Divergent non-heme iron enzymes in the nogalamycin biosynthetic pathway.

Oxidative Cyclization in Natural Product Biosynthesis. Chem Rev (2016) 0.81

Dioxygen activation by nonheme iron enzymes with the 2-His-1-carboxylate facial triad that generate high-valent oxoiron oxidants. J Biol Inorg Chem (2017) 0.77

New insights into bacterial type II polyketide biosynthesis. F1000Res (2017) 0.75

PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr D Biol Crystallogr (2010) 108.52

Phaser crystallographic software. J Appl Crystallogr (2007) 108.34

One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. Proc Natl Acad Sci U S A (2000) 96.90

Features and development of Coot. Acta Crystallogr D Biol Crystallogr (2010) 89.46

Overview of the CCP4 suite and current developments. Acta Crystallogr D Biol Crystallogr (2011) 67.55

XDS. Acta Crystallogr D Biol Crystallogr (2010) 67.46

MolProbity: all-atom structure validation for macromolecular crystallography. Acta Crystallogr D Biol Crystallogr (2009) 53.36

Inference of macromolecular assemblies from crystalline state. J Mol Biol (2007) 44.95

REFMAC5 for the refinement of macromolecular crystal structures. Acta Crystallogr D Biol Crystallogr (2011) 39.32

Dali server: conservation mapping in 3D. Nucleic Acids Res (2010) 24.29

The integration of macromolecular diffraction data. Acta Crystallogr D Biol Crystallogr (2005) 19.21

A broad-host-range Flp-FRT recombination system for site-specific excision of chromosomally-located DNA sequences: application for isolation of unmarked Pseudomonas aeruginosa mutants. Gene (1998) 15.03

Targeting DNA topoisomerase II in cancer chemotherapy. Nat Rev Cancer (2009) 5.06

A predictably selective aliphatic C-H oxidation reaction for complex molecule synthesis. Science (2007) 3.94

The first direct characterization of a high-valent iron intermediate in the reaction of an alpha-ketoglutarate-dependent dioxygenase: a high-spin FeIV complex in taurine/alpha-ketoglutarate dioxygenase (TauD) from Escherichia coli. Biochemistry (2003) 3.62

The 2-His-1-carboxylate facial triad--an emerging structural motif in mononuclear non-heme iron(II) enzymes. Eur J Biochem (1997) 3.36

The anthracyclines: will we ever find a better doxorubicin? Semin Oncol (1992) 3.28

Crystal structure of the non-haem iron halogenase SyrB2 in syringomycin biosynthesis. Nature (2006) 2.52

"Conditional Restraints": Restraining the Free Atoms in ARP/wARP. Structure (2009) 1.98

Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase. Nat Struct Biol (2000) 1.94

Streptomyces albus G mutants defective in the SalGI restriction-modification system. J Gen Microbiol (1980) 1.84

Regio- and stereodivergent antibiotic oxidative carbocyclizations catalysed by Rieske oxygenase-like enzymes. Nat Chem (2011) 1.82

Discovery of a two-component monooxygenase SnoaW/SnoaL2 involved in nogalamycin biosynthesis. Chem Biol (2012) 1.45

Free radical formation by antitumor quinones. Free Radic Biol Med (1989) 1.44

Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin. Nat Commun (2013) 1.31

Structure of human phytanoyl-CoA 2-hydroxylase identifies molecular mechanisms of Refsum disease. J Biol Chem (2005) 1.29

Molecular cloning and characterization of CYP80G2, a cytochrome P450 that catalyzes an intramolecular C-C phenol coupling of (S)-reticuline in magnoflorine biosynthesis, from cultured Coptis japonica cells. J Biol Chem (2008) 1.21

Role of the jelly-roll fold in substrate binding by 2-oxoglutarate oxygenases. Curr Opin Struct Biol (2012) 1.18

Mammalian cytochrome P450 enzymes catalyze the phenol-coupling step in endogenous morphine biosynthesis. J Biol Chem (2009) 1.08

Molecular pharmacology of the interaction of anthracyclines with iron. Mol Pharmacol (2005) 1.08

Crystal structure of the polyketide cyclase AknH with bound substrate and product analogue: implications for catalytic mechanism and product stereoselectivity. J Mol Biol (2006) 1.02

Mechanism of the C5 stereoinversion reaction in the biosynthesis of carbapenem antibiotics. Science (2014) 0.91

Identification of late-stage glycosylation steps in the biosynthetic pathway of the anthracycline nogalamycin. Chembiochem (2011) 0.87

Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamily. Proc Natl Acad Sci U S A (2015) 0.82

The enzymology of doxorubicin quinone reduction in tumour tissue. Biochem Pharmacol (1992) 0.81

Improved antitumor activity by modification of nogalamycin. J Nat Prod (1980) 0.80

Manganese triazacyclononane oxidation catalysts grafted under reaction conditions on solid cocatalytic supports. J Am Chem Soc (2011) 0.80

Crystal structure of the ectoine hydroxylase, a snapshot of the active site. J Biol Chem (2014) 0.80

A phase II study of menogaril (7R-O-methylnogarol) in patients with relapsed/refractory acute myeloid leukemia: a study of the Eastern Cooperative Oncology Group. Leukemia (1995) 0.76

The biochemical pharmacology of nogalamycin and its derivatives. Pharmacol Ther (1991) 0.76