Dysbiosis and the immune system.

IL-33 and the intestine: The good, the bad, and the inflammatory. Cytokine (2017) 0.75

The remedy within: will the microbiome fulfill its therapeutic promise? J Mol Med (Berl) (2017) 0.75

In Silico Screening of the Human Gut Metaproteome Identifies Th17-Promoting Peptides Encrypted in Proteins of Commensal Bacteria. Front Microbiol (2017) 0.75

γδ T cells in homeostasis and host defence of epithelial barrier tissues. Nat Rev Immunol (2017) 0.75

Dysbiosis and Its Discontents. MBio (2017) 0.75

Structure, function and diversity of the healthy human microbiome. Nature (2012) 30.40

The human microbiome project. Nature (2007) 28.53

Duodenal infusion of donor feces for recurrent Clostridium difficile. N Engl J Med (2013) 20.65

Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc Natl Acad Sci U S A (2007) 20.60

Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell (2009) 20.29

Human gut microbiome viewed across age and geography. Nature (2012) 19.31

Linking long-term dietary patterns with gut microbial enterotypes. Science (2011) 17.30

An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell (2005) 15.46

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature (2011) 13.53

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens. Nat Med (2008) 12.68

Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5. Science (2010) 12.54

Innate immunity and intestinal microbiota in the development of Type 1 diabetes. Nature (2008) 12.45

Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci U S A (2010) 11.21

Diet rapidly and reproducibly alters the human gut microbiome. Nature (2013) 11.04

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature (2012) 10.74

NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell (2011) 9.75

Succession of microbial consortia in the developing infant gut microbiome. Proc Natl Acad Sci U S A (2010) 9.57

Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med (2013) 9.44

The effect of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med (2002) 9.26

Diversity, stability and resilience of the human gut microbiota. Nature (2012) 9.09

Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity (2010) 8.90

Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science (2013) 8.81

The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science (2013) 8.53

Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system. Cell (2007) 8.42

Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell (2013) 8.11

Salmonella enterica serovar typhimurium exploits inflammation to compete with the intestinal microbiota. PLoS Biol (2007) 7.58

Intestinal inflammation targets cancer-inducing activity of the microbiota. Science (2012) 7.54

Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome. Nature (2013) 7.51

The treatment-naive microbiome in new-onset Crohn's disease. Cell Host Microbe (2014) 7.43

Childhood asthma after bacterial colonization of the airway in neonates. N Engl J Med (2007) 7.10

The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine. Science (2011) 7.07

Richness of human gut microbiome correlates with metabolic markers. Nature (2013) 6.93

Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota. Nature (2013) 6.77

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature (2013) 6.45

Antibiotics in early life alter the murine colonic microbiome and adiposity. Nature (2012) 6.37

Individuality in gut microbiota composition is a complex polygenic trait shaped by multiple environmental and host genetic factors. Proc Natl Acad Sci U S A (2010) 6.10

Enteric defensins are essential regulators of intestinal microbial ecology. Nat Immunol (2009) 6.10

Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. Gastroenterology (2012) 6.04

Genomic analysis identifies association of Fusobacterium with colorectal carcinoma. Genome Res (2011) 5.97

Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut. Proc Natl Acad Sci U S A (2004) 5.93

Microbial exposure during early life has persistent effects on natural killer T cell function. Science (2012) 5.90

Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma. Genome Res (2011) 5.58

Host-mediated inflammation disrupts the intestinal microbiota and promotes the overgrowth of Enterobacteriaceae. Cell Host Microbe (2007) 5.56

Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile. Nature (2014) 5.51

Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis. Elife (2013) 5.49

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature (2013) 5.47

IgA response to symbiotic bacteria as a mediator of gut homeostasis. Cell Host Microbe (2007) 5.18

Low-abundance biofilm species orchestrates inflammatory periodontal disease through the commensal microbiota and complement. Cell Host Microbe (2011) 5.06

Personalized Nutrition by Prediction of Glycemic Responses. Cell (2015) 5.05

Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota. Nature (2015) 4.98

Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4. Cancer Cell (2012) 4.98

Human genetics shape the gut microbiome. Cell (2014) 4.91

Host remodeling of the gut microbiome and metabolic changes during pregnancy. Cell (2012) 4.86

The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. Science (2013) 4.60

Microbiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens. Nature (2013) 4.43

Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis. Nature (2008) 4.42

Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Nat Med (2014) 4.29

Microbiota-Dependent Sequelae of Acute Infection Compromise Tissue-Specific Immunity. Cell (2015) 4.28

Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature (2014) 4.28

Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease. Cell (2014) 4.25

Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy. Science (2015) 4.23

Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria. Science (2012) 4.20

Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Nature (2011) 4.07

Gut microbiota are related to Parkinson's disease and clinical phenotype. Mov Disord (2014) 3.97

Nod2 is essential for temporal development of intestinal microbial communities. Gut (2011) 3.69

Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora. Science (2002) 3.58

Nod2 is required for the regulation of commensal microbiota in the intestine. Proc Natl Acad Sci U S A (2009) 3.58

Dietary intervention impact on gut microbial gene richness. Nature (2013) 3.56

Host-derived nitrate boosts growth of E. coli in the inflamed gut. Science (2013) 3.54

Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immune responses. Science (2010) 3.53

Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis. Cell (2014) 3.33

Disease-specific alterations in the enteric virome in inflammatory bowel disease. Cell (2015) 3.13

Diet-induced extinctions in the gut microbiota compound over generations. Nature (2016) 3.13

Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota. Science (2015) 3.12

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease. Cell (2016) 3.12

Diet dominates host genotype in shaping the murine gut microbiota. Cell Host Microbe (2014) 3.08

Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature (2015) 3.06

Crosstalk between B lymphocytes, microbiota and the intestinal epithelium governs immunity versus metabolism in the gut. Nat Med (2011) 3.06

Innate and adaptive immunity interact to quench microbiome flagellar motility in the gut. Cell Host Microbe (2013) 3.05

Longitudinal analysis of microbial interaction between humans and the indoor environment. Science (2014) 3.04

The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment. Nat Med (2015) 3.01

Host lifestyle affects human microbiota on daily timescales. Genome Biol (2014) 2.99

NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer. J Clin Invest (2013) 2.96

Temporal bacterial community dynamics vary among ulcerative colitis patients after fecal microbiota transplantation. Am J Gastroenterol (2013) 2.85

Early life antibiotic-driven changes in microbiota enhance susceptibility to allergic asthma. EMBO Rep (2012) 2.83

Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22. Immunity (2013) 2.78

Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis. Cell (2015) 2.77

Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk. Cell (2016) 2.64

Early infancy microbial and metabolic alterations affect risk of childhood asthma. Sci Transl Med (2015) 2.64

Invasive potential of gut mucosa-derived Fusobacterium nucleatum positively correlates with IBD status of the host. Inflamm Bowel Dis (2011) 2.62

Familial transmission rather than defective innate immunity shapes the distinct intestinal microbiota of TLR-deficient mice. J Exp Med (2012) 2.62

The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring. Science (2016) 2.58

The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes. Cell Host Microbe (2015) 2.58

NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion. Cell (2014) 2.56

Pyrosequencing study of fecal microflora of autistic and control children. Anaerobe (2010) 2.51

A pathobiont of the microbiota balances host colonization and intestinal inflammation. Cell Host Microbe (2010) 2.50

Short-term benefit from oral vancomycin treatment of regressive-onset autism. J Child Neurol (2000) 2.50

Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammation. Nat Med (2012) 2.49

The maternal microbiota drives early postnatal innate immune development. Science (2016) 2.49

Transient inability to manage proteobacteria promotes chronic gut inflammation in TLR5-deficient mice. Cell Host Microbe (2012) 2.48

Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature (2014) 4.28

Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis. Cell (2014) 3.33

Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling. Cell (2015) 2.04

The Spectrum and Regulatory Landscape of Intestinal Innate Lymphoid Cells Are Shaped by the Microbiome. Cell (2016) 1.51

The microbiome and innate immunity. Nature (2016) 1.05

Nuclear Retention of mRNA in Mammalian Tissues. Cell Rep (2015) 1.01

Microbiome-Modulated Metabolites at the Interface of Host Immunity. J Immunol (2017) 0.77

NFIL-trating the Host Circadian Rhythm-Microbes Fine-Tune the Epithelial Clock. Cell Metab (2017) 0.75

Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation. Science (2017) 0.75