Published in Nature on September 02, 2015
Targeting metastasis-initiating cells through the fatty acid receptor CD36. Nature (2016) 2.11
The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer. Nat Cell Biol (2017) 1.52
Stability of the hybrid epithelial/mesenchymal phenotype. Oncotarget (2016) 0.99
Emerging Biological Principles of Metastasis. Cell (2017) 0.94
Distinctive properties of metastasis-initiating cells. Genes Dev (2016) 0.91
Deformability of Tumor Cells versus Blood Cells. Sci Rep (2015) 0.88
New Insights into the Crossroads between EMT and Stemness in the Context of Cancer. J Clin Med (2016) 0.88
The role of phenotypic plasticity in the escape of cancer cells from targeted therapy. Biochem Pharmacol (2016) 0.86
Epithelial-mesenchymal transition in tumor metastasis. Mol Oncol (2016) 0.86
The matricellular protein CCN6 (WISP3) decreases Notch1 and suppresses breast cancer initiating cells. Oncotarget (2016) 0.85
EMT, CSCs, and drug resistance: the mechanistic link and clinical implications. Nat Rev Clin Oncol (2017) 0.85
MicroRNA Regulation of Human Breast Cancer Stem Cells. J Clin Med (2015) 0.84
Autophagy in cancer metastasis. Oncogene (2016) 0.81
Folate deficient tumor microenvironment promotes epithelial-to-mesenchymal transition and cancer stem-like phenotypes. Oncotarget (2016) 0.81
Meta-Analysis of EMT Datasets Reveals Different Types of EMT. PLoS One (2016) 0.81
Differences in expression of the cancer stem cell marker aldehyde dehydrogenase 1 among estrogen receptor-positive/human epidermal growth factor receptor type 2-negative breast cancer cases with early, late, and no recurrence. Breast Cancer Res (2016) 0.81
Ablation of miR-10b Suppresses Oncogene-Induced Mammary Tumorigenesis and Metastasis and Reactivates Tumor-Suppressive Pathways. Cancer Res (2016) 0.80
Intra-tumor heterogeneity from a cancer stem cell perspective. Mol Cancer (2017) 0.80
Links between cancer stem cells and epithelial-mesenchymal transition. Onco Targets Ther (2015) 0.79
Multifunctional DDX3: dual roles in various cancer development and its related signaling pathways. Am J Cancer Res (2016) 0.79
Genomic Instability Is Induced by Persistent Proliferation of Cells Undergoing Epithelial-to-Mesenchymal Transition. Cell Rep (2016) 0.79
Snail/Slug binding interactions with YAP/TAZ control skeletal stem cell self-renewal and differentiation. Nat Cell Biol (2016) 0.78
CD51 correlates with the TGF-beta pathway and is a functional marker for colorectal cancer stem cells. Oncogene (2016) 0.78
The immune checkpoint ligand PD-L1 is upregulated in EMT-activated human breast cancer cells by a mechanism involving ZEB-1 and miR-200. Oncoimmunology (2017) 0.78
Integrin-β4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells. Proc Natl Acad Sci U S A (2017) 0.78
Mechanical signals regulate and activate SNAIL1 protein to control the fibrogenic response of cancer-associated fibroblasts. J Cell Sci (2016) 0.78
CAP1 (Cyclase-Associated Protein 1) Exerts Distinct Functions in the Proliferation and Metastatic Potential of Breast Cancer Cells Mediated by ERK. Sci Rep (2016) 0.78
Cyclooxygenase-2 regulates TGFβ-induced cancer stemness in triple-negative breast cancer. Sci Rep (2017) 0.78
Motility and stem cell properties induced by the epithelial-mesenchymal transition require destabilization of lipid rafts. Oncotarget (2016) 0.78
C4.4A as a biomarker of head and neck squamous cell carcinoma and correlated with epithelial mesenchymal transition. Am J Cancer Res (2015) 0.78
Snail1-dependent p53 repression regulates expansion and activity of tumour-initiating cells in breast cancer. Nat Cell Biol (2016) 0.78
Drug Delivery Using Nanoparticles for Cancer Stem-Like Cell Targeting. Front Pharmacol (2016) 0.78
Tumor microenvironment: driving forces and potential therapeutic targets for breast cancer metastasis. Chin J Cancer (2017) 0.78
Epithelial-Mesenchymal Transition (EMT): A Biological Process in the Development, Stem Cell Differentiation and Tumorigenesis. J Cell Physiol (2017) 0.78
Cancer stem cell niche models and contribution by mesenchymal stroma/stem cells. Mol Cancer (2017) 0.78
BRCA1/FANCD2/BRG1-Driven DNA Repair Stabilizes the Differentiation State of Human Mammary Epithelial Cells. Mol Cell (2016) 0.77
Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer. J Exp Med (2016) 0.77
Targeting the epigenetics of the DNA damage response in breast cancer. Cell Death Dis (2016) 0.76
The Nuclear Receptor, RORγ, Regulates Pathways Necessary for Breast Cancer Metastasis. EBioMedicine (2016) 0.76
Correlated S-palmitoylation profiling of Snail-induced epithelial to mesenchymal transition. Mol Biosyst (2016) 0.76
Divide or Conquer: Cell Cycle Regulation of Invasive Behavior. Trends Cell Biol (2016) 0.76
Activation of anaphase-promoting complex by p53 induces a state of dormancy in cancer cells against chemotherapeutic stress. Oncotarget (2016) 0.76
Mechanisms of polarity protein expression control. Curr Opin Cell Biol (2016) 0.76
Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix. Mol Biol Cell (2017) 0.76
Epithelial-to-mesenchymal Transition contributes to Immunosuppression in Breast Carcinomas. Cancer Res (2017) 0.75
PLCE1 Promotes Esophageal Cancer Cell Progression by Maintaining the Transcriptional Activity of Snail. Neoplasia (2017) 0.75
Tumor-Initiating Cells: Emerging Biophysical Methods of Isolation. Curr Stem Cell Rep (2016) 0.75
TAp63 suppresses mammary tumorigenesis through regulation of the Hippo pathway. Oncogene (2016) 0.75
Inhibition of Snail Family Transcriptional Repressor 2 (SNAI2) Enhances Multidrug Resistance of Hepatocellular Carcinoma Cells. PLoS One (2016) 0.75
Uncovering the roles of long non-coding RNAs in cancer stem cells. J Hematol Oncol (2017) 0.75
CRB3 downregulation confers breast cancer stem cell traits through TAZ/β-catenin. Oncogenesis (2017) 0.75
Genome-wide gain-of-function screen for genes that induce epithelial-to-mesenchymal transition in breast cancer. Oncotarget (2016) 0.75
Expression Profiling of Clinical Specimens Supports the Existence of Neural Progenitor-Like Stem Cells in Basal Breast Cancers. Clin Breast Cancer (2017) 0.75
Snail reprograms glucose metabolism by repressing phosphofructokinase PFKP allowing cancer cell survival under metabolic stress. Nat Commun (2017) 0.75
Slug inhibits pancreatic cancer initiation by blocking Kras-induced acinar-ductal metaplasia. Sci Rep (2016) 0.75
Snail/Slug-YAP/TAZ Complexes Cooperatively Regulate Mesenchymal Stem Cell Function and Bone Formation. Cell Cycle (2017) 0.75
Context-specific roles of EMT programmes in cancer cell dissemination. Nat Cell Biol (2017) 0.75
Induced cancer stem cells generated by radiochemotherapy and their therapeutic implications. Oncotarget (2016) 0.75
Silencing of Prrx1b suppresses cellular proliferation, migration, invasion and epithelial-mesenchymal transition in triple-negative breast cancer. J Cell Mol Med (2016) 0.75
S100A4 is a biomarker and regulator of glioma stem cells that is critical for mesenchymal transition in glioblastoma. Cancer Res (2017) 0.75
The NOTCH1/SNAIL1/MEF2C Pathway Regulates Growth and Self-Renewal in Embryonal Rhabdomyosarcoma. Cell Rep (2017) 0.75
Epithelial requirement for in vitro proliferation and xenograft growth and metastasis of MDA-MB-468 human breast cancer cells: oncogenic rather than tumor-suppressive role of E-cadherin. Breast Cancer Res (2017) 0.75
Cancer stem cells revisited. Nat Med (2017) 0.75
The EMT spectrum and therapeutic opportunities. Mol Oncol (2017) 0.75
Breast Carcinoma: From Initial Tumor Cell Detachment to Settlement at Secondary Sites. Biomed Res Int (2017) 0.75
Hybrid clone cells derived from human breast epithelial cells and human breast cancer cells exhibit properties of cancer stem/initiating cells. BMC Cancer (2017) 0.75
Proline-Rich Homeodomain protein (PRH/HHEX) is a suppressor of breast tumour growth. Oncogenesis (2017) 0.75
EMT: Present and future in clinical oncology. Mol Oncol (2017) 0.75
Cancer metastasis through the prism of epithelial to mesenchymal transition in circulating tumor cells. Mol Oncol (2017) 0.75
Harnessing protein kinase A activation to induce mesenchymal-epithelial programs to eliminate chemoresistant, tumor-initiating breast cancer cells. Transl Cancer Res (2016) 0.75
Stem Cell-Like Properties of CK2β-down Regulated Mammary Cells. Cancers (Basel) (2017) 0.75
A double-negative feedback loop between EpCAM and ERK contributes to the regulation of epithelial-mesenchymal transition in cancer. Oncogene (2017) 0.75
Sirtuins at the crossroads of stemness, aging, and cancer. Aging Cell (2017) 0.75
Model-based analysis of ChIP-Seq (MACS). Genome Biol (2008) 51.63
Epithelial-mesenchymal transitions in development and disease. Cell (2009) 39.17
Generation of a functional mammary gland from a single stem cell. Nature (2006) 18.30
Purification and unique properties of mammary epithelial stem cells. Nature (2006) 15.98
Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. Nat Med (2009) 10.88
The snail superfamily of zinc-finger transcription factors. Nat Rev Mol Cell Biol (2002) 10.59
ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays. J Immunol Methods (2009) 9.00
The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Nat Cell Biol (2009) 8.63
Progression to malignancy in the polyoma middle T oncoprotein mouse breast cancer model provides a reliable model for human diseases. Am J Pathol (2003) 8.61
Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation. Nat Genet (1999) 8.17
An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients. Breast Cancer Res Treat (2009) 7.91
Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene. Cell (1988) 7.50
Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells. Cell (2011) 7.30
Cells of origin in cancer. Nature (2011) 6.85
The transcriptional repressor Snail promotes mammary tumor recurrence. Cancer Cell (2005) 5.81
Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state. Proc Natl Acad Sci U S A (2011) 5.53
Cancer stem cells: current status and evolving complexities. Cell Stem Cell (2012) 5.07
Slug and Sox9 cooperatively determine the mammary stem cell state. Cell (2012) 4.77
The melanocyte differentiation program predisposes to metastasis after neoplastic transformation. Nat Genet (2005) 4.70
BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells. Cell Stem Cell (2010) 4.66
Self-renewal and solid tumor stem cells. Oncogene (2004) 4.60
Evolution of the cancer stem cell model. Cell Stem Cell (2014) 4.38
Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis. Genes Dev (2009) 4.29
Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity. Cell (2013) 3.61
Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression. J Biol Chem (2002) 3.18
Unravelling cancer stem cell potential. Nat Rev Cancer (2013) 3.06
Collective invasion in breast cancer requires a conserved basal epithelial program. Cell (2013) 2.51
Cancer stem cells in solid tumors: an overview. Semin Radiat Oncol (2009) 1.98
An integrative genomic and transcriptomic analysis reveals molecular pathways and networks regulated by copy number aberrations in basal-like, HER2 and luminal cancers. Breast Cancer Res Treat (2009) 1.93
Protein kinase C α is a central signaling node and therapeutic target for breast cancer stem cells. Cancer Cell (2013) 1.86
The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance. EMBO Mol Med (2013) 1.59
Smad signaling is required to maintain epigenetic silencing during breast cancer progression. Cancer Res (2010) 1.47
Mammary stem cells have myoepithelial cell properties. Nat Cell Biol (2014) 1.39
An integrin-linked machinery of cytoskeletal regulation that enables experimental tumor initiation and metastatic colonization. Cancer Cell (2013) 1.36
Transient SNAIL1 expression is necessary for metastatic competence in breast cancer. Cancer Res (2014) 0.98
A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages. Nat Cell Biol (2014) 2.01