Dnmt3a is essential for hematopoietic stem cell differentiation.

Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nat Rev Genet (2012) 15.21

Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence. N Engl J Med (2014) 6.89

DNA methylation: roles in mammalian development. Nat Rev Genet (2013) 6.65

Age-related clonal hematopoiesis associated with adverse outcomes. N Engl J Med (2014) 6.12

The role of mutations in epigenetic regulators in myeloid malignancies. Nat Rev Cancer (2012) 4.97

Cancer genetics and epigenetics: two sides of the same coin? Cancer Cell (2012) 3.65

Interplay between the cancer genome and epigenome. Cell (2013) 3.05

Large conserved domains of low DNA methylation maintained by Dnmt3a. Nat Genet (2013) 2.16

The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers. Cancer Cell (2014) 1.98

DNA methylation dynamics during the mammalian life cycle. Philos Trans R Soc Lond B Biol Sci (2013) 1.85

Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation. Blood (2015) 1.75

Less is more: unveiling the functional core of hematopoietic stem cells through knockout mice. Cell Stem Cell (2012) 1.71

Leukemia-Associated Cohesin Mutants Dominantly Enforce Stem Cell Programs and Impair Human Hematopoietic Progenitor Differentiation. Cell Stem Cell (2015) 1.71

Oncogenic Nras has bimodal effects on stem cells that sustainably increase competitiveness. Nature (2013) 1.61

Epigenetic Perturbations by Arg882-Mutated DNMT3A Potentiate Aberrant Stem Cell Gene-Expression Program and Acute Leukemia Development. Cancer Cell (2016) 1.57

miR-29a maintains mouse hematopoietic stem cell self-renewal by regulating Dnmt3a. Blood (2015) 1.56

MOABS: model based analysis of bisulfite sequencing data. Genome Biol (2014) 1.53

Causes, consequences, and reversal of immune system aging. J Clin Invest (2013) 1.50

MSC Transplantation Improves Osteopenia via Epigenetic Regulation of Notch Signaling in Lupus. Cell Metab (2015) 1.49

Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing. Nat Biotechnol (2014) 1.43

Reprogramming the methylome: erasing memory and creating diversity. Cell Stem Cell (2014) 1.43

DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling. Nat Med (2016) 1.42

Targeted silencing of the oncogenic transcription factor SOX2 in breast cancer. Nucleic Acids Res (2012) 1.40

Enforced differentiation of Dnmt3a-null bone marrow leads to failure with c-Kit mutations driving leukemic transformation. Blood (2015) 1.39

Depletion of Jak2V617F myeloproliferative neoplasm-propagating stem cells by interferon-α in a murine model of polycythemia vera. Blood (2013) 1.38

A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells. Blood (2013) 1.38

Stem cell heterogeneity: implications for aging and regenerative medicine. Blood (2012) 1.38

DNMT3A and IDH mutations in acute myeloid leukemia and other myeloid malignancies: associations with prognosis and potential treatment strategies. Leukemia (2014) 1.38

Mutations in epigenetic modifiers in the pathogenesis and therapy of acute myeloid leukemia. Blood (2013) 1.37

Genome-wide DNA methylation profiles in hematopoietic stem and progenitor cells reveal overrepresentation of ETS transcription factor binding sites. Genome Res (2012) 1.37

Molecular analysis of patients with polycythemia vera or essential thrombocythemia receiving pegylated interferon α-2a. Blood (2013) 1.33

DNA methylation is required for the control of stem cell differentiation in the small intestine. Genes Dev (2014) 1.31

Pharmacokinetic and pharmacodynamic analysis of 5-aza-2'-deoxycytidine (decitabine) in the design of its dose-schedule for cancer therapy. Clin Epigenetics (2013) 1.30

Dnmt3a and Dnmt3b have overlapping and distinct functions in hematopoietic stem cells. Cell Stem Cell (2014) 1.28

Pre-leukemic evolution of hematopoietic stem cells: the importance of early mutations in leukemogenesis. Leukemia (2014) 1.28

Myeloid malignancies: mutations, models and management. BMC Cancer (2012) 1.24

Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders. J Exp Med (2013) 1.23

Evolutionary determinants of cancer. Cancer Discov (2015) 1.19

TET proteins and 5-methylcytosine oxidation in hematological cancers. Immunol Rev (2015) 1.18

Epigenetic silencing of microRNA-203 is required for EMT and cancer stem cell properties. Sci Rep (2013) 1.13

Genetic and environmental exposures constrain epigenetic drift over the human life course. Genome Res (2014) 1.13

Telomere dysfunction drives aberrant hematopoietic differentiation and myelodysplastic syndrome. Cancer Cell (2015) 1.13

DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus. Genome Biol (2013) 1.12

Aging-Induced Stem Cell Mutations as Drivers for Disease and Cancer. Cell Stem Cell (2015) 1.11

Stem cells and the impact of ROS signaling. Development (2014) 1.10

Concise review: preleukemic stem cells: molecular biology and clinical implications of the precursors to leukemia stem cells. Stem Cells Transl Med (2013) 1.09

Age-related epigenetic drift in the pathogenesis of MDS and AML. Genome Res (2014) 1.08

Molecular-defined clonal evolution in patients with chronic myeloid leukemia independent of the BCR-ABL status. Leukemia (2014) 1.08

Nutrient-sensing pathways and metabolic regulation in stem cells. J Cell Biol (2013) 1.08

Epigenetic modulators, modifiers and mediators in cancer aetiology and progression. Nat Rev Genet (2016) 1.07

Chromothriptic cure of WHIM syndrome. Cell (2015) 1.07

Clinical development of demethylating agents in hematology. J Clin Invest (2014) 1.07

The changing mutational landscape of acute myeloid leukemia and myelodysplastic syndrome. Mol Cancer Res (2013) 1.04

Hematopoietic stem and progenitor cells acquire distinct DNA-hypermethylation during in vitro culture. Sci Rep (2013) 1.04

DNMT3A Arg882 mutation drives chronic myelomonocytic leukemia through disturbing gene expression/DNA methylation in hematopoietic cells. Proc Natl Acad Sci U S A (2014) 1.02

Conserved DNA methylation patterns in healthy blood cells and extensive changes in leukemia measured by a new quantitative technique. Epigenetics (2012) 1.02

Differential methylation in CN-AML preferentially targets non-CGI regions and is dictated by DNMT3A mutational status and associated with predominant hypomethylation of HOX genes. Epigenetics (2014) 1.01

DNMT1, DNMT3A and DNMT3B gene variants in relation to ovarian cancer risk in the Polish population. Mol Biol Rep (2013) 1.00

Origins of aberrant DNA methylation in acute myeloid leukemia. Leukemia (2013) 1.00

Essential role for Dnmt1 in the prevention and maintenance of MYC-induced T-cell lymphomas. Mol Cell Biol (2013) 1.00

Tumor suppressor functions of Dnmt3a and Dnmt3b in the prevention of malignant mouse lymphopoiesis. Leukemia (2013) 0.99

Driver mutations of cancer epigenomes. Protein Cell (2014) 0.98

Targeting the unique methylation pattern of androgen receptor (AR) promoter in prostate stem/progenitor cells with 5-aza-2'-deoxycytidine (5-AZA) leads to suppressed prostate tumorigenesis. J Biol Chem (2012) 0.98

Acute myeloid leukaemia: a paradigm for the clonal evolution of cancer? Dis Model Mech (2014) 0.98

Transcriptional and epigenetic regulation of T-helper lineage specification. Immunol Rev (2014) 0.97

Using beta-binomial regression for high-precision differential methylation analysis in multifactor whole-genome bisulfite sequencing experiments. BMC Bioinformatics (2014) 0.97

Analyzing the cancer methylome through targeted bisulfite sequencing. Cancer Lett (2012) 0.96

Genome-wide map of quantified epigenetic changes during in vitro chondrogenic differentiation of primary human mesenchymal stem cells. BMC Genomics (2013) 0.96

Epimutations mimic genomic mutations of DNMT3A in acute myeloid leukemia. Leukemia (2013) 0.96

Dnmt3a silences hematopoietic stem cell self-renewal. Nat Genet (2011) 0.95

Architecture of epigenetic reprogramming following Twist1-mediated epithelial-mesenchymal transition. Genome Biol (2013) 0.95

Epigenetic Control of Stem Cell Potential during Homeostasis, Aging, and Disease. Cell Stem Cell (2015) 0.94

Molecular pathophysiology of myelodysplastic syndromes. Annu Rev Pathol (2012) 0.94

The epigenetic landscape of acute myeloid leukemia. Adv Hematol (2014) 0.94

Identification of DNA methylation changes at cis-regulatory elements during early steps of HSC differentiation using tagmentation-based whole genome bisulfite sequencing. Cell Cycle (2014) 0.93

Dnmt3a protects active chromosome domains against cancer-associated hypomethylation. PLoS Genet (2012) 0.93

Somatic stem cell heterogeneity: diversity in the blood, skin and intestinal stem cell compartments. Nat Rev Mol Cell Biol (2015) 0.93

Myeloproliferative neoplasm animal models. Hematol Oncol Clin North Am (2012) 0.93

Epigenetics of myelodysplastic syndromes. Leukemia (2013) 0.92

Human endometrial DNA methylome is cycle-dependent and is associated with gene expression regulation. Mol Endocrinol (2014) 0.92

Loss of 5-hydroxymethylcytosine in cancer: cause or consequence? Genomics (2014) 0.92

Progressive Chromatin Condensation and H3K9 Methylation Regulate the Differentiation of Embryonic and Hematopoietic Stem Cells. Stem Cell Reports (2015) 0.91

Hematopoiesis. Cold Spring Harb Perspect Biol (2012) 0.91

Loss of Dnmt3a and endogenous Kras(G12D/+) cooperate to regulate hematopoietic stem and progenitor cell functions in leukemogenesis. Leukemia (2015) 0.91

Comparison of DNA methylation profiles in human fetal and adult red blood cell progenitors. Genome Med (2015) 0.91

Dnmt3a regulates myeloproliferation and liver-specific expansion of hematopoietic stem and progenitor cells. Leukemia (2015) 0.90

The myelodysplastic syndrome as a prototypical epigenetic disease. Blood (2013) 0.90

Long non-coding RNAs control hematopoietic stem cell function. Cell Stem Cell (2015) 0.90

Mathematical model of adult stem cell regeneration with cross-talk between genetic and epigenetic regulation. Proc Natl Acad Sci U S A (2014) 0.90

Donor cell leukemia arising from clonal hematopoiesis after bone marrow transplantation. Leukemia (2016) 0.90

PIAS1 SUMO ligase regulates the self-renewal and differentiation of hematopoietic stem cells. EMBO J (2013) 0.89

Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults. Nat Commun (2016) 0.89

MUC1-C induces DNA methyltransferase 1 and represses tumor suppressor genes in acute myeloid leukemia. Oncotarget (2016) 0.88

HSC commitment-associated epigenetic signature is prognostic in acute myeloid leukemia. J Clin Invest (2014) 0.88

Acute loss of TET function results in aggressive myeloid cancer in mice. Nat Commun (2015) 0.88

Epigenetic regulation of stem cells differentiating along the neural lineage. Curr Opin Neurobiol (2012) 0.88

Unraveling the genetic underpinnings of myeloproliferative neoplasms and understanding their effect on disease course and response to therapy: proceedings from the 6th International Post-ASH Symposium. Am J Hematol (2012) 0.87

DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia. Blood (2016) 0.87

Methylation-independent repression of Dnmt3b contributes to oncogenic activity of Dnmt3a in mouse MYC-induced T-cell lymphomagenesis. Oncogene (2015) 0.87

Sensitive periods in epigenetics: bringing us closer to complex behavioral phenotypes. Epigenomics (2012) 0.87

Human DNA methylomes at base resolution show widespread epigenomic differences. Nature (2009) 34.27

Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science (2009) 32.97

Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature (2008) 30.29

DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell (1999) 25.75

Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo. J Exp Med (1996) 17.51

DNMT3A mutations in acute myeloid leukemia. N Engl J Med (2010) 14.07

Linking DNA methylation and histone modification: patterns and paradigms. Nat Rev Genet (2009) 12.08

Hematopoietic stem cell quiescence maintained by p21cip1/waf1. Science (2000) 10.81

AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell (1996) 9.74

De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells. Development (1996) 7.98

Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science (1994) 7.60

Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases. Nat Genet (1998) 7.52

Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting. Nature (2004) 7.42

Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia. Nat Genet (2011) 6.98

The Ikaros gene is required for the development of all lymphoid lineages. Cell (1994) 5.90

BSMAP: whole genome bisulfite sequence MAPping program. BMC Bioinformatics (2009) 5.67

Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b. Mol Cell Biol (2003) 5.27

Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators. Cell Stem Cell (2010) 5.05

Dnmt3a-dependent nonpromoter DNA methylation facilitates transcription of neurogenic genes. Science (2010) 4.60

DNA methyltransferases control telomere length and telomere recombination in mammalian cells. Nat Cell Biol (2006) 4.38

Genome-scale DNA methylation mapping of clinical samples at single-nucleotide resolution. Nat Methods (2010) 4.30

Recurrent DNMT3A mutations in patients with myelodysplastic syndromes. Leukemia (2011) 4.28

Hematopoietic fingerprints: an expression database of stem cells and their progeny. Cell Stem Cell (2007) 4.06

Molecular signatures of proliferation and quiescence in hematopoietic stem cells. PLoS Biol (2004) 3.94

Quiescent haematopoietic stem cells are activated by IFN-gamma in response to chronic infection. Nature (2010) 3.93

Array-based genomic resequencing of human leukemia. Oncogene (2010) 3.77

DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction. Nat Genet (2009) 3.73

Distinct hematopoietic stem cell subtypes are differentially regulated by TGF-beta1. Cell Stem Cell (2010) 3.69

Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors. Immunity (1995) 3.37

A rapid micro chromatin immunoprecipitation assay (microChIP). Nat Protoc (2008) 3.14

High-throughput bisulfite sequencing in mammalian genomes. Methods (2009) 3.14

DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells. Cell Stem Cell (2009) 3.08

Dependence of histone modifications and gene expression on DNA hypermethylation in cancer. Cancer Res (2002) 2.84

Specific method for the determination of genomic DNA methylation by liquid chromatography-electrospray ionization tandem mass spectrometry. Anal Chem (2005) 2.78

The p47 GTPase Lrg-47 (Irgm1) links host defense and hematopoietic stem cell proliferation. Cell Stem Cell (2008) 2.57

De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells. J Exp Med (2007) 2.50

Mouse hematopoietic stem cell identification and analysis. Cytometry A (2009) 2.32

Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation. Blood (2003) 2.29

Pbx1 regulates self-renewal of long-term hematopoietic stem cells by maintaining their quiescence. Cell Stem Cell (2008) 2.08

DNA methylation and the regulation of gene transcription. Cell Mol Life Sci (2002) 2.02

Differential DNA hypermethylation and hypomethylation signatures in colorectal cancer. Hum Mol Genet (2004) 1.60

Hypomethylation and hypermethylation of DNA in Wilms tumors. Oncogene (2002) 1.59

Aberrant CpG island methylation in acute myeloid leukemia is accentuated at relapse. Blood (2008) 1.52

Regulation of lymphoid versus myeloid fate 'choice' by the transcription factor Mef2c. Nat Immunol (2009) 1.49

Aberrant promoter hypermethylation and genomic hypomethylation in tumor, adjacent normal tissues and blood from breast cancer patients. Anticancer Res (2010) 1.46

The orphan nuclear receptor Nurr1 restricts the proliferation of haematopoietic stem cells. Nat Cell Biol (2010) 1.40

Runx1 isoforms show differential expression patterns during hematopoietic development but have similar functional effects in adult hematopoietic stem cells. Exp Hematol (2010) 1.28

Enforced expression of the GATA-3 transcription factor affects cell fate decisions in hematopoiesis. Exp Hematol (2001) 1.17

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature (2007) 65.18

Model-based analysis of ChIP-Seq (MACS). Genome Biol (2008) 51.63

A draft sequence of the rice genome (Oryza sativa L. ssp. indica). Science (2002) 42.78

Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature (2008) 30.29

In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature (2007) 28.24

ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing. Genet Med (2013) 22.73

Genome-wide analysis of estrogen receptor binding sites. Nat Genet (2006) 18.63

The mammalian epigenome. Cell (2007) 18.13

Dissecting direct reprogramming through integrative genomic analysis. Nature (2008) 16.47

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell (2010) 15.20

Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1. Cell (2005) 14.32

FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription. Cell (2008) 14.18

Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell (2010) 14.18

The NIH Roadmap Epigenomics Mapping Consortium. Nat Biotechnol (2010) 13.99

Model-based analysis of tiling-arrays for ChIP-chip. Proc Natl Acad Sci U S A (2006) 13.68

Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science (2007) 12.41

lincRNAs act in the circuitry controlling pluripotency and differentiation. Nature (2011) 11.31

Somatic mutations of calreticulin in myeloproliferative neoplasms. N Engl J Med (2013) 9.65

Cre-lox-regulated conditional RNA interference from transgenes. Proc Natl Acad Sci U S A (2004) 9.33

Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine. Nat Biotechnol (2010) 9.01

Genome-wide association studies of 14 agronomic traits in rice landraces. Nat Genet (2010) 8.75

The role of microRNA genes in papillary thyroid carcinoma. Proc Natl Acad Sci U S A (2005) 8.60

Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study. Cancer (2006) 8.57

Deploying whole genome sequencing in clinical practice and public health: meeting the challenge one bin at a time. Genet Med (2011) 8.48

Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science (2003) 8.48

c-Myc is dispensable for direct reprogramming of mouse fibroblasts. Cell Stem Cell (2007) 8.46

Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia. Blood (2006) 8.38

Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines. Cell (2011) 8.21

A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements. Nucleic Acids Res (2004) 7.92

Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation. Cancer Cell (2011) 7.37

Model-based analysis of two-color arrays (MA2C). Genome Biol (2007) 7.28

Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer. Cell (2009) 7.09

Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications. Nat Biotechnol (2010) 7.00

PlasmoDB: a functional genomic database for malaria parasites. Nucleic Acids Res (2008) 6.73

DNA methylation: roles in mammalian development. Nat Rev Genet (2013) 6.65

iPS cells produce viable mice through tetraploid complementation. Nature (2009) 6.51

A unique regulatory phase of DNA methylation in the early mammalian embryo. Nature (2012) 6.34

Origin and diversity of novel avian influenza A H7N9 viruses causing human infection: phylogenetic, structural, and coalescent analyses. Lancet (2013) 6.10

A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth. Mol Cell (2007) 5.99

Quantitative comparison of genome-wide DNA methylation mapping technologies. Nat Biotechnol (2010) 5.96

Charting a dynamic DNA methylation landscape of the human genome. Nature (2013) 5.80

Sca-1(pos) cells in the mouse mammary gland represent an enriched progenitor cell population. Dev Biol (2002) 5.74

BSMAP: whole genome bisulfite sequence MAPping program. BMC Bioinformatics (2009) 5.67

Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation. PLoS Biol (2007) 5.48

Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylation. Cell Stem Cell (2008) 5.40

ACMG clinical laboratory standards for next-generation sequencing. Genet Med (2013) 5.30

MGMT promoter methylation and field defect in sporadic colorectal cancer. J Natl Cancer Inst (2005) 5.22

Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals. Cell (2010) 5.22

Evidence that ternary complex (eIF2-GTP-tRNA(i)(Met))-deficient preinitiation complexes are core constituents of mammalian stress granules. Mol Biol Cell (2002) 5.20

Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters. PLoS Genet (2007) 5.16

Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation. Nat Genet (2008) 5.08

Bone marrow edema and its relation to progression of knee osteoarthritis. Ann Intern Med (2003) 4.98

Cardiovascular risk and events in 17 low-, middle-, and high-income countries. N Engl J Med (2014) 4.88

Recurrent reciprocal 1q21.1 deletions and duplications associated with microcephaly or macrocephaly and developmental and behavioral abnormalities. Nat Genet (2008) 4.87

Association of urinary sodium and potassium excretion with blood pressure. N Engl J Med (2014) 4.86

A G protein-coupled receptor is a plasma membrane receptor for the plant hormone abscisic acid. Science (2007) 4.61

ClinGen--the Clinical Genome Resource. N Engl J Med (2015) 4.45

RSeQC: quality control of RNA-seq experiments. Bioinformatics (2012) 4.31

Genome-scale DNA methylation mapping of clinical samples at single-nucleotide resolution. Nat Methods (2010) 4.30

Productivity is a poor predictor of plant species richness. Science (2011) 4.21

A novel influenza A (H1N1) vaccine in various age groups. N Engl J Med (2009) 4.20

Preparation of reduced representation bisulfite sequencing libraries for genome-scale DNA methylation profiling. Nat Protoc (2011) 4.18

Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer. Proc Natl Acad Sci U S A (2007) 4.16

5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging. Nat Neurosci (2011) 4.15

Systematic evaluation of variability in ChIP-chip experiments using predefined DNA targets. Genome Res (2008) 4.08

Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia. Nat Genet (2002) 4.06

Hematopoietic fingerprints: an expression database of stem cells and their progeny. Cell Stem Cell (2007) 4.06

Exploring concordance and discordance for return of incidental findings from clinical sequencing. Genet Med (2012) 4.04

Dynamic single-cell imaging of direct reprogramming reveals an early specifying event. Nat Biotechnol (2010) 3.98

Molecular signatures of proliferation and quiescence in hematopoietic stem cells. PLoS Biol (2004) 3.94

A broadly implementable research course in phage discovery and genomics for first-year undergraduate students. MBio (2014) 3.93

Quiescent haematopoietic stem cells are activated by IFN-gamma in response to chronic infection. Nature (2010) 3.93

Genome-wide chromatin state transitions associated with developmental and environmental cues. Cell (2013) 3.83

TriTrypDB: a functional genomic resource for the Trypanosomatidae. Nucleic Acids Res (2009) 3.79

Receptor-like cytoplasmic kinases integrate signaling from multiple plant immune receptors and are targeted by a Pseudomonas syringae effector. Cell Host Microbe (2010) 3.73

Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants. N Engl J Med (2009) 3.70

Distinct hematopoietic stem cell subtypes are differentially regulated by TGF-beta1. Cell Stem Cell (2010) 3.69

Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems. Nat Biotechnol (2013) 3.65

Pluripotency factors in embryonic stem cells regulate differentiation into germ layers. Cell (2011) 3.53

Meta-analysis of traditional Chinese patent medicine for ischemic stroke. Stroke (2007) 3.46

Common variants on 9q22.33 and 14q13.3 predispose to thyroid cancer in European populations. Nat Genet (2009) 3.46

REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis. Nat Genet (2009) 3.36

Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis. Nat Genet (2012) 3.33

The Felodipine Event Reduction (FEVER) Study: a randomized long-term placebo-controlled trial in Chinese hypertensive patients. J Hypertens (2005) 3.27