A permease-oxidase complex involved in high-affinity iron uptake in yeast.

PubWeight™: 4.60‹?› | Rank: Top 1%

🔗 View Article (PMID 8599111)

Published in Science on March 15, 1996

Authors

R Stearman1, D S Yuan, Y Yamaguchi-Iwai, R D Klausner, A Dancis

Author Affiliations

1: Cell Biology and Metabolism Branch, National Institutes of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

Articles citing this

(truncated to the top 100)

Siderophore-based iron acquisition and pathogen control. Microbiol Mol Biol Rev (2007) 4.87

Forging a field: the golden age of iron biology. Blood (2008) 3.83

Three genomes from the phylum Acidobacteria provide insight into the lifestyles of these microorganisms in soils. Appl Environ Microbiol (2009) 2.75

Iron-regulated DNA binding by the AFT1 protein controls the iron regulon in yeast. EMBO J (1996) 2.62

Molecular control of vertebrate iron homeostasis by iron regulatory proteins. Biochim Biophys Acta (2006) 2.23

Essential role for mammalian copper transporter Ctr1 in copper homeostasis and embryonic development. Proc Natl Acad Sci U S A (2001) 2.19

Transcriptional remodeling in response to iron deprivation in Saccharomyces cerevisiae. Mol Biol Cell (2003) 2.18

Pathogenesis of mucormycosis. Clin Infect Dis (2012) 2.14

The role of iron-deficiency stress responses in stimulating heavy-metal transport in plants Plant Physiol (1998) 2.01

The yeast A kinases differentially regulate iron uptake and respiratory function. Proc Natl Acad Sci U S A (2000) 1.98

The siderophore iron transporter of Candida albicans (Sit1p/Arn1p) mediates uptake of ferrichrome-type siderophores and is required for epithelial invasion. Infect Immun (2002) 1.91

Metal-responsive transcription factors that regulate iron, zinc, and copper homeostasis in eukaryotic cells. Eukaryot Cell (2004) 1.90

Copper active sites in biology. Chem Rev (2014) 1.90

Role of the Fur regulon in iron transport in Bacillus subtilis. J Bacteriol (2006) 1.84

Acquisition, transport, and storage of iron by pathogenic fungi. Clin Microbiol Rev (1999) 1.83

Copper-dependent iron assimilation pathway in the model photosynthetic eukaryote Chlamydomonas reinhardtii. Eukaryot Cell (2002) 1.80

The yeast CLC chloride channel functions in cation homeostasis. Proc Natl Acad Sci U S A (1998) 1.73

The membrane protein FeoB contains an intramolecular G protein essential for Fe(II) uptake in bacteria. Proc Natl Acad Sci U S A (2002) 1.66

Grd19/Snx3p functions as a cargo-specific adapter for retromer-dependent endocytic recycling. J Cell Biol (2007) 1.65

Saccharomyces cerevisiae expresses three functionally distinct homologues of the nramp family of metal transporters. Mol Cell Biol (2000) 1.65

Iron source preference and regulation of iron uptake in Cryptococcus neoformans. PLoS Pathog (2008) 1.65

The copper-iron connection in biology: structure of the metallo-oxidase Fet3p. Proc Natl Acad Sci U S A (2005) 1.55

Identification of a functional homolog of the yeast copper homeostasis gene ATX1 from Arabidopsis. Plant Physiol (1998) 1.49

A transcription factor cascade involving Fep1 and the CCAAT-binding factor Php4 regulates gene expression in response to iron deficiency in the fission yeast Schizosaccharomyces pombe. Eukaryot Cell (2006) 1.48

Dre2, a conserved eukaryotic Fe/S cluster protein, functions in cytosolic Fe/S protein biogenesis. Mol Cell Biol (2008) 1.47

Copper stress affects iron homeostasis by destabilizing iron-sulfur cluster formation in Bacillus subtilis. J Bacteriol (2010) 1.40

Characterization of the Aspergillus nidulans transporters for the siderophores enterobactin and triacetylfusarinine C. Biochem J (2003) 1.39

Iron acquisition: a novel perspective on mucormycosis pathogenesis and treatment. Curr Opin Infect Dis (2008) 1.38

Direct activation of genes involved in intracellular iron use by the yeast iron-responsive transcription factor Aft2 without its paralog Aft1. Mol Cell Biol (2005) 1.37

The long history of iron in the Universe and in health and disease. Biochim Biophys Acta (2011) 1.33

Cloning and functional analysis of the pbr lead resistance determinant of Ralstonia metallidurans CH34. J Bacteriol (2001) 1.33

Oxidation of phenolate siderophores by the multicopper oxidase encoded by the Escherichia coli yacK gene. J Bacteriol (2001) 1.32

FEA1, FEA2, and FRE1, encoding two homologous secreted proteins and a candidate ferrireductase, are expressed coordinately with FOX1 and FTR1 in iron-deficient Chlamydomonas reinhardtii. Eukaryot Cell (2007) 1.30

Functional characterization of missense mutations in ATP7B: Wilson disease mutation or normal variant? Am J Hum Genet (1998) 1.29

Characterization of VPS41, a gene required for vacuolar trafficking and high-affinity iron transport in yeast. Proc Natl Acad Sci U S A (1997) 1.28

Ferrous iron uptake in Cryptococcus neoformans. Infect Immun (1998) 1.28

Iron metabolism in eukaryotes: Mars and Venus at it again. Science (1996) 1.27

Mechanism underlying the iron-dependent nuclear export of the iron-responsive transcription factor Aft1p in Saccharomyces cerevisiae. Mol Biol Cell (2007) 1.27

The high affinity iron permease is a key virulence factor required for Rhizopus oryzae pathogenesis. Mol Microbiol (2010) 1.27

Regulation of cation balance in Saccharomyces cerevisiae. Genetics (2013) 1.25

Role of iron in Nramp1-mediated inhibition of mycobacterial growth. Infect Immun (1999) 1.24

Evidence that translation reinitiation leads to a partially functional Menkes protein containing two copper-binding sites. Am J Hum Genet (2006) 1.23

Copper transporting P-type ATPases and human disease. J Bioenerg Biomembr (2002) 1.22

The involvement of a multicopper oxidase in iron uptake by the green algae Chlamydomonas reinhardtii. Plant Physiol (2002) 1.20

Ferrichrome induces endosome to plasma membrane cycling of the ferrichrome transporter, Arn1p, in Saccharomyces cerevisiae. EMBO J (2002) 1.18

Fep1 represses expression of the fission yeast Schizosaccharomyces pombe siderophore-iron transport system. Nucleic Acids Res (2003) 1.18

Manganese-induced trafficking and turnover of the cis-Golgi glycoprotein GPP130. Mol Biol Cell (2010) 1.16

Cell-cycle arrest and inhibition of G1 cyclin translation by iron in AFT1-1(up) yeast. EMBO J (1998) 1.15

Adaptation of Cryptococcus neoformans to mammalian hosts: integrated regulation of metabolism and virulence. Eukaryot Cell (2011) 1.14

Mislocalisation of hephaestin, a multicopper ferroxidase involved in basolateral intestinal iron transport, in the sex linked anaemia mouse. Gut (2004) 1.13

Transcriptional analysis of biofilm formation processes in the anaerobic, hyperthermophilic bacterium Thermotoga maritima. Appl Environ Microbiol (2004) 1.13

The distal GATA sequences of the sid1 promoter of Ustilago maydis mediate iron repression of siderophore production and interact directly with Urbs1, a GATA family transcription factor. EMBO J (1997) 1.13

Chloride is an allosteric effector of copper assembly for the yeast multicopper oxidase Fet3p: an unexpected role for intracellular chloride channels. Proc Natl Acad Sci U S A (1998) 1.10

Global transcriptional responses of fission and budding yeast to changes in copper and iron levels: a comparative study. Genome Biol (2007) 1.09

The Fe(II) permease Fet4p functions as a low affinity copper transporter and supports normal copper trafficking in Saccharomyces cerevisiae. Biochem J (2000) 1.08

Role of PUG1 in inducible porphyrin and heme transport in Saccharomyces cerevisiae. Eukaryot Cell (2008) 1.08

Redox cycling in iron uptake, efflux, and trafficking. J Biol Chem (2010) 1.08

Potential role for extracellular glutathione-dependent ferric reductase in utilization of environmental and host ferric compounds by Histoplasma capsulatum. Infect Immun (2001) 1.07

Genome-wide screen for genes with effects on distinct iron uptake activities in Saccharomyces cerevisiae. Genetics (2004) 1.07

Endoplasmic reticulum quality control of unassembled iron transporter depends on Rer1p-mediated retrieval from the golgi. Mol Biol Cell (2003) 1.07

The Ftr1p iron permease in the yeast plasma membrane: orientation, topology and structure-function relationships. Biochem J (2004) 1.05

Investigation of in vivo diferric tyrosyl radical formation in Saccharomyces cerevisiae Rnr2 protein: requirement of Rnr4 and contribution of Grx3/4 AND Dre2 proteins. J Biol Chem (2011) 1.03

Iron-induced dissociation of the Aft1p transcriptional regulator from target gene promoters is an initial event in iron-dependent gene suppression. Mol Cell Biol (2012) 1.03

A novel extracellular multicopper oxidase from Phanerochaete chrysosporium with ferroxidase activity. Appl Environ Microbiol (2003) 1.03

Regulation of freA, acoA, lysF, and cycA expression by iron availability in Aspergillus nidulans. Appl Environ Microbiol (2002) 1.01

The ins and outs of algal metal transport. Biochim Biophys Acta (2012) 1.00

Metal ion transporters in mammals: structure, function and pathological implications. J Physiol (1999) 0.99

GGA2- and ubiquitin-dependent trafficking of Arn1, the ferrichrome transporter of Saccharomyces cerevisiae. Mol Biol Cell (2007) 0.98

Transcript profiling reveals new insights into the acclimation of the mesophilic fresh-water cyanobacterium Synechococcus elongatus PCC 7942 to iron starvation. Plant Physiol (2008) 0.98

A ferroxidase encoded by FOX1 contributes to iron assimilation under conditions of poor iron nutrition in Chlamydomonas. Eukaryot Cell (2008) 0.97

Desketoneoenactin-siderophore conjugates for Candida: evidence of iron transport-dependent species selectivity. Antimicrob Agents Chemother (2005) 0.97

The mechanism of ferrichrome transport through Arn1p and its metabolism in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2003) 0.95

Brain iron homeostasis: from molecular mechanisms to clinical significance and therapeutic opportunities. Antioxid Redox Signal (2013) 0.94

Genetic and physiologic characterization of ferric/cupric reductase constitutive mutants of Cryptococcus neoformans. Infect Immun (1999) 0.94

Mössbauer and EPR study of iron in vacuoles from fermenting Saccharomyces cerevisiae. Biochemistry (2011) 0.93

A receptor domain controls the intracellular sorting of the ferrichrome transporter, ARN1. EMBO J (2005) 0.92

The homeostasis of iron, copper, and zinc in paracoccidioides brasiliensis, cryptococcus neoformans var. Grubii, and cryptococcus gattii: a comparative analysis. Front Microbiol (2011) 0.91

Genome-wide assessment of the carriers involved in the cellular uptake of drugs: a model system in yeast. BMC Biol (2011) 0.90

Structural fold, conservation and Fe(II) binding of the intracellular domain of prokaryote FeoB. J Struct Biol (2010) 0.90

Evolution of the ferric reductase domain (FRD) superfamily: modularity, functional diversification, and signature motifs. PLoS One (2013) 0.89

Genetic evidence for coenzyme Q requirement in plasma membrane electron transport. J Bioenerg Biomembr (1998) 0.88

Targeted suppression of the ferroxidase and iron trafficking activities of the multicopper oxidase Fet3p from Saccharomyces cerevisiae. J Biol Inorg Chem (2003) 0.88

The hFbpABC transporter from Haemophilus influenzae functions as a binding-protein-dependent ABC transporter with high specificity and affinity for ferric iron. J Bacteriol (2004) 0.88

Functional expression cloning and characterization of SFT, a stimulator of Fe transport. J Cell Biol (1997) 0.88

Trafficking of siderophore transporters in Saccharomyces cerevisiae and intracellular fate of ferrioxamine B conjugates. Traffic (2007) 0.88

Characterization of iron-binding motifs in Candida albicans high-affinity iron permease CaFtr1p by site-directed mutagenesis. Biochem J (2002) 0.88

MavN is a Legionella pneumophila vacuole-associated protein required for efficient iron acquisition during intracellular growth. Proc Natl Acad Sci U S A (2015) 0.86

Analysis of the high-affinity iron uptake system at the Chlamydomonas reinhardtii plasma membrane. Eukaryot Cell (2010) 0.86

abc3+ encodes an iron-regulated vacuolar ABC-type transporter in Schizosaccharomyces pombe. Eukaryot Cell (2009) 0.86

High-resolution genome-wide scan of genes, gene-networks and cellular systems impacting the yeast ionome. BMC Genomics (2012) 0.85

BqsR/BqsS constitute a two-component system that senses extracellular Fe(II) in Pseudomonas aeruginosa. J Bacteriol (2011) 0.85

Manganese (Mn) oxidation increases intracellular Mn in Pseudomonas putida GB-1. PLoS One (2013) 0.85

The lack of synchronization between iron uptake and cell growth leads to iron overload in Saccharomyces cerevisiae during post-exponential growth modes. Biochemistry (2013) 0.84

The yeast homolog of heme oxygenase-1 affords cellular antioxidant protection via the transcriptional regulation of known antioxidant genes. J Biol Chem (2010) 0.84

Characterization of a dipartite iron uptake system from uropathogenic Escherichia coli strain F11. J Biol Chem (2011) 0.84

Whole genome sequencing of penicillin-resistant Streptococcus pneumoniae reveals mutations in penicillin-binding proteins and in a putative iron permease. Genome Biol (2011) 0.84

Genome-wide array-CGH analysis reveals YRF1 gene copy number variation that modulates genetic stability in distillery yeasts. Oncotarget (2015) 0.83

Retracted Endocytosis and vacuolar degradation of the yeast cell surface glucose sensors Rgt2 and Snf3. J Biol Chem (2014) 0.83

Essential role of the iron-sulfur cluster binding domain of the primase regulatory subunit Pri2 in DNA replication initiation. Protein Cell (2015) 0.82

The Haemophilus influenzae hFbpABC Fe3+ transporter: analysis of the membrane permease and development of a gallium-based screen for mutants. J Bacteriol (2007) 0.82

Articles by these authors

Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: evidence for membrane cycling from Golgi to ER. Cell (1989) 13.41

Microtubule-dependent retrograde transport of proteins into the ER in the presence of brefeldin A suggests an ER recycling pathway. Cell (1990) 9.19

Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells. EMBO J (1998) 7.36

The mammalian gene collection. Science (1999) 7.19

Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death. EMBO J (1998) 6.65

Biosynthesis, cleavage, and degradation of the human immunodeficiency virus 1 envelope glycoprotein gp160. Proc Natl Acad Sci U S A (1988) 6.33

Brefeldin A's effects on endosomes, lysosomes, and the TGN suggest a general mechanism for regulating organelle structure and membrane traffic. Cell (1991) 6.30

Brefeldin A inhibits Golgi membrane-catalysed exchange of guanine nucleotide onto ARF protein. Nature (1992) 6.11

Receptor-mediated endocytosis of transferrin and the uptake of fe in K562 cells: identification of a nonlysosomal acidic compartment. Proc Natl Acad Sci U S A (1982) 5.74

Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor. Proc Natl Acad Sci U S A (1990) 5.35

Iron-responsive elements: regulatory RNA sequences that control mRNA levels and translation. Science (1988) 4.86

A systematic, high-resolution linkage of the cytogenetic and physical maps of the human genome. Nat Genet (2000) 4.78

Binding of apotransferrin to K562 cells: explanation of the transferrin cycle. Proc Natl Acad Sci U S A (1983) 4.68

Degradation from the endoplasmic reticulum: disposing of newly synthesized proteins. Cell (1988) 4.42

A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains. Cell (1992) 4.39

Binding of a cytosolic protein to the iron-responsive element of human ferritin messenger RNA. Science (1988) 4.35

Novel interleukin-2 receptor subunit detected by cross-linking under high-affinity conditions. Science (1986) 4.30

Inhibition of transcription elongation by the VHL tumor suppressor protein. Science (1995) 4.23

ADP-ribosylation factor, a small GTP-binding protein, is required for binding of the coatomer protein beta-COP to Golgi membranes. Proc Natl Acad Sci U S A (1992) 4.22

Identification of the components of the murine T cell antigen receptor complex. Cell (1985) 4.20

Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells. Mol Cell Biol (1999) 4.20

Identification of the iron-responsive element for the translational regulation of human ferritin mRNA. Science (1987) 4.20

Brefeldin A, a drug that blocks secretion, prevents the assembly of non-clathrin-coated buds on Golgi cisternae. Cell (1991) 4.17

Dissociation of a 110-kD peripheral membrane protein from the Golgi apparatus is an early event in brefeldin A action. J Cell Biol (1990) 3.90

Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene. Proc Natl Acad Sci U S A (1996) 3.88

Molecular characterization of a copper transport protein in S. cerevisiae: an unexpected role for copper in iron transport. Cell (1994) 3.88

Overexpression of wild-type and mutant ARF1 and ARF6: distinct perturbations of nonoverlapping membrane compartments. J Cell Biol (1995) 3.82

The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins. Proc Natl Acad Sci U S A (1997) 3.75

Receptor-mediated endocytosis of transferrin in K562 cells. J Biol Chem (1983) 3.65

Failure to synthesize the T cell CD3-zeta chain: structure and function of a partial T cell receptor complex. Cell (1988) 3.59

Oxidation-reduction and the molecular mechanism of a regulatory RNA-protein interaction. Science (1989) 3.54

Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex. Proc Natl Acad Sci U S A (1999) 3.43

Binding of ARF and beta-COP to Golgi membranes: possible regulation by a trimeric G protein. Science (1991) 3.33

Antigen activation of murine T cells induces tyrosine phosphorylation of a polypeptide associated with the T cell antigen receptor. Cell (1986) 3.30

Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice. Proc Natl Acad Sci U S A (1997) 3.27

Membrane protein association by potential intramembrane charge pairs. Nature (1991) 3.27

Reduced X-ray resistance and homologous recombination frequencies in a RAD54-/- mutant of the chicken DT40 cell line. Cell (1997) 3.23

Lipid domains in membranes. Evidence derived from structural perturbations induced by free fatty acids and lifetime heterogeneity analysis. J Biol Chem (1980) 3.20

The cancer genome anatomy project: building an annotated gene index. Trends Genet (2000) 3.02

Brefeldin A implicates egress from endoplasmic reticulum in class I restricted antigen presentation. Nature (1989) 3.02

A cis-acting element is necessary and sufficient for translational regulation of human ferritin expression in response to iron. Proc Natl Acad Sci U S A (1987) 2.89

Ferric reductase of Saccharomyces cerevisiae: molecular characterization, role in iron uptake, and transcriptional control by iron. Proc Natl Acad Sci U S A (1992) 2.87

Genetic evidence that ferric reductase is required for iron uptake in Saccharomyces cerevisiae. Mol Cell Biol (1990) 2.83

A cytosolic protein binds to structural elements within the iron regulatory region of the transferrin receptor mRNA. Proc Natl Acad Sci U S A (1989) 2.81

AFT1: a mediator of iron regulated transcriptional control in Saccharomyces cerevisiae. EMBO J (1995) 2.76

Evidence that the pathway of transferrin receptor mRNA degradation involves an endonucleolytic cleavage within the 3' UTR and does not involve poly(A) tail shortening. EMBO J (1994) 2.70

Isolation of PEBP2 alpha B cDNA representing the mouse homolog of human acute myeloid leukemia gene, AML1. Oncogene (1993) 2.67

Activation of T cells by a tyrosine kinase activation domain in the cytoplasmic tail of CD3 epsilon. Science (1992) 2.67

Pre-Golgi degradation of newly synthesized T-cell antigen receptor chains: intrinsic sensitivity and the role of subunit assembly. J Cell Biol (1989) 2.65

Molecular cloning of the von Hippel-Lindau tumor suppressor gene and its role in renal carcinoma. Biochim Biophys Acta (1996) 2.64

Iron-regulated DNA binding by the AFT1 protein controls the iron regulon in yeast. EMBO J (1996) 2.62

New opportunities for uncovering the molecular basis of cancer. Nat Genet (1997) 2.61

RESPONSIVE-TO-ANTAGONIST1, a Menkes/Wilson disease-related copper transporter, is required for ethylene signaling in Arabidopsis. Cell (1999) 2.60

Building a multichain receptor: synthesis, degradation, and assembly of the T-cell antigen receptor. Proc Natl Acad Sci U S A (1987) 2.58

Molecular cloning of the zeta chain of the T cell antigen receptor. Science (1988) 2.58

The Saccharomyces cerevisiae copper transport protein (Ctr1p). Biochemical characterization, regulation by copper, and physiologic role in copper uptake. J Biol Chem (1994) 2.57

Iron regulation of transferrin receptor mRNA levels requires iron-responsive elements and a rapid turnover determinant in the 3' untranslated region of the mRNA. EMBO J (1989) 2.54

Fate of receptor and ligand during endocytosis of asialoglycoproteins by isolated hepatocytes. Proc Natl Acad Sci U S A (1982) 2.54

The Menkes/Wilson disease gene homologue in yeast provides copper to a ceruloplasmin-like oxidase required for iron uptake. Proc Natl Acad Sci U S A (1995) 2.50

T cell activation induces rapid tyrosine phosphorylation of a limited number of cellular substrates. J Biol Chem (1989) 2.50

Colocalized transmembrane determinants for ER degradation and subunit assembly explain the intracellular fate of TCR chains. Cell (1990) 2.49

Aluminum fluoride stimulates surface protrusions in cells overexpressing the ARF6 GTPase. J Cell Biol (1996) 2.47

Iron-sulfur clusters as biosensors of oxidants and iron. Trends Biochem Sci (1996) 2.46

A recycling pathway between the endoplasmic reticulum and the Golgi apparatus for retention of unassembled MHC class I molecules. Nature (1991) 2.45

Intracellular dissociation of receptor-bound asialoglycoproteins in cultured hepatocytes. A pH-mediated nonlysosomal event. J Biol Chem (1983) 2.45

Structural relationship between an iron-regulated RNA-binding protein (IRE-BP) and aconitase: functional implications. Cell (1991) 2.37

Selectivity of fluorescent lipid analogues for lipid domains. Biochemistry (1980) 2.35

Guanine nucleotides modulate the effects of brefeldin A in semipermeable cells: regulation of the association of a 110-kD peripheral membrane protein with the Golgi apparatus. J Cell Biol (1991) 2.33

T-cell and basophil activation through the cytoplasmic tail of T-cell-receptor zeta family proteins. Proc Natl Acad Sci U S A (1991) 2.32

A model for the structure and functions of iron-responsive elements. Gene (1988) 2.29

Regulation of interaction of the iron-responsive element binding protein with iron-responsive RNA elements. Mol Cell Biol (1989) 2.26

The concept of lipid domains in membranes. J Cell Biol (1982) 2.26

A role for the Saccharomyces cerevisiae ATX1 gene in copper trafficking and iron transport. J Biol Chem (1997) 2.18

Cellular regulation of the iron-responsive element binding protein: disassembly of the cubane iron-sulfur cluster results in high-affinity RNA binding. Proc Natl Acad Sci U S A (1992) 2.17

A peptide sequence confers retention and rapid degradation in the endoplasmic reticulum. Science (1990) 2.17

ARF: a key regulatory switch in membrane traffic and organelle structure. Curr Opin Cell Biol (1994) 2.15

Family of disulphide-linked dimers containing the zeta and eta chains of the T-cell receptor and the gamma chain of Fc receptors. Nature (1990) 2.14

Only high-affinity receptors for interleukin 2 mediate internalization of ligand. Proc Natl Acad Sci U S A (1986) 2.12

Role of potentially charged transmembrane residues in targeting proteins for retention and degradation within the endoplasmic reticulum. EMBO J (1991) 2.08

Selective degradation of T cell antigen receptor chains retained in a pre-Golgi compartment. J Cell Biol (1988) 2.07

Reciprocal control of RNA-binding and aconitase activity in the regulation of the iron-responsive element binding protein: role of the iron-sulfur cluster. Proc Natl Acad Sci U S A (1992) 2.06

A brefeldin A-like phenotype is induced by the overexpression of a human ERD-2-like protein, ELP-1. Cell (1992) 2.06

Tyrosine kinases and tyrosine-based activation motifs. Current research on activation via the T cell antigen receptor. J Biol Chem (1992) 2.05

The T cell antigen receptor zeta chain is tyrosine phosphorylated upon activation. J Biol Chem (1988) 2.04

Rapid internalization of the transferrin receptor in K562 cells is triggered by ligand binding or treatment with a phorbol ester. Proc Natl Acad Sci U S A (1984) 2.04

Cloning of the cDNA encoding an RNA regulatory protein--the human iron-responsive element-binding protein. Proc Natl Acad Sci U S A (1990) 2.03

Yeast mitochondrial protein, Nfs1p, coordinately regulates iron-sulfur cluster proteins, cellular iron uptake, and iron distribution. J Biol Chem (1999) 1.98

Molecular cloning and chromosomal localization of the human T-cell receptor zeta chain: distinction from the molecular CD3 complex. Proc Natl Acad Sci U S A (1988) 1.95

The iron-responsive element binding protein: a method for the affinity purification of a regulatory RNA-binding protein. Proc Natl Acad Sci U S A (1989) 1.95

Copper-dependent degradation of the Saccharomyces cerevisiae plasma membrane copper transporter Ctr1p in the apparent absence of endocytosis. EMBO J (1996) 1.93

Regulating the retention of T-cell receptor alpha chain variants within the endoplasmic reticulum: Ca(2+)-dependent association with BiP. J Cell Biol (1991) 1.93

Translation and the stability of mRNAs encoding the transferrin receptor and c-fos. Proc Natl Acad Sci U S A (1991) 1.93