Published in Arch Intern Med on August 01, 1989
Medical Students' and Residents' preferred site characteristics and preceptor behaviours for learning in the ambulatory setting: a cross-sectional survey. BMC Med Educ (2004) 1.39
Physician-patient communication from the perspective of library and information science. Bull Med Libr Assoc (1994) 0.85
Crystal structure of the ribonuclease H domain of HIV-1 reverse transcriptase. Science (1991) 5.42
Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. I. General features and binding of methotrexate. J Biol Chem (1982) 3.84
Dihydrofolate reductase: x-ray structure of the binary complex with methotrexate. Science (1977) 2.88
The mental health of patients with a chief complaint of chronic fatigue. A prospective evaluation and follow-up. Arch Intern Med (1988) 2.85
Crystal structure of avian dihydrofolate reductase containing phenyltriazine and NADPH. J Biol Chem (1982) 2.45
Depression and somatization in the chronic fatigue syndrome. Am J Med (1991) 2.33
The frequency of the chronic fatigue syndrome in patients with symptoms of persistent fatigue. Ann Intern Med (1988) 2.11
Dihydrofolate reductase from Lactobacillus casei. X-ray structure of the enzyme methotrexate.NADPH complex. J Biol Chem (1978) 1.94
Synaptic plasma membranes from rat brain synaptosomes: isolation and partial characterization. Biochim Biophys Acta (1971) 1.84
X-ray crystallographic study of boronic acid adducts with subtilisin BPN' (Novo). A model for the catalytic transition state. J Biol Chem (1975) 1.82
Identification of variable domains of the attachment (G) protein of subgroup A respiratory syncytial viruses. J Gen Virol (1991) 1.79
Analysis of respiratory syncytial virus strain variation in successive epidemics in one city. J Clin Microbiol (1994) 1.72
What makes the patient-doctor relationship therapeutic? Exploring the connexional dimension of medical care. Ann Intern Med (1988) 1.64
Health and disability costs of depressive illness in a major U.S. corporation. Am J Psychiatry (2000) 1.64
Crystal structure of rat liver dihydropteridine reductase. Proc Natl Acad Sci U S A (1992) 1.63
In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease. Antimicrob Agents Chemother (1999) 1.63
The splicing factor-associated protein, p32, regulates RNA splicing by inhibiting ASF/SF2 RNA binding and phosphorylation. EMBO J (1999) 1.63
Refined crystal structures of Escherichia coli and chicken liver dihydrofolate reductase containing bound trimethoprim. J Biol Chem (1985) 1.62
Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. II. Environment of bound NADPH and implications for catalysis. J Biol Chem (1982) 1.61
Alpha-delta sleep in patients with a chief complaint of chronic fatigue. South Med J (1994) 1.55
Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 4. Incorporation of P1 lactam moieties as L-glutamine replacements. J Med Chem (1999) 1.55
The low yield of physical examinations and laboratory investigations of patients with chronic fatigue. Am J Med Sci (1990) 1.47
Structure of and kinetic channelling in bifunctional dihydrofolate reductase-thymidylate synthase. Nat Struct Biol (1994) 1.47
Structure of the human cytomegalovirus protease catalytic domain reveals a novel serine protease fold and catalytic triad. Cell (1996) 1.37
An electron microscopic study of lesion-induced synaptogenesis in the dentate gyrus of the adult rat. I. Magnitude and time course of degeneration. Brain Res (1976) 1.36
Analysis of relatedness of subgroup A respiratory syncytial viruses isolated worldwide. Virus Res (1992) 1.30
Crystal structure of a novel trimethoprim-resistant dihydrofolate reductase specified in Escherichia coli by R-plasmid R67. Biochemistry (1986) 1.29
Conservation of amino acids in human rhinovirus 3C protease correlates with broad-spectrum antiviral activity of rupintrivir, a novel human rhinovirus 3C protease inhibitor. Antimicrob Agents Chemother (2005) 1.25
Tripeptide aldehyde inhibitors of human rhinovirus 3C protease: design, synthesis, biological evaluation, and cocrystal structure solution of P1 glutamine isosteric replacements. J Med Chem (1998) 1.24
Electrostatic channeling in the bifunctional enzyme dihydrofolate reductase-thymidylate synthase. J Mol Biol (1996) 1.23
Beginning careers in academic psychiatry for women--"Bermuda Triangle"? Am J Psychiatry (1993) 1.21
Design of thymidylate synthase inhibitors using protein crystal structures: the synthesis and biological evaluation of a novel class of 5-substituted quinazolinones. J Med Chem (1993) 1.20
Design, synthesis, and evaluation of nonpeptidic inhibitors of human rhinovirus 3C protease. J Med Chem (1996) 1.19
Dihydrofolate reductase. The stereochemistry of inhibitor selectivity. J Biol Chem (1985) 1.17
Normative implications of the relationship between reading vocabulary and Boston Naming Test performance. Arch Clin Neuropsychol (1993) 1.15
Re-examination of the charge relay system in subtilisin comparison with other serine proteases. J Biol Chem (1977) 1.14
Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 1. Michael acceptor structure-activity studies. J Med Chem (1998) 1.14
Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 2. Peptide structure-activity studies. J Med Chem (1998) 1.12
A comparison of the structured clinical interview for DSM-III-R and clinical diagnoses. J Nerv Ment Dis (1995) 1.12
A plasmid-encoded dihydrofolate reductase from trimethoprim-resistant bacteria has a novel D2-symmetric active site. Nat Struct Biol (1995) 1.12
Identification of mutations contributing to the reduced virulence of a modified strain of respiratory syncytial virus. Vaccine (1996) 1.11
An electron microscopic study of lesion-induced synaptogenesis in the dentate gyrus of the adult rat. II. Reappearance of morphologically normal synaptic contacts. Brain Res (1976) 1.09
Defining managed care in public-sector psychiatry. Hosp Community Psychiatry (1994) 1.08
Escherichia coli thymidylate synthase: amino acid substitutions by suppression of amber nonsense mutations. Proc Natl Acad Sci U S A (1990) 1.08
Proteolytic release and crystallization of the RNase H domain of human immunodeficiency virus type 1 reverse transcriptase. J Biol Chem (1991) 1.04
Induced acetylcholinesterase-rich layer in rat dentate gyrus following entorhinal lesions. Brain Res (1972) 1.04
Structural and mechanistic characteristics of dihydropteridine reductase: a member of the Tyr-(Xaa)3-Lys-containing family of reductases and dehydrogenases. Proc Natl Acad Sci U S A (1994) 1.04
Mitochondrial protein p32 can accumulate in the nucleus. Biochem Biophys Res Commun (2001) 1.03
Interaction between herpes simplex virus type 1 IE63 protein and cellular protein p32. J Virol (2000) 1.02
Chronic fatigue and chronic fatigue syndrome: clinical epidemiology and aetiological classification. Ciba Found Symp (1993) 1.00
Depression among patients with a chief complaint of chronic fatigue. J Affect Disord (1989) 0.99
Cognition, negative symptoms, and diagnosis: a comparison of schizophrenic, bipolar, and control samples. J Neuropsychiatry Clin Neurosci (1997) 0.98
Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 3. Structure-activity studies of ketomethylene-containing peptidomimetics. J Med Chem (1999) 0.98
An immunocytochemical study of choline acetyltransferase-containing neurons and axon terminals in normal and partially deafferented hippocampal formation. Brain Res (1987) 0.95
In vitro resistance study of rupintrivir, a novel inhibitor of human rhinovirus 3C protease. Antimicrob Agents Chemother (2007) 0.94
Applicants' choice of a residency training program. Am J Psychiatry (1987) 0.93
Development of cholinergic innervation in the hippocampal formation of the rat. I. Histochemical demonstration of acetylcholinesterase activity. Dev Biol (1974) 0.92
Dihydrofolate reductase from Lactobacillus casei. Stereochemistry of NADPH binding. J Biol Chem (1979) 0.89
The nucleotide sequences of intergenic regions between nine genes of pneumonia virus of mice establish the physical order of these genes in the viral genome. Virus Res (1991) 0.89
Affective reactivity of language in schizophrenia. J Nerv Ment Dis (1994) 0.88
Frequent polymerase errors observed in a restricted area of clones derived from the attachment (G) protein gene of respiratory syncytial virus. J Virol (1993) 0.87
Precursor of human adenovirus core polypeptide Mu targets the nucleolus and modulates the expression of E2 proteins. J Gen Virol (2004) 0.87
Synaptic rearrangement in the dentate gyrus: histochemical evidence of adjustments after lesions in immature and adult rats. Proc Natl Acad Sci U S A (1973) 0.87
Teaching about the doctor-patient relationship in the first postgraduate year. J Med Educ (1987) 0.87
Species-specific second antibodies reduce spurious staining in immunocytochemistry. J Histochem Cytochem (1984) 0.86
Preliminary x-ray diffraction characterization of crystalline rat liver dihydropteridine reductase. J Biol Chem (1986) 0.86
Development of cholinergic innervation in the hippocampal formation of the rat. II. Quantitative changes in choline acetyltransferase and acetylcholinesterase activities. Dev Biol (1974) 0.84
Chronic fatigue syndromes in clinical practice. Psychother Psychosom (1992) 0.84
Structure-based design of ketone-containing, tripeptidyl human rhinovirus 3C protease inhibitors. Bioorg Med Chem Lett (2000) 0.84
Religious commitment and health status. Arch Fam Med (1999) 0.83
Characterization and nucleotide binding properties of a mutant dihydropteridine reductase containing an aspartate 37-isoleucine replacement. J Biol Chem (1992) 0.83
Somatization disorder in patients with chronic fatigue. Psychosomatics (1989) 0.82
Interpretation of nuclear magnetic resonance spectra for Lactobacillus casei dihydrofolate reductase based on the X-ray structure of the enzyme-methotrexate-NADPH complex. Biochemistry (1979) 0.82
Serologic specificities of brain subcellular organelles. I. Antisera to synaptosomal fractions. J Immunol (1972) 0.81
Working memory, attention, and communication disturbances in schizophrenia. J Abnorm Psychol (1996) 0.81
Panic disorder among patients with chronic fatigue. South Med J (1991) 0.81
Dr. Marjory Warren and the origin of British geriatrics. J Am Geriatr Soc (1984) 0.80
Enhanced cationic liposome-mediated transfection using the DNA-binding peptide mu (mu) from the adenovirus core. Gene Ther (2001) 0.80
Differences in social environment between inpatient and day hospital-crisis respite settings. Psychiatr Serv (1996) 0.79
Affective reactivity of language in stable schizophrenic outpatients and their parents. J Nerv Ment Dis (1994) 0.79
Antecedent psychological factors in the onset of vasovagal syncope. Psychosom Med (1978) 0.79
Screening for somatization disorder in patients with chronic fatigue. Gen Hosp Psychiatry (1989) 0.79
Genomic mapping and evolution of human GABA(A) receptor subunit gene clusters. Mamm Genome (1999) 0.79
Yeast connection among 100 patients with chronic fatigue. Am J Med (1989) 0.79
Four-year evaluation of a psychiatric clerkship: 1982-1986. Am J Psychiatry (1988) 0.78
Resident and faculty evaluations of a psychiatry night-float system. Acad Psychiatry (1996) 0.78
Substance use disorders in patients with chronic fatigue. Hosp Community Psychiatry (1991) 0.77
Audiotape playback as a technique in the treatment of schizophrenic patients. Am J Psychiatry (1989) 0.77
Structure-based design of substituted diphenyl sulfones and sulfoxides as lipophilic inhibitors of thymidylate synthase. J Med Chem (1997) 0.77
Depression and chronic fatigue. Indications for psychiatric consultation. Prim Care (1991) 0.77
Genetically-associated variations in the development of hippocampal pyramidal neurons may produce differences in mossy fiber connectivity. J Comp Neurol (1977) 0.77
Isolation of rat brain subcellular fraction enriched in putative neurotransmitter receptors and synaptic junctions. Neurochem Res (1980) 0.77
Vasovagal syncope in aircrew. Psychosocial aspects. J Nerv Ment Dis (1979) 0.77
Design and synthesis of novel 6,7-imidazotetrahydroquinoline inhibitors of thymidylate synthase using iterative protein crystal structure analysis. J Med Chem (1992) 0.77
Substituted benzamide inhibitors of human rhinovirus 3C protease: structure-based design, synthesis, and biological evaluation. J Med Chem (2000) 0.76
Self-concept changes related to war captivity. Arch Gen Psychiatry (1980) 0.76
Food intolerance in patients with chronic fatigue. Int J Eat Disord (1993) 0.76
The pathophysiology of chronic fatigue syndrome: confirmations, contradictions, and conjectures. Int J Psychiatry Med (1992) 0.75
Can digit symbol-verbal fluency comparisons facilitate detection of pseudodementia? A preliminary study. Eur Arch Psychiatry Clin Neurosci (1995) 0.75