Published in Cell on September 22, 2006
MicroRNAs: target recognition and regulatory functions. Cell (2009) 92.17
MicroRNA targeting specificity in mammals: determinants beyond seed pairing. Mol Cell (2007) 38.42
The impact of microRNAs on protein output. Nature (2008) 32.39
miRecords: an integrated resource for microRNA-target interactions. Nucleic Acids Res (2008) 8.97
Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. Cell (2011) 7.02
The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44. Nat Med (2011) 6.85
MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype. Genome Biol (2007) 6.41
miRDB: a microRNA target prediction and functional annotation database with a wiki interface. RNA (2008) 5.48
MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review. EMBO Mol Med (2012) 5.46
miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements. Mol Cell (2009) 5.22
miR-19 is a key oncogenic component of mir-17-92. Genes Dev (2009) 4.95
Distance constraints between microRNA target sites dictate efficacy and cooperativity. Nucleic Acids Res (2007) 4.91
Revisiting the principles of microRNA target recognition and mode of action. Nat Rev Mol Cell Biol (2009) 4.38
starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data. Nucleic Acids Res (2013) 4.33
Predicting effective microRNA target sites in mammalian mRNAs. Elife (2015) 4.30
The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1. J Neurosci (2008) 4.28
Systematic identification of C. elegans miRISC proteins, miRNAs, and mRNA targets by their interactions with GW182 proteins AIN-1 and AIN-2. Mol Cell (2007) 4.22
Comprehensive discovery of endogenous Argonaute binding sites in Caenorhabditis elegans. Nat Struct Mol Biol (2010) 4.22
Oct4/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells. Mol Cell Biol (2008) 4.07
starBase: a database for exploring microRNA-mRNA interaction maps from Argonaute CLIP-Seq and Degradome-Seq data. Nucleic Acids Res (2010) 3.99
mirWIP: microRNA target prediction based on microRNA-containing ribonucleoprotein-enriched transcripts. Nat Methods (2008) 3.88
Desperately seeking microRNA targets. Nat Struct Mol Biol (2010) 3.85
Association of MicroRNA expression in hepatocellular carcinomas with hepatitis infection, cirrhosis, and patient survival. Clin Cancer Res (2008) 3.67
MicroRNA-mediated switching of chromatin-remodelling complexes in neural development. Nature (2009) 3.66
Genetic variants of miRNA sequences and non-small cell lung cancer survival. J Clin Invest (2008) 3.53
Downregulation of p53-inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma development. Cancer Cell (2010) 3.52
Systematic identification of mRNAs recruited to argonaute 2 by specific microRNAs and corresponding changes in transcript abundance. PLoS One (2008) 3.38
Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration and spreading through downregulating RhoGDIA. Nat Cell Biol (2010) 3.27
miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors. Mol Cell (2010) 3.27
Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver. J Clin Invest (2012) 3.14
p16(INK4a) translation suppressed by miR-24. PLoS One (2008) 3.08
MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system. Genome Biol (2007) 3.05
A novel microRNA targeting HDAC5 regulates osteoblast differentiation in mice and contributes to primary osteoporosis in humans. J Clin Invest (2009) 3.03
Single-nucleotide polymorphisms inside microRNA target sites influence tumor susceptibility. Cancer Res (2010) 2.82
MicroRNA: Biogenesis, Function and Role in Cancer. Curr Genomics (2010) 2.80
miR-34 miRNAs provide a barrier for somatic cell reprogramming. Nat Cell Biol (2011) 2.79
Ascl1a regulates Müller glia dedifferentiation and retinal regeneration through a Lin-28-dependent, let-7 microRNA signalling pathway. Nat Cell Biol (2010) 2.73
Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs. Proc Natl Acad Sci U S A (2015) 2.72
Practical Aspects of microRNA Target Prediction. Curr Mol Med (2011) 2.64
miR-296 regulates growth factor receptor overexpression in angiogenic endothelial cells. Cancer Cell (2008) 2.57
Energizing miRNA research: a review of the role of miRNAs in lipid metabolism, with a prediction that miR-103/107 regulates human metabolic pathways. Mol Genet Metab (2007) 2.52
miR-301a as an NF-κB activator in pancreatic cancer cells. EMBO J (2010) 2.47
The miR-17/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease. Cell Death Differ (2013) 2.41
MicroRNAs (miRNAs) in neurodegenerative diseases. Brain Pathol (2008) 2.39
microRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma. Blood (2010) 2.37
Hypoxia-induced microRNA-424 expression in human endothelial cells regulates HIF-α isoforms and promotes angiogenesis. J Clin Invest (2010) 2.32
The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice. J Clin Invest (2011) 2.30
Virus-encoded microRNAs. Virology (2011) 2.28
Existence of a microRNA pathway in anucleate platelets. Nat Struct Mol Biol (2009) 2.26
MicroRNA-181b regulates NF-κB-mediated vascular inflammation. J Clin Invest (2012) 2.24
A biophysical miRNA-mRNA interaction model infers canonical and noncanonical targets. Nat Methods (2013) 2.16
Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. Blood (2010) 2.15
MicroRNA, a new paradigm for understanding immunoregulation, inflammation, and autoimmune diseases. Transl Res (2011) 2.15
Impaired microRNA processing causes corpus luteum insufficiency and infertility in mice. J Clin Invest (2008) 2.15
A microRNA expression signature for cervical cancer prognosis. Cancer Res (2010) 2.14
The myc-miR-17~92 axis blunts TGF{beta} signaling and production of multiple TGF{beta}-dependent antiangiogenic factors. Cancer Res (2010) 2.13
The mechanism of micro-RNA-mediated translation repression is determined by the promoter of the target gene. Proc Natl Acad Sci U S A (2008) 2.09
MicroRNA-125b promotes neuronal differentiation in human cells by repressing multiple targets. Mol Cell Biol (2009) 2.08
Argonaute divides its RNA guide into domains with distinct functions and RNA-binding properties. Cell (2012) 2.07
A program of microRNAs controls osteogenic lineage progression by targeting transcription factor Runx2. Proc Natl Acad Sci U S A (2011) 2.05
MicroRNA-494 targeting both proapoptotic and antiapoptotic proteins protects against ischemia/reperfusion-induced cardiac injury. Circulation (2010) 2.03
Intronic microRNAs support their host genes by mediating synergistic and antagonistic regulatory effects. BMC Genomics (2010) 1.99
MicroRNA-containing T-regulatory-cell-derived exosomes suppress pathogenic T helper 1 cells. Immunity (2014) 1.95
MiRNA-miRNA synergistic network: construction via co-regulating functional modules and disease miRNA topological features. Nucleic Acids Res (2010) 1.94
Retracted Human chromosome 21-derived miRNAs are overexpressed in down syndrome brains and hearts. Biochem Biophys Res Commun (2008) 1.91
Defining embryonic stem cell identity using differentiation-related microRNAs and their potential targets. Mamm Genome (2007) 1.88
MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1. J Biol Chem (2008) 1.86
miR-145 participates with TP53 in a death-promoting regulatory loop and targets estrogen receptor-alpha in human breast cancer cells. Cell Death Differ (2009) 1.82
Identification of the human mature B cell miRNome. Immunity (2009) 1.82
Notch-dependent repression of miR-155 in the bone marrow niche regulates hematopoiesis in an NF-κB-dependent manner. Cell Stem Cell (2014) 1.81
NAViGaTing the micronome--using multiple microRNA prediction databases to identify signalling pathway-associated microRNAs. PLoS One (2011) 1.80
miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis. Nat Cell Biol (2013) 1.79
Negative regulation of the tumor suppressor p53 gene by microRNAs. Oncogene (2010) 1.78
Predicting microRNA targets and functions: traps for the unwary. Nat Methods (2009) 1.77
The role of miR-18b in MDM2-p53 pathway signaling and melanoma progression. J Natl Cancer Inst (2013) 1.76
Measuring microRNAs: comparisons of microarray and quantitative PCR measurements, and of different total RNA prep methods. BMC Biotechnol (2008) 1.75
Identification of keratinocyte growth factor as a target of microRNA-155 in lung fibroblasts: implication in epithelial-mesenchymal interactions. PLoS One (2009) 1.70
Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors. PLoS One (2009) 1.70
Down-regulation of BRCA1 expression by miR-146a and miR-146b-5p in triple negative sporadic breast cancers. EMBO Mol Med (2011) 1.68
MicroRNAs as a therapeutic target for cardiovascular diseases. J Cell Mol Med (2009) 1.67
MicroRNAs are essential for development and function of inner ear hair cells in vertebrates. Proc Natl Acad Sci U S A (2009) 1.67
MicroRNA expression pattern of undifferentiated and differentiated human embryonic stem cells. Stem Cells Dev (2007) 1.65
CpG island hypermethylation-associated silencing of non-coding RNAs transcribed from ultraconserved regions in human cancer. Oncogene (2010) 1.65
Loss of the miR-21 allele elevates the expression of its target genes and reduces tumorigenesis. Proc Natl Acad Sci U S A (2011) 1.64
miROrtho: computational survey of microRNA genes. Nucleic Acids Res (2008) 1.60
The microRNA miR-155 controls CD8(+) T cell responses by regulating interferon signaling. Nat Immunol (2013) 1.60
MicroRNAs as biomarkers in rheumatic diseases. Nat Rev Rheumatol (2010) 1.59
Comprehensive survey of human brain microRNA by deep sequencing. BMC Genomics (2010) 1.59
A Runx2/miR-3960/miR-2861 regulatory feedback loop during mouse osteoblast differentiation. J Biol Chem (2011) 1.57
MicroRNA-370 controls the expression of microRNA-122 and Cpt1alpha and affects lipid metabolism. J Lipid Res (2010) 1.56
miRSystem: an integrated system for characterizing enriched functions and pathways of microRNA targets. PLoS One (2012) 1.54
miR-107 regulates granulin/progranulin with implications for traumatic brain injury and neurodegenerative disease. Am J Pathol (2010) 1.54
A dictionary on microRNAs and their putative target pathways. Nucleic Acids Res (2010) 1.54
The roles of binding site arrangement and combinatorial targeting in microRNA repression of gene expression. Genome Biol (2007) 1.53
miR-1915 and miR-1225-5p regulate the expression of CD133, PAX2 and TLR2 in adult renal progenitor cells. PLoS One (2013) 1.52
MicroSNiPer: a web tool for prediction of SNP effects on putative microRNA targets. Hum Mutat (2010) 1.51
Identification of microRNA-regulated gene networks by expression analysis of target genes. Genome Res (2012) 1.51
miR-34/449 miRNAs are required for motile ciliogenesis by repressing cp110. Nature (2014) 1.50
Altered microRNA expression profiles in postmortem brain samples from individuals with schizophrenia and bipolar disorder. Biol Psychiatry (2011) 1.49
Got target? Computational methods for microRNA target prediction and their extension. Exp Mol Med (2010) 1.49
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet (2006) 20.76
A global map of p53 transcription-factor binding sites in the human genome. Cell (2006) 20.65
The draft genome of Ciona intestinalis: insights into chordate and vertebrate origins. Science (2002) 11.11
A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language? Cell (2011) 10.50
Accurate phylogenetic classification of variable-length DNA fragments. Nat Methods (2006) 9.93
MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation. Nature (2008) 9.83
Comment on " 'Stemness': transcriptional profiling of embryonic and adult stem cells" and "a stem cell molecular signature". Science (2003) 8.79
Dynamic changes in the human methylome during differentiation. Genome Res (2010) 7.96
Use of simulated data sets to evaluate the fidelity of metagenomic processing methods. Nat Methods (2007) 7.73
Metagenomic and functional analysis of hindgut microbiota of a wood-feeding higher termite. Nature (2007) 7.42
Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. Cell (2011) 7.02
Metagenomic analysis of two enhanced biological phosphorus removal (EBPR) sludge communities. Nat Biotechnol (2006) 5.71
In vivo identification of tumor- suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma. Cell (2011) 5.19
Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1. Nat Cell Biol (2006) 4.81
Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells. Mol Cell Biol (2005) 4.54
MicroRNA-125b is a novel negative regulator of p53. Genes Dev (2009) 4.43
Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome. Nature (2010) 4.38
Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb. Nat Cell Biol (2009) 4.32
The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1. J Neurosci (2008) 4.28
Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis. Cell (2012) 3.92
A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Nature (2010) 3.84
Retinoic acid increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TGF-beta-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression. J Immunol (2008) 3.37
Sall4 interacts with Nanog and co-occupies Nanog genomic sites in embryonic stem cells. J Biol Chem (2006) 3.24
Transcriptome profiling of human and murine ESCs identifies divergent paths required to maintain the stem cell state. Stem Cells (2005) 3.16
The amphioxus genome illuminates vertebrate origins and cephalochordate biology. Genome Res (2008) 3.04
MicroRNAs induced during adipogenesis that accelerate fat cell development are downregulated in obesity. Diabetes (2009) 3.02
Distal airway stem cells yield alveoli in vitro and during lung regeneration following H1N1 influenza infection. Cell (2011) 3.00
High-resolution metagenomics targets specific functional types in complex microbial communities. Nat Biotechnol (2008) 2.99
miR-200 enhances mouse breast cancer cell colonization to form distant metastases. PLoS One (2009) 2.97
The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells. Cell Stem Cell (2010) 2.89
Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia. Nat Med (2012) 2.86
Evaluation of annotation strategies using an entire genome sequence. Bioinformatics (2003) 2.66
Tbx3 improves the germ-line competency of induced pluripotent stem cells. Nature (2010) 2.46
T-cell factor 3 regulates embryonic stem cell pluripotency and self-renewal by the transcriptional control of multiple lineage pathways. Stem Cells (2008) 2.43
Arginine methylation of Piwi proteins catalysed by dPRMT5 is required for Ago3 and Aub stability. Nat Cell Biol (2009) 2.42
MicroRNA-134 modulates the differentiation of mouse embryonic stem cells, where it causes post-transcriptional attenuation of Nanog and LRH1. Stem Cells (2007) 2.40
Sall4 regulates distinct transcription circuitries in different blastocyst-derived stem cell lineages. Cell Stem Cell (2008) 2.28
Linking beta-catenin to androgen-signaling pathway. J Biol Chem (2002) 2.27
Reevaluation of human cytomegalovirus coding potential. Proc Natl Acad Sci U S A (2003) 2.27
What's in the mix: phylogenetic classification of metagenome sequence samples. Curr Opin Microbiol (2007) 2.23
Eset partners with Oct4 to restrict extraembryonic trophoblast lineage potential in embryonic stem cells. Genes Dev (2009) 2.18
Integrated transcriptional and competitive endogenous RNA networks are cross-regulated in permissive molecular environments. Proc Natl Acad Sci U S A (2013) 2.13
Derivation of clinically compliant MSCs from CD105+, CD24- differentiated human ESCs. Stem Cells (2006) 2.11
Short blocks from the noncoding parts of the human genome have instances within nearly all known genes and relate to biological processes. Proc Natl Acad Sci U S A (2006) 2.10
MicroRNA-125b promotes neuronal differentiation in human cells by repressing multiple targets. Mol Cell Biol (2009) 2.08
A precarious balance: pluripotency factors as lineage specifiers. Cell Stem Cell (2011) 2.07
Genome-wide mapping of RELA(p65) binding identifies E2F1 as a transcriptional activator recruited by NF-kappaB upon TLR4 activation. Mol Cell (2007) 2.05
MRNA stability and the control of gene expression: implications for human disease. Neurochem Res (2002) 1.94
Identification of common pathways mediating differentiation of bone marrow- and adipose tissue-derived human mesenchymal stem cells into three mesenchymal lineages. Stem Cells (2006) 1.93
Data mining and clinical data repositories: Insights from a 667,000 patient data set. Comput Biol Med (2005) 1.87
Protein kinase C α is a central signaling node and therapeutic target for breast cancer stem cells. Cancer Cell (2013) 1.86
Conserved long noncoding RNAs transcriptionally regulated by Oct4 and Nanog modulate pluripotency in mouse embryonic stem cells. RNA (2009) 1.78
Genomic analysis of immunity in a Urochordate and the emergence of the vertebrate immune system: "waiting for Godot". Immunogenetics (2003) 1.75
Smarcc1/Baf155 couples self-renewal gene repression with changes in chromatin structure in mouse embryonic stem cells. Stem Cells (2009) 1.72
RCP is a human breast cancer-promoting gene with Ras-activating function. J Clin Invest (2009) 1.71
The transcriptome of human oocytes. Proc Natl Acad Sci U S A (2006) 1.70
A new computational method for the detection of horizontal gene transfer events. Nucleic Acids Res (2005) 1.58
Novel binding of HuR and poly(C)-binding protein to a conserved UC-rich motif within the 3'-untranslated region of the androgen receptor messenger RNA. J Biol Chem (2002) 1.57
Conserved regulation of p53 network dosage by microRNA-125b occurs through evolving miRNA-target gene pairs. PLoS Genet (2011) 1.55
Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling. Cell Stem Cell (2012) 1.54
miR-34a contributes to megakaryocytic differentiation of K562 cells independently of p53. Blood (2009) 1.54
In silico pattern-based analysis of the human cytomegalovirus genome. J Virol (2003) 1.52
Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors. Stem Cells (2011) 1.51
Destructive extraction of phospholipids from Escherichia coli membranes by graphene nanosheets. Nat Nanotechnol (2013) 1.51
The microRNAs within the DLK1-DIO3 genomic region: involvement in disease pathogenesis. Cell Mol Life Sci (2012) 1.51
Oct4 and klf4 reprogram dermal papilla cells into induced pluripotent stem cells. Stem Cells (2010) 1.44
A linguistic model for the rational design of antimicrobial peptides. Nature (2006) 1.44
MicroRNA 125a and its regulation of the p53 tumor suppressor gene. FEBS Lett (2009) 1.40
Evolution of distinct EGF domains with specific functions. Protein Sci (2005) 1.33
Effects of ectopic Nanog and Oct4 overexpression on mesenchymal stem cells. Stem Cells Dev (2009) 1.32
B-MYB is essential for normal cell cycle progression and chromosomal stability of embryonic stem cells. PLoS One (2008) 1.32
Down-regulation of Myc is essential for terminal erythroid maturation. J Biol Chem (2010) 1.30
hZimp10 is an androgen receptor co-activator and forms a complex with SUMO-1 at replication foci. EMBO J (2003) 1.28
Pattern-based phylogenetic distance estimation and tree reconstruction. Evol Bioinform Online (2007) 1.24
BLOSUM62 miscalculations improve search performance. Nat Biotechnol (2008) 1.24
The complex transcriptional landscape of the anucleate human platelet. BMC Genomics (2013) 1.23
miR-191 regulates mouse erythroblast enucleation by down-regulating Riok3 and Mxi1. Genes Dev (2010) 1.23
The 3'-untranslated region of p21WAF1 mRNA is a composite cis-acting sequence bound by RNA-binding proteins from breast cancer cells, including HuR and poly(C)-binding protein. J Biol Chem (2002) 1.23
Single transcription factor reprogramming of hair follicle dermal papilla cells to induced pluripotent stem cells. Stem Cells (2011) 1.22
The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function. Mol Cell Biol (2002) 1.20
Graded Nodal/Activin signaling titrates conversion of quantitative phospho-Smad2 levels into qualitative embryonic stem cell fate decisions. PLoS Genet (2011) 1.20
Stage-specific modulation of cortical neuronal development by Mmu-miR-134. Cereb Cortex (2011) 1.19
microRNA-1 regulates sarcomere formation and suppresses smooth muscle gene expression in the mammalian heart. Elife (2013) 1.18
A sensitive, support-vector-machine method for the detection of horizontal gene transfers in viral, archaeal and bacterial genomes. Nucleic Acids Res (2005) 1.17
Transcriptional organization of the Clostridium acetobutylicum genome. Nucleic Acids Res (2004) 1.16
Retracted Autoimmunity as the consequence of a spontaneous mutation in Rasgrp1. Immunity (2003) 1.15