Oxidation-reduction and the molecular mechanism of a regulatory RNA-protein interaction.

PubWeight™: 3.54‹?› | Rank: Top 1%

🔗 View Article (PMID 2711187)

Published in Science on April 21, 1989

Authors

M W Hentze1, T A Rouault, J B Harford, R D Klausner

Author Affiliations

1: Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892.

Articles citing this

Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress. Proc Natl Acad Sci U S A (1996) 5.53

Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme. EMBO J (1992) 5.23

Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity. EMBO J (1992) 3.98

YAP1 dependent activation of TRX2 is essential for the response of Saccharomyces cerevisiae to oxidative stress by hydroperoxides. EMBO J (1994) 3.44

Thioredoxin regulates the DNA binding activity of NF-kappa B by reduction of a disulphide bond involving cysteine 62. Nucleic Acids Res (1992) 3.22

Modulation of transcription factor NF-kappa B binding activity by oxidation-reduction in vitro. Proc Natl Acad Sci U S A (1991) 3.07

Autoregulation of human thymidylate synthase messenger RNA translation by thymidylate synthase. Proc Natl Acad Sci U S A (1991) 2.67

Iron regulation of transferrin receptor mRNA levels requires iron-responsive elements and a rapid turnover determinant in the 3' untranslated region of the mRNA. EMBO J (1989) 2.54

Regulation of interaction of the iron-responsive element binding protein with iron-responsive RNA elements. Mol Cell Biol (1989) 2.26

Identification of a novel iron-responsive element in murine and human erythroid delta-aminolevulinic acid synthase mRNA. EMBO J (1991) 2.25

Cellular regulation of the iron-responsive element binding protein: disassembly of the cubane iron-sulfur cluster results in high-affinity RNA binding. Proc Natl Acad Sci U S A (1992) 2.17

Reciprocal control of RNA-binding and aconitase activity in the regulation of the iron-responsive element binding protein: role of the iron-sulfur cluster. Proc Natl Acad Sci U S A (1992) 2.06

Cloning of the cDNA encoding an RNA regulatory protein--the human iron-responsive element-binding protein. Proc Natl Acad Sci U S A (1990) 2.03

The iron-responsive element binding protein: a method for the affinity purification of a regulatory RNA-binding protein. Proc Natl Acad Sci U S A (1989) 1.95

Biosynthesis of nitric oxide activates iron regulatory factor in macrophages. EMBO J (1993) 1.83

Position is the critical determinant for function of iron-responsive elements as translational regulators. Mol Cell Biol (1992) 1.79

Regulation of transferrin receptor expression and ferritin content in human mononuclear phagocytes. Coordinate upregulation by iron transferrin and downregulation by interferon gamma. J Clin Invest (1993) 1.78

Requirements for iron-regulated degradation of the RNA binding protein, iron regulatory protein 2. EMBO J (1995) 1.76

Oxidation-reduction sensitive interaction of a cellular 50-kDa protein with an RNA hairpin in the 5' noncoding region of the poliovirus genome. Proc Natl Acad Sci U S A (1990) 1.72

Translational repression by a complex between the iron-responsive element of ferritin mRNA and its specific cytoplasmic binding protein is position-dependent in vivo. EMBO J (1990) 1.70

Homology between IRE-BP, a regulatory RNA-binding protein, aconitase, and isopropylmalate isomerase. Nucleic Acids Res (1991) 1.68

Structural requirements of iron-responsive elements for binding of the protein involved in both transferrin receptor and ferritin mRNA post-transcriptional regulation. Nucleic Acids Res (1990) 1.66

Translational regulation via iron-responsive elements by the nitric oxide/NO-synthase pathway. EMBO J (1993) 1.61

Rapid responses to oxidative stress mediated by iron regulatory protein. EMBO J (1995) 1.56

Reduction of a conserved Cys is essential for Myb DNA-binding. Nucleic Acids Res (1992) 1.55

Mutational analysis of the [4Fe-4S]-cluster converting iron regulatory factor from its RNA-binding form to cytoplasmic aconitase. EMBO J (1994) 1.50

Conserved cysteine residue in the DNA-binding domain of the bovine papillomavirus type 1 E2 protein confers redox regulation of the DNA-binding activity in vitro. Proc Natl Acad Sci U S A (1992) 1.49

Nitric oxide signaling to iron-regulatory protein: direct control of ferritin mRNA translation and transferrin receptor mRNA stability in transfected fibroblasts. Proc Natl Acad Sci U S A (1995) 1.45

A high yield affinity purification method for specific RNA-binding proteins: isolation of the iron regulatory factor from human placenta. Nucleic Acids Res (1990) 1.43

Specific binding of host cell proteins to the 3'-terminal stem-loop structure of rubella virus negative-strand RNA. J Virol (1991) 1.43

Modulation of the RNA-binding activity of a regulatory protein by iron in vitro: switching between enzymatic and genetic function? Proc Natl Acad Sci U S A (1992) 1.39

The mRNA-binding protein which controls ferritin and transferrin receptor expression is conserved during evolution. Nucleic Acids Res (1990) 1.37

Bacteriophage and spliceosomal proteins function as position-dependent cis/trans repressors of mRNA translation in vitro. Nucleic Acids Res (1992) 1.36

Translational regulation of mammalian and Drosophila citric acid cycle enzymes via iron-responsive elements. Proc Natl Acad Sci U S A (1996) 1.36

Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteine. J Clin Invest (1991) 1.34

Different Trypanosoma brucei guide RNA molecules associate with an identical complement of mitochondrial proteins in vitro. Nucleic Acids Res (1994) 1.34

Nitric oxide inhibits H2O2-induced transferrin receptor-dependent apoptosis in endothelial cells: Role of ubiquitin-proteasome pathway. Proc Natl Acad Sci U S A (2003) 1.26

Physical and functional sensitivity of zinc finger transcription factors to redox change. Mol Cell Biol (1996) 1.26

The bifunctional iron-responsive element binding protein/cytosolic aconitase: the role of active-site residues in ligand binding and regulation. Proc Natl Acad Sci U S A (1994) 1.26

Masking, unmasking, and regulated polyadenylation cooperate in the translational control of a dormant mRNA in mouse oocytes. Genes Dev (1998) 1.26

Ferritin mRNA: interactions of iron regulatory element with translational regulator protein P-90 and the effect on base-paired flanking regions. Proc Natl Acad Sci U S A (1991) 1.22

Expression of active iron regulatory factor from a full-length human cDNA by in vitro transcription/translation. Nucleic Acids Res (1992) 1.21

Ehrlichia chaffeensis and E. sennetsu, but not the human granulocytic ehrlichiosis agent, colocalize with transferrin receptor and up-regulate transferrin receptor mRNA by activating iron-responsive protein 1. Infect Immun (1999) 1.20

Interaction of proteins with the mRNA for ribosomal protein L1 in Xenopus: structural characterization of in vivo complexes and identification of proteins that bind in vitro to its 5'UTR. Nucleic Acids Res (1993) 1.20

Nitric oxide and oxidative stress (H2O2) control mammalian iron metabolism by different pathways. Mol Cell Biol (1996) 1.20

Dual regulation of heat-shock transcription factor (HSF) activation and DNA-binding activity by H2O2: role of thioredoxin. Biochem J (1996) 1.15

GRSF-1: a poly(A)+ mRNA binding protein which interacts with a conserved G-rich element. Nucleic Acids Res (1994) 1.13

Iron regulatory factor expressed from recombinant baculovirus: conversion between the RNA-binding apoprotein and Fe-S cluster containing aconitase. Nucleic Acids Res (1993) 1.13

A double life: cytosolic aconitase as a regulatory RNA binding protein. Mol Biol Cell (1993) 1.11

Identification of a thymidylate synthase ribonucleoprotein complex in human colon cancer cells. Mol Cell Biol (1994) 1.11

Translational repression by bacteriophage MS2 coat protein does not require cysteine residues. Nucleic Acids Res (1989) 1.06

Translational repression by the human iron-regulatory factor (IRF) in Saccharomyces cerevisiae. Nucleic Acids Res (1993) 1.06

Activation of iron regulatory protein-1 by oxidative stress in vitro. Proc Natl Acad Sci U S A (1998) 1.05

Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins. Cell Metab (2013) 1.02

The stimulus-sensitive H2O2-generating system present in human fat-cell plasma membranes is multireceptor-linked and under antagonistic control by hormones and cytokines. Biochem J (1995) 1.01

Binding of a 50-kD Protein to a U-Rich Sequence in an mRNA Encoding a Proline-Rich Protein That Is Destabilized by Fungal Elicitor. Plant Cell (1994) 1.00

Ultraviolet A radiation induces immediate release of iron in human primary skin fibroblasts: the role of ferritin. Proc Natl Acad Sci U S A (1999) 0.99

Leishmania donovani depletes labile iron pool to exploit iron uptake capacity of macrophage for its intracellular growth. Cell Microbiol (2008) 0.96

Identification of in vivo target RNA sequences bound by thymidylate synthase. Nucleic Acids Res (1996) 0.95

Transfection of beta-casein chimeric gene and hormonal induction of its expression in primary murine mammary epithelial cells. Proc Natl Acad Sci U S A (1990) 0.94

Iron-regulatory proteins: molecular biology and pathophysiological implications. Expert Rev Mol Med (2007) 0.93

Identification and characterization of a 44 kDa protein that binds specifically to the 3'-untranslated region of CYP2a5 mRNA: inducibility, subcellular distribution and possible role in mRNA stabilization. Biochem J (1996) 0.91

Ferritin synthesis is controlled by iron-dependent translational derepression and by changes in synthesis/transport of nuclear ferritin RNAs. Proc Natl Acad Sci U S A (1993) 0.90

Functional activation of the egr-1 (early growth response-1) gene by hydrogen peroxide. Biochem J (1996) 0.89

Down-regulation of iron regulatory protein 1 gene expression by nitric oxide. Proc Natl Acad Sci U S A (2000) 0.89

IRP1 Ser-711 is a phosphorylation site, critical for regulation of RNA-binding and aconitase activities. Biochem J (2005) 0.88

Translational upregulation of folate receptors is mediated by homocysteine via RNA-heterogeneous nuclear ribonucleoprotein E1 interactions. J Clin Invest (2004) 0.88

Iron regulatory protein 1 is not required for the modulation of ferritin and transferrin receptor expression by iron in a murine pro-B lymphocyte cell line. Proc Natl Acad Sci U S A (1997) 0.87

Role of cysteine amino acid residues on the RNA binding activity of human thymidylate synthase. Nucleic Acids Res (2003) 0.85

Preliminary demonstration of an allelic association of the IREB2 gene with Alzheimer's disease. J Alzheimers Dis (2006) 0.85

Oxalomalate, a competitive inhibitor of aconitase, modulates the RNA-binding activity of iron-regulatory proteins. Biochem J (2000) 0.84

Evidence that phosphorylation of iron regulatory protein 1 at Serine 138 destabilizes the [4Fe-4S] cluster in cytosolic aconitase by enhancing 4Fe-3Fe cycling. J Biol Chem (2009) 0.84

Inhibition of lung epithelial cell proliferation by hyperoxia. Posttranscriptional regulation of proliferation-related genes. J Clin Invest (1992) 0.84

Regulation of Nramp1 mRNA stability by oxidants and protein kinase C in RAW264.7 macrophages expressing Nramp1(Gly169). Biochem J (2000) 0.84

Role of iron in the pathogenesis of cysteamine-induced duodenal ulceration in rats. Am J Physiol Gastrointest Liver Physiol (2009) 0.84

High density lipoproteins stimulate the production and secretion of endothelin-1 from cultured bovine aortic endothelial cells. J Clin Invest (1994) 0.84

Crosslinking of hemin to a specific site on the 90-kDa ferritin repressor protein. Proc Natl Acad Sci U S A (1991) 0.82

Iron, lactoferrin and iron regulatory protein activity in the synovium; relative importance of iron loading and the inflammatory response. Ann Rheum Dis (1998) 0.82

Post-transcriptional regulation of transferrin receptor mRNA by IFN gamma. Nucleic Acids Res (1992) 0.82

Posttranscriptional down-regulation of ras oncogene expression by inhibitors of cellular glutathione. Mol Cell Biol (1993) 0.81

A fibroblast protein binds the 3'-untranslated region of pro-alpha 1(I) collagen mRNA. Biochem J (1993) 0.81

Divergent effects of alpha 1-antitrypsin on the regulation of iron metabolism in human erythroleukaemic (K562) and myelomonocytic (THP-1) cells. Biochem J (1996) 0.80

Adult T-cell leukaemia-derived factor/thioredoxin expression on the HTLV-I transformed T-cell lines: heterogeneous expression in ALT-2 cells. Immunology (1992) 0.79

Transferrin receptor induction in Toxoplasma gondii-infected HFF is associated with increased iron-responsive protein 1 activity and is mediated by secreted factors. Parasitol Res (2004) 0.79

Oxidative stress and superoxide dismutase in development, aging and gene regulation. Age (Omaha) (1998) 0.78

Transcription factors and aging. Mol Med (1997) 0.77

Electrophoretic mobility shift assay (EMSA) for the study of RNA-protein interactions: the IRE/IRP example. J Vis Exp (2014) 0.76

Relative contributions of the structural and catalytic roles of Rrp6 in exosomal degradation of individual mRNAs. RNA (2016) 0.75

Involvement of the iron regulatory protein from Eisenia andrei earthworms in the regulation of cellular iron homeostasis. PLoS One (2014) 0.75

Ferritin M of Paralichthys olivaceus possesses antimicrobial and antioxidative properties. Fish Physiol Biochem (2015) 0.75

Articles by these authors

Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: evidence for membrane cycling from Golgi to ER. Cell (1989) 13.41

Microtubule-dependent retrograde transport of proteins into the ER in the presence of brefeldin A suggests an ER recycling pathway. Cell (1990) 9.19

The mammalian gene collection. Science (1999) 7.19

Regulating the fate of mRNA: the control of cellular iron metabolism. Cell (1993) 6.47

Biosynthesis, cleavage, and degradation of the human immunodeficiency virus 1 envelope glycoprotein gp160. Proc Natl Acad Sci U S A (1988) 6.33

Brefeldin A's effects on endosomes, lysosomes, and the TGN suggest a general mechanism for regulating organelle structure and membrane traffic. Cell (1991) 6.30

Brefeldin A inhibits Golgi membrane-catalysed exchange of guanine nucleotide onto ARF protein. Nature (1992) 6.11

Receptor-mediated endocytosis of transferrin and the uptake of fe in K562 cells: identification of a nonlysosomal acidic compartment. Proc Natl Acad Sci U S A (1982) 5.74

Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor. Proc Natl Acad Sci U S A (1990) 5.35

Iron-responsive elements: regulatory RNA sequences that control mRNA levels and translation. Science (1988) 4.86

A systematic, high-resolution linkage of the cytogenetic and physical maps of the human genome. Nat Genet (2000) 4.78

Binding of apotransferrin to K562 cells: explanation of the transferrin cycle. Proc Natl Acad Sci U S A (1983) 4.68

A permease-oxidase complex involved in high-affinity iron uptake in yeast. Science (1996) 4.60

Degradation from the endoplasmic reticulum: disposing of newly synthesized proteins. Cell (1988) 4.42

A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains. Cell (1992) 4.39

Binding of a cytosolic protein to the iron-responsive element of human ferritin messenger RNA. Science (1988) 4.35

Novel interleukin-2 receptor subunit detected by cross-linking under high-affinity conditions. Science (1986) 4.30

Inhibition of transcription elongation by the VHL tumor suppressor protein. Science (1995) 4.23

ADP-ribosylation factor, a small GTP-binding protein, is required for binding of the coatomer protein beta-COP to Golgi membranes. Proc Natl Acad Sci U S A (1992) 4.22

Identification of the components of the murine T cell antigen receptor complex. Cell (1985) 4.20

Identification of the iron-responsive element for the translational regulation of human ferritin mRNA. Science (1987) 4.20

Brefeldin A, a drug that blocks secretion, prevents the assembly of non-clathrin-coated buds on Golgi cisternae. Cell (1991) 4.17

Dissociation of a 110-kD peripheral membrane protein from the Golgi apparatus is an early event in brefeldin A action. J Cell Biol (1990) 3.90

Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene. Proc Natl Acad Sci U S A (1996) 3.88

Molecular characterization of a copper transport protein in S. cerevisiae: an unexpected role for copper in iron transport. Cell (1994) 3.88

Overexpression of wild-type and mutant ARF1 and ARF6: distinct perturbations of nonoverlapping membrane compartments. J Cell Biol (1995) 3.82

The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins. Proc Natl Acad Sci U S A (1997) 3.75

Receptor-mediated endocytosis of transferrin in K562 cells. J Biol Chem (1983) 3.65

Failure to synthesize the T cell CD3-zeta chain: structure and function of a partial T cell receptor complex. Cell (1988) 3.59

Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex. Proc Natl Acad Sci U S A (1999) 3.43

Binding of ARF and beta-COP to Golgi membranes: possible regulation by a trimeric G protein. Science (1991) 3.33

Antigen activation of murine T cells induces tyrosine phosphorylation of a polypeptide associated with the T cell antigen receptor. Cell (1986) 3.30

Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice. Proc Natl Acad Sci U S A (1997) 3.27

Membrane protein association by potential intramembrane charge pairs. Nature (1991) 3.27

Lipid domains in membranes. Evidence derived from structural perturbations induced by free fatty acids and lifetime heterogeneity analysis. J Biol Chem (1980) 3.20

Brefeldin A implicates egress from endoplasmic reticulum in class I restricted antigen presentation. Nature (1989) 3.02

The cancer genome anatomy project: building an annotated gene index. Trends Genet (2000) 3.02

A cis-acting element is necessary and sufficient for translational regulation of human ferritin expression in response to iron. Proc Natl Acad Sci U S A (1987) 2.89

Ferric reductase of Saccharomyces cerevisiae: molecular characterization, role in iron uptake, and transcriptional control by iron. Proc Natl Acad Sci U S A (1992) 2.87

Genetic evidence that ferric reductase is required for iron uptake in Saccharomyces cerevisiae. Mol Cell Biol (1990) 2.83

cis-trans models for post-transcriptional gene regulation. Science (1989) 2.83

A cytosolic protein binds to structural elements within the iron regulatory region of the transferrin receptor mRNA. Proc Natl Acad Sci U S A (1989) 2.81

AFT1: a mediator of iron regulated transcriptional control in Saccharomyces cerevisiae. EMBO J (1995) 2.76

Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice. Nat Genet (2001) 2.76

Evidence that the pathway of transferrin receptor mRNA degradation involves an endonucleolytic cleavage within the 3' UTR and does not involve poly(A) tail shortening. EMBO J (1994) 2.70

Activation of T cells by a tyrosine kinase activation domain in the cytoplasmic tail of CD3 epsilon. Science (1992) 2.67

Pre-Golgi degradation of newly synthesized T-cell antigen receptor chains: intrinsic sensitivity and the role of subunit assembly. J Cell Biol (1989) 2.65

Molecular cloning of the von Hippel-Lindau tumor suppressor gene and its role in renal carcinoma. Biochim Biophys Acta (1996) 2.64

Iron-regulated DNA binding by the AFT1 protein controls the iron regulon in yeast. EMBO J (1996) 2.62

New opportunities for uncovering the molecular basis of cancer. Nat Genet (1997) 2.61

Building a multichain receptor: synthesis, degradation, and assembly of the T-cell antigen receptor. Proc Natl Acad Sci U S A (1987) 2.58

Molecular cloning of the zeta chain of the T cell antigen receptor. Science (1988) 2.58

The Saccharomyces cerevisiae copper transport protein (Ctr1p). Biochemical characterization, regulation by copper, and physiologic role in copper uptake. J Biol Chem (1994) 2.57

Iron regulation of transferrin receptor mRNA levels requires iron-responsive elements and a rapid turnover determinant in the 3' untranslated region of the mRNA. EMBO J (1989) 2.54

Fate of receptor and ligand during endocytosis of asialoglycoproteins by isolated hepatocytes. Proc Natl Acad Sci U S A (1982) 2.54

The Menkes/Wilson disease gene homologue in yeast provides copper to a ceruloplasmin-like oxidase required for iron uptake. Proc Natl Acad Sci U S A (1995) 2.50

T cell activation induces rapid tyrosine phosphorylation of a limited number of cellular substrates. J Biol Chem (1989) 2.50

Colocalized transmembrane determinants for ER degradation and subunit assembly explain the intracellular fate of TCR chains. Cell (1990) 2.49

Aluminum fluoride stimulates surface protrusions in cells overexpressing the ARF6 GTPase. J Cell Biol (1996) 2.47

Iron-sulfur clusters as biosensors of oxidants and iron. Trends Biochem Sci (1996) 2.46

A recycling pathway between the endoplasmic reticulum and the Golgi apparatus for retention of unassembled MHC class I molecules. Nature (1991) 2.45

Intracellular dissociation of receptor-bound asialoglycoproteins in cultured hepatocytes. A pH-mediated nonlysosomal event. J Biol Chem (1983) 2.45

Structural relationship between an iron-regulated RNA-binding protein (IRE-BP) and aconitase: functional implications. Cell (1991) 2.37

Selectivity of fluorescent lipid analogues for lipid domains. Biochemistry (1980) 2.35

Guanine nucleotides modulate the effects of brefeldin A in semipermeable cells: regulation of the association of a 110-kD peripheral membrane protein with the Golgi apparatus. J Cell Biol (1991) 2.33

T-cell and basophil activation through the cytoplasmic tail of T-cell-receptor zeta family proteins. Proc Natl Acad Sci U S A (1991) 2.32

A model for the structure and functions of iron-responsive elements. Gene (1988) 2.29

Regulation of interaction of the iron-responsive element binding protein with iron-responsive RNA elements. Mol Cell Biol (1989) 2.26

The concept of lipid domains in membranes. J Cell Biol (1982) 2.26

Cellular regulation of the iron-responsive element binding protein: disassembly of the cubane iron-sulfur cluster results in high-affinity RNA binding. Proc Natl Acad Sci U S A (1992) 2.17

A peptide sequence confers retention and rapid degradation in the endoplasmic reticulum. Science (1990) 2.17

ARF: a key regulatory switch in membrane traffic and organelle structure. Curr Opin Cell Biol (1994) 2.15

Family of disulphide-linked dimers containing the zeta and eta chains of the T-cell receptor and the gamma chain of Fc receptors. Nature (1990) 2.14

Only high-affinity receptors for interleukin 2 mediate internalization of ligand. Proc Natl Acad Sci U S A (1986) 2.12