Published in N Engl J Med on June 01, 1989
Effects of primer-template mismatches on the polymerase chain reaction: human immunodeficiency virus type 1 model studies. Nucleic Acids Res (1990) 9.28
Pathogenesis of human immunodeficiency virus infection. Microbiol Rev (1993) 5.88
Diagnosis of Chlamydia trachomatis cervical infection by detection of amplified DNA with an enzyme immunoassay. J Clin Microbiol (1990) 3.80
Intravaginal inoculation of rhesus macaques with cell-free simian immunodeficiency virus results in persistent or transient viremia. J Virol (1994) 3.05
Simple, sensitive, and specific detection of human immunodeficiency virus type 1 in clinical specimens by polymerase chain reaction with nested primers. J Clin Microbiol (1990) 2.71
Longitudinal predictors of reductions in unprotected anal intercourse among gay men in San Francisco: the AIDS Behavioral Research Project. Am J Public Health (1990) 2.22
Use of dried blood spot specimens in the detection of human immunodeficiency virus type 1 by the polymerase chain reaction. J Clin Microbiol (1991) 2.05
The multicenter AIDS Cohort Study, 1983 to …. Public Health (2011) 1.93
The response of general surgeons to HIV in England and Wales. Ann R Coll Surg Engl (1990) 1.89
Human immunodeficiency virus (HIV) nef-specific cytotoxic T lymphocytes in noninfected heterosexual contact of HIV-infected patients. J Clin Invest (1994) 1.75
Comparison of three nonradioisotopic polymerase chain reaction-based methods for detection of human immunodeficiency virus type 1. J Clin Microbiol (1992) 1.62
Biological significance of soluble IL-2 receptor. Mediators Inflamm (1993) 1.33
Sensitive microculture method for isolation of human immunodeficiency virus type 1 from blood leukocytes. J Clin Microbiol (1992) 1.29
Activation of infectious virus from latent human immunodeficiency virus infection of monocytes in vivo. J Clin Invest (1992) 1.29
Persistence of extraordinarily low levels of genetically homogeneous human immunodeficiency virus type 1 in exposed seronegative individuals. J Virol (2003) 1.28
Quantitation of human immunodeficiency virus DNA by using the polymerase chain reaction. J Clin Microbiol (1990) 1.25
Detection of human immunodeficiency virus type 1 DNA by polymerase chain reaction amplification and capture hybridization in microtiter wells. J Clin Microbiol (1991) 1.23
Microplate-based DNA hybridization assays for detection of human retroviral gene sequences. J Clin Microbiol (1994) 1.18
Systems biology of the vervet monkey. ILAR J (2013) 1.07
Polyclonal B-cell activation reveals antibodies against human immunodeficiency virus type 1 (HIV-1) in HIV-1-seronegative individuals. Proc Natl Acad Sci U S A (1990) 1.01
Detection of feline immunodeficiency virus (FIV) nucleic acids in FIV-seronegative cats. J Virol (1992) 1.01
Infection and infectious diseases. Postgrad Med J (1990) 0.96
Outcomes of a National Institute of Allergy and Infectious Diseases Workshop on understanding HIV-exposed but seronegative individuals. AIDS Res Hum Retroviruses (2011) 0.93
Productive human immunodeficiency virus infection levels correlate with AIDS-related manifestations in the patient. Proc Natl Acad Sci U S A (1990) 0.93
CD4+ lymphocytopenia due to common variable immunodeficiency mimicking AIDS. J Clin Pathol (1994) 0.92
Retroviral infections transmitted by blood transfusion. Yale J Biol Med (1991) 0.88
Low levels of human immunodeficiency virus type 1 DNA in high-risk seronegative men. J Virol (2005) 0.86
Mucosal immunology of HIV infection. Immunol Rev (2013) 0.86
Sensitive and specific target sequences selected from retrotransposons of Schistosoma japonicum for the diagnosis of schistosomiasis. PLoS Negl Trop Dis (2012) 0.84
HIV transmission to patients with hemophilia by heat-treated, donor-screened factor concentrate. CMAJ (1990) 0.83
Elevated levels of CD4 antigen in sera of human immunodeficiency virus-infected populations. J Clin Microbiol (1990) 0.83
The donation and sale of blood by intravenous drug users. Am J Public Health (1991) 0.83
Syphilis superinfection activates expression of human immunodeficiency virus I in latently infected rabbits. Am J Pathol (1991) 0.82
Regulatory variation in HIV-1 dependency factor ZNRD1 associates with host resistance to HIV-1 acquisition. J Infect Dis (2014) 0.81
Lesbian health care. What a primary care physician needs to know. West J Med (1995) 0.80
Genetic correlates influencing immunopathogenesis of HIV infection. Indian J Med Res (2011) 0.80
New FDA drug approval policies and HIV vaccine development. Am J Public Health (1990) 0.80
Detection of human immunodeficiency virus type 1 proviral DNA by PCR using an electrochemiluminescence-tagged probe. J Clin Microbiol (1995) 0.79
The ethics of screening for early intervention in HIV disease. Am J Public Health (1989) 0.78
Mucosal correlates of protection in HIV-1-exposed sero-negative persons. Am J Reprod Immunol (2014) 0.78
Topographic and quantitative display of integrated human immunodeficiency virus-1 provirus DNA in human lymph nodes by real-time polymerase chain reaction. J Mol Diagn (2005) 0.77
Absence of reproducibly detectable low-level HIV viremia in highly exposed seronegative men and women. AIDS (2011) 0.77
The search for protection against HIV infection. Ann Epidemiol (2009) 0.77
Detection of HIV genome in HIV antibody negative men. Genitourin Med (1989) 0.77
Serodeconversion of HIV antibody-positive AIDS patients following treatment with V-1 Immunitor. J Biomed Biotechnol (2008) 0.75
Guidelines on HIV infection. BMJ (1989) 0.75
Recombinant DNA and surgery. Ann Surg (1990) 0.75
Direct detection of proviral gag segment of human immunodeficiency virus in peripheral blood lymphocytes by colorimetric PCR assay as a clinical laboratory tool applied to different at-risk populations. J Clin Microbiol (1995) 0.75
Transfusion transmitted viral infections--recent developments in blood donor screening. Postgrad Med J (1990) 0.75
'Imported' sexually transmitted diseases. Can Fam Physician (1990) 0.75
P24 antigen detection, viral isolation, DNA-PCR and in vitro antibody production for the diagnosis of HIV-1 latent infection in heterosexual women at high risk for HIV-1 infection. Genitourin Med (1995) 0.75
Idiopathic CD4+ T-lymphocytopenia in two patients. CMAJ (1993) 0.75
Fever, thrombocytopenia, and diarrhoea. Postgrad Med J (1998) 0.75
Use of lithium in maintaining T-cell functions in persons with documented acquired immunodeficiency syndrome. J Natl Med Assoc (1992) 0.75
Counseling patients seropositive for human immunodeficiency virus. An approach for medical practice. West J Med (1990) 0.75
Transmission of hepatitis and AIDS: risks for the anaesthetist and the patient. Can J Anaesth (1991) 0.75
Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters. J Biol Chem (1982) 16.71
New use of BCG for recombinant vaccines. Nature (1991) 14.40
DNA amplification for direct detection of HIV-1 in DNA of peripheral blood mononuclear cells. Science (1988) 13.46
The role of a mutant CCR5 allele in HIV-1 transmission and disease progression. Nat Med (1996) 10.62
Recent advances in the polymerase chain reaction. Science (1991) 9.98
Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage. J Infect Dis (1999) 9.81
Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia. Nature (2000) 9.80
Temporal fluctuations in HIV quasispecies in vivo are not reflected by sequential HIV isolations. Cell (1989) 9.66
Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell (1994) 9.48
Effects of primer-template mismatches on the polymerase chain reaction: human immunodeficiency virus type 1 model studies. Nucleic Acids Res (1990) 9.28
Rapid and simple PCR assay for quantitation of human immunodeficiency virus type 1 RNA in plasma: application to acute retroviral infection. J Clin Microbiol (1994) 6.76
Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells. Nat Cell Biol (2001) 6.43
HIV-1 isolates are rapidly evolving quasispecies: evidence for viral mixtures and preferred nucleotide substitutions. J Acquir Immune Defic Syndr (1989) 6.16
A general statistical analysis for fMRI data. Neuroimage (2002) 5.92
Cellular targets of infection and route of viral dissemination after an intravaginal inoculation of simian immunodeficiency virus into rhesus macaques. J Exp Med (1996) 5.35
Identification of human immunodeficiency virus sequences by using in vitro enzymatic amplification and oligomer cleavage detection. J Virol (1987) 5.27
Persistence of HIV-1 transcription in peripheral-blood mononuclear cells in patients receiving potent antiretroviral therapy. N Engl J Med (1999) 5.18
Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin. Nature (1994) 5.12
Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposure. Nat Med (1996) 4.57
pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes. Genes Dev (1997) 4.36
The effects of frequent nocturnal home hemodialysis: the Frequent Hemodialysis Network Nocturnal Trial. Kidney Int (2011) 4.27
Cloning and expression of multiple protein kinase C cDNAs. Cell (1986) 4.23
Regulation of protein kinase C zeta by PI 3-kinase and PDK-1. Curr Biol (1998) 4.13
Rapid detection of herpes-simplex-virus DNA in cerebrospinal fluid of patients with herpes simplex encephalitis. Lancet (1990) 4.12
Cloning and endonuclease mapping of the hepatitis B viral genome. Nature (1979) 3.62
Shared role of the pRB-related p130 and p107 proteins in limb development. Genes Dev (1996) 3.61
AIDS--an immunologic reevaluation. N Engl J Med (1984) 3.53
Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937. Genes Dev (1996) 3.49
The acquired immunodeficiency syndrome. Ann Intern Med (1983) 3.49
Ablation of the CDK inhibitor p57Kip2 results in increased apoptosis and delayed differentiation during mouse development. Genes Dev (1997) 3.45
Cell-mediated immune response to human immunodeficiency virus (HIV) type 1 in seronegative homosexual men with recent sexual exposure to HIV-1. J Infect Dis (1992) 3.27
A sperm cytoskeletal protein that signals oocyte meiotic maturation and ovulation. Science (2001) 3.26
Preventing ventricular fibrillation by flattening cardiac restitution. Proc Natl Acad Sci U S A (2000) 3.15
A chemokine receptor CCR2 allele delays HIV-1 disease progression and is associated with a CCR5 promoter mutation. Nat Med (1998) 3.15
Immunoglobulin changes in disease: quantitation on the basis of heavy polypeptide chains, IgG (gammaG), IgA (gammaA), and IgM (gammaM), and of light polypeptide chains, type K (I) and type L (II). J Clin Invest (1965) 3.00
Enzymatic amplification of HTLV-I viral sequences from peripheral blood mononuclear cells and infected tissues. Blood (1988) 2.98
The genetic structure of natural populations of Drosophila melanogaster. IV. Heterozygous effects of radiation-induced mutations on viability in various genetic backgrounds. Genetics (1966) 2.95
Microsomal triglyceride transfer protein expression during mouse development. J Lipid Res (2000) 2.90
Enzymatic gene amplification: qualitative and quantitative methods for detecting proviral DNA amplified in vitro. J Infect Dis (1988) 2.90
Supramolecular assembly and acid resistance of Helicobacter pylori urease. Nat Struct Biol (2001) 2.83
Nerve sprouting and sudden cardiac death. Circ Res (2000) 2.80
Macrophage tropism of human immunodeficiency virus type 1 isolates from brain and lymphoid tissues predicts neurotropism independent of coreceptor specificity. J Virol (2001) 2.79
Effect of roxithromycin on airway responsiveness in children with bronchiectasis: a double-blind, placebo-controlled study. Eur Respir J (1997) 2.78
Limited periods of gene expression in immunoglobulin-synthesizing cells. Science (1969) 2.77
Maintaining the integrity of human immunodeficiency virus sequence databases. J Virol (1996) 2.68
Development of calibrated viral load standards for group M subtypes of human immunodeficiency virus type 1 and performance of an improved AMPLICOR HIV-1 MONITOR test with isolates of diverse subtypes. J Clin Microbiol (1999) 2.68
Human papillomavirus type 16 and 18 gene expression in cervical neoplasias. Hum Pathol (1992) 2.67
Pituitary apoplexy: its incidence and clinical significance. J Neurosurg (1981) 2.65
Immunological and virological analyses of persons infected by human immunodeficiency virus type 1 while participating in trials of recombinant gp120 subunit vaccines. J Virol (1998) 2.63
p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein. Proc Natl Acad Sci U S A (1994) 2.63
Primary intracranial germ cell tumors: a clinical analysis of 153 histologically verified cases. J Neurosurg (1997) 2.60
Quantitative changes in T helper or T suppressor/cytotoxic lymphocyte subsets that distinguish acquired immune deficiency syndrome from other immune subset disorders. Am J Med (1984) 2.60
Human papillomavirus types 6 and 11 mRNAs from genital condylomata acuminata. J Virol (1987) 2.57
Mixed human immunodeficiency virus (HIV) infection in an individual: demonstration of both HIV type 1 and type 2 proviral sequences by using polymerase chain reaction. J Infect Dis (1988) 2.56
Thalidomide for the treatment of oral aphthous ulcers in patients with human immunodeficiency virus infection. National Institute of Allergy and Infectious Diseases AIDS Clinical Trials Group. N Engl J Med (1997) 2.55
PC-1 nucleoside triphosphate pyrophosphohydrolase deficiency in idiopathic infantile arterial calcification. Am J Pathol (2001) 2.52
Relation between sexual practices and T-cell subsets in homosexually active men. Lancet (1983) 2.46
Human immunodeficiency virus type 1 (HIV-1) infection a median of 18 months before a diagnostic western blot. Evidence from a cohort of homosexual men. Ann Intern Med (1989) 2.44
Accelerated course of human immunodeficiency virus infection in gay men who conceal their homosexual identity. Psychosom Med (1996) 2.40
Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue. Cell Regul (1991) 2.38
Malignant melanoma. Effects of an early structured psychiatric intervention, coping, and affective state on recurrence and survival 6 years later. Arch Gen Psychiatry (1993) 2.38
High-affinity receptor-mediated internalization and degradation of interleukin 2 in human T cells. J Exp Med (1986) 2.37
Detection of hepatitis B virus sequences in serum by using in vitro enzymatic amplification. J Virol Methods (1988) 2.36
THE METABOLISM OF NORMAL PLASMA PROTEINS AND GAMMA-MYELOMA PROTEIN IN MICE BEARING PLASMA-CELL TUMORS. J Clin Invest (1961) 2.32
HTLV-I-induced lymphoma mimicking Hodgkin's disease. Diagnosis by polymerase chain reaction amplification of specific HTLV-I sequences in tumor DNA. Blood (1988) 2.30
Induction of IL-6 (B cell stimulatory factor-2/IFN-beta 2) production by HIV. J Immunol (1989) 2.27
Selective vulnerability in the gerbil hippocampus following transient ischemia. Acta Neuropathol (1984) 2.27
Use of in vivo complementation in Mycobacterium tuberculosis to identify a genomic fragment associated with virulence. Infect Immun (1994) 2.26
Detection of human T-cell lymphoma/leukemia virus type I DNA and antigen in spinal fluid and blood of patients with chronic progressive myelopathy. N Engl J Med (1988) 2.25
Randomized comparison of ultrasonic vs clamp transection of the liver. Arch Surg (2001) 2.25
Genetic restriction of HIV-1 pathogenesis to AIDS by promoter alleles of IL10. Proc Natl Acad Sci U S A (2000) 2.24
Dynamics of intramural and transmural reentry during ventricular fibrillation in isolated swine ventricles. Circ Res (2001) 2.24
Detection of ras gene mutations in pancreatic juice and peripheral blood of patients with pancreatic adenocarcinoma. Cancer Res (1993) 2.22
Long-term outcome of patients with asystole induced by head-up tilt test. Eur Heart J (2002) 2.21
Loss of human immunodeficiency virus type 1 (HIV-1) antibodies with evidence of viral infection in asymptomatic homosexual men. A report from the Multicenter AIDS Cohort Study. Ann Intern Med (1988) 2.18
Bleeding Dieulafoy's lesions and the choice of endoscopic method: comparing the hemostatic efficacy of mechanical and injection methods. Gastrointest Endosc (2000) 2.16
Multicenter evaluation of quantification methods for plasma human immunodeficiency virus type 1 RNA. J Infect Dis (1994) 2.15
Variables that affect assays for plasma cytokines and soluble activation markers. Clin Diagn Lab Immunol (1999) 2.15
Prospective comparison of laparoscopic and conventional anterior resection. Br J Surg (1993) 2.15
Human immunodeficiency virus type 1 genetic evolution in children with different rates of development of disease. J Virol (1997) 2.11
Infection with the human immunodeficiency virus (HIV) is associated with an in vivo increase in B lymphocyte activation and immaturity. J Immunol (1987) 2.11
Reduction of HIV-1 in blood and lymph nodes following potent antiretroviral therapy and the virologic correlates of treatment failure. Proc Natl Acad Sci U S A (1997) 2.11
Antibodies and immunoglobulins. II. Normal development and changes in disease. JAMA (1965) 2.10
CD4 percentage, CD4 number, and CD4:CD8 ratio in HIV infection: which to choose and how to use. J Acquir Immune Defic Syndr (1989) 2.10
The immunoglobulins of mice. VI. Response to immunization. J Immunol (1965) 2.08
Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively. Am J Hum Genet (2001) 2.08
Detection of HIV-1 DNA and messenger RNA in individual cells by PCR-driven in situ hybridization and flow cytometry. Science (1993) 2.07
The use of terminal blocking groups for the specific joining of oligonucleotides in RNA ligase reactions containing equimolar concentrations of acceptor and donor molecules. Nucleic Acids Res (1976) 2.03
Synergistic functions of phorbol ester and calcium in serotonin release from human platelets. Biochem Biophys Res Commun (1983) 2.03