Published in Cold Spring Harb Perspect Med on May 02, 2016
European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). Redox Biol (2017) 0.77
Dietary restriction and lifespan: Lessons from invertebrate models. Ageing Res Rev (2016) 0.77
A Brief Overview of Tauopathy: Causes, Consequences, and Therapeutic Strategies. Trends Pharmacol Sci (2017) 0.75
MicroRNAs miR-203-3p, miR-664-3p and miR-708-5p are associated with median strain lifespan in mice. Sci Rep (2017) 0.75
Differential Regulation of Cardiac Function and Intracardiac Cytokines by Rapamycin in Healthy and Diabetic Rats. Oxid Med Cell Longev (2017) 0.75
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature (2009) 19.56
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol Cell (2006) 18.36
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol (2011) 15.71
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell (2010) 12.24
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev Cell (2006) 11.48
Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science (2005) 11.31
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature (2002) 10.52
Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol (2004) 9.96
Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science (2009) 7.80
Genetics: influence of TOR kinase on lifespan in C. elegans. Nature (2003) 7.55
mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1). Biochem J (2008) 7.18
The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science (2011) 6.75
Efficacy and safety of sirolimus in lymphangioleiomyomatosis. N Engl J Med (2011) 6.74
Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science (2012) 6.69
Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev (2006) 6.62
A unifying model for mTORC1-mediated regulation of mRNA translation. Nature (2012) 6.44
The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells. J Exp Med (2008) 6.07
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci (2010) 5.54
Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell (2007) 5.51
Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice. Cell Cycle (2011) 5.42
A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB. EMBO J (2012) 5.03
A role for autophagy in the extension of lifespan by dietary restriction in C. elegans. PLoS Genet (2008) 4.93
Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling. EMBO J (2008) 4.79
Autophagy and aging: the importance of maintaining "clean" cells. Autophagy (2005) 4.61
Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function. Nat Med (2008) 4.44
Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster. Cell Metab (2010) 4.44
Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle. J Antibiot (Tokyo) (1975) 4.37
4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila. Cell (2009) 4.20
A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. Science (2013) 3.96
mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells. Sci Signal (2009) 3.94
Rapamycin slows aging in mice. Aging Cell (2012) 3.76
Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease. PLoS One (2010) 3.62
Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4. Cell (2008) 3.58
mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake. Nature (2012) 3.51
The TSC1-TSC2 complex is required for proper activation of mTOR complex 2. Mol Cell Biol (2008) 3.50
Activation of mTORC2 by association with the ribosome. Cell (2011) 3.38
MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae. PLoS Biol (2007) 3.19
Regulation of immune responses by mTOR. Annu Rev Immunol (2011) 3.08
eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans. Nature (2007) 3.07
The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice. Cell Metab (2014) 2.97
Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney. J Clin Invest (2010) 2.92
Activating mTOR mutations in a patient with an extraordinary response on a phase I trial of everolimus and pazopanib. Cancer Discov (2014) 2.79
mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin. Science (2013) 2.71
Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency. J Biol Chem (2005) 2.70
Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome. Cell (2014) 2.68
Regulation of mTORC1 by amino acids. Trends Cell Biol (2014) 2.64
Sirolimus is associated with new-onset diabetes in kidney transplant recipients. J Am Soc Nephrol (2008) 2.59
TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. Cell Metab (2012) 2.59
Role of autophagy in suppression of inflammation and cancer. Curr Opin Cell Biol (2010) 2.58
Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. Cell Metab (2014) 2.48
Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction. Aging Cell (2014) 2.35
Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells. Sci Transl Med (2011) 2.33
Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size. Mol Cell (2011) 2.32
Progressive vascular smooth muscle cell defects in a mouse model of Hutchinson-Gilford progeria syndrome. Proc Natl Acad Sci U S A (2006) 2.28
Rapamycin extends murine lifespan but has limited effects on aging. J Clin Invest (2013) 2.23
Rapalogs and mTOR inhibitors as anti-aging therapeutics. J Clin Invest (2013) 2.14
mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis. Cell Stem Cell (2012) 1.99
A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity. Cancer Discov (2014) 1.99
Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival. Sci Transl Med (2012) 1.98
Rapamycin extends life and health in C57BL/6 mice. J Gerontol A Biol Sci Med Sci (2013) 1.87
Promoting health and longevity through diet: from model organisms to humans. Cell (2015) 1.80
The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1. Cell Rep (2014) 1.72
Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males. Aging Cell (2013) 1.71
P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration. J Biol Chem (2007) 1.67
The TSC-mTOR pathway regulates macrophage polarization. Nat Commun (2013) 1.57
Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTOR/S6K1 and AMPK pathways. Diabetes (2011) 1.55
Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae. PLoS Genet (2011) 1.52
Branched-chain amino acids activate key enzymes in protein synthesis after physical exercise. J Nutr (2006) 1.50
S6 kinase inactivation impairs growth and translational target phosphorylation in muscle cells maintaining proper regulation of protein turnover. Am J Physiol Cell Physiol (2007) 1.44
Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling. Aging Cell (2012) 1.43
Feature Article: mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology. Proc Natl Acad Sci U S A (2013) 1.42
Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics. J Biol Chem (2012) 1.33
Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity. J Mol Med (Berl) (2011) 1.32
Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart. Aging Cell (2014) 1.30
Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome. PLoS One (2014) 1.26
Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan. Aging Cell (2014) 1.14
Rapamycin-induced metabolic defects are reversible in both lean and obese mice. Aging (Albany NY) (2014) 1.12
Cutaneous adverse events in renal transplant recipients receiving sirolimus-based therapy. Transplantation (2005) 1.11
Assessment of mitochondrial biogenesis and mTORC1 signaling during chronic rapamycin feeding in male and female mice. J Gerontol A Biol Sci Med Sci (2013) 1.08
Lifespan extension and cancer prevention in HER-2/neu transgenic mice treated with low intermittent doses of rapamycin. Cancer Biol Ther (2014) 1.08
PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12. Nat Cell Biol (2012) 1.08
Replication of extended lifespan phenotype in mice with deletion of insulin receptor substrate 1. PLoS One (2011) 1.07
Hepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2). FASEB J (2013) 1.03
mTOR complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase subunit Fbw8. Mol Cell (2012) 1.03
Rapamycin and mTOR: a serendipitous discovery and implications for breast cancer. Clin Transl Med (2012) 1.03
Altered composition of liver proteasome assemblies contributes to enhanced proteasome activity in the exceptionally long-lived naked mole-rat. PLoS One (2012) 1.02
The ribosomal protein Rpl22 controls ribosome composition by directly repressing expression of its own paralog, Rpl22l1. PLoS Genet (2013) 1.02
Haploinsufficiency of akt1 prolongs the lifespan of mice. PLoS One (2013) 1.02
Leucine nutrition in animals and humans: mTOR signaling and beyond. Amino Acids (2011) 1.00
Inhibition of Akt/mTOR attenuates age-related changes in mesenchymal stem cells. Stem Cells (2014) 0.96
STAT6-dependent and -independent mechanisms in Th2 polarization. Eur J Immunol (2012) 0.95
Leucine activates pancreatic translational machinery in rats and mice through mTOR independently of CCK and insulin. J Nutr (2006) 0.94
The TSC complex is required for the benefits of dietary protein restriction on stress resistance in vivo. Cell Rep (2014) 0.92
Remodeling of lipid metabolism by dietary restriction of essential amino acids. Diabetes (2013) 0.92
Chronic rapamycin treatment or lack of S6K1 does not reduce ribosome activity in vivo. Cell Cycle (2013) 0.91
Testing efficacy of administration of the antiaging drug rapamycin in a nonhuman primate, the common marmoset. J Gerontol A Biol Sci Med Sci (2014) 0.88
Combined treatment of rapamycin and dietary restriction has a larger effect on the transcriptome and metabolome of liver. Aging Cell (2013) 0.88
Pet dogs set to test anti-ageing drug. Nature (2014) 0.88
Influence of long-term caloric restriction on myocardial and cardiomyocyte contractile function and autophagy in mice. J Nutr Biochem (2012) 0.88
mTORC2 phosphorylates protein kinase Cζ to regulate its stability and activity. EMBO Rep (2013) 0.87