Published in Pharm Pat Anal on September 01, 2016
Tetrazine ligation: fast bioconjugation based on inverse-electron-demand Diels-Alder reactivity. J Am Chem Soc (2008) 5.52
Synthesis of 11C, 18F, 15O, and 13N radiolabels for positron emission tomography. Angew Chem Int Ed Engl (2008) 3.62
A fluoride-derived electrophilic late-stage fluorination reagent for PET imaging. Science (2011) 2.84
Fluorine in pharmaceutical industry: fluorine-containing drugs introduced to the market in the last decade (2001-2011). Chem Rev (2013) 2.38
Nickel-mediated oxidative fluorination for PET with aqueous [18F] fluoride. J Am Chem Soc (2012) 1.83
"Click labeling" with 2-[18f]fluoroethylazide for positron emission tomography. Bioconjug Chem (2007) 1.61
Applications of Fluorine in Medicinal Chemistry. J Med Chem (2015) 1.58
Fluorous synthesis of 18F radiotracers with the [18F]fluoride ion: nucleophilic fluorination as the detagging process. Angew Chem Int Ed Engl (2009) 1.49
Spirocyclic hypervalent iodine(III)-mediated radiofluorination of non-activated and hindered aromatics. Nat Commun (2014) 1.37
Copper-catalyzed [18F]fluorination of (mesityl)(aryl)iodonium salts. Org Lett (2014) 1.33
Toward [18F]-labeled aryltrifluoroborate radiotracers: in vivo positron emission tomography imaging of stable aryltrifluoroborate clearance in mice. J Am Chem Soc (2008) 1.28
Copper-mediated fluorination of aryl iodides. J Am Chem Soc (2012) 1.26
Catalysis of fluorine addition to double bond: an improvement of method for synthesis of (18)F PET agents. Appl Radiat Isot (2009) 1.21
(18)F-Labeling of Arenes and Heteroarenes for Applications in Positron Emission Tomography. Chem Rev (2016) 1.18
Late-stage [(18)F]Fluorination: New Solutions to Old Problems. Chem Sci (2014) 1.15
A general copper-mediated nucleophilic 18F fluorination of arenes. Angew Chem Int Ed Engl (2014) 1.14
Metal-free oxidative fluorination of phenols with [18F]fluoride. Angew Chem Int Ed Engl (2012) 1.10
Rapid and simple one-step F-18 labeling of peptides. Bioconjug Chem (2011) 1.06
Substituent effects on aryltrifluoroborate solvolysis in water: implications for Suzuki-Miyaura coupling and the design of stable (18)F-labeled aryltrifluoroborates for use in PET imaging. J Org Chem (2008) 1.06
A broadly applicable [18F]trifluoromethylation of aryl and heteroaryl iodides for PET imaging. Nat Chem (2013) 1.03
Application of palladium-mediated (18)F-fluorination to PET radiotracer development: overcoming hurdles to translation. PLoS One (2013) 1.03
Cu(OTf)2-mediated fluorination of aryltrifluoroborates with potassium fluoride. J Am Chem Soc (2013) 1.00
Late-stage fluorination: fancy novelty or useful tool? Angew Chem Int Ed Engl (2015) 1.00
Late stage benzylic C-H fluorination with [¹⁸F]fluoride for PET imaging. J Am Chem Soc (2014) 0.98
Radiofluorination using aluminum-fluoride (Al18F). EJNMMI Res (2013) 0.96
Synthesis and imaging validation of [¹⁸F]MDL100907 enabled by Ni-mediated fluorination. ACS Chem Neurosci (2014) 0.92
Synthesis of [(18)F]Arenes via the Copper-Mediated [(18)F]Fluorination of Boronic Acids. Org Lett (2015) 0.88
Copper-mediated aromatic radiofluorination revisited: efficient production of PET tracers on a preparative scale. Chemistry (2015) 0.87
The traceless Staudinger ligation for indirect 18F-radiolabelling. Org Biomol Chem (2010) 0.87
[(18)F]-Organotrifluoroborates as Radioprosthetic Groups for PET Imaging: From Design Principles to Preclinical Applications. Acc Chem Res (2016) 0.86
Radiation dosimetry and biodistribution of the hypoxia tracer (18)F-EF5 in oncologic patients. Cancer Biother Radiopharm (2012) 0.86
Enhanced copper-mediated (18)F-fluorination of aryl boronic esters provides eight radiotracers for PET applications. Chem Commun (Camb) (2016) 0.86
The use of (18)F-2-fluorodeoxyglucose (FDG) to label antibody fragments for immuno-PET of pancreatic cancer. ACS Cent Sci (2015) 0.86
Cu(I)-mediated (18)F-trifluoromethylation of arenes: rapid synthesis of (18)F-labeled trifluoromethyl arenes. Chem Commun (Camb) (2014) 0.85
A universal procedure for the [¹⁸F]trifluoromethylation of aryl iodides and aryl boronic acids with highly improved specific activity. Angew Chem Int Ed Engl (2014) 0.84
Al(18) F labeling of peptides and proteins. J Labelled Comp Radiopharm (2014) 0.83
Moving Metal-Mediated (18)F-Fluorination from Concept to Clinic. ACS Cent Sci (2016) 0.81
Sulfonium salts as leaving groups for aromatic labelling of drug-like small molecules with fluorine-18. Sci Rep (2015) 0.80
Efficient synthesis of fluorescent-PET probes based on [¹⁸F]BODIPY dye. Chem Commun (Camb) (2014) 0.80
Efficient bioconjugation of 5-fluoro-5-deoxy-ribose (FDR) to RGD peptides for positron emission tomography (PET) imaging of α(v)β(3) integrin receptor. Org Biomol Chem (2013) 0.78
A fully-automated one-pot synthesis of [18F]fluoromethylcholine with reduced dimethylaminoethanol contamination via [18F]fluoromethyl tosylate. Appl Radiat Isot (2013) 0.78
N-Succinimidyl 3-((4-(4-[(18)F]fluorobutyl)-1H-1,2,3-triazol-1-yl)methyl)-5-(guanidinomethyl)benzoate ([(18)F]SFBTMGMB): a residualizing label for (18)F-labeling of internalizing biomolecules. Org Biomol Chem (2015) 0.78
A Transmetalation Reaction Enables the Synthesis of [(18)F]5-Fluorouracil from [(18)F]Fluoride for Human PET Imaging. Organometallics (2016) 0.78
From Unorthodox to Established: The Current Status of (18)F-Trifluoroborate- and (18)F-SiFA-Based Radiopharmaceuticals in PET Nuclear Imaging. Bioconjug Chem (2015) 0.77
Development of a new precursor-minimizing base control method and its application for the automated synthesis and SPE purification of [(18) F]fluoromisonidazole ([(18) F]FMISO). J Labelled Comp Radiopharm (2013) 0.77
Green approaches to late-stage fluorination: radiosyntheses of (18)F-labelled radiopharmaceuticals in ethanol and water. Chem Commun (Camb) (2015) 0.77
Fast and efficient (18) F-labeling by [(18) f]fluorophenylazocarboxylic esters. Chemistry (2013) 0.77
Automated solid-phase radiofluorination using polymer-supported phosphazenes. Molecules (2013) 0.77
Production and Transport of Gaseous (18)F-Synthons: (18)F-Acyl Fluorides. J Fluor Chem (2015) 0.76
Corrigendum: Concerted nucleophilic aromatic substitution with (19)F(-) and (18)F(). Nature (2016) 0.76
Fluorine-18 patents (2009-2015). Part 1: novel radiotracers. Pharm Pat Anal (2015) 0.76
Fluorine-18 patents (2009-2015). Part 1: novel radiotracers. Pharm Pat Anal (2015) 0.76