DNMT3A Haploinsufficiency Transforms FLT3ITD Myeloproliferative Disease into a Rapid, Spontaneous, and Fully Penetrant Acute Myeloid Leukemia.

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🔗 View Article (PMID 27016502)

Published in Cancer Discov on March 25, 2016

Authors

Sara E Meyer1, Tingting Qin2, David E Muench1, Kohei Masuda1, Meenakshi Venkatasubramanian3, Emily Orr1, Lauren Suarez4, Steven D Gore5, Ruud Delwel6, Elisabeth Paietta7, Martin S Tallman8, Hugo Fernandez9, Ari Melnick10, Michelle M Le Beau11, Scott Kogan12, Nathan Salomonis3, Maria E Figueroa13, H Leighton Grimes14

Author Affiliations

1: Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
2: Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan.
3: Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
4: Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.
5: Division of Hematologic Malignancies, Yale Cancer Center, Yale School of Medicine, New Haven, Connecticut.
6: Department of Hematology, and Clinical Trial Center, Erasmus University Medical Center, Rotterdam, the Netherlands.
7: Division of Hemato-Oncology, Department of Medicine (Oncology), Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, New York.
8: Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, New York.
9: Blood and Marrow Transplantation, Moffitt Cancer Center, Oncologic Sciences, College of Medicine at University of South Florida, Tampa, Florida.
10: Department of Medicine, Hematology/Oncology Division, Weill Cornell Medical College, New York, New York.
11: Section of Hematology/Oncology, and the Comprehensive Cancer Center, University of Chicago, Chicago, Illinois.
12: Department of Laboratory Medicine and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California.
13: Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan. lee.grimes@cchmc.org marfigue@med.umich.edu.
14: Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. lee.grimes@cchmc.org marfigue@med.umich.edu.

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