Published in Methods Enzymol on January 01, 1997
An unbiased cell morphology-based screen for new, biologically active small molecules. PLoS Biol (2005) 2.11
HAMP domain conformers that propagate opposite signals in bacterial chemoreceptors. PLoS Biol (2013) 1.60
Structural analysis of CsoS1A and the protein shell of the Halothiobacillus neapolitanus carboxysome. PLoS Biol (2007) 1.57
Structural mechanism of ER retrieval of MHC class I by cowpox. PLoS Biol (2012) 1.49
The aspartate-less receiver (ALR) domains: distribution, structure and function. PLoS Pathog (2015) 1.43
Interactions between human glutamate carboxypeptidase II and urea-based inhibitors: structural characterization. J Med Chem (2008) 1.39
The structural basis of gas-responsive transcription by the human nuclear hormone receptor REV-ERBbeta. PLoS Biol (2009) 1.31
The crystal structure of the SV40 T-antigen origin binding domain in complex with DNA. PLoS Biol (2007) 1.12
Conformational change-induced repeat domain expansion regulates Rap phosphatase quorum-sensing signal receptors. PLoS Biol (2013) 0.99
Discovery of tricyclic indoles that potently inhibit Mcl-1 using fragment-based methods and structure-based design. J Med Chem (2015) 0.87
Synthesis, characterization, and computational study of a new dimethoxy-chalcone. J Mol Model (2014) 0.84
Structure-based mechanism for early PLP-mediated steps of rabbit cytosolic serine hydroxymethyltransferase reaction. Biomed Res Int (2013) 0.81
Structure and dynamics underlying elementary ligand binding events in human pacemaking channels. Elife (2016) 0.80
Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms. Elife (2016) 0.79
Structural properties, cytotoxicity, and anti-inflammatory activity of silver(I) complexes with tris(p-tolyl)phosphine and 5-chloro-2-mercaptobenzothiazole. Bioinorg Chem Appl (2010) 0.79
Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine. J Med Chem (2017) 0.78
Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15. Nature (2017) 0.78
1.92 Angstrom Zinc-Free APOBEC3F Catalytic Domain Crystal Structure. J Mol Biol (2016) 0.78
Integrating macromolecular X-ray diffraction data with the graphical user interface iMosflm. Nat Protoc (2017) 0.77
Heat Capacity Changes for Transition-State Analogue Binding and Catalysis with Human 5'-Methylthioadenosine Phosphorylase. ACS Chem Biol (2016) 0.77
Crystal structure of Mdm12 reveals the architecture and dynamic organization of the ERMES complex. EMBO Rep (2016) 0.77
Structural insights into the interaction of the ribosomal P stalk protein P2 with a type II ribosome-inactivating protein ricin. Sci Rep (2016) 0.77
Structure of the sirtuin-linked macrodomain SAV0325 from Staphylococcus aureus. Protein Sci (2016) 0.77
G-quadruplex RNA binding and recognition by the lysine-specific histone demethylase-1 enzyme. RNA (2016) 0.76
Structural insight for chain selection and stagger control in collagen. Sci Rep (2016) 0.76
Somatic Hypermutation-Induced Changes in the Structure and Dynamics of HIV-1 Broadly Neutralizing Antibodies. Structure (2016) 0.76
The large terminase DNA packaging motor grips DNA with its ATPase domain for cleavage by the flexible nuclease domain. Nucleic Acids Res (2017) 0.76
High resolution crystal structure of the catalytic domain of MCR-1. Sci Rep (2016) 0.75
Crystal Structure of a Putative Cytochrome P450 Alkane Hydroxylase (CYP153D17) from Sphingomonas sp. PAMC 26605 and Its Conformational Substrate Binding. Int J Mol Sci (2016) 0.75
Membrane skeletal association and post-translational allosteric regulation of Toxoplasma gondii GAPDH1. Mol Microbiol (2016) 0.75
Discovery and Biological Characterization of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors. FEBS Lett (2016) 0.75
Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site. Proc Natl Acad Sci U S A (2017) 0.75
S-Nitrosylation Induces Structural and Dynamical Changes in a Rhodanese Family Protein. J Mol Biol (2016) 0.75
Structural Insights into Substrate Recognition by Clostridium difficile Sortase. Front Cell Infect Microbiol (2016) 0.75
Design and Functional Characterization of a Novel Abscisic Acid Analog. Sci Rep (2017) 0.75
Chemically Linked Vemurafenib Inhibitors Promote an Inactive BRAF(V600E) Conformation. ACS Chem Biol (2016) 0.75
Lysine Decarboxylase with an Enhanced Affinity for Pyridoxal 5-Phosphate by Disulfide Bond-Mediated Spatial Reconstitution. PLoS One (2017) 0.75
A High-Resolution Crystal Structure of a Psychrohalophilic α-Carbonic Anhydrase from Photobacterium profundum Reveals a Unique Dimer Interface. PLoS One (2016) 0.75
La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs. Elife (2017) 0.75
Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts. Biochimie (2017) 0.75
Comprehensive understanding of acetohydroxyacid synthase inhibition by different herbicide families. Proc Natl Acad Sci U S A (2017) 0.75
Structural basis for redox sensitivity in Corynebacterium glutamicum diaminopimelate epimerase: an enzyme involved in l-lysine biosynthesis. Sci Rep (2017) 0.75
Insight into the 3D structure and substrate specificity of previously uncharacterized GNAT superfamily acetyltransferases from pathogenic bacteria. Biochim Biophys Acta (2016) 0.75
Structure and biochemistry of phenylacetaldehyde dehydrogenase from the Pseudomonas putida S12 styrene catabolic pathway. Arch Biochem Biophys (2017) 0.75
Structural basis of how stress-induced MDMX phosphorylation activates p53. Oncogene (2015) 0.75
Specific Recognition of a Single-Stranded RNA Sequence by a Synthetic Antibody Fragment. J Mol Biol (2016) 0.75
Structural Insights on PHA Binding Protein PhaP from Aeromonas hydrophila. Sci Rep (2016) 0.75
Binding of Crumbs to the Par-6 CRIB-PDZ Module Is Regulated by Cdc42. Biochemistry (2016) 0.75
Metal-Dependent Function of a Mammalian Acireductone Dioxygenase. Biochemistry (2016) 0.75
BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice. Proc Natl Acad Sci U S A (2017) 0.75
Structural Analysis of Thymidylate Synthase from Kaposi's Sarcoma-Associated Herpesvirus with the Anticancer Drug Raltitrexed. PLoS One (2016) 0.75
Lessons from the Crystal Structure of the S. aureus Surface Protein Clumping Factor A in Complex With Tefibazumab, an Inhibiting Monoclonal Antibody. EBioMedicine (2016) 0.75
Active Site Binding Is Not Sufficient for Reductive Deiodination by Iodotyrosine Deiodinase. Biochemistry (2017) 0.75
Protection of the Queuosine Biosynthesis Enzyme QueF from Irreversible Oxidation by a Conserved Intramolecular Disulfide. Biomolecules (2017) 0.75
Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases. Elife (2017) 0.75
Conformational Plasticity in the Transsynaptic Neurexin-Cerebellin-Glutamate Receptor Adhesion Complex. Structure (2016) 0.75
Novel Aldo-Keto Reductases for the Biocatalytic Conversion of 3-Hydroxybutanal to 1,3-Butanediol: Structural and Biochemical Studies. Appl Environ Microbiol (2017) 0.75
The Open Form Inducer Approach for Structure-Based Drug Design. PLoS One (2016) 0.75
Crystal structure and structure-based mutagenesis of actin-specific ADP-ribosylating toxin CPILE-a as novel enterotoxin. PLoS One (2017) 0.75
Crystal structure of a putative oligopeptide-binding periplasmic protein from a hyperthermophile. Extremophiles (2016) 0.75
Ligand binding phenomena that pertain to the metabolic function of renalase. Arch Biochem Biophys (2016) 0.75
Structural basis of subunit selectivity for competitive NMDA receptor antagonists with preference for GluN2A over GluN2B subunits. Proc Natl Acad Sci U S A (2017) 0.75
Structural Basis for the Mechanism of ATP-Dependent Acetone Carboxylation. Sci Rep (2017) 0.75
Structural Elements Recognized by Abacavir-Induced T Cells. Int J Mol Sci (2017) 0.75
Amino acetate functionalized Schiff base organotin(IV) complexes as anticancer drugs: synthesis, structural characterization, and in vitro cytotoxicity studies. Invest New Drugs (2008) 0.75
Understanding pre-mRNA splicing through crystallography. Methods (2017) 0.75
Evaluation of antiproliferative activities and apoptosis induction caused by copper(II)-benzothiazolesulfonamide complexes in Jurkat T lymphocytes and Caco-2 cells. J Biol Inorg Chem (2008) 0.75
Generating enzyme and radical-mediated bisubstrates as tools for investigating Gcn5-related N-acetyltransferases. FEBS Lett (2017) 0.75
NBS1 Phosphorylation Status Dictates Repair Choice of Dysfunctional Telomeres. Mol Cell (2017) 0.75
Three conserved regions in baculovirus sulfhydryl oxidase, P33, are critical for enzymatic activity and function. J Virol (2017) 0.75
Structural and functional analysis of a low-temperature-active alkaline esterase from South China Sea marine sediment microbial metagenomic library. J Ind Microbiol Biotechnol (2015) 0.75
Protection of calves by a prefusion-stabilized bovine RSV F vaccine. NPJ Vaccines (2017) 0.75
HKL-3000: the integration of data reduction and structure solution--from diffraction images to an initial model in minutes. Acta Crystallogr D Biol Crystallogr (2006) 13.29
Multiparametric scaling of diffraction intensities. Acta Crystallogr A (2003) 11.36
Double chromodomains cooperate to recognize the methylated histone H3 tail. Nature (2005) 5.53
A new generation of crystallographic validation tools for the protein data bank. Structure (2011) 3.41
In situ proteolysis for protein crystallization and structure determination. Nat Methods (2007) 3.05
A novel family of sequence-specific endoribonucleases associated with the clustered regularly interspaced short palindromic repeats. J Biol Chem (2008) 3.00
Structural basis for CoREST-dependent demethylation of nucleosomes by the human LSD1 histone demethylase. Mol Cell (2006) 2.32
Phosphorylation regulates SIRT1 function. PLoS One (2008) 2.30
Structure and control of the actin regulatory WAVE complex. Nature (2010) 2.25
Structural insight into the mechanism of substrate specificity and catalytic activity of an HD-domain phosphohydrolase: the 5'-deoxyribonucleotidase YfbR from Escherichia coli. J Mol Biol (2008) 2.19
Data mining of metal ion environments present in protein structures. J Inorg Biochem (2008) 2.14
The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity. Cancer Cell (2006) 2.09
The protein structure initiative structural genomics knowledgebase. Nucleic Acids Res (2008) 2.03
Structural basis for dsRNA recognition and interferon antagonism by Ebola VP35. Nat Struct Mol Biol (2010) 2.01
The structural genomics experimental pipeline: insights from global target lists. Proteins (2004) 1.98
Secondary structure of Huntingtin amino-terminal region. Structure (2009) 1.98
NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein. Nature (2010) 1.95
The Enzyme Function Initiative. Biochemistry (2011) 1.87
WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes. Proc Natl Acad Sci U S A (2010) 1.71
Protein crystallography for non-crystallographers, or how to get the best (but not more) from published macromolecular structures. FEBS J (2007) 1.70
Measurement errors and their consequences in protein crystallography. Acta Crystallogr D Biol Crystallogr (2003) 1.62
Identification of unknown protein function using metabolite cocktail screening. Structure (2012) 1.62
Structural and immunologic characterization of bovine, horse, and rabbit serum albumins. Mol Immunol (2012) 1.49
Methodology and applications of automatic electron-density map interpretation by six-dimensional rotational and translational search for molecular fragments. Acta Crystallogr D Biol Crystallogr (2002) 1.44
The Structural Biology Knowledgebase: a portal to protein structures, sequences, functions, and methods. J Struct Funct Genomics (2011) 1.36
High-resolution timing of cell cycle-regulated gene expression. Proc Natl Acad Sci U S A (2007) 1.35
Crystal structure of the MACPF domain of human complement protein C8 alpha in complex with the C8 gamma subunit. J Mol Biol (2008) 1.29
Crystal structure of Pseudomonas aeruginosa SPM-1 provides insights into variable zinc affinity of metallo-beta-lactamases. J Mol Biol (2006) 1.27
Diffraction data analysis in the presence of radiation damage. Acta Crystallogr D Biol Crystallogr (2010) 1.27
Biochemical and structural characterization of apolipoprotein A-I binding protein, a novel phosphoprotein with a potential role in sperm capacitation. Endocrinology (2008) 1.20
Mechanism of N10-formyltetrahydrofolate synthetase derived from complexes with intermediates and inhibitors. Protein Sci (2011) 1.19
Structural basis for Marburg virus VP35-mediated immune evasion mechanisms. Proc Natl Acad Sci U S A (2012) 1.18
Structural genomics: keeping up with expanding knowledge of the protein universe. Curr Opin Struct Biol (2007) 1.17
The many faces of radiation-induced changes. J Synchrotron Radiat (2006) 1.13
SCEPTRANS: an online tool for analyzing periodic transcription in yeast. Bioinformatics (2007) 1.13
From nonpeptide toward noncarbon protease inhibitors: metallacarboranes as specific and potent inhibitors of HIV protease. Proc Natl Acad Sci U S A (2005) 1.11
Crystal structure of RNase T, an exoribonuclease involved in tRNA maturation and end turnover. Structure (2007) 1.07
Unmet challenges of structural genomics. Curr Opin Struct Biol (2010) 1.06
Determination of protein structures--a series of fortunate events. Biophys J (2008) 1.06
Substrate specificity of mammalian N-terminal α-amino methyltransferase NRMT. Biochemistry (2012) 1.05
Molecular determinants for antibody binding on group 1 house dust mite allergens. J Biol Chem (2011) 1.05
Structural and functional insight into the universal stress protein family. Evol Appl (2013) 1.05
Single enantiomer of YK-4-279 demonstrates specificity in targeting the oncogene EWS-FLI1. Oncotarget (2012) 1.04
Harvesting the high-hanging fruit: the structure of the YdeN gene product from Bacillus subtilis at 1.8 angstroms resolution. Acta Crystallogr D Biol Crystallogr (2004) 1.04
Structural and immunologic characterization of Ara h 1, a major peanut allergen. J Biol Chem (2011) 1.03
Crystal structures of mite allergens Der f 1 and Der p 1 reveal differences in surface-exposed residues that may influence antibody binding. J Mol Biol (2008) 1.03
Asymmetric synthesis of 2,3-dihydro-2-arylquinazolin-4-ones: methodology and application to a potent fluorescent tubulin inhibitor with anticancer activity. J Med Chem (2008) 1.02
The HP1a disordered C terminus and chromo shadow domain cooperate to select target peptide partners. Chembiochem (2011) 1.02
X-ray crystallography: Assessment and validation of protein-small molecule complexes for drug discovery. Expert Opin Drug Discov (2011) 1.00
Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis. Chem Biol (2008) 1.00
Analysis of solvent content and oligomeric states in protein crystals--does symmetry matter? Protein Sci (2008) 1.00
Protein crystallography for aspiring crystallographers or how to avoid pitfalls and traps in macromolecular structure determination. FEBS J (2013) 0.99
Expression, purification and the 1.8 angstroms resolution crystal structure of human neuron specific enolase. J Mol Biol (2004) 0.99
3-(1-Pyridinio)propanesulfonate and 3-(benzyldimethylammonio)propanesulfonate monohydrate. Acta Crystallogr C (2007) 0.97
Structure of the human cohesin inhibitor Wapl. Proc Natl Acad Sci U S A (2013) 0.95
Structural, functional, and inhibition studies of a Gcn5-related N-acetyltransferase (GNAT) superfamily protein PA4794: a new C-terminal lysine protein acetyltransferase from pseudomonas aeruginosa. J Biol Chem (2013) 0.95
Structural and biochemical basis for polyamine binding to the Tp0655 lipoprotein of Treponema pallidum: putative role for Tp0655 (TpPotD) as a polyamine receptor. J Mol Biol (2007) 0.95
Bayesian statistical studies of the Ramachandran distribution. Stat Appl Genet Mol Biol (2005) 0.93
Broad-substrate screen as a tool to identify substrates for bacterial Gcn5-related N-acetyltransferases with unknown substrate specificity. Protein Sci (2012) 0.93
An extremely SAD case: structure of a putative redox-enzyme maturation protein from Archaeoglobus fulgidus at 3.4 A resolution. Acta Crystallogr D Biol Crystallogr (2007) 0.92
Structure of human thymidylate synthase under low-salt conditions. Acta Crystallogr D Biol Crystallogr (2005) 0.92
Molecular basis for phosphospecific recognition of histone H3 tails by Survivin paralogues at inner centromeres. Mol Biol Cell (2012) 0.91
Alternaria alternata allergen Alt a 1: a unique β-barrel protein dimer found exclusively in fungi. J Allergy Clin Immunol (2012) 0.91
Double trouble-Buffer selection and His-tag presence may be responsible for nonreproducibility of biomedical experiments. Protein Sci (2014) 0.91
The quality and validation of structures from structural genomics. Methods Mol Biol (2014) 0.90
Structure of the type III secretion effector protein ExoU in complex with its chaperone SpcU. PLoS One (2012) 0.89
Crystal structure of human complement protein C8gamma at 1.2 A resolution reveals a lipocalin fold and a distinct ligand binding site. Biochemistry (2002) 0.88
New surface contacts formed upon reductive lysine methylation: improving the probability of protein crystallization. Protein Sci (2010) 0.88
Identification of patterns in diffraction intensities affected by radiation exposure. J Synchrotron Radiat (2012) 0.87
Crystal structures of the effector-binding domain of repressor Central glycolytic gene Regulator from Bacillus subtilis reveal ligand-induced structural changes upon binding of several glycolytic intermediates. Mol Microbiol (2008) 0.87
Benefits of structural genomics for drug discovery research. Infect Disord Drug Targets (2009) 0.87
The crystal structure of the effector-binding domain of the trehalose repressor TreR from Bacillus subtilis 168 reveals a unique quarternary assembly. Proteins (2007) 0.86
Structure of the effector-binding domain of the arabinose repressor AraR from Bacillus subtilis. Acta Crystallogr D Biol Crystallogr (2012) 0.86
Structural analysis of a putative aminoglycoside N-acetyltransferase from Bacillus anthracis. J Mol Biol (2011) 0.86
Data management in the modern structural biology and biomedical research environment. Methods Mol Biol (2014) 0.86
Crystal structure of a transcriptional regulator TM1030 from Thermotoga maritima solved by an unusual MAD experiment. J Struct Biol (2007) 0.84
Crystal structure and molecular modeling study of N-carbamoylsarcosine amidase Ta0454 from Thermoplasma acidophilum. J Struct Biol (2009) 0.84
Ultratight crystal packing of a 10 kDa protein. Acta Crystallogr D Biol Crystallogr (2013) 0.84
Autoinhibition of Mint1 adaptor protein regulates amyloid precursor protein binding and processing. Proc Natl Acad Sci U S A (2012) 0.84
The future of crystallography in drug discovery. Expert Opin Drug Discov (2013) 0.84
Serum albumins-unusual allergens. Biochim Biophys Acta (2013) 0.84
Structural and functional characterizations of SsgB, a conserved activator of developmental cell division in morphologically complex actinomycetes. J Biol Chem (2009) 0.83
Kinetic, spectroscopic, and structural investigations of the soybean lipoxygenase-1 first-coordination sphere mutant, Asn694Gly. Biochemistry (2006) 0.83
Comparative genome sequencing reveals chemotype-specific gene clusters in the toxigenic black mold Stachybotrys. BMC Genomics (2014) 0.83
Structure of Escherichia coli RutC, a member of the YjgF family and putative aminoacrylate peracid reductase of the rut operon. Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 0.82
Crystallization and preliminary X-ray analysis of Ebola VP35 interferon inhibitory domain mutant proteins. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.80
Assessing the accuracy of template-based structure prediction metaservers by comparison with structural genomics structures. J Struct Funct Genomics (2012) 0.80
A multi-faceted analysis of RutD reveals a novel family of α/β hydrolases. Proteins (2012) 0.80
Crystal structure of a putative isochorismatase hydrolase from Oleispira antarctica. J Struct Funct Genomics (2012) 0.80
Crystal structures of TM0549 and NE1324--two orthologs of E. coli AHAS isozyme III small regulatory subunit. Protein Sci (2007) 0.79
Expression, purification and X-ray crystallographic analysis of thioredoxin from Streptomyces coelicolor. Acta Crystallogr Sect F Struct Biol Cryst Commun (2005) 0.79
Refinement by shifting secondary structure elements improves sequence alignments. Proteins (2015) 0.79
The crystal structure of the AF2331 protein from Archaeoglobus fulgidus DSM 4304 forms an unusual interdigitated dimer with a new type of alpha + beta fold. Protein Sci (2009) 0.78