Published in PLoS One on October 19, 2016
Global cancer statistics, 2012. CA Cancer J Clin (2015) 53.52
Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer (2007) 18.69
Generation of a functional mammary gland from a single stem cell. Nature (2006) 18.30
Tumour stem cells and drug resistance. Nat Rev Cancer (2005) 15.21
Cancer statistics in China, 2015. CA Cancer J Clin (2016) 12.92
The snail superfamily of zinc-finger transcription factors. Nat Rev Mol Cell Biol (2002) 10.59
Targeting multidrug resistance in cancer. Nat Rev Drug Discov (2006) 10.55
The Snail genes as inducers of cell movement and survival: implications in development and cancer. Development (2005) 8.42
Biochemical, cellular, and pharmacological aspects of the multidrug transporter. Annu Rev Pharmacol Toxicol (1999) 6.62
The SLUG zinc-finger protein represses E-cadherin in breast cancer. Cancer Res (2002) 6.47
The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors. J Cell Sci (2003) 6.24
Slug and Sox9 cooperatively determine the mammary stem cell state. Cell (2012) 4.77
The melanocyte differentiation program predisposes to metastasis after neoplastic transformation. Nat Genet (2005) 4.70
Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties. Hepatology (2006) 4.61
Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex. Mol Cell Biol (2004) 4.15
Cancer stem cells and epithelial-mesenchymal transition: concepts and molecular links. Semin Cancer Biol (2012) 3.98
Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma. Cell (2005) 3.73
Slug, a highly conserved zinc finger transcriptional repressor, protects hematopoietic progenitor cells from radiation-induced apoptosis in vivo. Cancer Cell (2002) 2.48
A switch in the expression of embryonic EMT-inducers drives the development of malignant melanoma. Cancer Cell (2013) 2.46
JASPAR 2016: a major expansion and update of the open-access database of transcription factor binding profiles. Nucleic Acids Res (2015) 2.22
The Slug gene is not essential for mesoderm or neural crest development in mice. Dev Biol (1998) 2.13
Slug confers resistance to the epidermal growth factor receptor tyrosine kinase inhibitor. Am J Respir Crit Care Med (2010) 1.95
Transcription repressor slug promotes carcinoma invasion and predicts outcome of patients with lung adenocarcinoma. Clin Cancer Res (2005) 1.84
Deletion of the SLUG (SNAI2) gene results in human piebaldism. Am J Med Genet A (2003) 1.72
EMT transcription factors snail and slug directly contribute to cisplatin resistance in ovarian cancer. BMC Cancer (2012) 1.70
Human hepatocellular carcinomas with "Stemness"-related marker expression: keratin 19 expression and a poor prognosis. Hepatology (2011) 1.67
Zinc-finger transcription factor Slug contributes to the function of the stem cell factor c-kit signaling pathway. Blood (2002) 1.64
SLUG (SNAI2) deletions in patients with Waardenburg disease. Hum Mol Genet (2002) 1.64
Human ATP-binding cassette (ABC) transporter family. Hum Genomics (2009) 1.61
MiR-124 targets Slug to regulate epithelial-mesenchymal transition and metastasis of breast cancer. Carcinogenesis (2012) 1.55
The modulation of ABC transporter-mediated multidrug resistance in cancer: a review of the past decade. Drug Resist Updat (2014) 1.54
The in vitro spheroid melanoma cell culture assay: cues on tumor initiation? J Invest Dermatol (2010) 1.53
Distinct EMT programs control normal mammary stem cells and tumour-initiating cells. Nature (2015) 1.53
Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus. Dev Cell (2008) 1.51
The epithelial-mesenchymal transition (EMT) regulatory factor SLUG (SNAI2) is a downstream target of SPARC and AKT in promoting melanoma cell invasion. PLoS One (2012) 1.23
Slug (SNAI2) down-regulation by RNA interference facilitates apoptosis and inhibits invasive growth in neuroblastoma preclinical models. Clin Cancer Res (2008) 1.18
Hypoxia inducible factor-1 mediates expression of galectin-1: the potential role in migration/invasion of colorectal cancer cells. Carcinogenesis (2010) 1.16
Hepatocellular carcinomas expressing 'stemness'-related markers: clinicopathological characteristics. Dig Dis (2014) 0.98
Slug inhibits proliferation of human prostate cancer cells via downregulation of cyclin D1 expression. Prostate (2010) 0.98
Adipose tissue mass is modulated by SLUG (SNAI2). Hum Mol Genet (2007) 0.95
The transcription factors Tbx18 and Wt1 control the epicardial epithelial-mesenchymal transition through bi-directional regulation of Slug in murine primary epicardial cells. PLoS One (2013) 0.93
Zinc-finger transcription factor slug contributes to the survival advantage of chronic myeloid leukemia cells. Cell Signal (2010) 0.91
BCRP/ABCG2 inhibition sensitizes hepatocellular carcinoma cells to sorafenib. PLoS One (2013) 0.88
Activation of the MDR1 upstream promoter in breast carcinoma as a surrogate for metastatic invasion. Clin Cancer Res (2004) 0.87
Slug is temporally regulated by cyclin E in cell cycle and controls genome stability. Oncogene (2014) 0.81
The promoter region of the MDR1 gene is largely invariant, but different single nucleotide polymorphism haplotypes affect MDR1 promoter activity differently in different cell lines. Mol Pharmacol (2006) 0.81
Polycomb chromobox 4 enhances migration and pulmonary metastasis of hepatocellular carcinoma cell line MHCC97L. Sci China Life Sci (2014) 0.80
SLUG is a direct transcriptional repressor of PTEN tumor suppressor. Prostate (2015) 0.76