Human MicroRNA targets.

MicroRNAs: target recognition and regulatory functions. Cell (2009) 92.17

Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes. Genome Res (2005) 44.08

miRBase: tools for microRNA genomics. Nucleic Acids Res (2007) 38.61

MicroRNA targeting specificity in mammals: determinants beyond seed pairing. Mol Cell (2007) 38.42

The impact of microRNAs on protein output. Nature (2008) 32.39

Principles of microRNA-target recognition. PLoS Biol (2005) 23.70

NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci U S A (2006) 21.58

miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci U S A (2005) 21.51

The microRNA.org resource: targets and expression. Nucleic Acids Res (2007) 16.26

Accumulation of miR-155 and BIC RNA in human B cell lymphomas. Proc Natl Acad Sci U S A (2005) 12.96

Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. Genome Res (2008) 10.18

MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc Natl Acad Sci U S A (2007) 9.82

Genome-wide association study identifies five new schizophrenia loci. Nat Genet (2011) 9.07

miRecords: an integrated resource for microRNA-target interactions. Nucleic Acids Res (2008) 8.97

The role of microRNA genes in papillary thyroid carcinoma. Proc Natl Acad Sci U S A (2005) 8.60

A MicroRNA feedback circuit in midbrain dopamine neurons. Science (2007) 8.33

microRNAs exhibit high frequency genomic alterations in human cancer. Proc Natl Acad Sci U S A (2006) 8.24

Characterization of microRNA expression profiles in normal human tissues. BMC Genomics (2007) 8.01

Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer. Science (2008) 7.59

Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster. Nat Genet (2006) 7.53

RNAhybrid: microRNA target prediction easy, fast and flexible. Nucleic Acids Res (2006) 7.39

High-throughput sequencing of Arabidopsis microRNAs: evidence for frequent birth and death of MIRNA genes. PLoS One (2007) 7.34

Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites. Genome Biol (2010) 7.15

Cell-type-specific signatures of microRNAs on target mRNA expression. Proc Natl Acad Sci U S A (2006) 7.11

mir-29 regulates Mcl-1 protein expression and apoptosis. Oncogene (2007) 7.02

microRNA target predictions across seven Drosophila species and comparison to mammalian targets. PLoS Comput Biol (2005) 6.77

Specific microRNAs modulate embryonic stem cell-derived neurogenesis. Stem Cells (2005) 6.72

A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis. Proc Natl Acad Sci U S A (2005) 6.61

Determinants of targeting by endogenous and exogenous microRNAs and siRNAs. RNA (2007) 6.44

Transcripts targeted by the microRNA-16 family cooperatively regulate cell cycle progression. Mol Cell Biol (2007) 6.43

MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype. Genome Biol (2007) 6.41

Inference of miRNA targets using evolutionary conservation and pathway analysis. BMC Bioinformatics (2007) 6.21

MicroRNA-mediated feedback and feedforward loops are recurrent network motifs in mammals. Mol Cell (2007) 5.67

SNPinfo: integrating GWAS and candidate gene information into functional SNP selection for genetic association studies. Nucleic Acids Res (2009) 5.40

MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators. Mol Cell Biol (2008) 5.21

A biochemical approach to identifying microRNA targets. Proc Natl Acad Sci U S A (2007) 5.16

A search for conserved sequences in coding regions reveals that the let-7 microRNA targets Dicer within its coding sequence. Proc Natl Acad Sci U S A (2008) 5.11

MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation. Immunity (2008) 5.03

MicroRNA profiling of the murine hematopoietic system. Genome Biol (2005) 4.94

Processing of pre-microRNAs by the Dicer-1-Loquacious complex in Drosophila cells. PLoS Biol (2005) 4.93

RAKE and LNA-ISH reveal microRNA expression and localization in archival human brain. RNA (2005) 4.91

miRGen: a database for the study of animal microRNA genomic organization and function. Nucleic Acids Res (2006) 4.91

A large-scale evaluation of computational protein function prediction. Nat Methods (2013) 4.61

MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase. Immunity (2008) 4.59

Molecular characterization of human Argonaute-containing ribonucleoprotein complexes and their bound target mRNAs. RNA (2008) 4.53

Genetic dissection of the miR-17~92 cluster of microRNAs in Myc-induced B-cell lymphomas. Genes Dev (2009) 4.43

Revisiting the principles of microRNA target recognition and mode of action. Nat Rev Mol Cell Biol (2009) 4.38

Global and local architecture of the mammalian microRNA-transcription factor regulatory network. PLoS Comput Biol (2007) 4.31

MiRNA-directed regulation of VEGF and other angiogenic factors under hypoxia. PLoS One (2006) 4.29

Mapping the human miRNA interactome by CLASH reveals frequent noncanonical binding. Cell (2013) 4.28

The RNA silencing endonuclease Argonaute 2 mediates specific antiviral immunity in Drosophila melanogaster. Genes Dev (2006) 4.26

Micro-RNA regulation of the mammalian lin-28 gene during neuronal differentiation of embryonal carcinoma cells. Mol Cell Biol (2005) 4.19

Kaposi's sarcoma-associated herpesvirus encodes an ortholog of miR-155. J Virol (2007) 4.19

RNA editing of human microRNAs. Genome Biol (2006) 4.16

Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation. Sci Signal (2010) 4.15

Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster. J Clin Invest (2009) 4.12

CD34+ hematopoietic stem-progenitor cell microRNA expression and function: a circuit diagram of differentiation control. Proc Natl Acad Sci U S A (2007) 4.06

MicroRNAs regulate the expression of the alternative splicing factor nPTB during muscle development. Genes Dev (2007) 4.01

starBase: a database for exploring microRNA-mRNA interaction maps from Argonaute CLIP-Seq and Degradome-Seq data. Nucleic Acids Res (2010) 3.99

Biased alternative polyadenylation in human tissues. Genome Biol (2005) 3.96

Desperately seeking microRNA targets. Nat Struct Mol Biol (2010) 3.85

Antagomir-17-5p abolishes the growth of therapy-resistant neuroblastoma through p21 and BIM. PLoS One (2008) 3.68

Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation. Mol Cell (2009) 3.68

Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs. Nat Biotechnol (2009) 3.66

miRNAMap: genomic maps of microRNA genes and their target genes in mammalian genomes. Nucleic Acids Res (2006) 3.59

An androgen-regulated miRNA suppresses Bak1 expression and induces androgen-independent growth of prostate cancer cells. Proc Natl Acad Sci U S A (2007) 3.54

Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes. Circ Res (2009) 3.53

MicroRNAs in cancer. Annu Rev Pathol (2013) 3.50

Systematic identification of mRNAs recruited to argonaute 2 by specific microRNAs and corresponding changes in transcript abundance. PLoS One (2008) 3.38

Target mRNA abundance dilutes microRNA and siRNA activity. Mol Syst Biol (2010) 3.37

Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals. Proc Natl Acad Sci U S A (2009) 3.27

Local translation of RhoA regulates growth cone collapse. Nature (2005) 3.26

MicroRNA-204 regulates Runx2 protein expression and mesenchymal progenitor cell differentiation. Stem Cells (2010) 3.16

Association of a microRNA/TP53 feedback circuitry with pathogenesis and outcome of B-cell chronic lymphocytic leukemia. JAMA (2011) 3.16

Cross talk between microRNA and epigenetic regulation in adult neurogenesis. J Cell Biol (2010) 3.16

Distinct microRNA expression profiles in acute myeloid leukemia with common translocations. Proc Natl Acad Sci U S A (2008) 3.13

Molecular architecture of a miRNA-regulated 3' UTR. RNA (2008) 3.11

MicroRNAs: regulators of gene expression and cell differentiation. Blood (2006) 3.08

miRNAMap 2.0: genomic maps of microRNAs in metazoan genomes. Nucleic Acids Res (2007) 3.05

The rise of regulatory RNA. Nat Rev Genet (2014) 3.02

A feedback regulatory loop involving microRNA-9 and nuclear receptor TLX in neural stem cell fate determination. Nat Struct Mol Biol (2009) 2.96

Effects of Dicer and Argonaute down-regulation on mRNA levels in human HEK293 cells. Nucleic Acids Res (2006) 2.96

The developmental miRNA profiles of zebrafish as determined by small RNA cloning. Genes Dev (2005) 2.94

MicroRNA regulation of DNA repair gene expression in hypoxic stress. Cancer Res (2009) 2.93

Target prediction for small, noncoding RNAs in bacteria. Nucleic Acids Res (2006) 2.90

MicroRNA miR-137 regulates neuronal maturation by targeting ubiquitin ligase mind bomb-1. Stem Cells (2010) 2.89

MicroRNA-21 is up-regulated in allergic airway inflammation and regulates IL-12p35 expression. J Immunol (2009) 2.89

MicroInspector: a web tool for detection of miRNA binding sites in an RNA sequence. Nucleic Acids Res (2005) 2.87

Transient focal ischemia induces extensive temporal changes in rat cerebral microRNAome. J Cereb Blood Flow Metab (2009) 2.87

MyoD inhibits Fstl1 and Utrn expression by inducing transcription of miR-206. J Cell Biol (2006) 2.85

Expression profiling of microRNAs by deep sequencing. Brief Bioinform (2009) 2.71

An Epstein-Barr virus-encoded microRNA targets PUMA to promote host cell survival. J Exp Med (2008) 2.68

Suppression of cell growth and invasion by miR-205 in breast cancer. Cell Res (2009) 2.65

Practical Aspects of microRNA Target Prediction. Curr Mol Med (2011) 2.64

MicroRNA expression and identification of putative miRNA targets in ovarian cancer. PLoS One (2008) 2.60

miRGator: an integrated system for functional annotation of microRNAs. Nucleic Acids Res (2007) 2.59

miR-296 regulates growth factor receptor overexpression in angiogenic endothelial cells. Cancer Cell (2008) 2.57

MicroRNA deregulation and pathway alterations in nasopharyngeal carcinoma. Br J Cancer (2009) 2.57

Energizing miRNA research: a review of the role of miRNAs in lipid metabolism, with a prediction that miR-103/107 regulates human metabolic pathways. Mol Genet Metab (2007) 2.52

Analysis of a noncanonical poly(A) site reveals a tripartite mechanism for vertebrate poly(A) site recognition. Genes Dev (2005) 2.52

Basic local alignment search tool. J Mol Biol (1990) 659.07

MicroRNAs: genomics, biogenesis, mechanism, and function. Cell (2004) 198.59

Improved tools for biological sequence comparison. Proc Natl Acad Sci U S A (1988) 193.60

Mfold web server for nucleic acid folding and hybridization prediction. Nucleic Acids Res (2003) 77.89

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell (1993) 64.62

Prediction of mammalian microRNA targets. Cell (2003) 53.70

Identification of novel genes coding for small expressed RNAs. Science (2001) 44.44

An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science (2001) 44.16

The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature (2000) 39.31

The nuclear RNase III Drosha initiates microRNA processing. Nature (2003) 35.49

Identification of tissue-specific microRNAs from mouse. Curr Biol (2002) 34.55

An extensive class of small RNAs in Caenorhabditis elegans. Science (2001) 34.17

Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A (2002) 32.26

MicroRNAs modulate hematopoietic lineage differentiation. Science (2003) 30.05

The microRNA Registry. Nucleic Acids Res (2004) 29.45

Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci U S A (2004) 28.29

RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev (2001) 26.16

The InterPro Database, 2003 brings increased coverage and new features. Nucleic Acids Res (2003) 24.72

MicroRNA targets in Drosophila. Genome Biol (2003) 23.59

A microRNA in a multiple-turnover RNAi enzyme complex. Science (2002) 23.36

Asymmetry in the assembly of the RNAi enzyme complex. Cell (2003) 22.18

bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila. Cell (2003) 22.14

Specificity of microRNA target selection in translational repression. Genes Dev (2004) 21.14

RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell (2000) 20.32

A uniform system for microRNA annotation. RNA (2003) 20.28

MicroRNAs in plants. Genes Dev (2002) 20.12

MicroRNA maturation: stepwise processing and subcellular localization. EMBO J (2002) 19.47

miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs. Genes Dev (2002) 19.24

Functional siRNAs and miRNAs exhibit strand bias. Cell (2003) 19.15

A gene-coexpression network for global discovery of conserved genetic modules. Science (2003) 18.75

Cleavage of Scarecrow-like mRNA targets directed by a class of Arabidopsis miRNA. Science (2002) 18.37

MicroRNA-directed cleavage of HOXB8 mRNA. Science (2004) 18.33

Fast and effective prediction of microRNA/target duplexes. RNA (2004) 18.10

The microRNAs of Caenorhabditis elegans. Genes Dev (2003) 17.70

Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev (2003) 17.64

EnsMart: a generic system for fast and flexible access to biological data. Genome Res (2004) 17.64

Vertebrate microRNA genes. Science (2003) 17.42

Reduced accumulation of specific microRNAs in colorectal neoplasia. Mol Cancer Res (2003) 17.13

Expression profiling reveals off-target gene regulation by RNAi. Nat Biotechnol (2003) 16.63

Nuclear export of microRNA precursors. Science (2003) 16.59

siRNAs can function as miRNAs. Genes Dev (2003) 16.08

Argonaute2, a link between genetic and biochemical analyses of RNAi. Science (2001) 15.32

Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation. Genome Biol (2004) 15.15

CARPEL FACTORY, a Dicer homolog, and HEN1, a novel protein, act in microRNA metabolism in Arabidopsis thaliana. Curr Biol (2002) 15.13

Single-stranded antisense siRNAs guide target RNA cleavage in RNAi. Cell (2002) 14.37

Rational siRNA design for RNA interference. Nat Biotechnol (2004) 14.16

MicroRNA pathways in flies and worms: growth, death, fat, stress, and timing. Cell (2003) 14.07

Embryonic stem cell-specific MicroRNAs. Dev Cell (2003) 13.05

Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs. Nat Rev Genet (2004) 12.97

A microRNA controlling left/right neuronal asymmetry in Caenorhabditis elegans. Nature (2003) 12.93

The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA. Cell (1997) 12.87

Identification of Drosophila MicroRNA targets. PLoS Biol (2003) 12.72

Identification of virus-encoded microRNAs. Science (2004) 12.56

Ensembl 2004. Nucleic Acids Res (2004) 11.88

High expression of precursor microRNA-155/BIC RNA in children with Burkitt lymphoma. Genes Chromosomes Cancer (2004) 11.79

The small RNA profile during Drosophila melanogaster development. Dev Cell (2003) 11.46

Control of leaf morphogenesis by microRNAs. Nature (2003) 11.36

The Drosophila microRNA Mir-14 suppresses cell death and is required for normal fat metabolism. Curr Biol (2003) 11.23

New microRNAs from mouse and human. RNA (2003) 10.35

Endogenous and silencing-associated small RNAs in plants. Plant Cell (2002) 10.07

AVID: A global alignment program. Genome Res (2003) 10.06

MicroRNAs and other tiny endogenous RNAs in C. elegans. Curr Biol (2003) 9.90

Computational identification of Drosophila microRNA genes. Genome Biol (2003) 9.86

A combined computational-experimental approach predicts human microRNA targets. Genes Dev (2004) 9.82

A microRNA array reveals extensive regulation of microRNAs during brain development. RNA (2003) 9.76

The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3'UTR. Genes Dev (2004) 8.42

Targeted mRNA degradation by double-stranded RNA in vitro. Genes Dev (1999) 8.21

Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome. Cell (2001) 8.04

Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. Proc Natl Acad Sci U S A (2003) 7.95

Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain. Nature (2004) 7.63

The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes. Nat Struct Biol (2003) 6.90

The Caenorhabditis elegans hunchback-like gene lin-57/hbl-1 controls developmental time and is regulated by microRNAs. Dev Cell (2003) 6.86

Computational identification of microRNA targets. Dev Biol (2004) 6.84

The C elegans hunchback homolog, hbl-1, controls temporal patterning and is a probable microRNA target. Dev Cell (2003) 6.74

Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function. Cell (2001) 6.50

Fragile X-related protein and VIG associate with the RNA interference machinery. Genes Dev (2002) 6.43

Numerous microRNPs in neuronal cells containing novel microRNAs. RNA (2003) 6.28

A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins. Genes Dev (2002) 6.10

RNAi: nature abhors a double-strand. Curr Opin Genet Dev (2002) 5.74

Structure and conserved RNA binding of the PAZ domain. Nature (2003) 5.28

Computational and experimental identification of C. elegans microRNAs. Mol Cell (2003) 5.22

Identifying mRNA subsets in messenger ribonucleoprotein complexes by using cDNA arrays. Proc Natl Acad Sci U S A (2000) 4.99

Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain. Nature (2003) 4.92

RNAi related mechanisms affect both transcriptional and posttranscriptional transgene silencing in Drosophila. Mol Cell (2002) 4.90

microRNAs: runts of the genome assert themselves. Curr Biol (2003) 4.75

Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway. Nat Neurosci (2004) 4.69

Imprinted microRNA genes transcribed antisense to a reciprocally imprinted retrotransposon-like gene. Nat Genet (2003) 4.68

Translational control by CPEB: a means to the end. Nat Rev Mol Cell Biol (2001) 4.44

Conservation of the heterochronic regulator Lin-28, its developmental expression and microRNA complementary sites. Dev Biol (2003) 4.04

Mutations that lead to reiterations in the cell lineages of C. elegans. Cell (1981) 3.89

Regulation of RNA polymerase II transcription by sequence-specific DNA binding factors. Cell (2004) 3.82

Arabidopsis HEN1: a genetic link between endogenous miRNA controlling development and siRNA controlling transgene silencing and virus resistance. Curr Biol (2003) 3.77

RNA cargoes associating with FMRP reveal deficits in cellular functioning in Fmr1 null mice. Neuron (2003) 3.58

Identification of eight members of the Argonaute family in the human genome. Genomics (2003) 3.55

A conserved family of elav-like genes in vertebrates. Proc Natl Acad Sci U S A (1995) 3.43

CPEB is a specificity factor that mediates cytoplasmic polyadenylation during Xenopus oocyte maturation. Cell (1994) 3.32

Short RNAs can identify new candidate transposable element families in Arabidopsis. Plant Physiol (2002) 3.27

Phosphorylation of CPE binding factor by Eg2 regulates translation of c-mos mRNA. Nature (2000) 3.12

On ontologies for biologists: the Gene Ontology--untangling the web. Novartis Found Symp (2002) 2.94

Control of developmental timing in Caenorhabditis elegans. Curr Opin Genet Dev (2000) 2.84

miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res (2006) 39.25

miRBase: tools for microRNA genomics. Nucleic Acids Res (2007) 38.61

Identification of tissue-specific microRNAs from mouse. Curr Biol (2002) 34.55

A mammalian microRNA expression atlas based on small RNA library sequencing. Cell (2007) 34.03

Silencing of microRNAs in vivo with 'antagomirs'. Nature (2005) 32.56

Integration of biological networks and gene expression data using Cytoscape. Nat Protoc (2007) 27.10

The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov (2012) 26.98

Integrative genomic profiling of human prostate cancer. Cancer Cell (2010) 23.61

MicroRNA targets in Drosophila. Genome Biol (2003) 23.59

Global mapping of the yeast genetic interaction network. Science (2004) 21.34

International network of cancer genome projects. Nature (2010) 20.35

A uniform system for microRNA annotation. RNA (2003) 20.28

Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal (2013) 19.54

Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAs. Science (2006) 18.14

Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP. Cell (2010) 17.87

Mechanisms of gene silencing by double-stranded RNA. Nature (2004) 16.82

The microRNA.org resource: targets and expression. Nucleic Acids Res (2007) 16.26

Requirement of bic/microRNA-155 for normal immune function. Science (2007) 16.24

Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs. Mol Cell (2004) 16.10

The HUPO PSI's molecular interaction format--a community standard for the representation of protein interaction data. Nat Biotechnol (2004) 16.08

A pancreatic islet-specific microRNA regulates insulin secretion. Nature (2004) 15.02

Single-stranded antisense siRNAs guide target RNA cleavage in RNAi. Cell (2002) 14.37

Characterizing gene sets with FuncAssociate. Bioinformatics (2003) 14.10

Identification of microRNAs of the herpesvirus family. Nat Methods (2005) 12.98

Identification of virus-encoded microRNAs. Science (2004) 12.56

The somatic genomic landscape of glioblastoma. Cell (2013) 11.73

The small RNA profile during Drosophila melanogaster development. Dev Cell (2003) 11.46

The Cancer Genome Atlas Pan-Cancer analysis project. Nat Genet (2013) 11.29

MicroRNAs regulate brain morphogenesis in zebrafish. Science (2005) 11.16

Predicting the functional impact of protein mutations: application to cancer genomics. Nucleic Acids Res (2011) 10.99

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature (2008) 10.73

New microRNAs from mouse and human. RNA (2003) 10.35

The BioPAX community standard for pathway data sharing. Nat Biotechnol (2010) 9.19

Pathway Commons, a web resource for biological pathway data. Nucleic Acids Res (2010) 9.18

A novel class of small RNAs bind to MILI protein in mouse testes. Nature (2006) 8.80

The Systems Biology Graphical Notation. Nat Biotechnol (2009) 8.53

Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing. RNA (2004) 7.71

Mutual exclusivity analysis identifies oncogenic network modules. Genome Res (2011) 7.22

Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites. Genome Biol (2010) 7.15

Structural basis for 5'-end-specific recognition of guide RNA by the A. fulgidus Piwi protein. Nature (2005) 7.12

Cellular cofactors affecting hepatitis C virus infection and replication. Proc Natl Acad Sci U S A (2007) 6.79

(V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway. Proc Natl Acad Sci U S A (2009) 6.78

microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells. Immunity (2007) 6.72

Genome sequencing identifies a basis for everolimus sensitivity. Science (2012) 6.71

Analysis of gene function in somatic mammalian cells using small interfering RNAs. Methods (2002) 6.67

The human DiGeorge syndrome critical region gene 8 and Its D. melanogaster homolog are required for miRNA biogenesis. Curr Biol (2004) 6.56

Emerging landscape of oncogenic signatures across human cancers. Nat Genet (2013) 6.48

miR-122, a mammalian liver-specific microRNA, is processed from hcr mRNA and may downregulate the high affinity cationic amino acid transporter CAT-1. RNA Biol (2004) 6.44

Identification of microRNAs and other small regulatory RNAs using cDNA library sequencing. Methods (2008) 6.22

Identification of novel argonaute-associated proteins. Curr Biol (2005) 6.13

Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy. Nat Genet (2010) 6.10

Pathguide: a pathway resource list. Nucleic Acids Res (2006) 6.05

miRNAs in human cancer. J Pathol (2010) 6.02

Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex. Nature (2008) 5.78

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. N Engl J Med (2015) 5.71

Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus. Immunity (2009) 5.70

Structure of the guide-strand-containing argonaute silencing complex. Nature (2008) 5.36

Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis. Nat Genet (2009) 5.31

Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes. Nature (2009) 5.24

Endogenous MHC class II processing of a viral nuclear antigen after autophagy. Science (2004) 5.10

MicroRNA profiling of the murine hematopoietic system. Genome Biol (2005) 4.94

Clustering and conservation patterns of human microRNAs. Nucleic Acids Res (2005) 4.79

siRNAs: applications in functional genomics and potential as therapeutics. Nat Rev Drug Discov (2004) 4.73

RISC is a 5' phosphomonoester-producing RNA endonuclease. Genes Dev (2004) 4.73

Protein 3D structure computed from evolutionary sequence variation. PLoS One (2011) 4.71

A Slicer-independent role for Argonaute 2 in hematopoiesis and the microRNA pathway. Genes Dev (2007) 4.69

MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase. Immunity (2008) 4.59

Molecular characterization of human Argonaute-containing ribonucleoprotein complexes and their bound target mRNAs. RNA (2008) 4.53

Genetic dissection of the miR-17~92 cluster of microRNAs in Myc-induced B-cell lymphomas. Genes Dev (2009) 4.43

The growing catalog of small RNAs and their association with distinct Argonaute/Piwi family members. Development (2008) 4.40

Evaluating cell lines as tumour models by comparison of genomic profiles. Nat Commun (2013) 4.35

Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability. Mol Cell (2011) 4.29

Functional copy-number alterations in cancer. PLoS One (2008) 4.27

RNA editing of human microRNAs. Genome Biol (2006) 4.16

The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo. Genes Dev (2009) 4.15

Crystal structure of A. aeolicus argonaute, a site-specific DNA-guided endoribonuclease, provides insights into RISC-mediated mRNA cleavage. Mol Cell (2005) 4.11

Direct-coupling analysis of residue coevolution captures native contacts across many protein families. Proc Natl Acad Sci U S A (2011) 4.08

Antisense-mediated depletion reveals essential and specific functions of microRNAs in Drosophila development. Cell (2005) 3.95

Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell (2013) 3.92

Specificity, duplex degradation and subcellular localization of antagomirs. Nucleic Acids Res (2007) 3.89

Cucumber mosaic virus-encoded 2b suppressor inhibits Arabidopsis Argonaute1 cleavage activity to counter plant defense. Genes Dev (2006) 3.77

Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs. Nat Biotechnol (2009) 3.66

Quantitative technologies establish a novel microRNA profile of chronic lymphocytic leukemia. Blood (2007) 3.64