responsible for trimethylamine formation in human gut and marine ecosystems. Microb Genom (2016) 0.75
The gut microbiome and liver cancer: mechanisms and clinical translation. Nat Rev Gastroenterol Hepatol (2017) 0.75
Relationship between gut microbiota and type 2 diabetic erectile dysfunction in Sprague-Dawley rats. J Huazhong Univ Sci Technolog Med Sci (2017) 0.75
Microbiota-dependent metabolite and cardiovascular disease marker trimethylamine-N-oxide (TMAO) is associated with monocyte activation but not platelet function in untreated HIV infection. BMC Infect Dis (2017) 0.75
Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System. Cell Metab (2017) 0.75
An obesity-associated gut microbiome with increased capacity for energy harvest. Nature (2006) 44.35
The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A (2004) 26.56
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature (2011) 13.53
Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med (2013) 9.44
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N Engl J Med (2013) 8.21
Mechanisms of thrombus formation. N Engl J Med (2008) 4.67
Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype. Nat Med (2007) 4.11
Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences. Cell (2014) 3.70
Dietary patterns and the risk of acute myocardial infarction in 52 countries: results of the INTERHEART study. Circulation (2008) 3.19
Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation. Cell Metab (2013) 3.01
Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis. Cell (2015) 2.77
Prognostic value of elevated levels of intestinal microbe-generated metabolite trimethylamine-N-oxide in patients with heart failure: refining the gut hypothesis. J Am Coll Cardiol (2014) 2.48
γ-Butyrobetaine is a proatherogenic intermediate in gut microbial metabolism of L-carnitine to TMAO. Cell Metab (2014) 2.20
Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide. Eur Heart J (2014) 2.08
Gut microbiota-dependent trimethylamine N-oxide (TMAO) pathway contributes to both development of renal insufficiency and mortality risk in chronic kidney disease. Circ Res (2014) 2.02
Calcium signaling in human platelets. Annu Rev Physiol (1990) 2.00
Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme. Proc Natl Acad Sci U S A (2012) 1.99
Consensus and update on the definition of on-treatment platelet reactivity to adenosine diphosphate associated with ischemia and bleeding. J Am Coll Cardiol (2013) 1.94
Meat consumption and mortality--results from the European Prospective Investigation into Cancer and Nutrition. BMC Med (2013) 1.77
Mechanisms of platelet activation: need for new strategies to protect against platelet-mediated atherothrombosis. Thromb Haemost (2009) 1.72
Advanced glycation end products induce a prothrombotic phenotype in mice via interaction with platelet CD36. Blood (2012) 1.69
A specific CD36-dependent signaling pathway is required for platelet activation by oxidized low-density lipoprotein. Circ Res (2008) 1.66
Correcting temperature-sensitive protein folding defects. J Clin Invest (1997) 1.61
Transmission of atherosclerosis susceptibility with gut microbial transplantation. J Biol Chem (2014) 1.53
The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance. Cell Rep (2015) 1.40
Measurement of trimethylamine-N-oxide by stable isotope dilution liquid chromatography tandem mass spectrometry. Anal Biochem (2014) 1.37
Microbiota-dependent metabolite trimethylamine-N-oxide is associated with disease severity and survival of patients with chronic heart failure. J Intern Med (2014) 1.35
Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis. Nat Commun (2015) 1.32
Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis. J Lipid Res (2014) 1.27
Intestinal microbiota composition modulates choline bioavailability from diet and accumulation of the proatherogenic metabolite trimethylamine-N-oxide. MBio (2015) 1.26
Betaine and Trimethylamine-N-Oxide as Predictors of Cardiovascular Outcomes Show Different Patterns in Diabetes Mellitus: An Observational Study. PLoS One (2014) 1.23
Platelet function predicts myocardial damage in patients with acute myocardial infarction. Circulation (2004) 1.16
Chemical chaperone rescue of mutant human cystathionine beta-synthase. Mol Genet Metab (2007) 1.14
Trimethylamine N-Oxide Promotes Vascular Inflammation Through Signaling of Mitogen-Activated Protein Kinase and Nuclear Factor-κB. J Am Heart Assoc (2016) 1.06
Human trace amine-associated receptor TAAR5 can be activated by trimethylamine. PLoS One (2013) 1.01
Choline Diet and Its Gut Microbe-Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload-Induced Heart Failure. Circ Heart Fail (2015) 0.99
Microbiology Meets Big Data: The Case of Gut Microbiota-Derived Trimethylamine. Annu Rev Microbiol (2015) 0.97
γ-Butyrobetaine is a proatherogenic intermediate in gut microbial metabolism of L-carnitine to TMAO. Cell Metab (2014) 2.20
Myeloid-specific genetic ablation of ATP-binding cassette transporter ABCA1 is protective against cancer. Oncotarget (2017) 0.75
Myeloid-specific genetic ablation of ATP-binding cassette transporter ABCA1 is protective against cancer. Oncotarget (2017) 0.75