Published in PLoS Genet on September 08, 2011
The hallmarks of aging. Cell (2013) 14.29
Replicative and chronological aging in Saccharomyces cerevisiae. Cell Metab (2012) 2.56
The ubiquitin-proteasome system of Saccharomyces cerevisiae. Genetics (2012) 1.73
Sequence composition of disordered regions fine-tunes protein half-life. Nat Struct Mol Biol (2015) 1.55
Accumulation of Basic Amino Acids at Mitochondria Dictates the Cytotoxicity of Aberrant Ubiquitin. Cell Rep (2015) 1.54
Regulation of proteasome activity in health and disease. Biochim Biophys Acta (2013) 1.52
Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol. Nature (2015) 1.23
Ribosome deficiency protects against ER stress in Saccharomyces cerevisiae. Genetics (2012) 1.23
A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging. Cell Metab (2015) 1.05
A network of ubiquitin ligases is important for the dynamics of misfolded protein aggregates in yeast. J Biol Chem (2012) 1.05
Altered composition of liver proteasome assemblies contributes to enhanced proteasome activity in the exceptionally long-lived naked mole-rat. PLoS One (2012) 1.02
Blm10 protein promotes proteasomal substrate turnover by an active gating mechanism. J Biol Chem (2011) 1.01
Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging. Aging Cell (2012) 0.94
mTOR Inhibition: From Aging to Autism and Beyond. Scientifica (Cairo) (2013) 0.94
20S proteasome activation promotes life span extension and resistance to proteotoxicity in Caenorhabditis elegans. FASEB J (2014) 0.93
Proteasome dysfunction in Drosophila signals to an Nrf2-dependent regulatory circuit aiming to restore proteostasis and prevent premature aging. Aging Cell (2013) 0.93
Enhancing protein disaggregation restores proteasome activity in aged cells. Aging (Albany NY) (2013) 0.92
Non-repair pathways for minimizing protein isoaspartyl damage in the yeast Saccharomyces cerevisiae. J Biol Chem (2014) 0.92
Ubiquitin sets the timer: impacts on aging and longevity. Nat Struct Mol Biol (2014) 0.92
Opposing roles of Ubp3-dependent deubiquitination regulate replicative life span and heat resistance. EMBO J (2014) 0.91
Caffeine impairs resection during DNA break repair by reducing the levels of nucleases Sae2 and Dna2. Nucleic Acids Res (2015) 0.88
Protein aggregates are associated with replicative aging without compromising protein quality control. Elife (2015) 0.88
Yeast as a model to understand the interaction between genotype and the response to calorie restriction. FEBS Lett (2012) 0.86
Calorie restriction does not elicit a robust extension of replicative lifespan in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2014) 0.85
Regulation of NAD+ metabolism, signaling and compartmentalization in the yeast Saccharomyces cerevisiae. DNA Repair (Amst) (2014) 0.85
High-throughput analysis of yeast replicative aging using a microfluidic system. Proc Natl Acad Sci U S A (2015) 0.85
High-throughput genetic and gene expression analysis of the RNAPII-CTD reveals unexpected connections to SRB10/CDK8. PLoS Genet (2013) 0.83
Proteasomes, Sir2, and Hxk2 form an interconnected aging network that impinges on the AMPK/Snf1-regulated transcriptional repressor Mig1. PLoS Genet (2015) 0.82
Proteasomes associated with the Blm10 activator protein antagonize mitochondrial fission through degradation of the fission protein Dnm1. J Biol Chem (2014) 0.82
Natural compounds and aging: between autophagy and inflammasome. Biomed Res Int (2014) 0.82
Microfluidic technologies for yeast replicative lifespan studies. Mech Ageing Dev (2016) 0.81
Testing predictions of the oxidative stress hypothesis of aging using a novel invertebrate model of longevity: the giant clam (Tridacna derasa). J Gerontol A Biol Sci Med Sci (2012) 0.81
Unraveling the message: insights into comparative genomics of the naked mole-rat. Mamm Genome (2016) 0.80
Divergent tissue and sex effects of rapamycin on the proteasome-chaperone network of old mice. Front Mol Neurosci (2014) 0.80
Allele-specific behavior of molecular networks: understanding small-molecule drug response in yeast. PLoS One (2013) 0.79
Genome-scale studies of aging: challenges and opportunities. Curr Genomics (2012) 0.79
18α-Glycyrrhetinic Acid Proteasome Activator Decelerates Aging and Alzheimer's Disease Progression in Caenorhabditis elegans and Neuronal Cultures. Antioxid Redox Signal (2016) 0.79
Inhibition of the Mechanistic Target of Rapamycin (mTOR)-Rapamycin and Beyond. Cold Spring Harb Perspect Med (2016) 0.78
Evidence for the hallmarks of human aging in replicatively aging yeast. Microb Cell (2016) 0.77
The many ways to age for a single yeast cell. Yeast (2014) 0.77
Current aging research in China. Protein Cell (2015) 0.77
Ubiquitin-dependent proteolysis in yeast cells expressing neurotoxic proteins. Front Mol Neurosci (2015) 0.77
N-terminal acetylation and replicative age affect proteasome localization and cell fitness during aging. J Cell Sci (2014) 0.77
Sch9 regulates intracellular protein ubiquitination by controlling stress responses. Redox Biol (2015) 0.76
The 2010 ESPEN Sir David Cuthbertson Lecture: new and old proteins: clinical implications. Clin Nutr (2013) 0.76
Tuning the proteasome to brighten the end of the journey. Am J Physiol Cell Physiol (2016) 0.76
Cold Temperature Induces the Reprogramming of Proteolytic Pathways in Yeast. J Biol Chem (2015) 0.76
The aggregation and inheritance of damaged proteins determines cell fate during mitosis. Cell Cycle (2014) 0.76
Determinants of rodent longevity in the chaperone-protein degradation network. Cell Stress Chaperones (2016) 0.76
A budding yeast's perspective on aging: the shape I'm in. Exp Biol Med (Maywood) (2015) 0.75
The role of hydrogen sulfide in aging and age-related pathologies. Aging (Albany NY) (2016) 0.75
Aneuploidy shortens replicative lifespan in Saccharomyces cerevisiae. Aging Cell (2016) 0.75
It's all about talking: two-way communication between proteasomal and lysosomal degradation pathways via ubiquitin. Am J Physiol Cell Physiol (2016) 0.75
Loss of Ubp3 increases silencing, decreases unequal recombination in rDNA, and shortens the replicative life span in Saccharomyces cerevisiae. Mol Biol Cell (2014) 0.75
Cell culture-based profiling across mammals reveals DNA repair and metabolism as determinants of species longevity. Elife (2016) 0.75
Stability analysis of a model gene network links aging, stress resistance, and negligible senescence. Sci Rep (2015) 0.75
The sole introduction of two single-point mutations establishes glycerol utilization in Saccharomyces cerevisiae CEN.PK derivatives. Biotechnol Biofuels (2017) 0.75
The proteasome activity reporter GFP-Cl1 is degraded by autophagy in the aging model Podospora anserina. F1000Res (2014) 0.75
Higher expression of somatic repair genes in long-lived ant queens than workers. Aging (Albany NY) (2016) 0.75
New insights into old worm proteomes. Worm (2016) 0.75
Restricted access: spatial sequestration of damaged proteins during stress and aging. EMBO Rep (2017) 0.75
Phospholipase Lpl1 Links Lipid Droplet Function with Quality Control Protein Degradation. Mol Biol Cell (2017) 0.75
Which Is the Most Significant Cause of Aging? Antioxidants (Basel) (2015) 0.75
Less is more: Nutrient limitation induces cross-talk of nutrient sensing pathways with NAD(+) homeostasis and contributes to longevity. Front Biol (Beijing) (2015) 0.75
Proteostasis and ageing: insights from long-lived mutant mice. J Physiol (2017) 0.75
Axonal Degeneration during Aging and Its Functional Role in Neurodegenerative Disorders. Front Neurosci (2017) 0.75
A proteomic atlas of insulin signalling reveals tissue-specific mechanisms of longevity assurance. Mol Syst Biol (2017) 0.75
Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae. Yeast (1998) 48.29
MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. Nat Biotechnol (2008) 38.00
Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science (1999) 36.25
Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains and plasmids for PCR-mediated gene disruption and other applications. Yeast (1998) 23.00
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev (1999) 14.43
Three new dominant drug resistance cassettes for gene disruption in Saccharomyces cerevisiae. Yeast (1999) 14.19
Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science (2005) 11.31
Comprehensive mass-spectrometry-based proteome quantification of haploid versus diploid yeast. Nature (2008) 10.28
Recognition and processing of ubiquitin-protein conjugates by the proteasome. Annu Rev Biochem (2009) 8.83
Gene expression profile of aging and its retardation by caloric restriction. Science (1999) 8.06
Full dynamic range proteome analysis of S. cerevisiae by targeted proteomics. Cell (2009) 6.54
Rapid and reliable protein extraction from yeast. Yeast (2000) 5.48
Biological and chemical approaches to diseases of proteostasis deficiency. Annu Rev Biochem (2009) 5.23
Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function. Nat Med (2008) 4.44
Regulatory networks revealed by transcriptional profiling of damaged Saccharomyces cerevisiae cells: Rpn4 links base excision repair with proteasomes. Mol Cell Biol (2000) 4.15
Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4. Cell (2008) 3.58
Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila. Autophagy (2007) 3.45
Deubiquitinating enzyme Ubp6 functions noncatalytically to delay proteasomal degradation. Cell (2006) 3.21
Sir2-independent life span extension by calorie restriction in yeast. PLoS Biol (2004) 3.20
Autophagy and aging: keeping that old broom working. Trends Genet (2008) 3.09
The TOR pathway comes of age. Biochim Biophys Acta (2009) 2.83
Active site mutants in the six regulatory particle ATPases reveal multiple roles for ATP in the proteasome. EMBO J (1998) 2.82
Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems. FEBS Lett (2009) 2.58
Mechanisms of aging: an appraisal of the oxidative stress hypothesis. Free Radic Biol Med (2002) 2.55
Rpn4p acts as a transcription factor by binding to PACE, a nonamer box found upstream of 26S proteasomal and other genes in yeast. FEBS Lett (1999) 2.54
Ump1p is required for proper maturation of the 20S proteasome and becomes its substrate upon completion of the assembly. Cell (1998) 2.39
Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans. Aging Cell (2008) 2.32
The base of the proteasome regulatory particle exhibits chaperone-like activity. Nat Cell Biol (1999) 2.22
Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat. Proc Natl Acad Sci U S A (2009) 2.14
Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity. Genes Dev (2008) 1.81
The HEAT repeat protein Blm10 regulates the yeast proteasome by capping the core particle. Nat Struct Mol Biol (2005) 1.78
Abnormal proteins can form aggresome in yeast: aggresome-targeting signals and components of the machinery. FASEB J (2008) 1.74
Genetic evidence linking age-dependent attenuation of the 26S proteasome with the aging process. Mol Cell Biol (2008) 1.69
Measuring replicative life span in the budding yeast. J Vis Exp (2009) 1.68
Aging perturbs 26S proteasome assembly in Drosophila melanogaster. FASEB J (2007) 1.49
Autophagy mediates pharmacological lifespan extension by spermidine and resveratrol. Aging (Albany NY) (2009) 1.48
Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase complex. Proc Natl Acad Sci U S A (2007) 1.46
Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity. PLoS One (2008) 1.45
Impairment of proteasome structure and function in aging. Int J Biochem Cell Biol (2002) 1.40
Plasticity in eucaryotic 20S proteasome ring assembly revealed by a subunit deletion in yeast. EMBO J (2004) 1.34
Aging: central role for autophagy and the lysosomal degradative system. Ageing Res Rev (2009) 1.31
A nucleus-based quality control mechanism for cytosolic proteins. Mol Biol Cell (2010) 1.28
Accumulation of altered proteins and ageing: causes and effects. Exp Gerontol (2006) 1.28
Aging and regulated protein degradation: who has the UPPer hand? Aging Cell (2007) 1.27
Rpn4 is a physiological substrate of the Ubr2 ubiquitin ligase. J Biol Chem (2004) 1.19
TOM1p, a yeast hect-domain protein which mediates transcriptional regulation through the ADA/SAGA coactivator complexes. J Mol Biol (1998) 1.18
Participation of the proteasomal lid subunit Rpn11 in mitochondrial morphology and function is mapped to a distinct C-terminal domain. Biochem J (2004) 1.18
Synergistic roles of the proteasome and autophagy for mitochondrial maintenance and chronological lifespan in fission yeast. Proc Natl Acad Sci U S A (2010) 1.17
Ump1 extends yeast lifespan and enhances viability during oxidative stress: central role for the proteasome? Free Radic Biol Med (2005) 1.10
Fibroblast cultures from healthy centenarians have an active proteasome. Exp Gerontol (2000) 1.07
Structure and properties of transcriptional networks driving selenite stress response in yeasts. BMC Genomics (2008) 1.07
The Yap family and its role in stress response. Yeast (2010) 1.06
Homeostatic regulation of the proteasome via an Rpn4-dependent feedback circuit. Biochem Biophys Res Commun (2004) 1.05
Biting the hand that feeds: Rpn4-dependent feedback regulation of proteasome function. Biochim Biophys Acta (2007) 1.05
Aging and dietary restriction alter proteasome biogenesis and composition in the brain and liver. Mech Ageing Dev (2009) 0.96
Genome-wide analysis identifies MYND-domain protein Mub1 as an essential factor for Rpn4 ubiquitylation. Mol Cell Biol (2007) 0.95
Involvement of calcineurin-dependent degradation of Yap1p in Ca2+-induced G2 cell-cycle regulation in Saccharomyces cerevisiae. EMBO Rep (2006) 0.91
Understanding and modulating ageing. IUBMB Life (2005) 0.89
Lifespan extension by suppression of autophagy genes in Caenorhabditis elegans. Genes Cells (2009) 0.87
Inhibition of proteasomal degradation of rpn4 impairs nonhomologous end-joining repair of DNA double-strand breaks. PLoS One (2010) 0.83
[Regulated nuclear localization of transcription factors: nuclear export of yAP-1 is sensitive to oxidative stress]. Tanpakushitsu Kakusan Koso (1999) 0.77
Global quantification of mammalian gene expression control. Nature (2011) 22.36
Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science (2005) 11.31
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature (2002) 8.45
Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev (2006) 6.62
mTOR is a key modulator of ageing and age-related disease. Nature (2013) 5.40
Substrate-specific activation of sirtuins by resveratrol. J Biol Chem (2005) 5.28
Multiple associated proteins regulate proteasome structure and function. Mol Cell (2002) 4.97
LMNA mutations in atypical Werner's syndrome. Lancet (2003) 4.81
Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature (2011) 4.48
Sirtuins in aging and age-related disease. Cell (2006) 3.95
Histone H4 lysine 16 acetylation regulates cellular lifespan. Nature (2009) 3.83
Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4. Cell (2008) 3.58
mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome. Science (2013) 3.41
Sir2-independent life span extension by calorie restriction in yeast. PLoS Biol (2004) 3.20
A molecular mechanism of chronological aging in yeast. Cell Cycle (2009) 3.12
Lifespan extension in Caenorhabditis elegans by complete removal of food. Aging Cell (2006) 2.95
Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. Cell (2010) 2.91
Ubiquitin chains are remodeled at the proteasome by opposing ubiquitin ligase and deubiquitinating activities. Cell (2006) 2.87
The TOR pathway comes of age. Biochim Biophys Acta (2009) 2.83
Proteasomal regulation of the hypoxic response modulates aging in C. elegans. Science (2009) 2.62
Replicative and chronological aging in Saccharomyces cerevisiae. Cell Metab (2012) 2.56
Werner and Hutchinson-Gilford progeria syndromes: mechanistic basis of human progeroid diseases. Nat Rev Mol Cell Biol (2007) 2.56
Quantitative evidence for conserved longevity pathways between divergent eukaryotic species. Genome Res (2008) 2.32
Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans. Aging Cell (2008) 2.32
A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradation. Proc Natl Acad Sci U S A (2004) 2.17
Global analysis of cellular protein translation by pulsed SILAC. Proteomics (2009) 2.15
Recent developments in yeast aging. PLoS Genet (2007) 2.13
The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO. Mol Cell (2013) 2.12
Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival. Sci Transl Med (2012) 1.98
Hexameric assembly of the proteasomal ATPases is templated through their C termini. Nature (2009) 1.97
Genes determining yeast replicative life span in a long-lived genetic background. Mech Ageing Dev (2005) 1.96
Progeria syndromes and ageing: what is the connection? Nat Rev Mol Cell Biol (2010) 1.93
Two deubiquitylases act on mitofusin and regulate mitochondrial fusion along independent pathways. Mol Cell (2013) 1.90
Characterization of the proteasome using native gel electrophoresis. Methods Enzymol (2005) 1.89
Increased life span due to calorie restriction in respiratory-deficient yeast. PLoS Genet (2005) 1.86
Management of opioid side effects in cancer-related and chronic noncancer pain: a systematic review. J Pain (2003) 1.85
When lamins go bad: nuclear structure and disease. Cell (2013) 1.84
The CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells. Nat Cell Biol (2010) 1.81
A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κB activation. Mol Cell (2010) 1.79
A method for high-throughput quantitative analysis of yeast chronological life span. J Gerontol A Biol Sci Med Sci (2008) 1.76
Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans. BMC Dev Biol (2008) 1.75
Lamin A/C and emerin are critical for skeletal muscle satellite cell differentiation. Genes Dev (2006) 1.73
Measuring replicative life span in the budding yeast. J Vis Exp (2009) 1.68
Late-life rapamycin treatment reverses age-related heart dysfunction. Aging Cell (2013) 1.60
Antizyme targets cyclin D1 for degradation. A novel mechanism for cell growth repression. J Biol Chem (2004) 1.58
Nonsteroidal anti-inflammatory drugs, alone or combined with opioids, for cancer pain: a systematic review. J Clin Oncol (2004) 1.57
Molecular insights into arrhythmogenic right ventricular cardiomyopathy caused by plakophilin-2 missense mutations. Circ Cardiovasc Genet (2012) 1.48
Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity. PLoS One (2008) 1.45
Large-scale identification in yeast of conserved ageing genes. Mech Ageing Dev (2005) 1.43
Measuring Caenorhabditis elegans life span on solid media. J Vis Exp (2009) 1.39
The sensitivity of yeast mutants to oleic acid implicates the peroxisome and other processes in membrane function. Genetics (2006) 1.36
HIF-1 modulates longevity and healthspan in a temperature-dependent manner. Aging Cell (2011) 1.35
Suppression of proliferative defects associated with processing-defective lamin A mutants by hTERT or inactivation of p53. Mol Biol Cell (2008) 1.32
Sirtuin-independent effects of nicotinamide on lifespan extension from calorie restriction in yeast. Aging Cell (2006) 1.32
Molecular mechanisms underlying genotype-dependent responses to dietary restriction. Aging Cell (2013) 1.31
Dietary restriction by bacterial deprivation increases life span in wild-derived nematodes. Exp Gerontol (2007) 1.31
Comment on "HST2 mediates SIR2-independent life-span extension by calorie restriction". Science (2006) 1.27
Yeast hypertrophy: cause or consequence of aging? Reply to Bilinski et al. FEMS Yeast Res (2012) 1.26
Ageing: A midlife longevity drug? Nature (2009) 1.25
Protein translation, 2007. Aging Cell (2007) 1.25
TOR and ageing: a complex pathway for a complex process. Philos Trans R Soc Lond B Biol Sci (2011) 1.25
Hot topics in aging research: protein translation, 2009. Aging Cell (2009) 1.24
Mutations in Saccharomyces cerevisiae gene SIR2 can have differential effects on in vivo silencing phenotypes and in vitro histone deacetylation activity. Mol Biol Cell (2002) 1.24
Hypertrophy and senescence factors in yeast aging. A reply to Bilinski et al. FEMS Yeast Res (2012) 1.23
Ribosome deficiency protects against ER stress in Saccharomyces cerevisiae. Genetics (2012) 1.23
A genomic analysis of chronological longevity factors in budding yeast. Cell Cycle (2011) 1.22
Hot topics in aging research: protein translation and TOR signaling, 2010. Aging Cell (2011) 1.22