Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival.

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Published in Sci Transl Med on July 25, 2012

Authors

Fresnida J Ramos1, Steven C Chen, Michael G Garelick, Dao-Fu Dai, Chen-Yu Liao, Katherine H Schreiber, Vivian L MacKay, Elroy H An, Randy Strong, Warren C Ladiges, Peter S Rabinovitch, Matt Kaeberlein, Brian K Kennedy

Author Affiliations

1: Department of Pathology, University of Washington, Seattle, WA 98195, USA.

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