Published in FEBS J on November 17, 2016
Heparanase regulation of cancer, autophagy and inflammation: new mechanisms and targets for therapy. FEBS J (2016) 0.80
Biglycan- and Sphingosine Kinase-1 Signaling Crosstalk Regulates the Synthesis of Macrophage Chemoattractants. Int J Mol Sci (2017) 0.75
Decorin and biglycan are necessary for maintaining collagen fibril structure, fiber realignment, and mechanical properties of mature tendons. Matrix Biol (2017) 0.75
Autophagy in the pathogenesis of disease. Cell (2008) 34.68
Immunity, inflammation, and cancer. Cell (2010) 28.27
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The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol (2000) 5.21
The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages. J Clin Invest (2005) 3.99
EGFR-mediated Beclin 1 phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistance. Cell (2013) 2.63
Gene expression signatures for tumor progression, tumor subtype, and tumor thickness in laser-microdissected melanoma tissues. Clin Cancer Res (2007) 2.62
Reactive oxygen species in inflammation and tissue injury. Antioxid Redox Signal (2013) 2.59
Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammation. J Clin Invest (2010) 2.48
Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation. Nat Cell Biol (2010) 2.37
Proteoglycans in cancer biology, tumour microenvironment and angiogenesis. J Cell Mol Med (2011) 2.21
The hypoxia-associated factor switches cells from HIF-1α- to HIF-2α-dependent signaling promoting stem cell characteristics, aggressive tumor growth and invasion. Cancer Res (2011) 2.21
Heparan sulfate proteoglycans: heavy hitters in the angiogenesis arena. J Clin Invest (2001) 2.18
Jekyll and Hyde: the role of the microenvironment on the progression of cancer. J Pathol (2010) 2.14
The role of decorin in collagen fibrillogenesis and skin homeostasis. Glycoconj J (2003) 2.13
Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors. J Biol Chem (2009) 2.12
The proteoglycan biglycan regulates expression of the B cell chemoattractant CXCL13 and aggravates murine lupus nephritis. J Clin Invest (2010) 2.07
Decorin is a biological ligand for the epidermal growth factor receptor. J Biol Chem (1999) 1.93
Proteoglycan form and function: A comprehensive nomenclature of proteoglycans. Matrix Biol (2015) 1.91
Model structure of decorin and implications for collagen fibrillogenesis. J Biol Chem (1996) 1.88
Modulation of canonical Wnt signaling by the extracellular matrix component biglycan. Proc Natl Acad Sci U S A (2011) 1.85
Endothelial deletion of hypoxia-inducible factor-2alpha (HIF-2alpha) alters vascular function and tumor angiogenesis. Blood (2009) 1.81
Decorin is a novel antagonistic ligand of the Met receptor. J Cell Biol (2009) 1.76
Decorin suppresses tumor cell growth by activating the epidermal growth factor receptor. J Clin Invest (1998) 1.70
Decorin prevents metastatic spreading of breast cancer. Oncogene (2005) 1.69
Imprinted tumor suppressor genes ARHI and PEG3 are the most frequently down-regulated in human ovarian cancers by loss of heterozygosity and promoter methylation. Cancer (2008) 1.69
Endorepellin, a novel inhibitor of angiogenesis derived from the C terminus of perlecan. J Biol Chem (2002) 1.67
Interleukin-1beta and the autoinflammatory diseases. N Engl J Med (2009) 1.63
Decorin binds to a narrow region of the epidermal growth factor (EGF) receptor, partially overlapping but distinct from the EGF-binding epitope. J Biol Chem (2002) 1.53
Heparan sulfate chains of perlecan are indispensable in the lens capsule but not in the kidney. EMBO J (2003) 1.53
Basement membrane proteoglycans: modulators Par Excellence of cancer growth and angiogenesis. Mol Cells (2009) 1.51
Tumor microenvironment: Modulation by decorin and related molecules harboring leucine-rich tandem motifs. Int J Cancer (2008) 1.51
Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21. Sci Signal (2011) 1.50
Decorin evokes protracted internalization and degradation of the epidermal growth factor receptor via caveolar endocytosis. J Biol Chem (2005) 1.50
Decorin: a guardian from the matrix. Am J Pathol (2012) 1.46
Gene expression profiling indicates that immunohistochemical expression of CD40 is a marker of an inflammatory reaction in the tumor stroma of diffuse large B-cell lymphoma. Leuk Lymphoma (2012) 1.43
Suppression of tumorigenicity by adenovirus-mediated gene transfer of decorin. Oncogene (2002) 1.42
Decorin binds near the C terminus of type I collagen. J Biol Chem (2000) 1.40
Biologically active decorin is a monomer in solution. J Biol Chem (2003) 1.40
Matrix control of transforming growth factor-β function. J Biochem (2012) 1.39
Impaired angiogenesis, delayed wound healing and retarded tumor growth in perlecan heparan sulfate-deficient mice. Cancer Res (2004) 1.36
An antimetastatic role for decorin in breast cancer. Am J Pathol (2008) 1.34
A role for decorin in cutaneous wound healing and angiogenesis. Wound Repair Regen (2006) 1.33
Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels. J Biol Chem (2010) 1.32
Complexity of danger: the diverse nature of damage-associated molecular patterns. J Biol Chem (2014) 1.32
The glycosaminoglycan chain of decorin plays an important role in collagen fibril formation at the early stages of fibrillogenesis. FEBS J (2007) 1.31
Fibroblast growth factor-binding protein is a novel partner for perlecan protein core. J Biol Chem (2001) 1.29
CD47 deficiency confers cell and tissue radioprotection by activation of autophagy. Autophagy (2012) 1.27
Decorin causes autophagy in endothelial cells via Peg3. Proc Natl Acad Sci U S A (2013) 1.22
Biological interplay between proteoglycans and their innate immune receptors in inflammation. FEBS J (2013) 1.22
Erythropoietin promotes MCF-7 breast cancer cell migration by an ERK/mitogen-activated protein kinase-dependent pathway and is primarily responsible for the increase in migration observed in hypoxia. J Biol Chem (2005) 1.21
Biglycan is overexpressed in pancreatic cancer and induces G1-arrest in pancreatic cancer cell lines. Gastroenterology (2001) 1.20
Decorin antagonizes the angiogenic network: concurrent inhibition of Met, hypoxia inducible factor 1α, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3. J Biol Chem (2011) 1.20
Endorepellin in vivo: targeting the tumor vasculature and retarding cancer growth and metabolism. J Natl Cancer Inst (2006) 1.17
Integrating proteomic and transcriptomic high-throughput surveys for search of new biomarkers of colon tumors. Funct Integr Genomics (2010) 1.12
Prognostic significance of HIF-2alpha/EPAS1 expression in hepatocellular carcinoma. World J Gastroenterol (2007) 1.11
Small leucine-rich proteoglycans, at the crossroad of cancer growth and inflammation. Curr Opin Genet Dev (2012) 1.11
Transcriptional regulation of decorin gene expression. Induction by quiescence and repression by tumor necrosis factor-alpha. J Biol Chem (1995) 1.11
Small leucine-rich proteoglycans orchestrate receptor crosstalk during inflammation. Cell Cycle (2012) 1.11
Decorin protein core affects the global gene expression profile of the tumor microenvironment in a triple-negative orthotopic breast carcinoma xenograft model. PLoS One (2012) 1.09
Hypoxia-induced, perinecrotic expression of endothelial Per-ARNT-Sim domain protein-1/hypoxia-inducible factor-2alpha correlates with tumor progression, vascularization, and focal macrophage infiltration in bladder cancer. Clin Cancer Res (2002) 1.09
The extracellular matrix: Tools and insights for the "omics" era. Matrix Biol (2015) 1.08
The protein core of the proteoglycan perlecan binds specifically to fibroblast growth factor-7. J Biol Chem (2000) 1.08
Decorin-TGFβ axis in hepatic fibrosis and cirrhosis. J Histochem Cytochem (2012) 1.08
The class A scavenger receptor binds to proteoglycans and mediates adhesion of macrophages to the extracellular matrix. J Biol Chem (2002) 1.08
Molecular mechanisms underlying chronic inflammation-associated cancers. Cancer Lett (2013) 1.06
Biglycan is a specific marker and an autocrine angiogenic factor of tumour endothelial cells. Br J Cancer (2012) 1.06
Tumour suppressor activity of human imprinted gene PEG3 in a glioma cell line. Genes Cells (2001) 1.05
A role for perlecan in the suppression of growth and invasion in fibrosarcoma cells. Cancer Res (1997) 1.05
The extracellular matrix and transforming growth factor-β1: Tale of a strained relationship. Matrix Biol (2015) 1.03
Integrin alpha2beta1 is the required receptor for endorepellin angiostatic activity. J Biol Chem (2007) 1.03
Perlecan regulates developmental angiogenesis by modulating the VEGF-VEGFR2 axis. Matrix Biol (2009) 1.01
Abnormal expression of perlecan proteoglycan in metastatic melanomas. Cancer Res (1994) 1.01
Latent TGF-β-binding proteins. Matrix Biol (2015) 1.01
Heparan and chondroitin sulfate on growth plate perlecan mediate binding and delivery of FGF-2 to FGF receptors. Matrix Biol (2006) 1.00
Identification of novel candidate tumour marker genes for intrahepatic cholangiocarcinoma. J Hepatol (2008) 1.00
Overexpression of human NOX1 complex induces genome instability in mammalian cells. Free Radic Biol Med (2007) 0.98
The systemic delivery of an oncolytic adenovirus expressing decorin inhibits bone metastasis in a mouse model of human prostate cancer. Gene Ther (2014) 0.97
Biglycan enhances gastric cancer invasion by activating FAK signaling pathway. Oncotarget (2014) 0.96
MT1-MMP-mediated cleavage of decorin in corneal angiogenesis. J Vasc Res (2009) 0.94
Matrilysin/matrix metalloproteinase-7(MMP7) cleavage of perlecan/HSPG2 creates a molecular switch to alter prostate cancer cell behavior. Matrix Biol (2014) 0.94
Erythropoietin induces lymph node lymphangiogenesis and lymph node tumor metastasis. Cancer Res (2011) 0.94
Biglycan-triggered TLR-2- and TLR-4-signaling exacerbates the pathophysiology of ischemic acute kidney injury. Matrix Biol (2014) 0.93
Insights into the key roles of proteoglycans in breast cancer biology and translational medicine. Biochim Biophys Acta (2015) 0.92
NLRP3 suppresses NK cell-mediated responses to carcinogen-induced tumors and metastases. Cancer Res (2012) 0.92
Cell-matrix interactions: focus on proteoglycan-proteinase interplay and pharmacological targeting in cancer. FEBS J (2014) 0.92
Up-regulated biglycan expression correlates with the malignancy in human colorectal cancers. Clin Exp Med (2011) 0.91
Active site specificity profiling of the matrix metalloproteinase family: Proteomic identification of 4300 cleavage sites by nine MMPs explored with structural and synthetic peptide cleavage analyses. Matrix Biol (2015) 0.90
Decoding the Matrix: Instructive Roles of Proteoglycan Receptors. Biochemistry (2015) 0.90
Pivotal role for decorin in angiogenesis. Matrix Biol (2015) 0.90
Decorin interferes with platelet-derived growth factor receptor signaling in experimental hepatocarcinogenesis. FEBS J (2013) 0.89
Decorin induces mitophagy in breast carcinoma cells via peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) and mitostatin. J Biol Chem (2014) 0.89
The ECM proteoglycan decorin links desmoplasia and inflammation in chronic pancreatitis. J Clin Pathol (2006) 0.89
Decorin activates AMPK, an energy sensor kinase, to induce autophagy in endothelial cells. Matrix Biol (2014) 0.88