Published in Proc Natl Acad Sci U S A on June 17, 2013
Structure of cohesin subcomplex pinpoints direct shugoshin-Wapl antagonism in centromeric cohesion. Nat Struct Mol Biol (2014) 1.30
Structural Basis and IP6 Requirement for Pds5-Dependent Cohesin Dynamics. Mol Cell (2016) 0.96
Cohesin Releases DNA through Asymmetric ATPase-Driven Ring Opening. Mol Cell (2016) 0.96
Sororin pre-mRNA splicing is required for proper sister chromatid cohesion in human cells. EMBO Rep (2014) 0.90
Structure and function of cohesin's Scc3/SA regulatory subunit. FEBS Lett (2014) 0.88
Arabidopsis thaliana WAPL is essential for the prophase removal of cohesin during meiosis. PLoS Genet (2014) 0.88
Cohesin recruits the Esco1 acetyltransferase genome wide to repress transcription and promote cohesion in somatic cells. Proc Natl Acad Sci U S A (2015) 0.84
Cohesin mutations in human cancer. Biochim Biophys Acta (2016) 0.81
Intact Cohesion, Anaphase, and Chromosome Segregation in Human Cells Harboring Tumor-Derived Mutations in STAG2. PLoS Genet (2016) 0.80
Structural Insights into Ring Formation of Cohesin and Related Smc Complexes. Trends Cell Biol (2016) 0.78
Topology and structure of an engineered human cohesin complex bound to Pds5B. Nat Commun (2016) 0.77
Cohesin Can Remain Associated with Chromosomes during DNA Replication. Cell Rep (2017) 0.76
Opposing Functions of the N-terminal Acetyltransferases Naa50 and NatA in Sister-chromatid Cohesion. J Biol Chem (2016) 0.75
The Opposing Actions of Arabidopsis CHROMOSOME TRANSMISSION FIDELITY7 and WINGS APART-LIKE1 and 2 Differ in Mitotic and Meiotic Cells. Plant Cell (2016) 0.75
Scc2/Nipbl hops between chromosomal cohesin rings after loading. Elife (2017) 0.75
In Favor of Establishment: Regulation of Chromatid Cohesion in Plants. Front Plant Sci (2017) 0.75
Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr (2004) 227.01
Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr D Biol Crystallogr (1997) 137.43
HKL-3000: the integration of data reduction and structure solution--from diffraction images to an initial model in minutes. Acta Crystallogr D Biol Crystallogr (2006) 13.29
Two distinct pathways remove mammalian cohesin from chromosome arms in prophase and from centromeres in anaphase. Cell (2000) 5.10
Shugoshin collaborates with protein phosphatase 2A to protect cohesin. Nature (2006) 4.23
Mitotic chromosomal instability and cancer: mouse modelling of the human disease. Nat Rev Cancer (2010) 3.95
PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation. Dev Cell (2006) 3.88
Wapl controls the dynamic association of cohesin with chromatin. Cell (2006) 3.83
Eco1-dependent cohesin acetylation during establishment of sister chromatid cohesion. Science (2008) 3.72
Dissociation of cohesin from chromosome arms and loss of arm cohesion during early mitosis depends on phosphorylation of SA2. PLoS Biol (2005) 3.72
A molecular determinant for the establishment of sister chromatid cohesion. Science (2008) 3.39
Building sister chromatid cohesion: smc3 acetylation counteracts an antiestablishment activity. Mol Cell (2009) 3.33
The cohesin complex and its roles in chromosome biology. Genes Dev (2008) 3.33
Human Wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase. Curr Biol (2006) 3.14
Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast. Mol Cell (2008) 3.01
Sister chromatid cohesion: a simple concept with a complex reality. Annu Rev Cell Dev Biol (2008) 2.99
Sororin mediates sister chromatid cohesion by antagonizing Wapl. Cell (2010) 2.12
Cohesin: a catenase with separate entry and exit gates? Nat Cell Biol (2011) 2.11
Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates. Mol Cell (2005) 2.05
Eco1 is a novel acetyltransferase that can acetylate proteins involved in cohesion. Curr Biol (2002) 2.04
Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase. Curr Biol (2007) 1.79
Releasing cohesin from chromosome arms in early mitosis: opposing actions of Wapl-Pds5 and Sgo1. Genes Dev (2009) 1.77
Cohesin's DNA exit gate is distinct from its entrance gate and is regulated by acetylation. Cell (2012) 1.75
Two human orthologues of Eco1/Ctf7 acetyltransferases are both required for proper sister-chromatid cohesion. Mol Biol Cell (2005) 1.73
Sororin cooperates with the acetyltransferase Eco2 to ensure DNA replication-dependent sister chromatid cohesion. Proc Natl Acad Sci U S A (2010) 1.41
Genetic and molecular analysis of wings apart-like (wapl), a gene controlling heterochromatin organization in Drosophila melanogaster. Genetics (2000) 1.41
Phosphorylation-enabled binding of SGO1-PP2A to cohesin protects sororin and centromeric cohesion during mitosis. Nat Cell Biol (2012) 1.38
Prophase pathway-dependent removal of cohesin from human chromosomes requires opening of the Smc3-Scc1 gate. EMBO J (2013) 1.19
Disengaging the Smc3/kleisin interface releases cohesin from Drosophila chromosomes during interphase and mitosis. EMBO J (2013) 1.16
Regulation of sororin by Cdk1-mediated phosphorylation. J Cell Sci (2011) 1.08
Interaction of Sororin protein with polo-like kinase 1 mediates resolution of chromosomal arm cohesion. J Biol Chem (2011) 1.03
Scc1 sumoylation by Mms21 promotes sister chromatid recombination through counteracting Wapl. Genes Dev (2012) 1.02
Structural insights into the regulation of cohesion establishment by Wpl1. EMBO J (2013) 0.93
HKL-3000: the integration of data reduction and structure solution--from diffraction images to an initial model in minutes. Acta Crystallogr D Biol Crystallogr (2006) 13.29
Mutational inactivation of STAG2 causes aneuploidy in human cancer. Science (2011) 5.04
PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation. Dev Cell (2006) 3.88
Three-dimensional structure of the complexin/SNARE complex. Neuron (2002) 3.69
The spindle checkpoint, aneuploidy, and cancer. Oncogene (2004) 3.61
A new generation of crystallographic validation tools for the protein data bank. Structure (2011) 3.41
Self-regulated Plk1 recruitment to kinetochores by the Plk1-PBIP1 interaction is critical for proper chromosome segregation. Mol Cell (2006) 3.38
Structural basis of actin filament nucleation and processive capping by a formin homology 2 domain. Nature (2005) 3.31
The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20. Mol Cell (2002) 3.24
The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins. Nat Struct Mol Biol (2007) 3.15
Ubiquitin-induced oligomerization of the RNA sensors RIG-I and MDA5 activates antiviral innate immune response. Immunity (2012) 3.07
The Mad2 spindle checkpoint protein has two distinct natively folded states. Nat Struct Mol Biol (2004) 2.87
Hierarchical regulation of WASP/WAVE proteins. Mol Cell (2008) 2.86
SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity. Cancer Cell (2011) 2.73
Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint. Mol Cell (2004) 2.66
Mechanistic insight into the allosteric activation of a ubiquitin-conjugating enzyme by RING-type ubiquitin ligases. Proc Natl Acad Sci U S A (2005) 2.60
Conformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpoint. EMBO J (2004) 2.57
Recorded scan times can limit the accuracy of sedimentation coefficients in analytical ultracentrifugation. Anal Biochem (2013) 2.57
Human Bub1 protects centromeric sister-chromatid cohesion through Shugoshin during mitosis. Proc Natl Acad Sci U S A (2004) 2.52
Structure of the photolyase-like domain of cryptochrome 1 from Arabidopsis thaliana. Proc Natl Acad Sci U S A (2004) 2.48
Side chain and backbone contributions of Phe508 to CFTR folding. Nat Struct Mol Biol (2004) 2.43
Structural basis for CoREST-dependent demethylation of nucleosomes by the human LSD1 histone demethylase. Mol Cell (2006) 2.32
Human MMS21/NSE2 is a SUMO ligase required for DNA repair. Mol Cell Biol (2005) 2.31
Crystal structure of a 12 ANK repeat stack from human ankyrinR. EMBO J (2002) 2.27
ATP binding and ATP hydrolysis play distinct roles in the function of 26S proteasome. Mol Cell (2006) 2.26
p31comet blocks Mad2 activation through structural mimicry. Cell (2007) 2.26
Structure and control of the actin regulatory WAVE complex. Nature (2010) 2.25
Structural basis of Rho GTPase-mediated activation of the formin mDia1. Mol Cell (2005) 2.16
Nde1-mediated inhibition of ciliogenesis affects cell cycle re-entry. Nat Cell Biol (2011) 2.15
Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaks. EMBO J (2006) 2.13
Artificial ligand binding within the HIF2alpha PAS-B domain of the HIF2 transcription factor. Proc Natl Acad Sci U S A (2009) 2.02
Structural basis for dsRNA recognition and interferon antagonism by Ebola VP35. Nat Struct Mol Biol (2010) 2.01
Nucleoporin levels regulate cell cycle progression and phase-specific gene expression. Dev Cell (2008) 2.00
The structural genomics experimental pipeline: insights from global target lists. Proteins (2004) 1.98
Secondary structure of Huntingtin amino-terminal region. Structure (2009) 1.98
High-precision isothermal titration calorimetry with automated peak-shape analysis. Anal Chem (2012) 1.92
[20] Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol (1997) 1.92
FWD1-mediated degradation of FREQUENCY in Neurospora establishes a conserved mechanism for circadian clock regulation. EMBO J (2003) 1.89
Identification of two novel components of the human NDC80 kinetochore complex. J Biol Chem (2003) 1.89
Structural basis for a Munc13-1 homodimer to Munc13-1/RIM heterodimer switch. PLoS Biol (2006) 1.88
Protein metamorphosis: the two-state behavior of Mad2. Structure (2008) 1.83
Requirements for efficient correction of ΔF508 CFTR revealed by analyses of evolved sequences. Cell (2012) 1.81
Enzyme structure and dynamics affect hydrogen tunneling: the impact of a remote side chain (I553) in soybean lipoxygenase-1. Proc Natl Acad Sci U S A (2008) 1.80
Mechanism of actin filament nucleation by the bacterial effector VopL. Nat Struct Mol Biol (2011) 1.80
WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes. Proc Natl Acad Sci U S A (2010) 1.71
Arp2/3 complex is bound and activated by two WASP proteins. Proc Natl Acad Sci U S A (2011) 1.70
Phospho-H2A and cohesin specify distinct tension-regulated Sgo1 pools at kinetochores and inner centromeres. Curr Biol (2013) 1.69
Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1. Mol Biol Cell (2006) 1.68
Tracking spindle checkpoint signals from kinetochores to APC/C. Trends Biochem Sci (2013) 1.66
A requirement for breast-cancer-associated gene 1 (BRCA1) in the spindle checkpoint. Proc Natl Acad Sci U S A (2004) 1.63
Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates. J Biol Chem (2004) 1.63
Measurement errors and their consequences in protein crystallography. Acta Crystallogr D Biol Crystallogr (2003) 1.62
Cohesion fatigue induces chromatid separation in cells delayed at metaphase. Curr Biol (2011) 1.60
Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6. EMBO J (2003) 1.60
Structural basis of histone demethylation by LSD1 revealed by suicide inactivation. Nat Struct Mol Biol (2007) 1.59
The assembly of a GTPase-kinase signalling complex by a bacterial catalytic scaffold. Nature (2010) 1.58
Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis. Nat Struct Mol Biol (2010) 1.58
Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC. Cell (2003) 1.56
Structural and energetic mechanisms of cooperative autoinhibition and activation of Vav1. Cell (2010) 1.51
Kinetic and structural insights into the mechanism of AMPylation by VopS Fic domain. J Biol Chem (2010) 1.51
A TOG:αβ-tubulin complex structure reveals conformation-based mechanisms for a microtubule polymerase. Science (2012) 1.50
Adsorption of ionizable organic contaminants on multi-walled carbon nanotubes with different oxygen contents. J Hazard Mater (2010) 1.45
Methodology and applications of automatic electron-density map interpretation by six-dimensional rotational and translational search for molecular fragments. Acta Crystallogr D Biol Crystallogr (2002) 1.44
Structural insights into histone lysine demethylation. Curr Opin Struct Biol (2010) 1.44
Structural basis for the inhibition of the LSD1 histone demethylase by the antidepressant trans-2-phenylcyclopropylamine. Biochemistry (2007) 1.44
Changes at the KinA PAS-A dimerization interface influence histidine kinase function. Biochemistry (2008) 1.43
Sororin cooperates with the acetyltransferase Eco2 to ensure DNA replication-dependent sister chromatid cohesion. Proc Natl Acad Sci U S A (2010) 1.41
Overview of current methods in sedimentation velocity and sedimentation equilibrium analytical ultracentrifugation. Curr Protoc Protein Sci (2013) 1.41
Dynamic evolution of the human immunodeficiency virus type 1 pathogenic factor, Nef. J Virol (2006) 1.41
Insights into mad2 regulation in the spindle checkpoint revealed by the crystal structure of the symmetric mad2 dimer. PLoS Biol (2008) 1.41
Autophosphorylation-dependent activation of human Mps1 is required for the spindle checkpoint. Proc Natl Acad Sci U S A (2007) 1.39
Clustering of Nck by a 12-residue Tir phosphopeptide is sufficient to trigger localized actin assembly. J Cell Biol (2004) 1.39
Gold nanoparticle based label-free SERS probe for ultrasensitive and selective detection of trinitrotoluene. J Am Chem Soc (2009) 1.38
Structure of human nicotinamide/nicotinic acid mononucleotide adenylyltransferase. Basis for the dual substrate specificity and activation of the oncolytic agent tiazofurin. J Biol Chem (2002) 1.38
Phosphorylation-enabled binding of SGO1-PP2A to cohesin protects sororin and centromeric cohesion during mitosis. Nat Cell Biol (2012) 1.38
Crystal structure of human dihydrolipoamide dehydrogenase: NAD+/NADH binding and the structural basis of disease-causing mutations. J Mol Biol (2005) 1.37
Structure of human Mad1 C-terminal domain reveals its involvement in kinetochore targeting. Proc Natl Acad Sci U S A (2012) 1.37
Determination of protein complex stoichiometry through multisignal sedimentation velocity experiments. Anal Biochem (2010) 1.36
High-resolution timing of cell cycle-regulated gene expression. Proc Natl Acad Sci U S A (2007) 1.35
Two distinct pathways for inhibiting pds1 ubiquitination in response to DNA damage. J Biol Chem (2003) 1.35
Structure and substrate recruitment of the human spindle checkpoint kinase Bub1. Mol Cell (2008) 1.32
The crystal structure of a Munc13 C-terminal module exhibits a remarkable similarity to vesicle tethering factors. Structure (2011) 1.32
The Smc complexes in DNA damage response. Cell Biosci (2012) 1.31
Structural analysis of human Cdc20 supports multisite degron recognition by APC/C. Proc Natl Acad Sci U S A (2012) 1.31
Functional analysis of the spindle-checkpoint proteins using an in vitro ubiquitination assay. Methods Mol Biol (2004) 1.30