Integrative analysis of miRNA and gene expression reveals regulatory networks in tamoxifen-resistant breast cancer.

PubWeight™: 0.77‹?›

🔗 View Article (PMID 27528030)

Published in Oncotarget on August 30, 2016

Authors

Tejal Joshi1,2, Daniel Elias1,3, Jan Stenvang1,4, Carla L Alves1,3, Fei Teng1,5, Maria B Lyng1,3, Anne E Lykkesfeldt1,6, Nils Brünner1,4, Jun Wang1,5, Ramneek Gupta1,2, Christopher T Workman2, Henrik J Ditzel1,3,7

Author Affiliations

1: Sino-Danish Breast Cancer Research Centre, University of Copenhagen, Copenhagen, Denmark.
2: Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Kongens Lyngby, Denmark.
3: Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
4: Section of Molecular Disease Biology, Department of Veterinary Disease Biology, University of Copenhagen, Copenhagen, Denmark.
5: BGI (Beijing Genomics Institute), Beishan Industrial Zone, Shenzhen, China.
6: Breast Cancer Group, Cell Death and Metabolism, Danish Cancer Society Research Center, Copenhagen, Denmark.
7: Department of Oncology, Odense University Hospital, Odense, Denmark.

Articles cited by this

Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics (2003) 100.88

Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell (2005) 96.87

Differential expression analysis for sequence count data. Genome Biol (2010) 64.56

Combinatorial microRNA target predictions. Nat Genet (2005) 50.48

Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med (2012) 44.56

Most mammalian mRNAs are conserved targets of microRNAs. Genome Res (2008) 37.16

Human MicroRNA targets. PLoS Biol (2004) 34.51

affy--analysis of Affymetrix GeneChip data at the probe level. Bioinformatics (2004) 32.08

Widespread changes in protein synthesis induced by microRNAs. Nature (2008) 31.44

ROCR: visualizing classifier performance in R. Bioinformatics (2005) 19.60

A pattern-based method for the identification of MicroRNA binding sites and their corresponding heteroduplexes. Cell (2006) 14.70

Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials. Lancet (2011) 10.62

miRWalk--database: prediction of possible miRNA binding sites by "walking" the genes of three genomes. J Biomed Inform (2011) 8.50

A new non-linear normalization method for reducing variability in DNA microarray experiments. Genome Biol (2002) 7.12

microRNA target predictions across seven Drosophila species and comparison to mammalian targets. PLoS Comput Biol (2005) 6.77

BIC and miR-155 are highly expressed in Hodgkin, primary mediastinal and diffuse large B cell lymphomas. J Pathol (2005) 6.57

Biological determinants of endocrine resistance in breast cancer. Nat Rev Cancer (2009) 5.89

miRDB: a microRNA target prediction and functional annotation database with a wiki interface. RNA (2008) 5.48

MicroRNA-221/222 confers tamoxifen resistance in breast cancer by targeting p27Kip1. J Biol Chem (2008) 4.56

ESR1 ligand-binding domain mutations in hormone-resistant breast cancer. Nat Genet (2013) 4.03

Activating ESR1 mutations in hormone-resistant metastatic breast cancer. Nat Genet (2013) 3.96

Retracted MicroRNA-221/222 negatively regulates estrogen receptor alpha and is associated with tamoxifen resistance in breast cancer. J Biol Chem (2008) 3.63

Tamoxifen resistance in breast tumors is driven by growth factor receptor signaling with repression of classic estrogen receptor genomic function. Cancer Res (2008) 3.32

Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions. Mol Endocrinol (1994) 2.62

SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein. Mol Cell (1999) 2.52

The estrogen receptor-alpha-induced microRNA signature regulates itself and its transcriptional response. Proc Natl Acad Sci U S A (2009) 2.29

Changes in estrogen receptor, progesterone receptor, and pS2 expression in tamoxifen-resistant human breast cancer. Cancer Res (1995) 2.05

miR-22 inhibits estrogen signaling by directly targeting the estrogen receptor alpha mRNA. Mol Cell Biol (2009) 1.70

Epigenetic information and estrogen receptor alpha expression in breast cancer. Oncologist (2006) 1.70

Re-expression of microRNA-375 reverses both tamoxifen resistance and accompanying EMT-like properties in breast cancer. Oncogene (2012) 1.62

Tamoxifen downregulation of miR-451 increases 14-3-3ζ and promotes breast cancer cell survival and endocrine resistance. Oncogene (2011) 1.51

Downregulation of miR-342 is associated with tamoxifen resistant breast tumors. Mol Cancer (2010) 1.46

MicroRNA-135a contributes to the development of portal vein tumor thrombus by promoting metastasis in hepatocellular carcinoma. J Hepatol (2011) 1.37

Measurement of steroid hormone receptors in breast cancer patients on tamoxifen. Breast Cancer Res Treat (1993) 1.36

FOXM1 is a transcriptional target of ERalpha and has a critical role in breast cancer endocrine sensitivity and resistance. Oncogene (2010) 1.34

Anti-microRNA-222 (anti-miR-222) and -181B suppress growth of tamoxifen-resistant xenografts in mouse by targeting TIMP3 protein and modulating mitogenic signal. J Biol Chem (2011) 1.24

Altered expression of estrogen-regulated genes in a tamoxifen-resistant and ICI 164,384 and ICI 182,780 sensitive human breast cancer cell line, MCF-7/TAMR-1. Cancer Res (1994) 1.24

Global microRNA expression profiling of high-risk ER+ breast cancers from patients receiving adjuvant tamoxifen mono-therapy: a DBCG study. PLoS One (2012) 1.11

Estrogen receptor α is the major driving factor for growth in tamoxifen-resistant breast cancer and supported by HER/ERK signaling. Breast Cancer Res Treat (2013) 1.10

Reversal of endocrine resistance in breast cancer: interrelationships among 14-3-3ζ, FOXM1, and a gene signature associated with mitosis. Breast Cancer Res (2011) 1.10

14-3-3gamma induces oncogenic transformation by stimulating MAP kinase and PI3K signaling. PLoS One (2010) 1.02

Gene expression profiling identifies FYN as an important molecule in tamoxifen resistance and a predictor of early recurrence in patients treated with endocrine therapy. Oncogene (2014) 1.00

Effect of estrogen and antiestrogen on the human breast cancer cell line MCF-7 adapted to growth at low serum concentration. Cancer Res (1984) 0.96

Enhancing Endocrine Therapy for Hormone Receptor-Positive Advanced Breast Cancer: Cotargeting Signaling Pathways. J Natl Cancer Inst (2015) 0.95

Integrative analyses of gene expression and DNA methylation profiles in breast cancer cell line models of tamoxifen-resistance indicate a potential role of cells with stem-like properties. Breast Cancer Res (2013) 0.94

Indirect mechanism of oestradiol stimulation of cell proliferation of human breast cancer cell lines. Br J Cancer (1986) 0.94

Dual targeting of EphA2 and ER restores tamoxifen sensitivity in ER/EphA2-positive breast cancer. Breast Cancer Res Treat (2010) 0.87

The C/EBPδ protein is stabilized by estrogen receptor α activity, inhibits SNAI2 expression and associates with good prognosis in breast cancer. Oncogene (2016) 0.76