Published in Lab Invest on November 14, 2016
A simple method for displaying the hydropathic character of a protein. J Mol Biol (1982) 150.65
An international classification and grading system for age-related maculopathy and age-related macular degeneration. The International ARM Epidemiological Study Group. Surv Ophthalmol (1995) 10.05
HTRA1 promoter polymorphism in wet age-related macular degeneration. Science (2006) 7.12
The epidemiology of age-related macular degeneration. Am J Ophthalmol (2004) 5.86
A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration. Science (2006) 5.67
Age-related macular degeneration. N Engl J Med (2006) 5.06
A temperature-dependent switch from chaperone to protease in a widely conserved heat shock protein. Cell (1999) 4.78
Age-related macular degeneration is associated with an unstable ARMS2 (LOC387715) mRNA. Nat Genet (2008) 4.16
A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration. Proc Natl Acad Sci U S A (2007) 3.50
Association of HTRA1 mutations and familial ischemic cerebral small-vessel disease. N Engl J Med (2009) 1.96
Genetic and functional dissection of HTRA1 and LOC387715 in age-related macular degeneration. PLoS Genet (2010) 1.83
Human HtrA, an evolutionarily conserved serine protease identified as a differentially expressed gene product in osteoarthritic cartilage. J Biol Chem (1998) 1.53
Risk- and non-risk-associated variants at the 10q26 AMD locus influence ARMS2 mRNA expression but exclude pathogenic effects due to protein deficiency. Hum Mol Genet (2011) 1.53
Implications of the serine protease HtrA1 in amyloid precursor protein processing. Proc Natl Acad Sci U S A (2005) 1.47
Primary structure of a putative serine protease specific for IGF-binding proteins. FEBS Lett (1996) 1.46
Increased expression of multifunctional serine protease, HTRA1, in retinal pigment epithelium induces polypoidal choroidal vasculopathy in mice. Proc Natl Acad Sci U S A (2011) 1.45
The HtrA1 serine protease is down-regulated during human melanoma progression and represses growth of metastatic melanoma cells. Oncogene (2002) 1.44
Overexpression of HTRA1 leads to ultrastructural changes in the elastic layer of Bruch's membrane via cleavage of extracellular matrix components. PLoS One (2011) 1.42
A web-accessible complete transcriptome of normal human and DMD muscle. Neuromuscul Disord (2002) 1.38
Binding of proteins to the PDZ domain regulates proteolytic activity of HtrA1 serine protease. Biochem J (2004) 1.30
Developmentally regulated expression of mouse HtrA3 and its role as an inhibitor of TGF-beta signaling. Dev Growth Differ (2004) 1.29
HTRA1 variants in exudative age-related macular degeneration and interactions with smoking and CFH. Invest Ophthalmol Vis Sci (2008) 1.28
Human HtrA1 in the archived eyes with age-related macular degeneration. Trans Am Ophthalmol Soc (2007) 1.15
Serine protease HtrA1 associates with microtubules and inhibits cell migration. Mol Cell Biol (2009) 1.12
Downregulation of HtrA1 promotes resistance to anoikis and peritoneal dissemination of ovarian cancer cells. Cancer Res (2010) 1.10
HtrA proteins as targets in therapy of cancer and other diseases. Expert Opin Ther Targets (2010) 1.09
Cerebral small-vessel disease protein HTRA1 controls the amount of TGF-β1 via cleavage of proTGF-β1. Hum Mol Genet (2011) 1.08
Identification of novel substrates for the serine protease HTRA1 in the human RPE secretome. Invest Ophthalmol Vis Sci (2010) 1.08
Localization of age-related macular degeneration-associated ARMS2 in cytosol, not mitochondria. Invest Ophthalmol Vis Sci (2009) 1.07
Analysis of the indel at the ARMS2 3'UTR in age-related macular degeneration. Hum Genet (2010) 1.04
Elevated expression of serine protease HtrA1 in preeclampsia and its role in trophoblast cell migration and invasion. Am J Obstet Gynecol (2008) 0.99
Left ventricular global transcriptional profiling in human end-stage dilated cardiomyopathy. Genomics (2009) 0.98
Structural and functional analysis of HtrA1 and its subdomains. Structure (2012) 0.96
Intracellular localization of the tumor suppressor HtrA1/Prss11 and its association with HPV16 E6 and E7 proteins. J Cell Biochem (2008) 0.96
Differentiation of exudative age-related macular degeneration and polypoidal choroidal vasculopathy in the ARMS2/HTRA1 locus. Invest Ophthalmol Vis Sci (2012) 0.93
The serine protease HtrA1 is upregulated in the human placenta during pregnancy. J Histochem Cytochem (2004) 0.93
Interactive expressions of HtrA1 and VEGF in human vitreous humors and fetal RPE cells. Invest Ophthalmol Vis Sci (2011) 0.91
Structural features in the NH2-terminal region of a model eukaryotic signal peptide influence the site of its cleavage by signal peptidase. J Biol Chem (1990) 0.89
Biologically active fibronectin fragments stimulate release of MCP-1 and catabolic cytokines from murine retinal pigment epithelium. Invest Ophthalmol Vis Sci (2009) 0.88
A missense variant in FGD6 confers increased risk of polypoidal choroidal vasculopathy. Nat Genet (2016) 0.75
Longitudinal Evaluation of Wound Healing after Penetrating Corneal Injury: Anterior Segment Optical Coherence Tomography Study. Curr Eye Res (2017) 0.75
Disruption of retinal pigment epithelial cell properties under the exposure of cotinine. Sci Rep (2017) 0.75